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Review

The plastid-derived organelle ofprotozoan human parasites asa target of established and emerging drugs

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Pages 23-44 | Published online: 22 Apr 2005

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Carsten G. K. Lüder & Frank Seeber. 2016. Molecular Parasitology. Molecular Parasitology 217 239 .
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Koustav Maity, Bharat Somireddy Venkata, Neha Kapoor, Namita Surolia, Avadhesha Surolia & Kaza Suguna. (2011) Structural basis for the functional and inhibitory mechanisms of β-hydroxyacyl-acyl carrier protein dehydratase (FabZ) of Plasmodium falciparum. Journal of Structural Biology 176:2, pages 238-249.
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Marcos A. Vannier-Santos & Henrique L. Lenzi. (2011) Parasites or Cohabitants: Cruel Omnipresent Usurpers or Creative “Éminences Grises”?. Journal of Parasitology Research 2011, pages 1-19.
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Gyanendra Kumar, Tanushree Banerjee, Neha Kapoor, Namita Surolia & Avadhesha Surolia. (2010) SAR and pharmacophore models for the rhodanine inhibitors of Plasmodium falciparum enoyl‐acyl carrier protein reductase . IUBMB Life 62:3, pages 204-213.
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Cveta Tomova, Bruno M. Humbel, Willie J. C. Geerts, Rolf Entzeroth, Joost C. M. Holthuis & Arie J. Verkleij. (2009) Membrane Contact Sites between Apicoplast and ER in Toxoplasma gondii Revealed by Electron Tomography . Traffic 10:10, pages 1471-1480.
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Agam Prasad Singh, Namita Surolia & Avadhesha Surolia. (2009) Triclosan inhibit the growth of the late liver‐stage of Plasmodium . IUBMB Life 61:9, pages 923-928.
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MARILYN PARSONS, ANURADHA KARNATAKI & AMY E. DEROCHER. (2009) Evolving Insights into Protein Trafficking to the Multiple Compartments of the Apicomplexan Plastid. Journal of Eukaryotic Microbiology 56:3, pages 214-220.
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Frank Seeber. 2009. Antiparasitic and Antibacterial Drug Discovery. Antiparasitic and Antibacterial Drug Discovery 277 298 .
Ashley M. Vaughan, Matthew T. O'Neill, Alice S. Tarun, Nelly Camargo, Thuan M. Phuong, Ahmed S. I. Aly, Alan F. Cowman & Stefan H. I. Kappe. (2009) Type II fatty acid synthesis is essential only for malaria parasite late liver stage development. Cellular Microbiology 11:3, pages 506-520.
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Amy E. DeRocher, Isabelle Coppens, Anuradha Karnataki, Luke A. Gilbert, Michael E. Rome, Jean E. Feagin, Peter J. Bradley & Marilyn Parsons. (2008) A Thioredoxin Family Protein of the Apicoplast Periphery Identifies Abundant Candidate Transport Vesicles in Toxoplasma gondii . Eukaryotic Cell 7:9, pages 1518-1529.
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Johann Perruchon, Regina Ortmann, Mirko Altenkämper, Katrin Silber, Jochen Wiesner, Hassan Jomaa, Gerhard Klebe & Martin Schlitzer. (2008) Studies Addressing the Importance of Charge in the Binding of Fosmidomycin-Like Molecules to Deoxyxylulosephosphate Reductoisomerase. ChemMedChem 3:8, pages 1232-1241.
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Noriko OkamotoGeoffrey I McFadden. (2008) The mother of all parasites. Future Microbiology 3:4, pages 391-395.
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Tomoya Saito, Manami Nishi, Muoy I. Lim, Bo Wu, Takuya Maeda, Hisayuki Hashimoto, Tsutomu Takeuchi, David S. Roos & Takashi Asai. (2008) A Novel GDP-dependent Pyruvate Kinase Isozyme from Toxoplasma gondii Localizes to Both the Apicoplast and the Mitochondrion. Journal of Biological Chemistry 283:20, pages 14041-14052.
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Satyendra Mishra, Krishanpal Karmodiya, Prasanna Parasuraman, Avadhesha Surolia & Namita Surolia. (2008) Design, synthesis, and application of novel triclosan prodrugs as potential antimalarial and antibacterial agents. Bioorganic & Medicinal Chemistry 16:10, pages 5536-5546.
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Martin Schlitzer. (2008) Antimalarial Drugs – What is in Use and What is in the Pipeline. Archiv der Pharmazie 341:3, pages 149-163.
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Thomas Kurz, Christoph Behrendt, Miriam Pein, Uwe Kaula, Bärbel Bergmann & Rolf D. Walter. (2007) γ‐Substituted Bis(pivaloyloxymethyl)ester Analogues of Fosmidomycin and FR900098. Archiv der Pharmazie 340:12, pages 661-666.
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Jochen Wiesner, Regina Ortmann, Hassan Jomaa & Martin Schlitzer. (2007) Double Ester Prodrugs of FR900098 Display Enhanced In‐Vitro Antimalarial Activity . Archiv der Pharmazie 340:12, pages 667-669.
