Advanced search
Publication Cover
Expert Opinion on Therapeutic Targets Volume 9, 2005 - Issue 5
Submit an article Journal homepage
115
Views
43
CrossRef citations to date
0
Altmetric
Review

The epidermal growth factor receptor gene family as a target for therapeutic intervention in numerous cancers: what’s genetics got to do with it?

John G Shelton Brody School of Medicine at East Carolina University, Department of Microbiology & Immunology, Greenville, NC 27858,USA
,
Linda S Steelman Brody School of Medicine at East Carolina University, Department of Microbiology & Immunology, Greenville, NC 27858,USA
,
Steve L Abrams Brody School of Medicine at East Carolina University, Department of Microbiology & Immunology, Greenville, NC 27858,USA
,
Fred E Bertrand Brody School of Medicine at East Carolina University, Department of Microbiology & Immunology, Greenville, NC 27858,USA
,
Richard A Franklin Brody School of Medicine at East Carolina University, Department of Microbiology & Immunology, Greenville, NC 27858,USA
,
Martin McMahon University of California, San Fransisco/Mt. Zion Cancer Center, 2340 Sutter Street, S-329 Box 0128San Francisco, CA 94115,USA
&
James A McCubrey Brody School of Medicine at East Carolina University, Leo Jenkins Cancer Center, Greenville, NC 27858,USA. [email protected]
 show all
Pages 1009-1030 | Published online: 27 Sep 2005

Citations (43)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (4)

Linda S. Steelman, Patrick Navolanic, William H. Chappell, Stephen L. Abrams, Ellis W.T. Wong, Alberto M. Martelli, Lucio Cocco, Franca Stivala, Massimo Libra, Ferdinando Nicoletti, Lyudmyla B. Drobot, Richard A. Franklin & James A. McCubrey. (2011) Involvement of Akt and mTOR in chemotherapeutic- and hormonal-based drug resistance and response to radiation in breast cancer cells. Cell Cycle 10:17, pages 3003-3015.
Read now
James A McCubrey, Linda S Steelman, Steven L Abrams, William H Chappell, Suzanne Russo, Roger Ove, Michele Milella, Agostino Tafuri, Paolo Lunghi, Antonio Bonati, Franca Stivala, Ferdinando Nicoletti, Massimo Libra, Alberto M Martelli, Giuseppe Montalto & Melchiorre Cervello. (2010) Emerging MEK inhibitors. Expert Opinion on Emerging Drugs 15:2, pages 203-223.
Read now
James A McCubrey, Linda S Steelman, Steven L Abrams, William H Chappell, Suzanne Russo, Roger Ove, Michele Milella, Agostino Tafuri, Paolo Lunghi, Antonio Bonati, Franca Stivala, Ferdinando Nicoletti, Massimo Libra, Alberto M Martelli, Giuseppe Montalto & Melchiorre Cervello. (2009) Emerging Raf inhibitors. Expert Opinion on Emerging Drugs 14:4, pages 633-648.
Read now
Linda S Steelman, Kristin M Stadelman, William H Chappell, Stefan Horn, Jörg Bäsecke, Melchiorre Cervello, Ferdinando Nicoletti, Massimo Libra, Franca Stivala, Alberto M Martelli & James A McCubrey. (2008) Akt as a therapeutic target in cancer. Expert Opinion on Therapeutic Targets 12:9, pages 1139-1165.
Read now

Articles from other publishers (39)

Boaz Wong, Anabel Bergeron, Nouf Alluqmani, Glib Maznyi, Andrew Chen, Rozanne Arulanandam & Jean-Simon Diallo. (2022) Dependency of EGFR activation in vanadium-based sensitization to oncolytic virotherapy. Molecular Therapy - Oncolytics 25, pages 146-159.
Crossref
Xing Song, Yingjie Shao, Tianwei Jiang, Yun Ding, Bin Xu, Xiao Zheng, Qi Wang, Xin Chen, Wendong Gu, Changping Wu & Jingting Jiang. (2018) Radiotherapy Upregulates Programmed Death Ligand-1 through the Pathways Downstream of Epidermal Growth Factor Receptor in Glioma. EBioMedicine 28, pages 105-113.
Crossref
Lieyu Xu, Yicheng Qi, Yunze Xu, Jianpo Lian, Xiaojing Wang, Guang Ning, Weiqing Wang & Yu Zhu. (2016) Co-inhibition of EGFR and IGF1R synergistically impacts therapeutically on adrenocortical carcinoma. Oncotarget 7:24, pages 36235-36246.
