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Macrophage migration inhibitory factor

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Pages 153-164 | Published online: 02 Mar 2005

Keep up to date with the latest research on this topic with citation updates for this article.

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Shou-Gang Kuai, Qin-Fang Ou, De-Hong You, Zhong-Bo Shang, Jun Wang, Jun Liu, Xi-Ke Zhou, Hao Pei & Li-Hua Huang. (2016) Functional polymorphisms in the gene encoding macrophage migration inhibitory factor (MIF) are associated with active pulmonary tuberculosis. Infectious Diseases 48:3, pages 222-228.
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Xiao Zhang, Wenhao Weng, Wen Xu, Yulan Wang, Wenjun Yu, Xun Tang, Lifang Ma, Qiuhui Pan, Jiayi Wang & Fenyong Sun. (2015) The association between the migration inhibitory factor −173G/C polymorphism and cancer risk: a meta-analysis. OncoTargets and Therapy 8, pages 601-613.
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Chao Zhang, Ting Liang, Jing Song, Shiqin Jiang, Lili Qu & Guihua Hou. (2011) Evaluation of macrophage migration inhibitory factor as an imaging marker for hepatocellular carcinoma in murine models. Scandinavian Journal of Gastroenterology 46:6, pages 720-726.
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Dorothee Greven, Lin Leng & Richard Bucala. (2010) Autoimmune diseases: MIF as a therapeutic target. Expert Opinion on Therapeutic Targets 14:3, pages 253-264.
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Shin Kariya, Patricia A. Schachern, Sebahattin Cureoglu, Vladimir Tsuprun, Mitsuhiro Okano, Kazunori Nishizaki & Steven K. Juhn. (2008) Up-regulation of macrophage migration inhibitory factor induced by endotoxin in experimental otitis media with effusion in mice. Acta Oto-Laryngologica 128:7, pages 750-755.
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Articles from other publishers (66)

Faramarz Farzad, Neda Yaghoubi, Farnaz Zahedi Avval, Majid Khadem-Rezaiyan, Farahzad Jabbari Azad & Masoud Youssefi. (2023) Increasing Levels of Macrophage Migration Inhibitory Factor in COVID-19 Infection and Its Pathophysiological Role; Cut-off Value Determination Might Be Clinically Misleading. Archives of Clinical Infectious Diseases 18:2.
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Miloš Vratarić, Vladimir Šenk, Biljana Bursać, Ljupka Gligorovska, Djurdjica Ignjatović, Sanja Kovačević, Nataša Veličković & Ana Djordjevic. (2021) Fructose diet ameliorates effects of macrophage migration inhibitory factor deficiency on prefrontal cortex inflammation, neural plasticity, and behavior in male mice. BioFactors 49:1, pages 90-107.
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Chunfang Zan, Bishan Yang, Markus Brandhofer, Omar El Bounkari & Jürgen Bernhagen. (2022) D‐dopachrome tautomerase in cardiovascular and inflammatory diseases—A new kid on the block or just another MIF ? . The FASEB Journal 36:11.
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Nuzhat Maisha, Nidhi Naik, Mawuyon Okesola, Tobias Coombs, Rose Zilberberg, Narendra Pandala & Erin Lavik. (2021) Engineering PEGylated Polyester Nanoparticles to Reduce Complement-Mediated Infusion Reaction. Bioconjugate Chemistry 32:10, pages 2154-2166.
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Francesco Nucera, Federica Lo Bello, Sj S. Shen, Paolo Ruggeri, Irene Coppolino, Antonino Di Stefano, Cristiana Stellato, Vincenzo Casolaro, Phil M. Hansbro, Ian M. Adcock & Gaetano Caramori. (2021) Role of Atypical Chemokines and Chemokine Receptors Pathways in the Pathogenesis of COPD. Current Medicinal Chemistry 28:13, pages 2577-2653.
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Christopher Ludtka, Justin Silberman, Erika Moore & Josephine B. Allen. (2021) Macrophages in microgravity: the impact of space on immune cells. npj Microgravity 7:1.
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Kusumawadee Utispan & Sittichai Koontongkaew. (2021) Macrophage migration inhibitory factor modulates proliferation, cell cycle, and apoptotic activity in head and neck cancer cell lines. Journal of Dental Sciences 16:1, pages 342-348.
