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Review

Safety review of kava (Piper methysticum) by the Natural Standard Research Collaboration

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Pages 779-794 | Published online: 12 Jul 2005

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Amy C. Brown, Janet Onopa, Peter Holck, Pakieli Kaufusi, Derek Kabasawa, Winston J. Craig, Klaus Dragull, Arieh M. Levine & Jonathan D. Baker. (2007) Traditional kava beverage consumption and liver function tests in a predominantly Tongan population in Hawaii. Clinical Toxicology 45:5, pages 549-556.
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Articles from other publishers (48)

Jian Xiang Yang. (2023) A New Kavalactone Dimer from Piper methysticum. Chemistry of Natural Compounds 59:3, pages 420-423.
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Deborah R. Simkin, Shayna Swick, Krishna S. Taneja & Noshene Ranjbar. (2023) Complementary and Integrative Medicine for Anxiety in Children, Adolescents, and Young Adults. Child and Adolescent Psychiatric Clinics of North America 32:2, pages 193-216.
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Lydia Sandrah Kaforau, Gizachew A. Tessema, Jonine Jancey, Hugo Bugoro & Gavin Pereira. (2023) Prevalence and Factors Associated With Low Birth Weight in the Solomon Islands: Evidence From the 2015 Solomon Islands Demographic and Health Survey data. Asia Pacific Journal of Public Health 35:2-3, pages 136-144.
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Deana Goldin & Deborah Salani. (2022) Calm Down With Kava: What Clinicians Need to Know. Journal of Psychosocial Nursing and Mental Health Services 60:12, pages 17-24.
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Rafael Rocha da Silva Santos, Matheus Corrêa Ramos, Juliana Veloso Ferreira, José Eduardo Gonçalves & Isabela Costa César. (2022) Biopharmaceutical evaluation of kavain in Piper methysticum G. Forst dried extract: Equilibrium solubility and intestinal permeability in Caco-2 cell model. Journal of Ethnopharmacology 296, pages 115480.
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Rita B. Soares, Ricardo Jorge Dinis-Oliveira & Nuno G. Oliveira. (2022) An Updated Review on the Psychoactive, Toxic and Anticancer Properties of Kava. Journal of Clinical Medicine 11:14, pages 4039.
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María Adelina Jiménez-Arellanes & Mariana Z. Pérez-González. 2022. Phenolic Compounds - Chemistry, Synthesis, Diversity, Non-Conventional Industrial, Pharmaceutical and Therapeutic Applications. Phenolic Compounds - Chemistry, Synthesis, Diversity, Non-Conventional Industrial, Pharmaceutical and Therapeutic Applications.
Yingli Wang, Chao Su, Bo Zhang, Yang Niu, Ruru Ren, Xiaojun Zhao, Lingling Yang, Wannian Zhang & Xueqin Ma. (2021) Biological Activity, Hepatotoxicity, and Structure-Activity Relationship of Kavalactones and Flavokavins, the Two Main Bioactive Components in Kava (Piper methysticum). Evidence-Based Complementary and Alternative Medicine 2021, pages 1-14.
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Mariana Zuleima Pérez-González & María Adelina Jiménez-Arellanes. (2021) Biotechnological processes to obtain bioactive secondary metabolites from some Mexican medicinal plants. Applied Microbiology and Biotechnology 105:16-17, pages 6257-6274.
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Ajay Srivastava & Prafulla Kumar. 2021. Nutraceuticals. Nutraceuticals 63 72 .
Tengfei Bian, Pedro Corral, Yuzhi Wang, Jordy Botello, Rick Kingston, Tyler Daniels, Ramzi G. Salloum, Edward Johnston, Zhiguang Huo, Junxuan Lu, Andrew C. Liu & Chengguo Xing. (2020) Kava as a Clinical Nutrient: Promises and Challenges. Nutrients 12:10, pages 3044.
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Yijin Tang & Christine Fields. (2019) A UHPLC-UV Method Development and Validation for Determining Kavalactones and Flavokavains in Piper methysticum (Kava). Molecules 24:7, pages 1245.
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C. Michael White. (2018) The Pharmacology, Pharmacokinetics, Efficacy, and Adverse Events Associated With Kava. The Journal of Clinical Pharmacology 58:11, pages 1396-1405.
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Haruhiro Yamashita, Mark J. Hoenerhoff, Keith R. Shockley, Shyamal D. Peddada, Kevin E. Gerrish, Deloris Sutton, Connie A. Cummings, Yu Wang, Foley F. Julie, Mamta Behl, Suramya Waidyanatha, Robert C. Sills & Arun R. Pandiri. (2018) Reduced Disc Shedding and Phagocytosis of Photoreceptor Outer Segment Contributes to Kava Kava Extract–induced Retinal Degeneration in F344/N Rats. Toxicologic Pathology 46:5, pages 564-573.
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. 2016. Meyler's Side Effects of Drugs. Meyler's Side Effects of Drugs 777 780 .
E. A. Davies & M. S. O'Mahony. (2015) Adverse drug reactions in special populations - the elderly. British Journal of Clinical Pharmacology 80:4, pages 796-807.
