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DPP-4 inhibitors: pharmacological differences and their clinical implications

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Joshua R. Barton, Adam E. Snook & Scott A. Waldman. (2021) From leptin to lasers: the past and present of mouse models of obesity. Expert Opinion on Drug Discovery 16:7, pages 777-790.
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André J Scheen. (2015) Safety of dipeptidyl peptidase-4 inhibitors for treating type 2 diabetes. Expert Opinion on Drug Safety 14:4, pages 505-524.
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Hyounggyoon Yoo, Wonsuk Shin, BackHwan Lee, JinSoo Park, Yilseob Lee & Anhye Kim. (2023) Pharmacokinetics and Food Effect Between a 100‐mg Sustained‐Release Tablet and a 50‐mg Immediate‐Release Tablet of Vildagliptin in Healthy Subjects. Clinical Pharmacology in Drug Development.
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Jaya P. Ambhore, Purushottam R. Laddha, Anjali Nandedkar, Prashant V. Ajmire, Deshraj S. Chumbhale, Ashish B. Navghare, Vitthal G. Kuchake, Prashant J. Chaudhari & Vaibhav S. Adhao. (2023) Medicinal chemistry of non-peptidomimetic dipeptidyl peptidase IV (DPP IV) inhibitors for treatment of Type-2 diabetes mellitus: Insights on recent development. Journal of Molecular Structure 1284, pages 135249.
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Eiji Kutoh, Alexandra N. Kuto, Midori Akiyama, Eri Ozawa & Rumi Kurihara. (2023) Alogliptin: a DPP-4 inhibitor modulating adipose tissue insulin resistance and atherogenic lipid. European Journal of Clinical Pharmacology 79:7, pages 947-959.
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Kunika Saini, Smriti Sharma & Yousuf Khan. (2023) DPP-4 inhibitors for treating T2DM - hype or hope? an analysis based on the current literature. Frontiers in Molecular Biosciences 10.
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Lu Wang, Jinmiao Lu, Sufeng Zhou, Yuqing Zhao, Lijun Xie, Chen Zhou, Juan Chen, Sijia Ding, Daosheng Xie, Juping Ding, Qiang Yu, Hong Shen, Guangtao Hao & Feng Shao. (2021) First-in-Human, Single-Ascending Dose and Food Effect Studies to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Cetagliptin, a Dipeptidyl Peptidase-4 Inhibitor for the Treatment of Type 2 Diabetes Mellitus. Clinical Drug Investigation 41:11, pages 999-1010.
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Habib Yaribeygi, Stephen L. Atkin, Fabrizio Montecucco, Tannaz Jamialahmadi & Amirhossein Sahebkar. (2021) Renoprotective Effects of Incretin-Based Therapy in Diabetes Mellitus. BioMed Research International 2021, pages 1-7.
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Min Wu, Qian‐Qian Li, Hong Zhang, Xiao‐Xue Zhu, Xiao‐Jiao Li, Ying Li, Hai‐Gang Sun & Yan‐Hua Ding. (2021) Safety, Pharmacokinetics, and Pharmacodynamics of a Dipeptidyl Peptidase‐4 Inhibitor: A Randomized, Double‐Blinded, Placebo‐Controlled Daily Administration of Fotagliptin Benzoate for 14 Days for Type 2 Diabetes Mellitus. Clinical Pharmacology in Drug Development 10:6, pages 660-668.
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Jing Huang, Yuntao Jia, Shusen Sun & Long Meng. (2020) Adverse event profiles of dipeptidyl peptidase-4 inhibitors: data mining of the public version of the FDA adverse event reporting system. BMC Pharmacology and Toxicology 21:1.
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Meng-meng Ning, Wen-ji Yang, Wen-bo Guan, Yi-pei Gu, Ying Feng & Ying Leng. (2020) Dipeptidyl peptidase 4 inhibitor sitagliptin protected against dextran sulfate sodium-induced experimental colitis by potentiating the action of GLP-2. Acta Pharmacologica Sinica 41:11, pages 1446-1456.
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Anca Pantea Stoian, Alexandros Sachinidis, Roxana Adriana Stoica, Dragana Nikolic, Angelo Maria Patti & Ali A. Rizvi. (2020) The efficacy and safety of dipeptidyl peptidase-4 inhibitors compared to other oral glucose-lowering medications in the treatment of type 2 diabetes. Metabolism 109, pages 154295.
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Ying Han, Liqing Chen, Wei Liu, Xin Xin, Lingwei Meng, Xiaoyang Chu, Wei Huang, Mingji Jin & Zhonggao Gao. (2019) An HPLC–MS/MS method for quantitation of trelagliptin and application in a comparative pharmacokinetic study. Bioanalysis 11:19, pages 1755-1765.
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Eiji Kutoh, Asuka Wada & Jyunka Hayashi. (2018) Regulation of Free Fatty Acid by Sitagliptin Monotherapy in DRUG-NAÏVE Subjects with Type 2 Diabetes. Endocrine Practice 24:12, pages 1063-1072.
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Chayakrit Krittanawong, Andrew Xanthopoulos, Takeshi Kitai, Natalia Branis, HongJu Zhang & Marrick Kukin. (2017) DPP-4 inhibitors and heart failure: a potential role for pharmacogenomics. Heart Failure Reviews 23:3, pages 355-361.