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Idrissa Diallo, Abderrahim Benmoussa, Jonathan Laugier, Abdimajid Osman, Walter E. Hitzler & Patrick Provost. (2020) Platelet Pathogen Reduction Technologies Alter the MicroRNA Profile of Platelet-Derived Microparticles. Frontiers in Cardiovascular Medicine 7.
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A.A. Wright, M. Todorovic, M. Murtaza, J.A. St John & J.A. Ekberg. (2020) Macrophage migration inhibitory factor and its binding partner HTRA1 are expressed by olfactory ensheathing cells. Molecular and Cellular Neuroscience 102, pages 103450.
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Dzmitry Sinitski, Katrin Gruner, Markus Brandhofer, Christos Kontos, Pascal Winkler, Anja Reinstädler, Priscila Bourilhon, Zhangping Xiao, Robbert Cool, Aphrodite Kapurniotu, Frank J. Dekker, Ralph Panstruga & Jürgen Bernhagen. (2020) Cross-kingdom mimicry of the receptor signaling and leukocyte recruitment activity of a human cytokine by its plant orthologs. Journal of Biological Chemistry 295:3, pages 850-867.
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Dzmitry Sinitski, Katrin Gruner, Jürgen Bernhagen & Ralph Panstruga. 2020. Macrophage Migration Inhibitory Factor. Macrophage Migration Inhibitory Factor 249 261 .
Yveth Marlene Ortiz-García, Gabriela Morales-Velazquez, Alejandra García-Orozco, Annie Riera-Leal, Alma Lizbeth Hernández-Hernández, Belinda Claudia Gómez-Meda, Guillermo Moises Zúñiga-González & Ana Lourdes Zamora-Perez. 2019. Gingival Disease - A Professional Approach for Treatment and Prevention. Gingival Disease - A Professional Approach for Treatment and Prevention.
Aphrodite Kapurniotu, Ozgun Gokce & Jürgen Bernhagen. (2019) The Multitasking Potential of Alarmins and Atypical Chemokines. Frontiers in Medicine 6.
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Esther L. Ashworth Briggs, Tze’Yo Toh, Rajaraman Eri, Alex W. Hewitt & Anthony L. Cook. (2018) Uteroglobin and FLRG concentrations in aqueous humor are associated with age in primary open angle glaucoma patients. BMC Ophthalmology 18:1.
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K. M. Dubova, A. V. Sokolov, N. P. Gorbunov & V. R. Samygina. (2018) Preliminary X-ray Diffraction Study of Macrophage Migration Inhibitory Factor at Near-Atomic Resolution. Crystallography Reports 63:6, pages 951-954.
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M. V. Petoukhov, A. V. Sokolov, L. A. Dadinova, N. P. Gorbunov, D. I. Svergun & V. R. Samygina. (2018) Small-Angle X-ray Scattering Study of Macrophage Migration Inhibitory Factor Complexed with Albumin. Crystallography Reports 63:4, pages 589-593.
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Vinay Trivedi‐Parmar, Michael J. Robertson, José A. Cisneros, Stefan G. Krimmer & William L. Jorgensen. (2018) Optimization of Pyrazoles as Phenol Surrogates to Yield Potent Inhibitors of Macrophage Migration Inhibitory Factor. ChemMedChem 13:11, pages 1092-1097.
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Michael Lacy, Christos Kontos, Markus Brandhofer, Kathleen Hille, Sabine Gröning, Dzmitry Sinitski, Priscila Bourilhon, Eric Rosenberg, Christine Krammer, Tharshika Thavayogarajah, Georgios Pantouris, Maria Bakou, Christian Weber, Elias Lolis, Jürgen Bernhagen & Aphrodite Kapurniotu. (2018) Identification of an Arg-Leu-Arg tripeptide that contributes to the binding interface between the cytokine MIF and the chemokine receptor CXCR4. Scientific Reports 8:1.
