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Expert Opinion on Drug Safety Volume 8, 2009 - Issue 3
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Immune mediation of hypersensitivity adverse drug reactions: implications for therapy

Michael J Rieder CIHR-GSK Chair in Paediatric Clinical Pharmacology, Division of Clinical Pharmacology, Department of Paediatrics, Children's Hospital of Western Ontario, 800 Commissioner's Road East, London, Ontario, N6C 2V5, Canada +1 519 685 8293; +1 519 685 8156; [email protected]
, MD PhD
Pages 331-343 | Published online: 12 May 2009

Citations (17)

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Read on this site (2)

Abdelbaset A. Elzagallaai & Michael J. Rieder. (2022) Genetic markers of drug hypersensitivity in pediatrics: current state and promise. Expert Review of Clinical Pharmacology 15:6, pages 715-728.
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Wei Tang & Anthony Y.H. Lu. (2010) Metabolic bioactivation and drug-related adverse effects: current status and future directions from a pharmaceutical research perspective. Drug Metabolism Reviews 42:2, pages 225-249.
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Articles from other publishers (15)

Abdelbaset A. Elzagallaai & Michael J. Rieder. (2023) Pathophysiology of drug hypersensitivity. British Journal of Clinical Pharmacology.
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Pedro Ayuso, Elena García-Martín & José A. G. Agúndez. (2021) Variability of the Genes Involved in the Cellular Redox Status and Their Implication in Drug Hypersensitivity Reactions. Antioxidants 10:2, pages 294.
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Abdelbaset A. Elzagallaai, Elham A. Sultan, John R. Bend, Awatif M. Abuzgaia, Eman Loubani & Michael J. Rieder. (2019) Role of Oxidative Stress in Hypersensitivity Reactions to Sulfonamides. The Journal of Clinical Pharmacology 60:3, pages 409-421.
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Michael Rieder. (2019) Adverse Drug Reactions in Children: Pediatric Pharmacy and Drug Safety. The Journal of Pediatric Pharmacology and Therapeutics 24:1, pages 4-9.
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AA Elzagallaai, MJE Greff & MJ Rieder. (2017) Adverse Drug Reactions in Children: The Double-Edged Sword of Therapeutics. Clinical Pharmacology & Therapeutics 101:6, pages 725-735.
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Abdelbaset A. Elzagallaai & Michael J. Rieder. (2015) In vitro testing for diagnosis of idiosyncratic adverse drug reactions: Implications for pathophysiology . British Journal of Clinical Pharmacology 80:4, pages 889-900.
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Ursula Amstutz, Neil H. Shear, Michael J. Rieder, Soomi Hwang, Vincent Fung, Hidefumi Nakamura, Mary B. Connolly, Shinya Ito & Bruce C. Carleton. (2014) Recommendations for HLA-B*15:02 and HLA-A*31:01 genetic testing to reduce the risk of carbamazepine-induced hypersensitivity reactions. Epilepsia 55:4, pages 496-506.
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Sheena N. Ramasamy, Cameron S. Korb-Wells, Diluk R. W. Kannangara, Myles W. H. Smith, Nan Wang, Darren M. Roberts, Garry G. Graham, Kenneth M. Williams & Richard O. Day. (2013) Allopurinol Hypersensitivity: A Systematic Review of All Published Cases, 1950–2012. Drug Safety 36:10, pages 953-980.
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Akitoshi Tamura, Izuru Miyawaki, Toru Yamada, Juki Kimura & Hitoshi Funabashi. (2013) Oral administration of drugs with hypersensitivity potential induces germinal center hyperplasia in secondary lymphoid organ/tissue in Brown Norway rats, and this histological lesion is a promising candidate as a predictive biomarker for drug hypersensitivity occurrence in humans. Toxicology and Applied Pharmacology 271:1, pages 30-40.
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Michael Rieder. (2012) New Ways to Detect Adverse Drug Reactions in Pediatrics. Pediatric Clinics of North America 59:5, pages 1071-1092.
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Michael Rieder & John R. Bend. 2012. Recent Trends in Medicinal Plants Research. Recent Trends in Medicinal Plants Research 385 408 .
D. J. Snodin & A. Suitters. 2011. Stephens' Detection and Evaluation of Adverse Drug Reactions. Stephens' Detection and Evaluation of Adverse Drug Reactions 157 214 .
Allison L Bahm, Facundo Garcia-Bournissen & Jeremy N Friedman. (2011) Case 2: Where did you get that DRESS?. Paediatrics & Child Health 16:4, pages 207-209.
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Abdelbaset A. Elzagallaai, Zahra Jahedmotlagh, Blanca R. Del Pozzo-Magaña, Sandra R. Knowles, Asuri N. Prasad, Neil H. Shear, Michael J. Rieder & Gideon Koren. (2012) Predictive Value of the Lymphocyte Toxicity Assay in the Diagnosis of Drug Hypersensitivity Syndrome. Molecular Diagnosis & Therapy 14:5, pages 317-322.
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Frank C SchmalstiegJrJr & Armond S Goldman. (2010) The Therapeutic Test: An Ancient Malady in the 21 st Century. Annals of Pharmacotherapy 44:9, pages 1471-1477.
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