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Expert Opinion on Therapeutic Targets Volume 7, 2003 - Issue 5
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Review

Why is the Plasmodium falciparum hexose transporter a promising new drug target?

T Joët Department of Cellular and Molecular Medicine, Infectious Diseases, St George’s Hospital Medical School, Cranmer Terrace, London, SW17 ORE, UK. [email protected]
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C Morin Department of Cellular and Molecular Medicine, Infectious Diseases, St George’s Hospital Medical School, Cranmer Terrace, London, SW17 ORE, UK. [email protected]
,
J Fischbarg Department of Cellular and Molecular Medicine, Infectious Diseases, St George’s Hospital Medical School, Cranmer Terrace, London, SW17 ORE, UK. [email protected]
,
Abraham I Louw Department of Cellular and Molecular Medicine, Infectious Diseases, St George’s Hospital Medical School, Cranmer Terrace, London, SW17 ORE, UK. [email protected]
,
U Eckstein-Ludwig Department of Cellular and Molecular Medicine, Infectious Diseases, St George’s Hospital Medical School, Cranmer Terrace, London, SW17 ORE, UK. [email protected]
,
C Woodrow Department of Cellular and Molecular Medicine, Infectious Diseases, St George’s Hospital Medical School, Cranmer Terrace, London, SW17 ORE, UK. [email protected]
&
S Krishna Department of Cellular and Molecular Medicine, Infectious Diseases, St George’s Hospital Medical School, Cranmer Terrace, London, SW17 ORE, UK. [email protected]
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Pages 593-602 | Published online: 02 Mar 2005

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Vivek K. Vyas, Sapna Bhati, Shivani Patel & Manjunath Ghate. (2022) Structure- and ligand-based drug design methods for the modeling of antimalarial agents: a review of updates from 2012 onwards. Journal of Biomolecular Structure and Dynamics 40:20, pages 10481-10506.
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Athar Alam, Manish Goyal, Mohd Shameel Iqbal, Chinmay Pal, Sumanta Dey, Samik Bindu, Pallab Maity & Uday Bandyopadhyay. (2009) Novel antimalarial drug targets: hope for new antimalarial drugs. Expert Review of Clinical Pharmacology 2:5, pages 469-489.
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Articles from other publishers (14)

Xin Jiang. (2022) An overview of the Plasmodium falciparum hexose transporter and its therapeutic interventions . Proteins: Structure, Function, and Bioinformatics 90:10, pages 1766-1778.
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Rowena E. Martin. (2019) The transportome of the malaria parasite. Biological Reviews 95:2, pages 305-332.
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Monique R. Heitmeier, Richard C. Hresko, Rachel L. Edwards, Michael J. Prinsen, Ma Xenia G. Ilagan, Audrey R. Odom John & Paul W. Hruz. (2019) Identification of druggable small molecule antagonists of the Plasmodium falciparum hexose transporter PfHT and assessment of ligand access to the glucose permeation pathway via FLAG-mediated protein engineering. PLOS ONE 14:5, pages e0216457.
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Awanish Kumar, Pragya Misra, Brijesh Sisodia, Ajit Kumar Shasany, Shyam Sundar & Anuradha Dube. (2015) Proteomic analyses of membrane enriched proteins of Leishmania donovani Indian clinical isolate by mass spectrometry. Parasitology International 64:4, pages 36-42.
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Irwin W. Sherman. 2008. Reflections on a Century of Malaria Biochemistry. Reflections on a Century of Malaria Biochemistry 325 394 .
Marina Ionita, Sanjeev Krishna, Pierre-Marc Léo, Christophe Morin & Asha Parbhu Patel. (2007) Interaction of O-(undec-10-en)-yl-d-glucose derivatives with the Plasmodium falciparum hexose transporter (PfHT). Bioorganic & Medicinal Chemistry Letters 17:17, pages 4934-4937.
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Zhi Qun TangHong Huang LinHai Lei ZhangLian Yi HanXin ChenYu Zong Chen. (2007) Prediction of Functional Class of Proteins and Peptides Irrespective of Sequence Homology by Support Vector Machines. Bioinformatics and Biology Insights 1, pages BBI.S315.
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Vahab Ali & Tomoyoshi Nozaki. (2007) Current Therapeutics, Their Problems, and Sulfur-Containing-Amino-Acid Metabolism as a Novel Target against Infections by “Amitochondriate” Protozoan Parasites. Clinical Microbiology Reviews 20:1, pages 164-187.
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Martine Fayolle, Marina Ionita, Sanjeev Krishna, Christophe Morin & Asha Parbhu Patel. (2006) Probing structure/affinity relationships for the Plasmodium falciparum hexose transporter with glucose derivatives. Bioorganic & Medicinal Chemistry Letters 16:5, pages 1267-1271.
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H. H. Lin, L. Y. Han, C. Z. Cai, Z. L. Ji & Y. Z. Chen. (2005) Prediction of transporter family from protein sequence by support vector machine approach. Proteins: Structure, Function, and Bioinformatics 62:1, pages 218-231.
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Charles J. Woodrow & Sanjeev Krishna. 2005. Molecular Approaches to Malaria. Molecular Approaches to Malaria 221 233 .
Giancarlo A. BiaginiErica M. PasiniRuth HughesHarry P. De KoningHenri J. VialPaul M. O'NeillStephen A. WardPatrick G. Bray. (2004) Characterization of the choline carrier of Plasmodium falciparum: a route for the selective delivery of novel antimalarial drugs. Blood 104:10, pages 3372-3377.
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Thierry JOËTKesinee CHOTIVANICH, Kamolrat SILAMUT, Asha P. PATELChristophe MORIN & Sanjeev KRISHNA. (2004) Analysis of Plasmodium vivax hexose transporters and effects of a parasitocidal inhibitor . Biochemical Journal 381:3, pages 905-909.
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Thierry Joët & Sanjeev Krishna. (2004) The hexose transporter of Plasmodium falciparum is a worthy drug target. Acta Tropica 89:3, pages 371-374.
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