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Werner Höllriegl, Alexander Bauer, Bernhard Baumgartner, Barbara Dietrich, Patrice Douillard, Randolf J. Kerschbaumer, Gerald Höbarth, Jeffrey S. McKee, Alexander Schinagl, Frederick W.K. Tam, Michael Thiele, Alfred Weber, Martin Wolfsegger, Marietta Turecek, Eva-Maria Muchitsch, Friedrich Scheiflinger & Helmut Glantschnig. (2018) Pharmacokinetics, disease-modifying activity, and safety of an experimental therapeutic targeting an immunological isoform of macrophage migration inhibitory factor, in rat glomerulonephritis. European Journal of Pharmacology 820, pages 206-216.
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Zhong-bo Shang, Jun Wang, Shou-gang Kuai, Yin-yin Zhang, Qin-fang Ou, Hao Pei & Li-hua Huang. (2018) Serum Macrophage Migration Inhibitory Factor as a Biomarker of Active Pulmonary Tuberculosis. Annals of Laboratory Medicine 38:1, pages 9-16.
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Fei Ma, Dimitrios E. Kouzoukas, Katherine L. Meyer-Siegler, David E. Hunt, Lin Leng, Richard Bucala & Pedro L. Vera. (2017) Macrophage migration inhibitory factor mediates protease-activated receptor 4-induced bladder pain through urothelial high mobility group box 1. Physiological Reports 5:24, pages e13549.
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Veronica Marin, Kyle Poulsen, Gemma Odena, Megan R. McMullen, Jose Altamirano, Pau Sancho-Bru, Claudio Tiribelli, Juan Caballeria, Natalia Rosso, Ramon Bataller & Laura E. Nagy. (2017) Hepatocyte-derived macrophage migration inhibitory factor mediates alcohol-induced liver injury in mice and patients. Journal of Hepatology 67:5, pages 1018-1025.
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Camila Cristina Guimarães Nobre, Josélio Maria Galvão de Araújo, Thales Allyrio Araújo de Medeiros Fernandes, Ricardo Ney Oliveira Cobucci, Daniel Carlos Ferreira Lanza, Vânia Sousa Andrade & José Veríssimo Fernandes. (2016) Macrophage Migration Inhibitory Factor (MIF): Biological Activities and Relation with Cancer. Pathology & Oncology Research 23:2, pages 235-244.
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Romina A. Cutrullis, Patricia B. Petray & Ricardo S. Corral. (2017) MIF-driven activation of macrophages induces killing of intracellular Trypanosoma cruzi dependent on endogenous production of tumor necrosis factor, nitric oxide and reactive oxygen species. Immunobiology 222:2, pages 423-431.
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Hiroshi Yukitake, Masayuki Takizawa & Haruhide Kimura. (2017) Macrophage Migration Inhibitory Factor as an Emerging Drug Target to Regulate Antioxidant Response Element System. Oxidative Medicine and Cellular Longevity 2017, pages 1-6.
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Abhay Kumar Singh, Georgios Pantouris, Sebastian Borosch, Siripong Rojanasthien & Thomas Yoonsang Cho. (2017) Structural basis for decreased induction of class IB PI3-kinases expression by MIF inhibitors. Journal of Cellular and Molecular Medicine 21:1, pages 142-153.
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Saisha A. Nalawade, Yousef Al-Abed & Thomas G. Forsthuber. 2017. MIF Family Cytokines in Innate Immunity and Homeostasis. MIF Family Cytokines in Innate Immunity and Homeostasis 77 95 .
Li-Rong Lin, Dan-Hong Lin, Man-Li Tong, Li-Li Liu, Jin-Yi Fan, Xiao-Zhen Zhu, Kun Gao, Mei-Jun Chen, Wei-Hong Zheng, Hui-Lin Zhang, Shu-Lian Li, Hui-Ling Lin, Zhi-Feng Lin, Jian-Jun Niu & Tian-Ci Yang. (2016) Macrophage migration inhibitory factor as a novel cerebrospinal fluid marker for neurosyphilis among HIV-negative patients. Clinica Chimica Acta 463, pages 103-108.
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Valeria A. Kostevich, Alexey V. Sokolov, Natalia A. Grudinina, Elena T. Zakharova, Valeria R. Samygina & Vadim B. Vasilyev. (2015) Interaction of macrophage migration inhibitory factor with ceruloplasmin: role of labile copper ions. BioMetals 28:5, pages 817-826.
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Maor Sauler, Richard Bucala & Patty J. Lee. (2015) Role of macrophage migration inhibitory factor in age-related lung disease. American Journal of Physiology-Lung Cellular and Molecular Physiology 309:1, pages L1-L10.