Crossref
Andreas Charalambous & Melanie Charalambous. (2016) “I Lost My Image, the Image Others Know Me By”: Findings From a Hermeneutic Phenomenological Study of Patients Living With Treatment-Induced Cutaneous Toxicities. Research in Nursing & Health 39:3, pages 187-196.
Crossref
Yingxing Yue, Ying Wang, Yang He, Shuting Yang, Zixing Chen, Yuanyuan Wang, Shanshan Xing, Congcong Shen, Hesham M. Amin, Depei Wu & Yao-Hua Song. (2014) Reversal of Bortezomib Resistance in Myelodysplastic Syndrome Cells by MAPK Inhibitors. PLoS ONE 9:3, pages e90992.
Crossref
Anatoliy Samoylenko, Bozhena Vynnytska-Myronovska, Nadiya Byts, Nina Kozlova, Olga Basaraba, Ganna Pasichnyk, Kseniya Palyvoda, Yaroslav Bobak, Maryna Barska, Oksana Mayevska, Yuriy Rzhepetsky, Halyna Shuvayeva, Valeriy Lyzogubov, Vasyl Usenko, Volodymyr Savran, Nataliya Volodko, Vladimir Buchman, Thomas Kietzmann & Lyudmyla Drobot. (2012) Increased levels of the HER1 adaptor protein Ruk l /CIN85 contribute to breast cancer malignancy. Carcinogenesis 33:10, pages 1976-1984.
Crossref
James A. McCubrey, Stephen L. Abrams, Kazuo Umezawa, Lucio Cocco, Alberto M. Martelli, Richard A. Franklin, William H. Chappell & Linda S. Steelman. (2012) Novel approaches to target cancer initiating cells–Eliminating the root of the cancer. Advances in Biological Regulation 52:1, pages 249-264.
Crossref
James A. McCubrey, Linda S. Steelman, C. Ruth Kempf, William H. Chappell, Stephen L. Abrams, Franca Stivala, Graziella Malaponte, Ferdinando Nicoletti, Massimo Libra, Jörg Bäsecke, Danijela Maksimovic-Ivanic, Sanja Mijatovic, Giuseppe Montalto, Melchiorre Cervello, Lucio Cocco & Alberto M. Martelli. (2011) Therapeutic resistance resulting from mutations in Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR signaling pathways. Journal of Cellular Physiology 226:11, pages 2762-2781.
Crossref
Iris H. I. M. HollinkMarry M. van den Heuvel-EibrinkSusan T. C. J. M. Arentsen-PetersMarta Pratcorona, Saman Abbas, Jenny E. KuipersJanneke F. van GalenH. Berna BeverlooEdwin SonneveldGert-Jan J. L. KaspersJan TrkaAndre BaruchelMartin Zimmermann, Ursula Creutzig, Dirk Reinhardt, Rob PietersPeter J. M. Valk & C. Michel Zwaan. (2011) NUP98/NSD1 characterizes a novel poor prognostic group in acute myeloid leukemia with a distinct HOX gene expression pattern. Blood 118:13, pages 3645-3656.
Crossref
Jackson R. Taylor, Brian D. Lehmann, William H. Chappell, Stephen L. Abrams, Linda S. Steelman & James A. McCubrey. (2011) Cooperative Effects of Akt-1 and Raf-1 on the Induction of Cellular Senescence in Doxorubicin or Tamoxifen Treated Breast Cancer Cells. Oncotarget 2:8, pages 610-626.
Crossref
Melissa L. SokoloskyKristin M. StadelmanWilliam H. Chappell, Stephen L. Abrams, Alberto M. Martelli, Franca Stivala, Massimo Libra, Ferdinando Nicoletti, Lyudmyla B. Drobot, Richard A. Franklin, Linda S. Steelman & James A. McCubrey. (2011) Involvement of Akt-1 and mTOR in Sensitivity of Breast Cancer to Targeted Therapy. Oncotarget 2:7, pages 538-550.
Crossref
Roderick L. Beijersbergen & Oliver C. Steinbach. 2011. RNA Interference. RNA Interference 76 122 .
James A. McCubrey, William H. Chappell, Stephen L. Abrams, Richard A. Franklin, Jacquelyn M. Long, Jennifer A. Sattler, C. Ruth Kempf, Piotr Laidler & Linda S. Steelman. (2011) Targeting the cancer initiating cell: The Achilles’ heel of cancer. Advances in Enzyme Regulation 51:1, pages 152-162.