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R. Gómez-Huelgas, F. Gómez Peralta, L. Rodríguez Mañas, F. Formiga, M. Puig Domingo, J.J. Mediavilla Bravo, C. Miranda & J. Ena. (2018) Tratamiento de la diabetes mellitus tipo 2 en el paciente anciano. Revista Española de Geriatría y Gerontología 53:2, pages 89-99.
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R. Gómez-Huelgas, F. Gómez Peralta, L. Rodríguez Mañas, F. Formiga, M. Puig Domingo, J.J. Mediavilla Bravo, C. Miranda & J. Ena. (2018) Treatment of type 2 diabetes mellitus in elderly patients. Revista Clínica Española (English Edition) 218:2, pages 74-88.
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R. Gómez-Huelgas, F. Gómez Peralta, L. Rodríguez Mañas, F. Formiga, M. Puig Domingo, J.J. Mediavilla Bravo, C. Miranda & J. Ena. (2018) Tratamiento de la diabetes mellitus tipo 2 en el paciente anciano. Revista Clínica Española 218:2, pages 74-88.
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Vladimir V. Kouznetsov & Carlos E. Puerto Galvis. (2018) Strecker reaction and α-amino nitriles: Recent advances in their chemistry, synthesis, and biological properties. Tetrahedron 74:8, pages 773-810.
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Beverley Balkau, Bernard Charbonnel, Alfred Penfornis, Nora Chraibi, Amir Lahouegue, Céline Faure, Florence Thomas-Delecourt & Bruno Detournay. (2017) The Use of Saxagliptin in People with Type 2 Diabetes in France: The Diapazon Epidemiological Study. Diabetes Therapy 8:5, pages 1147-1162.
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Stephen L. Atkin, Niki Katsiki, Maciej Banach, Dimitri P. Mikhailidis, Matteo Pirro & Amirhossein Sahebkar. (2017) Effect of dipeptidyl peptidase-4 inhibitors on circulating tumor necrosis factor-α concentrations: A systematic review and meta-analysis of controlled trials. Journal of Diabetes and its Complications 31:9, pages 1458-1464.
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Christoph Reichetzeder, Karoline von Websky, Oleg Tsuprykov, Azadeh Mohagheghi Samarin, Luise Gabriele Falke, Sulistyo Emantoko Dwi Putra, Ahmed Abdallah Hasan, Viktoriia Antonenko, Caterina Curato, Jörg Rippmann, Thomas Klein & Berthold Hocher. (2017) Head-to-head comparison of structurally unrelated dipeptidyl peptidase 4 inhibitors in the setting of renal ischemia reperfusion injury. British Journal of Pharmacology 174:14, pages 2273-2286.
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Charles E. Grimshaw, Andy Jennings, Ruhi Kamran, Hikaru Ueno, Nobuhiro Nishigaki, Takuo Kosaka, Akiyoshi Tani, Hiroki Sano, Yoshinobu Kinugawa, Emiko Koumura, Lihong Shi & Koji Takeuchi. (2016) Trelagliptin (SYR-472, Zafatek), Novel Once-Weekly Treatment for Type 2 Diabetes, Inhibits Dipeptidyl Peptidase-4 (DPP-4) via a Non-Covalent Mechanism. PLOS ONE 11:6, pages e0157509.
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J. Kongwatcharapong, P. Dilokthornsakul, S. Nathisuwan, A. Phrommintikul & N. Chaiyakunapruk. (2016) Effect of dipeptidyl peptidase-4 inhibitors on heart failure: A meta-analysis of randomized clinical trials. International Journal of Cardiology 211, pages 88-95.
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Zhengchao Xia, Hongyan Wei, Jingjing Duan, Ting Zhou, Zhen Yang & Feng Xu. (2016) Chronic unpredicted mild stress-induced depression alter saxagliptin pharmacokinetics and CYP450 activity in GK rats. PeerJ 4, pages e1611.
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Alok Sharma, Geetanjali Paliwal, Nisha Upadhyay & Archana Tiwari. (2015) RETRACTED ARTICLE: Therapeutic stimulation of GLP-1 and GIP protein with DPP-4 inhibitors for type-2 diabetes treatment. Journal of Diabetes & Metabolic Disorders 14:1.
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Julio Rosenstock, Nikolaus Marx, Dietmar Neubacher, Thomas Seck, Sanjay Patel, Hans-Juergen Woerle & Odd Erik Johansen. (2015) Cardiovascular safety of linagliptin in type 2 diabetes: a comprehensive patient-level pooled analysis of prospectively adjudicated cardiovascular events. Cardiovascular Diabetology 14:1.
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Xiao-Wu Chen, Zhi-Xu He, Zhi-Wei Zhou, Tianxin Yang, Xueji Zhang, Yin-Xue Yang, Wei Duan & Shu-Feng Zhou. (2015) An update on the clinical pharmacology of the dipeptidyl peptidase 4 inhibitor alogliptin used for the treatment of type 2 diabetes mellitus. Clinical and Experimental Pharmacology and Physiology 42:12, pages 1225-1238.
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E. Kutoh, M. Hirate & A. Wada. (2015) Distinct glucose-lowering properties in good responders treated with sitagliptin and alogliptin. International Journal of Clinical Practice 69:11, pages 1296-1302.
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Qing Li, Muxing Zhou, Li Han, Qing Cao, Xinning Wang, LeiLei Zhao, Jinpei Zhou & Huibin Zhang. (2015) Design, Synthesis and Biological Evaluation of Imidazo[1,2-a]pyridine Derivatives as Novel DPP-4 Inhibitors. Chemical Biology & Drug Design 86:4, pages 849-856.
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