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Li Chen, Xia Zhou, Lucy X. Fan, Ying Yao, Katherine I. Swenson-Fields, Mihaela Gadjeva, Darren P. Wallace, Dorien J.M. Peters, Alan Yu, Jared J. Grantham & Xiaogang Li. (2015) Macrophage migration inhibitory factor promotes cyst growth in polycystic kidney disease. Journal of Clinical Investigation 125:6, pages 2399-2412.
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Bong-Sung Kim, Norbert Pallua, Jürgen Bernhagen & Richard Bucala. (2015) The macrophage migration inhibitory factor protein superfamily in obesity and wound repair. Experimental & Molecular Medicine 47:5, pages e161-e161.
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Adrian Israelson, Dara Ditsworth, Shuying Sun, SungWon Song, Jason Liang, Marian Hruska-Plochan, Melissa McAlonis-Downes, Salah Abu-Hamad, Guy Zoltsman, Tom Shani, Marcus Maldonado, Anh Bui, Michael Navarro, Huilin Zhou, Martin Marsala, Brian K. Kaspar, Sandrine Da Cruz & Don W. Cleveland. (2015) Macrophage Migration Inhibitory Factor as a Chaperone Inhibiting Accumulation of Misfolded SOD1. Neuron 86:1, pages 218-232.
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Doreen Nazeih Assaad Younan, Naglaa Agamia, Adel Elshafei & Nancy Ebeid. (2015) Serum Level of Macrophage Migration Inhibitory Factor (MIF) in Egyptians With Alopecia Areata and Its Relation to the Clinical Severity of the Disease. Journal of Clinical Laboratory Analysis 29:1, pages 74-79.
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Brian S. Fulton. 2014. Drug Discovery for the Treatment of Addiction. Drug Discovery for the Treatment of Addiction 290 333 .
Guanggang Qu, Raymond Fetterer, Lin Leng, Xin Du, Dante Zarlenga, Zhiqiang Shen, Wenyu Han, Richard Bucala & Wenbin Tuo. (2014) Ostertagia ostertagi macrophage migration inhibitory factor is present in all developmental stages and may cross-regulate host functions through interaction with the host receptor. International Journal for Parasitology 44:6, pages 355-367.
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Biji Mathew, Jeffrey R. Jacobson, Jessica H. Siegler, Jaideep Moitra, Michael Blasco, Lishi Xie, Crystal Unzueta, Tong Zhou, Carrie Evenoski, Mohammed Al-Sakka, Rajesh Sharma, Ben Huey, Aydogan Bulent, Brett Smith, Sundararajan Jayaraman, Narsa M. Reddy, Shekhar P. Reddy, Günter Fingerle-Rowson, Richard Bucala, Steven M. Dudek, Viswanathan Natarajan, Ralph R. Weichselbaum & Joe G. N. Garcia. (2013) Role of Migratory Inhibition Factor in Age-Related Susceptibility to Radiation Lung Injury via NF-E2–Related Factor–2 and Antioxidant Regulation. American Journal of Respiratory Cell and Molecular Biology 49:2, pages 269-278.
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Lei Xu, Youyong Li, Huiyong Sun, Xuechu Zhen, Chunhua Qiao, Sheng Tian & Tingjun Hou. (2013) Current developments of macrophage migration inhibitory factor (MIF) inhibitors. Drug Discovery Today 18:11-12, pages 592-600.
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Wei-Lun Yu, Brian D. Jones, MinJin Kang, Justin C. Hammons, James J. La Clair & Michael D. Burkart. (2013) Spirohexenolide A Targets Human Macrophage Migration Inhibitory Factor (hMIF). Journal of Natural Products 76:5, pages 817-823.
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Cláudia de Jesus Fernandes Covas, Cynthia Chester Cardoso, Adriano Gomes-Silva, Joanna Reis Santos Oliveira, Alda Maria Da-Cruz & Milton Ozório Moraes. (2013) Candidate gene case-control and functional study shows macrophage inhibitory factor (MIF) polymorphism is associated with cutaneous leishmaniasis. Cytokine 61:1, pages 168-172.
