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Expert Opinion on Drug Safety Volume 14, 2015 - Issue 1
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Drug Safety Evaluation

Dimethyl fumarate for treating relapsing multiple sclerosis

William SheremataUniversity of Miami, Miller School of Medicine, Department of Neurology, 1120 NW 14th Street, Miami, FL 33136, [email protected]
, MD FRCPC FACP FAAN (Emeritus Professor of Neurology) ,
Andrew D BrownFlorida International University, Department of Neurology, Miami, FL 33136, USA;University of Miami, Miller School of Medicine, 1120 NW 14th Street, Miami, FL 33136, USA
, MD (Assistant Professor) (Fellow in Multiple Sclerosis) (Assistant Professor) (Fellow in Multiple Sclerosis) &
Kottil W RammohanUniversity of Miami, Miller School of Medicine, Department of Neurology, 1120 NW 14th Street, Miami, FL 33136, USA
, MD (Professor of Clinical Neurology)
Pages 161-170 | Published online: 08 Nov 2014

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Xiran Lin & Tian Huang. (2016) Oxidative stress in psoriasis and potential therapeutic use of antioxidants. Free Radical Research 50:6, pages 585-595.
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M. J. van Geel, P. C. M. van de Kerkhof, A. M. Oostveen, E. M. G. J. de Jong & M. M. B. Seyger. (2016) Fumaric acid esters in recalcitrant pediatric psoriasis: A prospective, daily clinical practice case series. Journal of Dermatological Treatment 27:3, pages 214-220.
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Michele Faulkner. (2015) Risk of progressive multifocal leukoencephalopathy in patients with multiple sclerosis. Expert Opinion on Drug Safety 14:11, pages 1737-1748.
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Daniela Giustarini, Aldo Milzani, Isabella Dalle-Donne & Ranieri Rossi. (2023) How to Increase Cellular Glutathione. Antioxidants 12:5, pages 1094.
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Rossella Basilotta, Marika Lanza, Alessia Filippone, Giovanna Casili, Deborah Mannino, Federica De Gaetano, Giulia Chisari, Lorenzo Colarossi, Gianmarco Motta, Michela Campolo, Salvatore Cuzzocrea, Irene Paterniti & Emanuela Esposito. (2023) Therapeutic Potential of Dimethyl Fumarate in Counteract Oral Squamous Cell Carcinoma Progression by Modulating Apoptosis, Oxidative Stress and Epithelial–Mesenchymal Transition. International Journal of Molecular Sciences 24:3, pages 2777.
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Yuxia Xiong, Jinshu Wang, Shilei Wang, Haixia Li & Xun Zhou. (2022) Tryptanthrin ameliorates imiquimod-induced psoriasis in mice by suppressing inflammation and oxidative stress via NF-κB/MAPK/Nrf2 pathways. Journal of Natural Medicines 77:1, pages 188-201.
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Jian Chen, Zhijun Chen, Putao Yuan, Hai Huang, Jiying Wang, Peihua Shi & Xuewu Sun. (2022) ERK1 loss accelerates the progression of osteoarthritis in aged mice via NRF2/BACH1 signaling. Biochemical and Biophysical Research Communications 622, pages 129-135.
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Marco Biolato, Assunta Bianco, Matteo Lucchini, Antonio Gasbarrini, Massimiliano Mirabella & Antonio Grieco. (2021) The Disease-Modifying Therapies of Relapsing-Remitting Multiple Sclerosis and Liver Injury: A Narrative Review. CNS Drugs 35:8, pages 861-880.
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Nahanna Zimmermann Menezes Carvalho, Gabriela Bortolança Chiarotto, Danielle Bernardes, Paula Regina Gelinski Kempe & Alexandre Leite Rodrigues Oliveira. (2020) Neuroprotection by dimethyl fumarate following ventral root crush in C57BL/6J mice. Brain Research Bulletin 164, pages 184-197.
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Maria Rosito, Claudia Testi, Giacomo Parisi, Barbara Cortese, Paola Baiocco & Silvia Di Angelantonio. (2020) Exploring the Use of Dimethyl Fumarate as Microglia Modulator for Neurodegenerative Diseases Treatment. Antioxidants 9:8, pages 700.
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Ioannis Zalachoras, Fiona Hollis, Eva Ramos-Fernández, Laura Trovo, Sarah Sonnay, Eveline Geiser, Nicolas Preitner, Pascal Steiner, Carmen Sandi & Laia Morató. (2020) Therapeutic potential of glutathione-enhancers in stress-related psychopathologies. Neuroscience & Biobehavioral Reviews 114, pages 134-155.
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Lei Liu, Mary K. Vollmer, Marie G. Kelly, Victoria M. Fernandez, Tyler G. Fernandez, Hocheol Kim & Sylvain Doré. (2019) Reactive Gliosis Contributes to Nrf2-Dependent Neuroprotection by Pretreatment with Dimethyl Fumarate or Korean Red Ginseng Against Hypoxic-Ischemia: Focus on Hippocampal Injury. Molecular Neurobiology 57:1, pages 105-117.
