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The safety of antiemetic medications for the prevention of chemotherapy-induced nausea and vomiting

Pages 343-356 | Received 16 Nov 2015, Accepted 21 Dec 2015, Published online: 14 Jan 2016

Keep up to date with the latest research on this topic with citation updates for this article.

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Siyuan Gao, Mei Zhang, Kaishan Wu, Jianhong Zhu, Zhichao He, Jianfang Li, Chuxiong Chen, Kaifeng Qiu, Xiaoxia Yu & Junyan Wu. (2020) Risk of adverse events in lymphoma patients treated with brentuximab vedotin: a systematic review and meta-analysis. Expert Opinion on Drug Safety 19:5, pages 617-623.
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Rudolph M Navari. (2019) The safety of rolapitant for the treatment of nausea and vomiting associated with chemotherapy. Expert Opinion on Drug Safety 18:12, pages 1127-1132.
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Rudolph M Navari & Lee S Schwartzberg. (2018) Evolving role of neurokinin 1-receptor antagonists for chemotherapy-induced nausea and vomiting. OncoTargets and Therapy 11, pages 6459-6478.
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Anastasia Spartinou, Vasileia Nyktari & Alexandra Papaioannou. (2017) Granisetron: a review of pharmacokinetics and clinical experience in chemotherapy induced - nausea and vomiting. Expert Opinion on Drug Metabolism & Toxicology 13:12, pages 1289-1297.
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Bernardo Leon Rapoport, Matti Aapro, Martin R Chasen, Karin Jordan, Rudolph M Navari, Ian Schnadig & Lee Schwartzberg. (2017) Recent developments in the clinical pharmacology of rolapitant: subanalyses in specific populations. Drug Design, Development and Therapy 11, pages 2621-2629.
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Bernardo Leon Rapoport. (2017) Differential pharmacology and clinical utility of rolapitant in chemotherapy-induced nausea and vomiting. Cancer Management and Research 9, pages 41-50.
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Bernardo Rapoport & Teresa Smit. (2017) Clinical pharmacology of neurokinin-1 receptor antagonists for the treatment of nausea and vomiting associated with chemotherapy. Expert Opinion on Drug Safety 16:6, pages 697-710.
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Bernardo Rapoport, Ronwyn van Eeden & Teresa Smit. (2017) Rolapitant for the prevention of delayed nausea and vomiting over initial and repeat courses of emetogenic chemotherapy. Expert Review of Clinical Pharmacology 10:1, pages 17-29.
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Articles from other publishers (17)

Yunjing He, Jingrui Zheng, Binbin Ye, Yongzhao Dai & Ke Nie. (2023) Chemotherapy-induced gastrointestinal toxicity: Pathogenesis and current management. Biochemical Pharmacology 216, pages 115787.
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Toshinobu Hayashi, Mototsugu Shimokawa, Koichi Matsuo, Masanobu Uchiyama, Kei Kawada, Takafumi Nakano & Takashi Egawa. (2023) Effectiveness of Palonosetron, 1-Day Dexamethasone, and Aprepitant in Patients Undergoing Carboplatin-Based Chemotherapy. Oncology, pages 1-7.
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Hakan Nazlı, Burcu Mesut, Özlem Akbal-Dağıstan & Yıldız Özsoy. (2023) A Novel Semi-Solid Self-Emulsifying Formulation of Aprepitant for Oral Delivery: An In Vitro Evaluation. Pharmaceutics 15:5, pages 1509.
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Jihee Choi, Jounghee Lee, Kijoon Kim, Hyo-Kyoung Choi, Se-A Lee & Hae-Jeung Lee. (2022) Effects of Ginger Intake on Chemotherapy-Induced Nausea and Vomiting: A Systematic Review of Randomized Clinical Trials. Nutrients 14:23, pages 4982.
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Manik Chatterjee, Anja Gesierich, Matthias Kroiß & Volker Kunzmann. 2022. Medikamentöse Tumortherapie von Kopf-Hals-Tumoren. Medikamentöse Tumortherapie von Kopf-Hals-Tumoren 121 146 .
Tingting QiuPeng Men, Xiaohan Xu, Suodi Zhai & Xiangli Cui. (2020) Antiemetic regimen with aprepitant in the prevention of chemotherapy-induced nausea and vomiting. Medicine 99:33, pages e21559.
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Didem Ondaş Aybar, Serap Parlar Kılıc & Havva Yeşil Çınkır. (2020) The effect of breathing exercise on nausea, vomiting and functional status in breast cancer patients undergoing chemotherapy. Complementary Therapies in Clinical Practice 40, pages 101213.
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Lee Schwartzberg, Rudolph Navari, Rebecca Clark-Snow, Ekaterine Arkania, Irena Radyukova, Kamal Patel, Daniel Voisin, Giada Rizzi, Rita Wickham, Richard J. Gralla, Matti Aapro & Eric Roeland. (2020) Phase IIIb Safety and Efficacy of Intravenous NEPA for Prevention of Chemotherapy-Induced Nausea and Vomiting (CINV) in Patients with Breast Cancer Receiving Initial and Repeat Cycles of Anthracycline and Cyclophosphamide (AC) Chemotherapy. The Oncologist 25:3, pages e589-e597.
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Matti Aapro, Li Zhang, Sriram Yennu, Thomas W LeBlanc & Lee Schwartzberg. (2019) Preventing chemotherapy-induced nausea and vomiting with netupitant/palonosetron, the first fixed combination antiemetic: current and future perspective. Future Oncology 15:10, pages 1067-1084.
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Akihiko Osaki, Kenichi Inoue, Hiroshi Sakai, Kazuhiko Yamada, Koichi Minato, Fumiyoshi Ohyanagi, Yutaka Tokuda, Norihiko Ikeda, Hiroshi Kagamu, Kaoru Kubota, Tomohide Tamura & Toshiaki Saeki. (2019) A dose-finding randomized Phase II study of oral netupitant in combination with palonosetron .75 mg intravenous for the prevention of chemotherapy-induced nausea and vomiting in Japanese patients receiving highly emetogenic chemotherapy. Japanese Journal of Clinical Oncology 49:2, pages 121-129.
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Rudolph M Navari. (2019) HTX-019: polysorbate 80- and synthetic surfactant-free neurokinin 1 receptor antagonist for chemotherapy-induced nausea and vomiting prophylaxis. Future Oncology 15:3, pages 241-255.
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Marie-Luce Rosseels, Renaud Fleurance & Susan M.G. Goody. 2019. Advanced Issue Resolution in Safety Pharmacology. Advanced Issue Resolution in Safety Pharmacology 77 101 .
Weixia Zhong & Nissar A. Darmani. 2018. Calcium and Signal Transduction. Calcium and Signal Transduction.
Rudolph M. Navari, Bernardo L. Rapoport, Dan Powers, Sujata Arora & Rebecca Clark‐Snow. (2018) Rolapitant for the prevention of nausea in patients receiving highly or moderately emetogenic chemotherapy. Cancer Medicine 7:7, pages 2943-2950.
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Renzo Carletti, Stefano Tacconi, Manolo Mugnaini & Philip Gerrard. (2017) Receptor distribution studies. Current Opinion in Pharmacology 35, pages 94-100.
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Bernardo L. Rapoport. (2017) Delayed Chemotherapy-Induced Nausea and Vomiting: Pathogenesis, Incidence, and Current Management. Frontiers in Pharmacology 08.
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Weixia Zhong, Andrew J. Picca, Albert S. Lee & Nissar A. Darmani. (2017) Ca2+ signaling and emesis: Recent progress and new perspectives. Autonomic Neuroscience 202, pages 18-27.
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