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Expert Opinion on Therapeutic Targets Volume 7, 2003 - Issue 2
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Review

Targeting aggregation in the development of therapeutics for the treatment of Huntington’s disease and other polyglutamine repeat diseases

Joan S Steffan Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92697-4260, USA
&
Leslie Michels Thompson Department of Biological Chemistry, University of California, Irvine, CA 92697-4260, USA
Pages 201-213 | Published online: 02 Mar 2005

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Yixuan Zeng, Wenyuan Guo, Guangqing Xu, Qinmei Wang, Luyang Feng, Simei Long, Fengyin Liang, Yi Huang, Xilin Lu, Shichang Li, Jiebin Zhou, Jean-Marc Burgunder, Jiyan Pang & Zhong Pei. (2016) Xyloketal-derived small molecules show protective effect by decreasing mutant Huntingtin protein aggregates in Caenorhabditis elegans model of Huntington’s disease. Drug Design, Development and Therapy 10, pages 1443-1451.
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Tracey Newman, Christopher Sinadinos, Alex Johnston, Megan Sealey & Amrit Mudher. (2011) Using Drosophila models of neurodegenerative diseases for drug discovery. Expert Opinion on Drug Discovery 6:2, pages 129-140.
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Susan L Perlman. (2003) Spinocerebellar degeneration. Expert Opinion on Pharmacotherapy 4:10, pages 1637-1641.
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Articles from other publishers (13)

Li-Fang Lei, Guo-Ping Yang, Jun-Ling Wang, De-Maw Chuang, Wei-Hong Song, Bei-Sha Tang & Hong Jiang. (2016) Safety and efficacy of valproic acid treatment in SCA3/MJD patients. Parkinsonism & Related Disorders 26, pages 55-61.
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Barbara Calamini, Donald C. Lo & Linda S. Kaltenbach. (2013) Experimental Models for Identifying Modifiers of Polyglutamine-Induced Aggregation and Neurodegeneration. Neurotherapeutics 10:3, pages 400-415.
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Susan L. Perlman. 2012. Ataxic Disorders. Ataxic Disorders 635 654 .
Caroline L. Benn, Ruth Luthi-Carter, Alexandre Kuhn, Ghazaleh Sadri-Vakili, Kwabena L. Blankson, Sudeb C. Dalai, Darlene R. Goldstein, Tara L. Spires, Joel Pritchard, James M. Olson, Anton van Dellen, Anthony J. Hannan & Jang-Ho J. Cha. (2010) Environmental Enrichment Reduces Neuronal Intranuclear Inclusion Load But Has No Effect on Messenger RNA Expression in a Mouse Model of Huntington Disease. Journal of Neuropathology & Experimental Neurology 69:8, pages 817-827.
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Pengfei Ge, Yinan Luo, Haifeng Wang & Feng Ling. (2009) Anti-protein aggregation is a potential target for preventing delayed neuronal death after transient ischemia. Medical Hypotheses 73:6, pages 994-995.
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Anton van Dellen, Patricia M Cordery, Tara L Spires, Colin Blakemore & Anthony J Hannan. (2008) Wheel running from a juvenile age delays onset of specific motor deficits but does not alter protein aggregate density in a mouse model of Huntington's disease. BMC Neuroscience 9:1.
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Bin Huang, Johannes Schiefer, Christian Sass, Christoph M. Kosinski & Stefan Kochanek. (2008) Inducing huntingtin inclusion formation in primary neuronal cell culture and in vivo by high‐capacity adenoviral vectors expressing truncated and full‐length huntingtin with polyglutamine expansion . The Journal of Gene Medicine 10:3, pages 269-279.
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Aaron D. Gitler. (2008) Beer and Bread to Brains and Beyond: Can Yeast Cells Teach Us about Neurodegenerative Disease?. Neurosignals 16:1, pages 52-62.
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GEORGE R. JACKSON, TZU-KANG SANG & J. PAUL TAYLOR. 2006. Genetic Instabilities and Neurological Diseases. Genetic Instabilities and Neurological Diseases 587 594 .
AIDA ABU-BAKER & GUY A. ROULEAU. 2006. Genetic Instabilities and Neurological Diseases. Genetic Instabilities and Neurological Diseases 487 513 .
Huda Y. Zoghbi. 2006. Principles of Molecular Medicine. Principles of Molecular Medicine 1114 1122 .
Susan L. Perlman. (2004) Symptomatic and Disease-Modifying Therapy for the Progressive Ataxias. The Neurologist 10:5, pages 275-289.
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Joan S. SteffanNamita AgrawalJudit PallosErica RockabrandLloyd C. TrotmanNatalia SlepkoKatalin IllesTamas LukacsovichYa-Zhen ZhuElena CattaneoPier Paolo PandolfiLeslie Michels ThompsonJ. Lawrence Marsh. (2004) SUMO Modification of Huntingtin and Huntington's Disease Pathology. Science 304:5667, pages 100-104.
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