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Fengwei Bai, Oluwatoyin A. Asojo, Pier Cirillo, Mihai Ciustea, Michel Ledizet, Paul A. Aristoff, Lin Leng, Raymond A. Koski, Thomas J. Powell, Richard Bucala & Karen G. Anthony. (2012) A Novel Allosteric Inhibitor of Macrophage Migration Inhibitory Factor (MIF). Journal of Biological Chemistry 287:36, pages 30653-30663.
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Qinbo Yuan, Meilin Wang, Miaomiao Wang, Zhengdong Zhang & Wei Zhang. (2011) Macrophage migration inhibitory factor gene -173G>C polymorphism and risk of bladder cancer in southeast China: a case–control analysis. Molecular Biology Reports 39:3, pages 3109-3115.
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FuZhou Wang, HaiBo Wu, ShiQin Xu, XiRong Guo, Jie Yang & XiaoFeng Shen. (2011) Macrophage migration inhibitory factor activates cyclooxygenase 2–prostaglandin E2 in cultured spinal microglia. Neuroscience Research 71:3, pages 210-218.
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William L. Jorgensen, Alexander Trofimov, Xin Du, Alissa A. Hare, Lin Leng & Richard Bucala. (2011) Benzisothiazolones as modulators of macrophage migration inhibitory factor. Bioorganic & Medicinal Chemistry Letters 21:15, pages 4545-4549.
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Diane Tshikudi Malu, Benoit Bélanger, François Desautels, Karine Kelendji, Esther Dalko, Jaime Sanchez-Dardon, Lin Leng, Richard Bucala, Abhay R. Satoskar & Tatiana Scorza. (2011) Macrophage Migration Inhibitory Factor: A Downregulator of Early T Cell-Dependent IFN-γ Responses in Plasmodium chabaudi adami (556 KA)-Infected Mice . The Journal of Immunology 186:11, pages 6271-6279.
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Yeming Han & Chao Zhang. (2010) Macrophage migration inhibitory factor plays a pivotal role in hepatocellular carcinoma and may be a noninvasive imaging target. Medical Hypotheses 75:6, pages 530-532.
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Haruhide Kimura, Yoshimi Sato, Yasukazu Tajima, Hirobumi Suzuki, Hiroshi Yukitake, Toshihiro Imaeda, Masahiro Kajino, Hideyuki Oki, Masayuki Takizawa & Seiichi Tanida. (2010) BTZO-1, a Cardioprotective Agent, Reveals that Macrophage Migration Inhibitory Factor Regulates ARE-Mediated Gene Expression. Chemistry & Biology 17:12, pages 1282-1294.
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Hajer Ouertatani-Sakouhi, Farah El-Turk, Bruno Fauvet, Min-Kyu Cho, Damla Pinar Karpinar, Didier Le Roy, Manfred Dewor, Thierry Roger, Jürgen Bernhagen, Thierry Calandra, Markus Zweckstetter & Hilal A. Lashuel. (2010) Identification and Characterization of Novel Classes of Macrophage Migration Inhibitory Factor (MIF) Inhibitors with Distinct Mechanisms of Action. Journal of Biological Chemistry 285:34, pages 26581-26598.
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Yoonsang ChoGregg V. CrichlowJon J. VermeireLin Leng, Xin Du, Michael E. HodsdonRichard Bucala, Michael CappelloMatt GrossFederico GaetaKirk Johnson & Elias J. Lolis. (2010) Allosteric inhibition of macrophage migration inhibitory factor revealed by ibudilast. Proceedings of the National Academy of Sciences 107:25, pages 11313-11318.
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Katherine L. Meyer-Siegler, Jacob Cox, Lin Leng, Richard Bucala & Pedro L. Vera. (2010) Macrophage migration inhibitory factor anti-thrombin III complexes are decreased in bladder cancer patient serum: Complex formation as a mechanism of inactivation. Cancer Letters 290:1, pages 49-57.
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Jonathan L Jesneck, Sayan Mukherjee, Zoya Yurkovetsky, Merlise Clyde, Jeffrey R Marks, Anna E Lokshin & Joseph Y Lo. (2009) Do serum biomarkers really measure breast cancer?. BMC Cancer 9:1.
