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Review

Thiopurine hepatotoxicity in inflammatory bowel disease: the role for adding allopurinol

, MBBS MD FRACP, , MBChB PhD FRACP & , MBBS FRACP
Pages 607-616 | Published online: 01 Sep 2008

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Christian P Selinger, Alvin Odouri Ochieng, Varun George & Rupert W Leong. (2019) The Accuracy of Adherence Self-report Scales in Patients on Thiopurines for Inflammatory Bowel Disease: A Comparison With Drug Metabolite Levels and Medication Possession Ratios. Inflammatory Bowel Diseases 25:5, pages 919-924.
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Kwang Il SeoSang-Bum Kang. (2019) Hepatobiliary Manifestation of Inflammatory Bowel Disease. The Korean Journal of Gastroenterology 73:5, pages 248.
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Sheng Zhang Lim & Eng Wee Chua. (2018) Revisiting the Role of Thiopurines in Inflammatory Bowel Disease Through Pharmacogenomics and Use of Novel Methods for Therapeutic Drug Monitoring. Frontiers in Pharmacology 9.
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Sophie Restellini, Olivier Chazouillères & Jean‐Louis Frossard. (2016) Hepatic manifestations of inflammatory bowel diseases. Liver International 37:4, pages 475-489.
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U. Kopylov, D. Amre, Y. Theoret, C. Deslandres & E.G. Seidman. (2014) Thiopurine Metabolite Ratios for Monitoring Therapy in Pediatric Crohn Disease. Journal of Pediatric Gastroenterology & Nutrition 59:4, pages 511-515.
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Viraj C. Kariyawasam, Christian P. Selinger, Peter H. Katelaris, D. Brian Jones, Charles McDonald, Gavin Barr, Grace Chapman, James Colliwshaw, Paul C. Lunney, Kate Middleton, Rosy R. Wang, Tony Huang, Jane Andrews & Rupert W. Leong. (2014) Early Use of Thiopurines or Methotrexate Reduces Major Abdominal and Perianal Surgery in Crohnʼs Disease. Inflammatory Bowel Diseases 20:8, pages 1382-1390.
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Maxime Doré, Anne Julie Frenette, Anne-Marie Mansour, Yves Troyanov & Josiane Bégin. (2014) Febuxostat as a Novel Option to Optimize Thiopurines’ Metabolism in Patients With Inadequate Metabolite Levels. Annals of Pharmacotherapy 48:5, pages 648-651.
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Ivanka Curkovic, Katharina M. Rentsch, Pascal Frei, Michael Fried, Gerhard Rogler, Gerd A. Kullak-Ublick & Alexander Jetter. (2013) Low allopurinol doses are sufficient to optimize azathioprine therapy in inflammatory bowel disease patients with inadequate thiopurine metabolite concentrations. European Journal of Clinical Pharmacology 69:8, pages 1521-1531.
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Yunki Yau, Rupert W Leong, Ming Zeng & Valerie C Wasinger. (2013) Proteomics and metabolomics in inflammatory bowel disease. Journal of Gastroenterology and Hepatology 28:7, pages 1076-1086.
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N. A. Kennedy, T. L. Asser, R. E. Mountifield, M. P. Doogue, J. M. Andrews & P. A. Bampton. (2013) Thiopurine metabolite measurement leads to changes in management of inflammatory bowel disease. Internal Medicine Journal 43:3, pages 278-286.
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Maren E. S. Cotes & Robert A. Swerlick. (2013) Practical guidelines for the use of steroid-sparing agents in the treatment of chronic pruritus. Dermatologic Therapy 26:2, pages 120-134.
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L. Chouchana, C. Narjoz, P. Beaune, M.‐A. Loriot & X. Roblin. (2011) Review article: the benefits of pharmacogenetics for improving thiopurine therapy in inflammatory bowel disease. Alimentary Pharmacology & Therapeutics 35:1, pages 15-36.
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Xavier Roblin, Abderrahim Oussalah, Jean-Baptiste Chevaux, Miles Sparrow & Laurent Peyrin-Biroulet. (2011) Use of thiopurine testing in the management of inflammatory bowel diseases in clinical practice: A worldwide survey of experts. Inflammatory Bowel Diseases 17:12, pages 2480-2487.
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Melissa L. Haines, Yousef Ajlouni, Peter M. Irving, Miles P. Sparrow, Rosemary Rose, Richard B. Gearry & Peter R. Gibson. (2011) Clinical usefulness of therapeutic drug monitoring of thiopurines in patients with inadequately controlled inflammatory bowel disease. Inflammatory Bowel Diseases 17:6, pages 1301-1307.
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Terreia S. Jones & Mary V. Relling. 2011. Pharmacogenomic Testing in Current Clinical Practice. Pharmacogenomic Testing in Current Clinical Practice 91 114 .
David Dunkin, Nanda Kerkar, Ronen Arnon, Frederick Suchy & Tamir Miloh. (2010) Allopurinol Salvage Therapy in Pediatric Overlap Autoimmune Hepatitis-Primary Sclerosing Cholangitis With 6-MMP Toxicity. Journal of Pediatric Gastroenterology & Nutrition 51:4, pages 524-526.
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Richard B Gearry, Andrew S Day, Murray L Barclay, Rupert WL Leong & Miles P Sparrow. (2010) Azathioprine and allopurinol: A two-edged interaction. Journal of Gastroenterology and Hepatology 25:4, pages 653-655.
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Choon Jin Ooi, Kwong Ming Fock, Govind K Makharia, Khean Lee Goh, Khoon Lin Ling, Ida Hilmi, Wee Chian Lim, Thia Kelvin, Peter R Gibson, Richard B Gearry, Qin Ouyang, Jose Sollano, Sathaporn Manatsathit, Rungsun Rerknimitr, Shu-chen Wei, Wai Keung Leung, H Janaka De Silva & Rupert WL Leong. (2010) The Asia-Pacific consensus on ulcerative colitis. Journal of Gastroenterology and Hepatology 25:3, pages 453-468.
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