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Iris Wainiqolo, Bridget Kool, Vili Nosa & Shanthi Ameratunga. (2015) Is driving under the influence of kava associated with motor vehicle crashes? A systematic review of the epidemiological literature. Australian and New Zealand Journal of Public Health 39:5, pages 495-499.
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Dong Fu & Iqbal Ramzan. 2015. Phytotherapies. Phytotherapies 312 329 .
Raimo A. Ketola, Jenni Viinamäki, Ilpo Rasanen, Anna Pelander & Sirkka Goebeler. (2015) Fatal kavalactone intoxication by suicidal intravenous injection. Forensic Science International 249, pages e7-e11.
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Cydney E. McQueen & Katherine Kelly Orr. 2015. Handbook of Nonprescription Drugs: An Interactive Approach to Self-Care, 18th Edition. Handbook of Nonprescription Drugs: An Interactive Approach to Self-Care, 18th Edition.
Sarah Hannam, Michael Murray, Lucia Romani, Meciusela Tuicakau & Margot J Whitfeld. (2014) Kava dermopathy in Fiji: an acquired ichthyosis?. International Journal of Dermatology 53:12, pages 1490-1494.
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Simona Rossi & Victor J. Navarro. (2014) Herbs and Liver Injury: A Clinical Perspective. Clinical Gastroenterology and Hepatology 12:7, pages 1069-1076.
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L.R. Olsen & C. Skonberg. 2014. Encyclopedia of Toxicology. Encyclopedia of Toxicology 741 745 .
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Paul Posadzki, Leala Watson & Edzard Ernst. (2013) Herb–drug interactions: an overview of systematic reviews. British Journal of Clinical Pharmacology 75:3, pages 603-618.
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Paul Posadzki, Leala K Watson & Edzard Ernst. (2013) Adverse effects of herbal medicines: an overview of systematic reviews. Clinical Medicine 13:1, pages 7-12.
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Anthony Rowe & Iqbal Ramzan. (2012) Are Mould Hepatotoxins Responsible for Kava Hepatotoxicity?. Phytotherapy Research 26:11, pages 1768-1770.
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Alexander V. LyubimovBill Gurley, Kim E. Fifer & Zöe Gardner. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 79 .
Karen Pilkington & Anelia Boshnakova. (2012) Complementary medicine and safety: A systematic investigation of design and reporting of systematic reviews. Complementary Therapies in Medicine 20:1-2, pages 73-82.
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Rolf Teschke & Vincent Lebot. (2011) Proposal for a Kava Quality Standardization Code. Food and Chemical Toxicology 49:10, pages 2503-2516.
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. (2011) Clinical Roundup: How Do You Treat Stress in Your Practice? Part 2. Alternative and Complementary Therapies 17:3, pages 181-187.
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Anthony Rowe, Lillian Yuan Zhang & Iqbal Ramzan. (2011) Toxicokinetics of Kava. Advances in Pharmacological Sciences 2011, pages 1-6.
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. 2011. A Guide to Evidence-based Integrative and Complementary Medicine. A Guide to Evidence-based Integrative and Complementary Medicine 855 875 .
Rolf Teschke. (2010) Kava hepatotoxicity: pathogenetic aspects and prospective considerations. Liver International 30:9, pages 1270-1279.
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X. Z. Li & I. Ramzan. (2009) Role of ethanol in kava hepatotoxicity. Phytotherapy Research 24:4, pages 475-480.
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J. Sarris, D.J. Kavanagh, J. Adams, K. Bone & G. Byrne. (2009) Kava Anxiety Depression Spectrum Study (KADSS): A mixed methods RCT using an aqueous extract of Piper methysticum. Complementary Therapies in Medicine 17:3, pages 176-178.
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B J Gurley, A Swain, M A Hubbard, F Hartsfield, J Thaden, D K Williams, W B Gentry & Y Tong. (2007) Supplementation With Goldenseal (Hydrastis canadensis), but not Kava Kava (Piper methysticum), Inhibits Human CYP3A Activity In Vivo. Clinical Pharmacology & Therapeutics 83:1, pages 61-69.
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Stacie E. Geller & Laura Studee. (2007) Botanical and dietary supplements for mood and anxiety in menopausal women. Menopause 14:3, pages 541-549.
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Bill J. Gurley, Ashley Swain, Gary W. Barone, D. Keith Williams, Philip Breen, C. Ryan Yates, Leslie B. Stuart, Martha A. Hubbard, Yudong Tong & Sreekhar Cheboyina. (2007) Effect of Goldenseal ( Hydrastis canadensis ) and Kava Kava ( Piper methysticum ) Supplementation on Digoxin Pharmacokinetics in Humans . Drug Metabolism and Disposition 35:2, pages 240-245.
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Natasha P. Clayton, Katsuhiko Yoshizawa, Grace E. Kissling, Leo T. Burka, Po-Chuen Chan & Abraham Nyska. (2007) Immunohistochemical analysis of expressions of hepatic cytochrome P450 in F344 rats following oral treatment with kava extract. Experimental and Toxicologic Pathology 58:4, pages 223-236.
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