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Zoe Cournia, Lin Leng, Sunilkumar Gandavadi, Xin Du, Richard Bucala & William L. Jorgensen. (2008) Discovery of Human Macrophage Migration Inhibitory Factor (MIF)-CD74 Antagonists via Virtual Screening. Journal of Medicinal Chemistry 52:2, pages 416-424.
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Katherine L. Meyer-Siegler, Shen-Ling Xia & Pedro L. Vera. (2009) Substance P Increases Cell-Surface Expression of CD74 (Receptor for Macrophage Migration Inhibitory Factor): In Vivo Biotinylation of Urothelial Cell-Surface Proteins. Mediators of Inflammation 2009, pages 1-8.
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Qiang Zhou, Xiaocai Yan, Jill Gershan, Rimas J. Orentas & Bryon D. Johnson. (2008) Expression of Macrophage Migration Inhibitory Factor by Neuroblastoma Leads to the Inhibition of Antitumor T Cell Reactivity In Vivo. The Journal of Immunology 181:3, pages 1877-1886.
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R.L. Tiwari, V. Singh & M.K. Barthwal. (2007) Macrophages: An elusive yet emerging therapeutic target of atherosclerosis. Medicinal Research Reviews 28:4, pages 483-544.
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Alex Kudrin & David Ray. (2007) Cunning factor: macrophage migration inhibitory factor as a redox‐regulated target. Immunology & Cell Biology 86:3, pages 232-238.
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Martin Keller, Andreas Rüegg, Sabine Werner & Hans-Dietmar Beer. (2008) Active Caspase-1 Is a Regulator of Unconventional Protein Secretion. Cell 132:5, pages 818-831.
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Rhona Stein, M. Jules Mattes, Thomas M. Cardillo, Hans J. Hansen, Chien-Hsing Chang, Jack Burton, Serengulam Govindan & David M. Goldenberg. (2007) CD74: A New Candidate Target for the Immunotherapy of B-Cell Neoplasms. Clinical Cancer Research 13:18, pages 5556s-5563s.
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Xuerong Shi, Lin Leng, Tian Wang, Wenkui Wang, Xin Du, Ji Li, Courtney McDonald, Zun Chen, James W. Murphy, Elias Lolis, Paul Noble, Warren Knudson & Richard Bucala. (2006) CD44 Is the Signaling Component of the Macrophage Migration Inhibitory Factor-CD74 Receptor Complex. Immunity 25:4, pages 595-606.
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K.A. Skjolaas, T.E. Burkey, S.S. Dritz & J.E. Minton. (2006) Effects of Salmonella enterica serovars Typhimurium (ST) and Choleraesuis (SC) on chemokine and cytokine expression in swine ileum and jejunal epithelial cells. Veterinary Immunology and Immunopathology 111:3-4, pages 199-209.
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Xinchun Lin, Huan Yang, Tohru Sakuragi, Maowen Hu, Lin L. Mantell, Shinichiro Hayashi, Yousef Al-Abed, Kevin J. Tracey, Luis Ulloa & Edmund J. Miller. (2005) α-Chemokine receptor blockade reduces high mobility group box 1 protein-induced lung inflammation and injury and improves survival in sepsis. American Journal of Physiology-Lung Cellular and Molecular Physiology 289:4, pages L583-L590.
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János Garai, Tamás Lóránd & Valéria Molnár. (2005) Ketone bodies affect the enzymatic activity of macrophage migration inhibitory factor. Life Sciences 77:12, pages 1375-1380.
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Ruth Müller, Jörg Klug, Miriam Rodewald & Andreas Meinhardt. (2005) Macrophage migration inhibitory factor suppresses transforming growth factor-β2 secretion in cultured rat testicular peritubular cells. Reproduction, Fertility and Development 17:4, pages 435.
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Katherine L Meyer-Siegler, Erica C Leifheit & Pedro L Vera. (2004) Inhibition of macrophage migration inhibitory factor decreases proliferation and cytokine expression in bladder cancer cells. BMC Cancer 4:1.
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Brian F. Jones & Michael Cappello. (2004) Hookworm infection: molecular mechanisms of disease and targets for control. Drug Discovery Today: Disease Mechanisms 1:2, pages 217-222.
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Thierry Calandra & Thierry Roger. (2003) Macrophage migration inhibitory factor: a regulator of innate immunity. Nature Reviews Immunology 3:10, pages 791-800.
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