Crossref
Patrick Adam, Stefanie Hahner, Martina Hartmann, Barbara Heinrich, Marcus Quinkler, Holger S Willenberg, Wolfgang Saeger, Silviu Sbiera, Sebastian Schmull, Hans-Ullrich Voelker, Philipp Ströbel, Bruno Allolio & Martin Fassnacht. (2010) Epidermal growth factor receptor in adrenocortical tumors: analysis of gene sequence, protein expression and correlation with clinical outcome. Modern Pathology 23:12, pages 1596-1604.
Crossref
Murielle Mimeault & Surinder K. Batra. (2010) Frequent Deregulations in the Hedgehog Signaling Network and Cross-Talks with the Epidermal Growth Factor Receptor Pathway Involved in Cancer Progression and Targeted Therapies. Pharmacological Reviews 62:3, pages 497-524.
Crossref
Lidia Moserle, Margherita Ghisi, Alberto Amadori & Stefano Indraccolo. (2010) Side population and cancer stem cells: Therapeutic implications. Cancer Letters 288:1, pages 1-9.
Crossref
H. Rassi. (2009) Stem cell therapy for hereditary breast cancer. Cytology and Genetics 43:3, pages 216-222.
Crossref
Shiyu Song, Paul Dent & Steven Grant. 2009. The Impact of Tumor Biology on Cancer Treatment and Multidisciplinary Strategies. The Impact of Tumor Biology on Cancer Treatment and Multidisciplinary Strategies 191 219 .
Murielle Mimeault & Surinder K. Batra. 2009. Stem Cells and Cancer. Stem Cells and Cancer 287 308 .
L S Steelman, P M Navolanic, M L Sokolosky, J R Taylor, B D Lehmann, W H Chappell, S L Abrams, E W T Wong, K M Stadelman, D M Terrian, N R Leslie, A M Martelli, F Stivala, M Libra, R A Franklin & J A McCubrey. (2008) Suppression of PTEN function increases breast cancer chemotherapeutic drug resistance while conferring sensitivity to mTOR inhibitors. Oncogene 27:29, pages 4086-4095.
Crossref
L S Steelman, S L Abrams, J Whelan, F E Bertrand, D E Ludwig, J Bäsecke, M Libra, F Stivala, M Milella, A Tafuri, P Lunghi, A Bonati, A M Martelli & J A McCubrey. (2008) Contributions of the Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways to leukemia. Leukemia 22:4, pages 686-707.
Crossref
James A. McCubrey, Melissa L. Sokolosky, Brian D. Lehmann, Jackson R. Taylor, Patrick M. Navolanic, William H. Chappell, Stephen L. Abrams, Kristin M. Stadelman, Ellis W.T. Wong, Negin Misaghian, Stefan Horn, Jörg Bäsecke, Massimo Libra, Franca Stivala, Giovanni Ligresti, Agostino Tafuri, Michele Milella, Marek Zarzycki, Andrzej Dzugaj, Francesca Chiarini, Camilla Evangelisti, Alberto M. Martelli, David M. Terrian, Richard A. Franklin & Linda S. Steelman. (2008) Alteration of Akt activity increases chemotherapeutic drug and hormonal resistance in breast cancer yet confers an achilles heel by sensitization to targeted therapy. Advances in Enzyme Regulation 48:1, pages 113-135.
Crossref
James A. McCubrey, Richard A. Franklin, Fred E. Bertrand, Jackson R. Taylor, William H. Chappell, Melissa L. Midgett, Ellis W. T. Wong, Stephen L. Abrams, Kristin M. Stadelman, Negin Misaghian, Dale L. Ludwig, Jorg Basecke, Massimo Libra, Franca Stivala, Michele Milella, Agostino Tafuri, Alberto M. Martelli, Paolo Lungi, Antonio Bonati, David M. Terrian, Brian D. Lehmann & Linda S. Steelman. 2008. Sensitization of Cancer Cells for Chemo/Immuno/Radio-therapy. Sensitization of Cancer Cells for Chemo/Immuno/Radio-therapy 81 114 .
J Lackey, J Barnett, L Davidson, I H Batty, N R Leslie & C P Downes. (2007) Loss of PTEN selectively desensitizes upstream IGF1 and insulin signaling. Oncogene 26:50, pages 7132-7142.
