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Editorial

The role of early in vivo toxicity testing in drug discovery toxicology

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Pages 107-110 | Published online: 06 Mar 2008

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Read on this site (5)

Simon Loiodice, Andre Nogueira da Costa & Franck Atienzar. (2019) Current trends in in silico, in vitro toxicology, and safety biomarkers in early drug development. Drug and Chemical Toxicology 42:2, pages 113-121.
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Poonam Advani, Blessy Joseph, Premlata Ambre, Raghuvir Pissurlenkar, Vijay Khedkar, Krishna Iyer, Satish Gabhe, Radhakrishnan P. Iyer & Evans Coutinho. (2016) In silico optimization of pharmacokinetic properties and receptor binding affinity simultaneously: a ‘parallel progression approach to drug design’ applied to β-blockers. Journal of Biomolecular Structure and Dynamics 34:2, pages 384-398.
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Lesley J Burgess & Marli Terblanche. (2011) The future of the pharmaceutical, biological and medical device industry. Open Access Journal of Clinical Trials 3, pages 45-50.
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Jeffrey A Kramer. (2008) Designing safe drugs: what to consider?. Expert Opinion on Drug Discovery 3:7, pages 707-713.
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Doha Naga, Smaragda Dimitrakopoulou, Sonia Roberts, Elisabeth Husar, Susanne Mohr, Helen Booler & Eunice Musvasva. (2023) CSL-Tox: an open-source analytical framework for the comparison of short-term and long-term toxicity end points and assessing the need of chronic studies in drug development. Scientific Reports 13:1.
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Chi Yang, Wangwen Xiao, Rui Wang, Yan Hu, Ke Yi, Xuan Sun, Guanghui Wang & Xiaohui Xu. (2023) Tumor organoid model of colorectal cancer (Review). Oncology Letters 26:2.
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Farizatul Akmawati Yahya, Nur Fariesha Md Hashim, Daud Ahmad Israf Ali, Tham Chau Ling & Manraj Singh Cheema. (2021) A brief overview to systems biology in toxicology: The journey from in to vivo, in-vitro and –omics. Journal of King Saud University - Science 33:1, pages 101254.
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Martyn L. Foster. (2017) Pre-clinical disease models in drug toxicity evaluation. Current Opinion in Toxicology 3, pages 48-54.
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Adriana Prado, Georg A. Petroianu, Dietrich E. Lorke & Jeremy W. Chambers. (2015) A trivalent approach for determining in vitro toxicology: Examination of oxime K027 . Journal of Applied Toxicology 35:2, pages 219-227.
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Aurel Cami & Ben Y Reis. (2014) Concordance and predictive value of two adverse drug event data sets. BMC Medical Informatics and Decision Making 14:1.
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Varun Ahuja & Sharad Sharma. (2014) Drug safety testing paradigm, current progress and future challenges: an overview. Journal of Applied Toxicology 34:6, pages 576-594.
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Minjun Chen, Jürgen Borlak & Weida Tong. (2013) High lipophilicity and high daily dose of oral medications are associated with significant risk for drug-induced liver injury. Hepatology 58:1, pages 388-396.
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Pritam Sahota, James Popp, Jerry Hardisty & Chirukandath GopinathThomas Monticello & Jeanine Bussiere. 2013. Toxicologic Pathology. Toxicologic Pathology 25 54 .
J. Fraczek, J. Bolleyn, T. Vanhaecke, V. Rogiers & M. Vinken. (2012) Primary hepatocyte cultures for pharmaco-toxicological studies: at the busy crossroad of various anti-dedifferentiation strategies. Archives of Toxicology 87:4, pages 577-610.
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Yuye He, Chin Yee Liew, Nitin Sharma, Sze Kwang Woo, Yi Ting Chau & Chun Wei Yap. (2012) PaDEL‐DDPredictor: Open‐source software for PD‐PK‐T prediction. Journal of Computational Chemistry 34:7, pages 604-610.
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Myrtle Davis, Kim Boekelheide, Darrell R. Boverhof, Gary Eichenbaum, Thomas Hartung, Michael P. Holsapple, Thomas W. Jones, Ann M. Richard & Paul B. Watkins. (2013) The new revolution in toxicology: The good, the bad, and the ugly. Annals of the New York Academy of Sciences 1278:1, pages 11-24.
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K. Tilmant, H.H.J. Gerets, P. De Ron, C. Cossu-Leguille, P. Vasseur, S. Dhalluin & F.A. Atienzar. (2013) The automated micronucleus assay for early assessment of genotoxicity in drug discovery. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 751:1, pages 1-11.
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John Higgins, Mark E. Cartwright & Allen C. Templeton. (2012) Progressing preclinical drug candidates: strategies on preclinical safety studies and the quest for adequate exposure. Drug Discovery Today 17:15-16, pages 828-836.
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Tewes Tralau & Andreas Luch. (2012) Drug-mediated toxicity: illuminating the ‘bad’ in the test tube by means of cellular assays?. Trends in Pharmacological Sciences 33:7, pages 353-364.
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Timothy A. MoellerSunita J. ShuklaMenghang Xia. (2012) Assessment of Compound Hepatotoxicity Using Human Plateable Cryopreserved Hepatocytes in a 1536-Well-Plate Format. ASSAY and Drug Development Technologies 10:1, pages 78-87.
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Aurel CamiAlana ArnoldShannon ManziBen Reis. (2011) Predicting Adverse Drug Events Using Pharmacological Network Models. Science Translational Medicine 3:114.
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K. Tilmant, H.H.J. Gerets, S. Dhalluin, E. Hanon, O. Depelchin, C. Cossu-Leguille, P. Vasseur & F.A. Atienzar. (2011) Comparison of a genomic and a multiplex cell imaging approach for the detection of phospholipidosis. Toxicology in Vitro 25:7, pages 1414-1424.
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Alberto Lodola. 2011. Pharmaceutical Toxicology in Practice. Pharmaceutical Toxicology in Practice 109 138 .
Sarah R Langdon, Joanna Mulgrew, Gaia V Paolini & Willem P van Hoorn. (2010) Predicting cytotoxicity from heterogeneous data sources with Bayesian learning. Journal of Cheminformatics 2:1.
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Jeffrey A. Kramer, Emily O’Neill, Megan E. Phillips, Debra Bruce, Traci Smith, Melinda M. Albright, Sairam Bellum, Suma Gopinathan, William E. Heydorn, Xuemei Liu, Amr Nouraldeen, Bobby Joe Payne, Robert Read, Peter Vogel, Xiang-Qing Yu & Alan G. E. Wilson. (2010) Early Toxicology Signal Generation in the Mouse. Toxicologic Pathology 38:3, pages 452-471.
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Robert Powers. (2009) NMR metabolomics and drug discovery. Magnetic Resonance in Chemistry 47:S1, pages S2-S11.
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