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Expert Opinion on Drug Safety Volume 10, 2011 - Issue 4
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Leflunomide-induced interstitial pneumonitis might be a representative of disease-modifying antirheumatic drug-induced lung injury

Shigeko InokumaDepartment of Allergy and Rheumatic Diseases, Rheumatology Center, Japanese Red Cross Medical Center, 4-1-22 Hiroo, Shibuya-ku, Tokyo 150-8935, Japan+81 3 3400 1311; +81 3 3409 1604/3400 0163; [email protected]
, MD
Pages 603-611 | Published online: 17 Mar 2011

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Koichi Okamura, Yukio Yonemoto, Takahito Suto, Chisa Okura & Kenji Takagishi. (2015) Efficacy at 52 weeks of daily clinical use of iguratimod in patients with rheumatoid arthritis. Modern Rheumatology 25:4, pages 534-539.
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Joshua J Solomon & Kevin K Brown. (2012) Rheumatoid arthritis-associated interstitial lung disease. Open Access Rheumatology: Research and Reviews 4, pages 21-31.
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Articles from other publishers (20)

E. N. Popova, M. I. Mitkina, L. A. Ponomareva, A. В. Ponomarev, A. A. Tchinova & S. N. Moiseev. (2023) Lung involvement in rheumatoid arthritis. Modern Rheumatology Journal 17:2, pages 77-81.
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Kuang-Hui Yu, Hsin-Hua Chen, Tien-Tsai Cheng, Yeong-Jian Jan, Meng-Yu Weng, Yeong-Jang Lin, Hung-An Chen, Jui-Tseng Cheng, Kuang-Yung Huang, Ko-Jen Li, Yu-Jih Su, Pui-Ying Leong, Wen-Chan Tsai, Joung-Liang Lan & Der-Yuan Chen. (2022) Consensus recommendations on managing the selected comorbidities including cardiovascular disease, osteoporosis, and interstitial lung disease in rheumatoid arthritis. Medicine 101:1, pages e28501.
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Matt Lewis, Lorinda Chung & David Fiorentino. 2022. Interdisciplinary Approaches to Overlap Disorders in Dermatology & Rheumatology. Interdisciplinary Approaches to Overlap Disorders in Dermatology & Rheumatology 53 91 .
Joanna Kur-Zalewska, Bartłomiej Kisiel, Marta Kania-Pudło, Małgorzata Tłustochowicz, Andrzej Chciałowski & Witold Tłustochowicz. (2021) A dose-dependent beneficial effect of methotrexate on the risk of interstitial lung disease in rheumatoid arthritis patients. PLOS ONE 16:4, pages e0250339.
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Alessandro Conforti, Ilenia Di Cola, Viktoriya Pavlych, Piero Ruscitti, Onorina Berardicurti, Francesco Ursini, Roberto Giacomelli & Paola Cipriani. (2021) Beyond the joints, the extra-articular manifestations in rheumatoid arthritis. Autoimmunity Reviews 20:2, pages 102735.
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Hiroyuki Kamiya & Ogee Mer Panlaqui. (2020) The efficacy of recombinant human soluble thrombomodulin (rhsTM) treatment for acute exacerbation of idiopathic pulmonary fibrosis: a systematic review and meta-analysis. BMC Pulmonary Medicine 20:1.
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Hiroyuki Kamiya & Ogee Mer Panlaqui. (2020) Systematic review and meta-analysis of prognostic factors of acute exacerbation of idiopathic pulmonary fibrosis. BMJ Open 10:6, pages e035420.
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Wanying Wang, Hua Zhou & Liang Liu. (2020) The role of Chinese herbal medicine in the management of adverse drug reactions of leflunomide in treating rheumatoid arthritis. Phytomedicine 68, pages 153136.
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Izumi Kurata, Hiroto Tsuboi, Mayu Terasaki, Masaru Shimizu, Hirofumi Toko, Fumika Honda, Ayako Ohyama, Mizuki Yagishita, Atsumu Osada, Hiroshi Ebe, Hoshimi Kawaguchi, Hiroyuki Takahashi, Shinya Hagiwara, Hiromitsu Asashima, Yuya Kondo, Isao Matsumoto & Takayuki Sumida. (2019) Effect of Biological Disease-modifying Anti-rheumatic Drugs on Airway and Interstitial Lung Disease in Patients with Rheumatoid Arthritis. Internal Medicine 58:12, pages 1703-1712.