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Martin Schlitzer. (2007) Malaria Chemotherapeutics Part I: History of Antimalarial Drug Development, Currently Used Therapeutics, and Drugs in Clinical Development. ChemMedChem 2:7, pages 944-986.
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Marilyn Parsons, Anuradha Karnataki, Jean E. Feagin & Amy DeRocher. (2007) Protein Trafficking to the Apicoplast: Deciphering the Apicomplexan Solution to Secondary Endosymbiosis. Eukaryotic Cell 6:7, pages 1081-1088.
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Tobias Fleige, Karsten Fischer, David J. P. Ferguson, Uwe Gross & Wolfgang Bohne. (2007) Carbohydrate Metabolism in the Toxoplasma gondii Apicoplast: Localization of Three Glycolytic Isoenzymes, the Single Pyruvate Dehydrogenase Complex, and a Plastid Phosphate Translocator . Eukaryotic Cell 6:6, pages 984-996.
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Dominik Burkhardt, Jochen Wiesner, Nicole Stoesser, Michael Ramharter, Anne-Catrin Uhlemann, Saadou Issifou, Hassan Jomaa, Sanjeev Krishna, Peter G. Kremsner & Steffen Borrmann. (2007) Delayed parasite elimination in human infections treated with clindamycin parallels ‘delayed death’ of Plasmodium falciparum in vitro. International Journal for Parasitology 37:7, pages 777-785.
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Gyanendra Kumar, Prasanna Parasuraman, Shailendra Kumar Sharma, Tanushree Banerjee, Krishanpal Karmodiya, Namita Surolia & Avadhesha Surolia. (2007) Discovery of a Rhodanine Class of Compounds as Inhibitors of Plasmodium falciparum Enoyl-Acyl Carrier Protein Reductase . Journal of Medicinal Chemistry 50:11, pages 2665-2675.
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Anuradha Karnataki, Amy DeRocher, Isabelle Coppens, Coral Nash, Jean E. Feagin & Marilyn Parsons. (2007) Cell cycle-regulated vesicular trafficking of Toxoplasma APT1, a protein localized to multiple apicoplast membranes. Molecular Microbiology 63:6, pages 1653-1668.
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Shailendra Kumar Sharma, Prasanna Parasuraman, Gyanendra Kumar, Namita Surolia & Avadhesha Surolia. (2007) Green Tea Catechins Potentiate Triclosan Binding to Enoyl-ACP Reductase from Plasmodium falciparum (PfENR) . Journal of Medicinal Chemistry 50:4, pages 765-775.
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Vahab Ali & Tomoyoshi Nozaki. (2007) Current Therapeutics, Their Problems, and Sulfur-Containing-Amino-Acid Metabolism as a Novel Target against Infections by “Amitochondriate” Protozoan Parasites. Clinical Microbiology Reviews 20:1, pages 164-187.
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Kathrin Stelter, Najib M. El-Sayed & Frank Seeber. (2007) The Expression of a Plant-type Ferredoxin Redox System provides Molecular Evidence for a Plastid in the Early Dinoflagellate Perkinsus marinus. Protist 158:1, pages 119-130.
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Katrin Schlüter, Rolf D. Walter, Bärbel Bergmann & Thomas Kurz. (2006) Arylmethyl substituted derivatives of Fosmidomycin: Synthesis and antimalarial activity. European Journal of Medicinal Chemistry 41:12, pages 1385-1397.
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Manmohan Chhibber, Gyanendra Kumar, Prasanna Parasuraman, T.N.C. Ramya, Namita Surolia & Avadhesha Surolia. (2006) Novel diphenyl ethers: Design, docking studies, synthesis and inhibition of enoyl ACP reductase of Plasmodium falciparum and Escherichia coli. Bioorganic & Medicinal Chemistry 14:23, pages 8086-8098.
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Dominique Laurent & Francesco Pietra. (2006) Antiplasmodial Marine Natural Products in the Perspective of Current Chemotherapy and Prevention of Malaria. A Review. Marine Biotechnology 8:5, pages 433-447.
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Thomas Kurz, Katrin Schlüter, Uwe Kaula, Bärbel Bergmann, Rolf D. Walter & Detlef Geffken. (2006) Synthesis and antimalarial activity of chain substituted pivaloyloxymethyl ester analogues of Fosmidomycin and FR900098. Bioorganic & Medicinal Chemistry 14:15, pages 5121-5135.
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Deniz Tasdemir. (2006) Type II Fatty Acid Biosynthesis, a New Approach in Antimalarial Natural Product Discovery. Phytochemistry Reviews 5:1, pages 99-108.
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René C. Röhrich, Nadine Englert, Katrin Troschke, Armin Reichenberg, Martin Hintz, Frank Seeber, Emanuela Balconi, Alessandro Aliverti, Giuliana Zanetti, Uwe Köhler, Matthias Pfeiffer, Ewald Beck, Hassan Jomaa & Jochen Wiesner. (2005) Reconstitution of an apicoplast-localised electron transfer pathway involved in the isoprenoid biosynthesis of Plasmodium falciparum . FEBS Letters 579:28, pages 6433-6438.
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