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Review

Toxicogenomics: an opportunity to optimise drug development and safety evaluation

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Pages 275-286 | Published online: 23 Feb 2005

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Jana PetkoviĆ, Bojana Žegura, Magdalena StevanoviĆ, Nataša Drnovšek, Dragan UskokoviĆ, Saša Novak & Metka FilipiČ. (2011) DNA damage and alterations in expression of DNA damage responsive genes induced by TiO2 nanoparticles in human hepatoma HepG2 cells. Nanotoxicology 5:3, pages 341-353.
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Cindy J Gross & Jeffrey A Kramer. (2003) The role of investigative molecular toxicology in early stage drug development. Expert Opinion on Drug Safety 2:2, pages 147-159.
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Articles from other publishers (21)

Guillaume Pain, Gordon Hickey, Matthieu Mondou, Doug Crump, Markus Hecker, Niladri Basu & Steven Maguire. (2020) Drivers of and Obstacles to the Adoption of Toxicogenomics for Chemical Risk Assessment: Insights from Social Science Perspectives. Environmental Health Perspectives 128:10.
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Mohan S. Rao, Terry R. Van Vleet, Rita Ciurlionis, Wayne R. Buck, Scott W. Mittelstadt, Eric A. G. Blomme & Michael J. Liguori. (2019) Comparison of RNA-Seq and Microarray Gene Expression Platforms for the Toxicogenomic Evaluation of Liver From Short-Term Rat Toxicity Studies. Frontiers in Genetics 9.
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Laura Suter-Dick & Friedlieb Pfannkuch. 2014. Predictive Toxicology. Predictive Toxicology 1 10 .
Yuefeng Cai, Luqing Pan, Fengxiao Hu, Qian Jin & Tong Liu. (2014) Deep sequencing-based transcriptome profiling analysis of Chlamys farreri exposed to benzo[a]pyrene. Gene 551:2, pages 261-270.
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Myrtle A. Davis, Sandy Eldridge & Calvert Louden. 2013. Haschek and Rousseaux's Handbook of Toxicologic Pathology. Haschek and Rousseaux's Handbook of Toxicologic Pathology 317 352 .
B. Žegura, G. Gajski, A. Štraser, V. Garaj-Vrhovac & M. Filipič. (2011) Microcystin-LR induced DNA damage in human peripheral blood lymphocytes. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 726:2, pages 116-122.
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Mourad A. M. Aboul-Soud, Abdulaziz M. Al-Othman, Gaber E. El-Desoky, Zeid A. Al-Othman, Kareem Yusuf, Javed Ahmad & Abdulaziz A. Al-Khedhairy. (2011) Hepatoprotective effects of vitamin E/selenium against malathion-induced injuries on the antioxidant status and apoptosis-related gene expression in rats. The Journal of Toxicological Sciences 36:3, pages 285-296.
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Brad HirakawaBart A. JessenOscar IllanesAnn de Peyster, Thomas McDermottGregory J. Stevens. (2017) Toxicogenomic Analysis of Cardiotoxicity in Rats. Genomics Insights 1, pages GEI.S851.
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Jeffrey A. Kramer, John E. Sagartz & Dale L. Morris. (2007) The application of discovery toxicology and pathology towards the design of safer pharmaceutical lead candidates. Nature Reviews Drug Discovery 6:8, pages 636-649.
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S.E. DePrimo. 2007. Comprehensive Medicinal Chemistry II. Comprehensive Medicinal Chemistry II 69 85 .
François Pognan. 2007. Systems Biological Approaches in Infectious Diseases. Systems Biological Approaches in Infectious Diseases 217 238 .
Anders Wallqvist, John Connelly, Edward A. Sausville, David G. Covell & Anne Monks. (2006) Differential Gene Expression as a Potential Classifier of 2-(4-Amino-3-methylphenyl)-5-fluorobenzothiazole-Sensitive and -Insensitive Cell Lines. Molecular Pharmacology 69:3, pages 737-748.
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Robert A. Jolly, Keith M. Goldstein, Tao Wei, Hong Gao, Peining Chen, Shuguang Huang, Jean-Marie Colet, Timothy P. Ryan, Craig E. Thomas & Shawn T. Estrem. (2005) Pooling samples within microarray studies: a comparative analysis of rat liver transcription response to prototypical toxicants. Physiological Genomics 22:3, pages 346-355.
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Heidrun Ellinger-Ziegelbauer, Barry Stuart, Brad Wahle, Werner Bomann & Hans Juergen Ahr. (2005) Comparison of the expression profiles induced by genotoxic and nongenotoxic carcinogens in rat liver. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 575:1-2, pages 61-84.
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Mark R Fielden, Cecelia Pearson, Richard Brennan & Kyle L Kolaja. (2005) Preclinical Drug Safety Analysis by Chemogenomic Profiling in the Liver. American Journal of PharmacoGenomics 5:3, pages 161-171.
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Donna M. Dambach, Barbara A. Andrews & Frederic Moulin. (2016) New Technologies and Screening Strategies for Hepatotoxicity: Use of In Vitro Models. Toxicologic Pathology 33:1, pages 17-26.
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Sandra Kraljevic, Peter J Stambrook & Kresimir Pavelic. (2004) Accelerating drug discovery. EMBO reports 5:9, pages 837-842.
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J. Andrew Whitney. (2004) Reference Systems for Kinase Drug Discovery: Chemical Genetic Approaches to Cell-Based Assays. ASSAY and Drug Development Technologies 2:4, pages 417-430.
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Marjana Tomic-Canic & Harold Brem. (2004) Gene array technology and pathogenesis of chronic wounds. The American Journal of Surgery 188:1, pages 67-72.
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Larry D Kier, Robin Neft, Lei Tang, Robert Suizu, Tari Cook, Kathy Onsurez, Karen Tiegler, Yumiko Sakai, Michael Ortiz, Tim Nolan, Usha Sankar & Albert P Li. (2004) Applications of microarrays with toxicologically relevant genes (tox genes) for the evaluation of chemical toxicants in Sprague Dawley rats in vivo and human hepatocytes in vitro. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 549:1-2, pages 101-113.
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Wan-Seon LEE, Gyoum-Jung LEE, Gyoung-Jae LEE, Chan-Dong YEO, Jong-Soo KANG, Yong-Hyun KIM, Seung-Jun KIM, Jun-Sub KIM, Seung Yong HWANG, Joon-Suk PARK, Jae-Woong HWANG, Kyung-Sun KANG, Yong-Soon LEE, Ki-Seon JEON, Chan-Hwi UM, Seok-Il HONG & Yang-Seok KIM. (2004) The Intelligent Data Management System for Toxicogenomics. Journal of Veterinary Medical Science 66:11, pages 1335-1338.
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