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Gerardo G. Piroli, Allison M. Manuel, Tulsi Patel, Michael D. Walla, Liang Shi, Scott A. Lanci, Jingtian Wang, Ashley Galloway, Pavel I. Ortinski, Deanna S. Smith & Norma Frizzell. (2019) Identification of Novel Protein Targets of Dimethyl Fumarate Modification in Neurons and Astrocytes Reveals Actions Independent of Nrf2 Stabilization. Molecular & Cellular Proteomics 18:3, pages 504-519.
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Jing Sun, Jingqi Fu, Yang Zhong, Lu Li, Chengjie Chen, Xiaolei Wang, Linlin Wang, Yongyong Hou, Huihui Wang, Rui Zhao, Xixuan Zhang, Masayuki Yamamoto, Yuanyuan Xu & Jingbo Pi. (2018) NRF2 mitigates acute alcohol-induced hepatic and pancreatic injury in mice. Food and Chemical Toxicology 121, pages 495-503.
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Sang-sun Lee, Yun-Jeong Choe, Hyein Lee, Sun-Young Lee & Ho-Shik Kim. (2018) PGA2-induced expression of HO-1 is mediated by transcriptional upregulation of Nrf2. Molecular & Cellular Toxicology 14:4, pages 391-398.
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Lin Gou, Jinhyuk Lee, Jun-Mo Yang, Yong-Doo Park, Hai-Meng Zhou, Yi Zhan & Zhi-Rong Lü. (2017) Inhibition of tyrosinase by fumaric acid: Integration of inhibition kinetics with computational docking simulations. International Journal of Biological Macromolecules 105, pages 1663-1669.
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Amira Zarrouk, Thomas Nury, El-Mostafa Karym, Anne Vejux, Randa Sghaier, Catherine Gondcaille, Pierre Andreoletti, Doriane Trompier, Stéphane Savary, Mustapha Cherkaoui-Malki, Meryam Debbabi, Agnès Fromont, Jean-Marc Riedinger, Thibault Moreau & Gérard Lizard. (2017) Attenuation of 7-ketocholesterol-induced overproduction of reactive oxygen species, apoptosis, and autophagy by dimethyl fumarate on 158 N murine oligodendrocytes. The Journal of Steroid Biochemistry and Molecular Biology 169, pages 29-38.
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Begoña M. Escribano, Francisco J. Medina-Fernández, Macarena Aguilar-Luque, Eduardo Agüera, Montserrat Feijoo, Fe I. Garcia-Maceira, Rafael Lillo, Patricia Vieyra-Reyes, Ana I. Giraldo, Evelio Luque, René Drucker-Colín & Isaac Túnez. (2016) Lipopolysaccharide Binding Protein and Oxidative Stress in a Multiple Sclerosis Model. Neurotherapeutics 14:1, pages 199-211.
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Diogo Mendes, Carlos Alves & Francisco Batel-Marques. (2016) Benefit–Risk of Therapies for Relapsing–Remitting Multiple Sclerosis: Testing the Number Needed to Treat to Benefit (NNTB), Number Needed to Treat to Harm (NNTH) and the Likelihood to be Helped or Harmed (LHH): A Systematic Review and Meta-Analysis. CNS Drugs 30:10, pages 909-929.
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Christoph Jüngst, Yoo‐Jin Kim & Frank Lammert. (2016) Severe drug‐induced liver injury related to therapy with dimethyl fumarate. Hepatology 64:4, pages 1367-1369.
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Steven K. LundyQi WuQin WangCatherine A. DowlingSophina H. TaitanoGuangmei MaoYang Mao-Draayer. (2016) Dimethyl fumarate treatment of relapsing-remitting multiple sclerosis influences B-cell subsets. Neurology Neuroimmunology & Neuroinflammation 3:2.
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Wen-Xian Zhang, Jian-Hong Zhao, Fu-Min Ping, Zhi-Jun Liu, Jun-Xia Gu & Xin-Qing Lu. (2016) Effect of dimethyl fumarate on rats with chronic pancreatitis. Asian Pacific Journal of Tropical Medicine 9:3, pages 261-264.
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Jens Ingwersen, Orhan Aktas & Hans-Peter Hartung. (2015) Advances in and Algorithms for the Treatment of Relapsing-Remitting Multiple Sclerosis. Neurotherapeutics 13:1, pages 47-57.
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Tjalf Ziemssen, Nicola De Stefano, Maria Pia Sormani, Bart Van Wijmeersch, Heinz Wiendl & Bernd C. Kieseier. (2015) Optimizing therapy early in multiple sclerosis: An evidence-based view. Multiple Sclerosis and Related Disorders 4:5, pages 460-469.
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Christian Wüthrich, Stephanie Batson & Igor J. Koralnik. (2015) Lack of Major Histocompatibility Complex Class I Upregulation and Restrictive Infection by JC Virus Hamper Detection of Neurons by T Lymphocytes in the Central Nervous System. Journal of Neuropathology & Experimental Neurology 74:8, pages 791-803.
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Frank Block & Annett Schoenhof. (2015) Potenzielle Nebenwirkungen und Monitoring moderner MS-Therapien. NeuroTransmitter 26:7-8, pages 39-43.
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Hassen S. Wollebo, Martyn K. White, Jennifer Gordon, Joseph R. Berger & Kamel Khalili. (2015) Persistence and pathogenesis of the neurotropic polyomavirus JC. Annals of Neurology 77:4, pages 560-570.
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