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Review

Long-term safety of proton pump inhibitors: risks of gastric neoplasia and infections

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Pages 29-38 | Published online: 23 Feb 2005

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Yanna Ko, James Tang, Santosh Sanagapalli, Bong Sik Matthew Kim & Rupert W Leong. (2016) Safety of proton pump inhibitors and risk of gastric cancers: review of literature and pathophysiological mechanisms. Expert Opinion on Drug Safety 15:1, pages 53-63.
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Federica Cavalcoli, Alessandra Zilli, Dario Conte, Clorinda Ciafardini & Sara Massironi. (2015) Gastric neuroendocrine neoplasms and proton pump inhibitors: fact or coincidence?. Scandinavian Journal of Gastroenterology 50:11, pages 1397-1403.
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Malcolm Boyce & Liv Thomsen. (2015) Gastric neuroendocrine tumors: prevalence in Europe, USA, and Japan, and rationale for treatment with a gastrin/CCK2 receptor antagonist. Scandinavian Journal of Gastroenterology 50:5, pages 550-559.
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Helge L. Waldum, Gunnar Qvigstad, Reidar Fossmark, Per M. Kleveland & Arne K. Sandvik. (2010) Rebound acid hypersecretion from a physiological, pathophysiological and clinical viewpoint. Scandinavian Journal of Gastroenterology 45:4, pages 389-394.
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Reidar Fossmark, Eiliv Brenna & Helge L. Waldum. (2007) pH 4.0. Scandinavian Journal of Gastroenterology 42:3, pages 297-298.
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John S. Fordtran. (2006) Colitis Due to Clostridium Difficile Toxins: Underdiagnosed, Highly Virulent, and Nosocomial. Baylor University Medical Center Proceedings 19:1, pages 3-12.
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Articles from other publishers (36)

