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Prospects for MEK inhibitors for treating cancer

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Shi-Lan Zhang, Hong-Yi Zhu, Bing-Yi Zhou, Yi Chu, Ji-Rong Huo, Yu-Yong Tan & De-Liang Liu. (2019) Histone deacetylase 6 is overexpressed and promotes tumor growth of colon cancer through regulation of the MAPK/ERK signal pathway. OncoTargets and Therapy 12, pages 2409-2419.
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Juan Martin-Liberal & James Larkin. (2014) New RAF kinase inhibitors in cancer therapy. Expert Opinion on Pharmacotherapy 15:9, pages 1235-1245.
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鑫 陈. (2022) Research Progress of Exosome in Gastric Cancer. Advances in Clinical Medicine 12:10, pages 9255-9260.
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Dennis Kobelt, Daniel Perez-Hernandez, Claudia Fleuter, Mathias Dahlmann, Fabian Zincke, Janice Smith, Rebekka Migotti, Oliver Popp, Susen Burock, Wolfgang Walther, Gunnar Dittmar, Philipp Mertins & Ulrike Stein. (2021) The newly identified MEK1 tyrosine phosphorylation target MACC1 is druggable by approved MEK1 inhibitors to restrict colorectal cancer metastasis. Oncogene 40:34, pages 5286-5301.
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Tadashi Honda & Iwao Ojima. 2021. The Curious World of Fluorinated Molecules. The Curious World of Fluorinated Molecules 241 276 .
Akosua A. Nti, Leona W. Serrano, Harpal S. Sandhu, Katherine E. Uyhazi, Ilaina D. Edelstein, Elaine J. Zhou, Scott Bowman, Delu Song, Tara C. Gangadhar, Lynn M. Schuchter, Sheryl Mitnick, Alexander Huang, Charles W. Nichols, Ravi K. Amaravadi, Benjamin J. Kim & Tomas S. Aleman. (2019) FREQUENT SUBCLINICAL MACULAR CHANGES IN COMBINED BRAF/MEK INHIBITION WITH HIGH-DOSE HYDROXYCHLOROQUINE AS TREATMENT FOR ADVANCED METASTATIC BRAF MUTANT MELANOMA. Retina 39:3, pages 502-513.
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Pan Wang, Xinhua Song, Kirsten Utpatel, Runze Shang, Yoon Mee Yang, Meng Xu, Jie Zhang, Li Che, John Gordan, Antonio Cigliano, Ekihiro Seki, Matthias Evert, Diego F. Calvisi, Xiaosong Hu & Xin Chen. (2019) MEK inhibition suppresses K-Ras wild-type cholangiocarcinoma in vitro and in vivo via inhibiting cell proliferation and modulating tumor microenvironment. Cell Death & Disease 10:2.
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Leticia Serrano-Oviedo, Marta Ortega-Muelas, Jesús García-Cano, María Ll. Valero, Francisco J. Cimas, Raquel Pascual-Serra, Diego M. Fernandez-Aroca, Olga Roche, María J. Ruiz-Hidalgo, Borja Belandia, José M. Giménez-Bachs, Antonio S. Salinas & Ricardo Sanchez-Prieto. (2018) Autophagic cell death associated to Sorafenib in renal cell carcinoma is mediated through Akt inhibition in an ERK1/2 independent fashion. PLOS ONE 13:7, pages e0200878.
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Francesca Ricci, Federica Guffanti, Giovanna Damia & Massimo Broggini. (2017) Combination of paclitaxel, bevacizumab and MEK162 in second line treatment in platinum-relapsing patient derived ovarian cancer xenografts. Molecular Cancer 16:1.
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Ying Cheng & Hongqi Tian. (2017) Current Development Status of MEK Inhibitors. Molecules 22:10, pages 1551.
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Tiina Keränen, Tuija Hömmö, Eeva Moilanen & Riku Korhonen. (2017) β 2 -receptor agonists salbutamol and terbutaline attenuated cytokine production by suppressing ERK pathway through cAMP in macrophages. Cytokine 94, pages 1-7.
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Alex A. Adjei, Patricia LoRusso, Antoni Ribas, Jeffrey A. Sosman, Anna Pavlick, Grace K. Dy, Xiaofei Zhou, Esha Gangolli, Michelle Kneissl, Stephanie Faucette, Rachel Neuwirth & Viviana Bózon. (2016) A phase I dose-escalation study of TAK-733, an investigational oral MEK inhibitor, in patients with advanced solid tumors. Investigational New Drugs 35:1, pages 47-58.
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Yu Zhou, Jiang Wang, Zhanni Gu, Shuni Wang, Wei Zhu, José Luis Aceña, Vadim A. Soloshonok, Kunisuke Izawa & Hong Liu. (2016) Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas. Chemical Reviews 116:2, pages 422-518.
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Jennifer L. Gorman & James R. Woodgett. 2015. Kinomics. Kinomics 1 45 .
Gaeun Yoo, Sejin Ahn, Taeri Joe, Jaehyun Kim & Deug-Chan Lee. (2015) Inhibitory Effects of 1-(5-Benzyl-4-(4-chlorophenyl)-2-methylfuran-3-yl)ethan-1-one on Allergic Inflammatory Responses in Rat Basophilic Leukemia Cells. Bulletin of the Korean Chemical Society 36:8, pages 2166-2169.
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Zutao Yu, Shiqi Ye, Gaoyun Hu, Meng Lv, Zhijun Tu, Kun Zhou & Qianbin Li. (2015) The RAF-MEK-ERK pathway: targeting ERK to overcome obstacles to effective cancer therapy. Future Medicinal Chemistry 7:3, pages 269-289.
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