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Beth I. Wallace, Chelsea A. Harris, Lu Wang, Mochuan Liu, Jung-Sheng Chen, Chang-Fu Kuo & Kevin C. Chung. (2019) Impact of Cumulative Corticosteroid Dosage on Preventable Hospitalization among Taiwanese Patients with Ankylosing Spondylitis and Inflammatory Bowel Disease. Journal of Clinical Medicine 8:5, pages 614.
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Hiroyuki Kamiya & Ogee Mer Panlaqui. (2019) Prognostic factors for acute exacerbation of idiopathic pulmonary fibrosis: protocol for a systematic review and meta-analysis. BMJ Open 9:5, pages e028226.
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Carlos Fernández-Díaz, Javier Loricera, Santos Castañeda, Raquel López-Mejías, Clara Ojeda-García, Alejandro Olivé, Samantha Rodríguez-Muguruza, Patricia E. Carreira, Trinidad Pérez-Sandoval, Miriam Retuerto, Evelin C. Cervantes-Pérez, Bryan J. Flores-Robles, Blanca Hernández-Cruz, Ana Urruticoechea, Olga Maíz-Alonso, Luis Arboleya, Gema Bonilla, Íñigo Hernández-Rodríguez, Desirée Palma, Concepción Delgado, Rosa Expósito-Molinero, Ana Ruibal-Escribano, Belén Álvarez-Rodríguez, Juan Blanco-Madrigal, José A. Bernal, Paloma Vela-Casasempere, Manuel Rodríguez-Gómez, Concepción Fito, Francisco Ortiz-Sanjuán, Javier Narváez, Manuel Moreno, Mireia López-Corbeto, Natalia Mena-Vázquez, Clara Aguilera-Cros, Susana Romero-Yuste, Sergi Ordóñez, Ignacio Villa-Blanco, M. Carmen Gonzélez-Vela, Víctor Mora-Cuesta, Natalia Palmou-Fontana, José L. Hernández, Miguel A. González-Gay & Ricardo Blanco. (2018) Abatacept in patients with rheumatoid arthritis and interstitial lung disease: A national multicenter study of 63 patients. Seminars in Arthritis and Rheumatism 48:1, pages 22-27.
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Li-Ta Keng, Mong-Wei Lin, Hsien-Neng Huang & Kuei-Pin Chung. (2016) Diffuse alveolar damage in a patient with rheumatoid arthritis under prolonged leflunomide treatment. Medicine 95:26, pages e4044.
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Nasr K. Affara, Alaa M. Refaat, Mohamed H. Elgawish, Mohammad A. Zakaria & Khaledah A. Dashti. (2016) High-resolution CT and pulmonary function tests in rheumatoid arthritis patients with subclinical interstitial lung disease in Kuwait. The Egyptian Rheumatologist 38:2, pages 77-83.
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Takanori Sasaki, Wataru Nakamura, Shigeko Inokuma & Erika Matsubara. (2015) Characteristic features of tacrolimus-induced lung disease in rheumatoid arthritis patients. Clinical Rheumatology 35:2, pages 541-545.
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Susannah L. Collins, Daniel F. Carr & Munir Pirmohamed. (2015) Advances in the Pharmacogenomics of Adverse Drug Reactions. Drug Safety 39:1, pages 15-27.
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Kundan Iqbal & Clive Kelly. (2015) Treatment of rheumatoid arthritis-associated interstitial lung disease: a perspective review. Therapeutic Advances in Musculoskeletal Disease 7:6, pages 247-267.
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Peter G. Pappas. 2015. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases 860 873.e2 .
Robert W. Hallowell & Maureen R. Horton. (2014) Interstitial Lung Disease in Patients with Rheumatoid Arthritis: Spontaneous and Drug Induced. Drugs 74:4, pages 443-450.
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Lorenzo Cavagna, Sara Monti, Vittorio Grosso, Nicola Boffini, Eva Scorletti, Gloria Crepaldi & Roberto Caporali. (2013) The Multifaceted Aspects of Interstitial Lung Disease in Rheumatoid Arthritis. BioMed Research International 2013, pages 1-13.
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