Rania M. Salama, Rodaina H. Ahmed, Alaa A. Farid, Basma A. AbdElSattar, Radwa M. AbdelBaset, Merna E. Youssef & Sara A. El Wakeel. (2023) Gastroprotective effect of dapagliflozin in ethanol-induced gastric lesions in rats: Crosstalk between HMGB1/RAGE/PTX3 and TLR4/MyD88/VEGF/PDGF signaling pathways. International Immunopharmacology 115, pages 109686.
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Yansheng Wang, Xinnan Liu, Lipeng Liang, Yanru Zhu, Jingze Zhang, Lifei Luo, Ping Wang & Dailin Liu. (2022) The protective effect of quinoa on the gastric mucosal injury induced by absolute ethanol. Journal of the Science of Food and Agriculture 103:2, pages 944-956.
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Ion G. Motofei. (2022) Biology of cancer; from cellular and molecular mechanisms to developmental processes and adaptation. Seminars in Cancer Biology 86, pages 600-615.
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Helge L. Waldum. (2020) The increase in early-onset gastric carcinomas from 1995 is probably due to the introduction of proton pump inhibitors. Surgery 168:3, pages 568-569.
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Helge Waldum & Patricia G. Mjønes. (2020) Correct Identification of Cell of Origin May Explain Many Aspects of Cancer: The Role of Neuroendocrine Cells as Exemplified from the Stomach. International Journal of Molecular Sciences 21:16, pages 5751.
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Helena Jenzer & Leila Sadeghi-Reeves. (2020) Nutrigenomics-Associated Impacts of Nutrients on Genes and Enzymes With Special Consideration of Aromatase. Frontiers in Nutrition 7.
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Helge L. Waldum & Reidar Fossmark. 2020. Encyclopedia of Gastroenterology. Encyclopedia of Gastroenterology 265 272 .
Martinsen, Fossmark & Waldum. (2019) The Phylogeny and Biological Function of Gastric Juice—Microbiological Consequences of Removing Gastric Acid. International Journal of Molecular Sciences 20:23, pages 6031.
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Lama Soubra & Mohamed Issa. (2019) Prescribing of proton pump inhibitors for gastrointestinal bleeding prophylaxis in the Lebanese outpatient setting: patterns, compliance with guidelines and risks. International Journal of Pharmacy Practice 27:4, pages 386-392.
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Laura Malchodi, Kari Wagner, Apryl Susi, Gregory Gorman & Elizabeth Hisle-Gorman. (2019) Early Acid Suppression Therapy Exposure and Fracture in Young Children. Pediatrics 144:1.
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Nelson Cunha & António Pedro Machado. (2018) Proton pump inhibitors and the risk of severe adverse events – A cardiovascular bombshell?. Revista Portuguesa de Cardiologia (English Edition) 37:10, pages 859-863.
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Nelson Cunha & António Pedro Machado. (2018) Inibidores da bomba de protões e o risco de eventos adversos graves – uma bomba cardiovascular?. Revista Portuguesa de Cardiologia 37:10, pages 859-863.
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Nele Brusselaers, Lars Engstrand & Jesper Lagergren. (2018) PPI use and oesophageal cancer: What if the results are true?. Cancer Epidemiology 54, pages 139-140.
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A.J. McCarthy & K. Sheahan. 2018. Comprehensive Toxicology. Comprehensive Toxicology 113 138 .
Leon Fisher & Alexander Fisher. (2017) Acid-Suppressive Therapy and Risk of Infections: Pros and Cons. Clinical Drug Investigation 37:7, pages 587-624.
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Shuye Lin, Bonan Lin, Xiaoyue Wang, Yuanming Pan, Qing Xu, Jin-Shen He, Wanghua Gong, Rui Xing, Yuqi He, Lihua Guo, Youyong Lu, Ji Ming Wang & Jiaqiang Huang. (2017) Silencing of ATP4B of ATPase H + /K + Transporting Beta Subunit by Intragenic Epigenetic Alteration in Human Gastric Cancer Cells . Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics 25:3, pages 317-329.
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Gianmauro Numico, Vittorio Fusco, Pierfrancesco Franco & Fausto Roila. (2017) Proton Pump Inhibitors in cancer patients: How useful they are? A review of the most common indications for their use. Critical Reviews in Oncology/Hematology 111, pages 144-151.
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Yikai Zhang, Jing Jia, Yi Ding, Yongzheng Ma, Peijin Shang, Tianlong Liu, Guangfei Hui, Lin Wang, Mingming Wang, Zhihui Zhu, Yuwen Li & Aidong Wen. (2016) Alpha-boswellic acid protects against ethanol-induced gastric injury in rats: involvement of nuclear factor erythroid-2-related factor 2/heme oxygenase-1 pathway. Journal of Pharmacy and Pharmacology 68:4, pages 514-522.
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Helge L. Waldum. (2016) Protonpumpehemmere og magekreft. Tidsskrift for Den norske legeforening 136:1, pages 13-14.
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H. L. Waldum, Ø. Hauso & R. Fossmark. (2014) The regulation of gastric acid secretion - clinical perspectives. Acta Physiologica 210:2, pages 239-256.
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I. V. Kompanets, O. G. Korotkiy, T. P. Karpovets, S. V. Pilipenko, V. V. Nikolska, L. I. Ostapchenko & D. S. Yankovsky. (2013) Interferon titer and the 2',5'-oligoadenylate-synthetase activity in rat thymus lymphocytes in conditions of Omeprazol-caused hypergastrinemia. Biopolymers and Cell 29:1, pages 64-69.
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Arunkumar Krishnan, Rajesh Prabhu Ponnusamy & Vimala Ramakrishnan. (2017) Long-term Acid Suppression Therapy: Its Influence on Gastric Mucosa. Euroasian Journal of Hepato-Gastroenterology 3:1, pages 19-22.
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C. S. Jianu, R. Fossmark, T. Viset, G. Qvigstad, Ø. Sørdal, R. Mårvik & H. L. Waldum. (2012) Gastric carcinoids after long‐term use of a proton pump inhibitor. Alimentary Pharmacology & Therapeutics 36:7, pages 644-649.
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Joel J. Heidelbaugh, Andrea H. Kim, Robert Chang & Paul C. Walker. (2012) Overutilization of proton-pump inhibitors: what the clinician needs to know. Therapeutic Advances in Gastroenterology 5:4, pages 219-232.
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Gati A. Goel, Abhishek Deshpande, Rocio Lopez, Geraldine S. Hall, David van Duin & William D. Carey. (2012) Increased Rate of Spontaneous Bacterial Peritonitis Among Cirrhotic Patients Receiving Pharmacologic Acid Suppression. Clinical Gastroenterology and Hepatology 10:4, pages 422-427.
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Karin E. Bakkelund, Ivar S. Nordrum, Reidar Fossmark & Helge L. Waldum. (2012) Gastric Carcinomas Localized to the Cardia. Gastroenterology Research and Practice 2012, pages 1-6.
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Jeremiah V. Ojeaburu, Tetsuhide Ito, Pellegrino Crafa, Cesare Bordi & Robert T. Jensen. (2010) Mechanism of Acid Hypersecretion Post Curative Gastrinoma Resection. Digestive Diseases and Sciences 56:1, pages 139-154.
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B. Al-Judaibi, N. Chande, G.K. DresserN. SultanJ.C. Gregor. (2010) Gastric Acid-Related Diseases: Focus on Esomeprazole. Clinical Medicine Insights: Therapeutics 2, pages CMT.S4500.
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Robert A. EttlinJunji KurodaStephanie PlassmannDavid E. Prentice. (2010) Successful Drug Development Despite Adverse Preclinical Findings Part 1: Processes to Address Issues and Most Important Findings. Journal of Toxicologic Pathology 23:4, pages 189-211.
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K. Sakamoto. 2010. Comprehensive Toxicology. Comprehensive Toxicology 93 115 .
Eva Untersmayr & Erika Jensen-Jarolim. (2008) The role of protein digestibility and antacids on food allergy outcomes. Journal of Allergy and Clinical Immunology 121:6, pages 1301-1308.
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Vasundhara Tolia, Phyllis R. Bishop, V. Marc Tsou, David Gremse, Elaine F. Soffer & Gail M. Comer. (2006) Multicenter, Randomized, Double-Blind Study Comparing 10, 20 and 40 mg Pantoprazole in Children (5-11 Years) With Symptomatic Gastroesophageal Reflux Disease. Journal of Pediatric Gastroenterology & Nutrition 42:4, pages 384-391.
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Robert T. Jensen. (2006) Consequences of Long-Term Proton Pump Blockade: Insights from Studies of Patients with Gastrinomas. Basic <html_ent glyph="@amp;" ascii="&"/> Clinical Pharmacology <html_ent glyph="@amp;" ascii="&"/> Toxicology 98:1, pages 4-19.
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Helge L. Waldum, Bjørn Gustafsson, Reidar Fossmark & Gunnar Qvigstad. (2005) Antiulcer Drugs and Gastric Cancer. Digestive Diseases and Sciences 50:S1, pages S39-S44.
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Helge L. Waldum, Tom Chr. Martinsen & Eiliv Brenna. (2005) Nonulcer dyspepsia and proton pump inhibitors. Gastroenterology 128:3, pages 805.
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Tom C. Martinsen, Kare Bergh & Helge L. Waldum. (2005) Gastric Juice: A Barrier Against Infectious Diseases. Basic <html_ent glyph="@amp;" ascii="&"/> Clinical Pharmacology <html_ent glyph="@amp;" ascii="&"/> Toxicology 96:2, pages 94-102.
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