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QT prolongation in the intensive care unit: commonly used medications and the impact of drug–drug interactions

, PharmD, , PharmD, , PharmD & , MS PharmD MSc FCCM
Pages 699-712 | Published online: 09 Apr 2010

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Dario Cattaneo, Alberto Corona, Francesco Giuseppe De Rosa, Cristina Gervasoni, Danijela Kocic & Deborah Je Marriott. (2020) The management of anti-infective agents in intensive care units: the potential role of a ‘fast’ pharmacology. Expert Review of Clinical Pharmacology 13:4, pages 355-366.
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Qasim Khan, Mohammad Ismail & Iqbal Haider. (2018) High prevalence of the risk factors for QT interval prolongation and associated drug–drug interactions in coronary care units. Postgraduate Medicine 130:8, pages 660-665.
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Articles from other publishers (21)

Shadi Baniasadi, Behrooz Farzanegan, Zeinab Hosseinpoor, Seyyed R Seyyedi & Mehdi Rajabi. (2019) An Observational Study of QTc Prolongation in Critically Ill Patients: Identification of Incidence and Predictors. Indian Journal of Critical Care Medicine 24:4, pages 270-275.
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Maryam Hassanzad, Sabereh Tashayoie Nejad, Amir Ali Mahboobipour, Farzaneh Salem & Shadi Baniasadi. (2020) Potential drug-drug interactions in hospitalized pediatric patients with respiratory disorders: a retrospective review of clinically important interactions. Drug Metabolism and Personalized Therapy 0:0.
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Zeinab Hosseinpoor, Behrooz Farzanegan, Seyyed Reza Seyyedi, Mehdi Rajabi & Shadi Baniasadi. (2019) Drug interactions and creatinine levels are associated with QTc prolongation in intensive care units: a prospective, observational study. Drug Metabolism and Personalized Therapy 34:4.
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Flávia Medeiros Fernandes, Aryelle Mayara da Silva Paulino, Bruna Camelo Sedda, Eliane Pereira da Silva, Rand Randall Martins & Antonio Gouveia Oliveira. (2019) Assessment of the risk of QT-interval prolongation associated with potential drug-drug interactions in patients admitted to Intensive Care Units. Saudi Pharmaceutical Journal 27:2, pages 229-234.
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Slobodan M. Janković, Ana V. Pejčić, Miloš N. Milosavljević, Valentina D. Opančina, Nikola V. Pešić, Tamara T. Nedeljković & Goran M. Babić. (2018) Risk factors for potential drug-drug interactions in intensive care unit patients. Journal of Critical Care 43, pages 1-6.
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Maryam Hassanzad, Sara Arenas-Lopez & Shadi Baniasadi. (2018) Potential Drug-Drug Interactions Among Critically Ill Pediatric Patients in a Tertiary Pulmonary Center. The Journal of Clinical Pharmacology 58:2, pages 221-227.
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Qasim Khan, Mohammad Ismail, Iqbal Haider & Fahadullah Khan. (2017) Prevalence of QT interval prolonging drug–drug interactions (QT-DDIs) in psychiatry wards of tertiary care hospitals in Pakistan: a multicenter cross-sectional study. International Journal of Clinical Pharmacy 39:6, pages 1256-1264.
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Genevieve M. Hale, Sandra L. Kane-Gill, Lara Groetzinger & Pamela L. Smithburger. (2016) An Evaluation of Adverse Drug Reactions Associated With Antipsychotic Use for the Treatment of Delirium in the Intensive Care Unit. Journal of Pharmacy Practice 29:4, pages 355-360.
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Julius Cuong Pham, Michael C. Banks, David L. Narotsky, Todd Dorman & Bradford D. Winters. (2015) The prevalence of long QT interval in post-operative intensive care unit patients. Journal of Clinical Monitoring and Computing 30:4, pages 437-443.
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Miklos D. Kertai, Yunqi Ji, Yi-Ju Li, Joseph P. Mathew, James P. Daubert & Mihai V. Podgoreanu. (2016) Interleukin-1β gene variants are associated with QTc interval prolongation following cardiac surgery: a prospective observational studyAssociation entre les variantes génétiques de l’interleukine-1β et une prolongation de l’intervalle QTc après une chirurgie cardiaque: une étude observationnelle prospective. Canadian Journal of Anesthesia/Journal canadien d'anesthésie 63:4, pages 397-410.
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Shadi Baniasadi, Behrooz Farzanegan & Maryam Alehashem. (2015) Important drug classes associated with potential drug–drug interactions in critically ill patients: highlights for cardiothoracic intensivists. Annals of Intensive Care 5:1.
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Sandra L. Kane-Gill & Stuart L. Goldstein. (2015) Drug-Induced Acute Kidney Injury. Critical Care Clinics 31:4, pages 675-684.
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Behrooz Farzanegan, Maryam Alehashem, Marjan Bastani & Shadi Baniasadi. (2015) Potential drug-drug interactions in cardiothoracic intensive care unit of a pulmonary teaching hospital. The Journal of Clinical Pharmacology 55:2, pages 132-136.
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Umjeet Singh Jolly & Jaimie Manlucu. 2015. Handbook of ICU Therapy. Handbook of ICU Therapy 319 333 .
. 2015. Handbook of ICU Therapy. Handbook of ICU Therapy 261 460 .
Sandra L. Kane-Gill, Jaclyn M. LeBlanc, Joseph F. Dasta & Sandeep Devabhakthuni. (2014) A Multicenter Study of the Point Prevalence of Drug-Induced Hypotension in the ICU. Critical Care Medicine 42:10, pages 2197-2203.
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Detlef Obal, Dongsheng Yang & Daniel I. Sessler. (2014) Perioperative Doses of Ondansetron or Dolasetron Do Not Lengthen the QT Interval. Mayo Clinic Proceedings 89:1, pages 69-80.
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James B. Besunder & John Pope. 2014. Pediatric Critical Care Medicine. Pediatric Critical Care Medicine 55 73 .
Michael J. Armahizer, Amy L. Seybert, Pamela L. Smithburger & Sandra L. Kane-Gill. (2013) Drug-drug interactions contributing to QT prolongation in cardiac intensive care units. Journal of Critical Care 28:3, pages 243-249.
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Justin M. Fongemie, Nada S. Al‐Qadheeb, N. A. Mark EstesIIIIII, Russel J. Roberts, Yutthapong Temtanakitpaisan, Robin Ruthazer & John W. Devlin. (2013) Agreement Between ICU Clinicians and Electrophysiology Cardiologists on the Decision to Initiate a QT c‐interval Prolonging Medication in Critically Ill Patients with Potential Risk Factors for Torsade de Pointes: A Comparative, Case‐Based Evaluation . Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 33:6, pages 589-597.
Crossref
Peter Nagele, Swatilika Pal, Frank Brown, Jane Blood, J. Philipp Miller & Joshua Johnston. (2012) Postoperative QT Interval Prolongation in Patients Undergoing Noncardiac Surgery under General Anesthesia. Anesthesiology 117:2, pages 321-328.
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