Crossref
M. Mimeault & S.K. Batra. (2007) Interplay of distinct growth factors during epithelial–mesenchymal transition of cancer progenitor cells and molecular targeting as novel cancer therapies. Annals of Oncology 18:10, pages 1605-1619.
Crossref
Nikhil S. Chari & Timothy J. McDonnell. (2007) The Sonic Hedgehog Signaling Network in Development and Neoplasia. Advances in Anatomic Pathology 14:5, pages 344-352.
Crossref
Galina V. Shurin, Zoya R. Yurkovetsky, Gurkamal S. Chatta, Irina L. Tourkova, Michael R. Shurin & Anna E. Lokshin. (2007) Dynamic alteration of soluble serum biomarkers in healthy aging. Cytokine 39:2, pages 123-129.
Crossref
James A. McCubrey, Linda S. Steelman, William H. Chappell, Stephen L. Abrams, Ellis W.T. Wong, Fumin Chang, Brian Lehmann, David M. Terrian, Michele Milella, Agostino Tafuri, Franca Stivala, Massimo Libra, Jorg Basecke, Camilla Evangelisti, Alberto M. Martelli & Richard A. Franklin. (2007) Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1773:8, pages 1263-1284.
Crossref
Kristoffer Valerie, Adly Yacoub, Michael P. Hagan, David T. Curiel, Paul B. Fisher, Steven Grant & Paul Dent. (2007) Radiation-induced cell signaling: inside-out and outside-in. Molecular Cancer Therapeutics 6:3, pages 789-801.
Crossref
Marco Betz, Martin Vogtherr, Ulrich Schieborr, Bettina Elshorst, Susanne Grimme, Barbara Pescatore, Thomas Langer, Krishna Saxena & Harald Schwalbe. 2007. Chemical Biology. Chemical Biology 852 890 .
Adrian P. QuayleAsim S. SiddiquiSteven J. M. Jones. (2017) Perturbation of Interaction Networks for Application to Cancer Therapy. Cancer Informatics 5, pages 117693510700500.
Crossref
Kermit L. CarrawayIIIIII, Melanie Funes, Heather C. Workman & Colleen Sweeney. 2007. 1 22 .
Murielle Mimeault & Surinder K. Batra. (2009) Concise Review: Recent Advances on the Significance of Stem Cells in Tissue Regeneration and Cancer Therapies. STEM CELLS 24:11, pages 2319-2345.
Crossref
Karl-Ludwig Schaefer, Kristin Brachwitz, Yvonne Braun, Raihanatou Diallo, Daniel H. Wai, Susanne Zahn, Dominik T. Schneider, Cornelius Kuhnen, Arabel Vollmann, Gero Brockhoff, Helmut E. Gabbert & Christopher Poremba. (2006) Constitutive Activation of Neuregulin/ERBB3 Signaling Pathway in Clear Cell Sarcoma of Soft Tissue. Neoplasia 8:7, pages 613-622.
Crossref
Gerhard S. Mundinger, Virginia Espina, Lance A. Liotta, Emanuel F. PetricoinIIIIII & Katherine R. Calvo. (2006) Clinical phosphoproteomic profiling for personalized targeted medicine using reverse phase protein microarray. Targeted Oncology 1:3.
Crossref
Charles Massie & Ian G. Mills. (2006) The developing role of receptors and adaptors. Nature Reviews Cancer 6:5, pages 403-409.
Crossref
James A. McCubrey, Linda S. Steelman, Steven L. Abrams, John T. Lee, Fumin Chang, Fred E. Bertrand, Patrick M. Navolanic, David M. Terrian, Richard A. Franklin, Antonio B. D’Assoro, Jeffrey L. Salisbury, Maria Clorinda Mazzarino, Franca Stivala & Massimo Libra. (2006) Roles of the RAF/MEK/ERK and PI3K/PTEN/AKT pathways in malignant transformation and drug resistance. Advances in Enzyme Regulation 46:1, pages 249-279.
Crossref
Eli M. Wallace, Tammie C. Yeh, Ellen R. Laird, James F. Blake & Joseph Lyssikatos. 2007. Cancer. Cancer 83 132 .
Kelley A. Parato, Donna Senger, Peter A. J. Forsyth & John C. Bell. (2005) Recent progress in the battle between oncolytic viruses and tumours. Nature Reviews Cancer 5:12, pages 965-976.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.