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Review

The reformulation of Amphotericin B for oral administration to treat systemic fungal infections and visceral leishmaniasis

& , PhD
Pages 271-284 | Published online: 28 Mar 2009

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Xiaoming Zhong, Jianqiong Yang, Hongyan Liu, Zhiwen Yang & Ping Luo. (2023) Potential lipid-based strategies of amphotericin B designed for oral administration in clinical application. Drug Delivery 30:1.
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Raj J. Ahiwale, Bothiraja Chellampillai & Atmaram P. Pawar. (2022) Investigation of novel sorafenib tosylate loaded biomaterial based nano-cochleates dispersion system for treatment of hepatocellular carcinoma. Journal of Dispersion Science and Technology 43:10, pages 1568-1586.
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Min Liu, Meiwan Chen & Zhiwen Yang. (2017) Design of amphotericin B oral formulation for antifungal therapy. Drug Delivery 24:1, pages 1-9.
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Zhiwen Yang, Meiwan Chen, Muhua Yang, Jian Chen, Weijun Fang & Ping Xu. (2014) Evaluating the potential of cubosomal nanoparticles for oral delivery of amphotericin B in treating fungal infection. International Journal of Nanomedicine 9, pages 327-336.
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Fady Ibrahim, Pavel Gershkovich, Olena Sivak, Ellen K. Wasan & Kishor M. Wasan. (2013) Pharmacokinetics and tissue distribution of amphotericin B following oral administration of three lipid-based formulations to rats. Drug Development and Industrial Pharmacy 39:9, pages 1277-1283.
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Sheila J. Thornton, Kishor M. Wasan, Anna Piecuch, Larry L D. Lynd & Ellen K. Wasan. (2010) Barriers to treatment for visceral leishmaniasis in hyperendemic areas: India, Bangladesh, Nepal, Brazil and Sudan. Drug Development and Industrial Pharmacy 36:11, pages 1312-1319.
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Pore Vandana Sudhir, Deshpande Sunita Ranjan & Aher Nilkanth Ganpat. (2010) Antifungal agents, WO2009025733. Expert Opinion on Therapeutic Patents 20:1, pages 137-143.
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Articles from other publishers (31)

Ellen Wasan, Tavonga Mandava, Pablo Crespo-Moran, Adrienne Nagy & Kishor M. Wasan. (2022) Review of Novel Oral Amphotericin B Formulations for the Treatment of Parasitic Infections. Pharmaceutics 14:11, pages 2316.
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Mohamed G. El-Melegy, Hoda M. Eltaher, Ahmed Gaballah & Amal H. El-Kamel. (2021) Enhanced oral permeability of Trans-Resveratrol using nanocochleates for boosting anticancer efficacy; in-vitro and ex-vivo appraisal. European Journal of Pharmaceutics and Biopharmaceutics 168, pages 166-183.
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Jawad ur Rehman, Imdad Ali, Salim Saifullah, Shafi Ullah, Muhammad Imran & Muhammad Raza Shah. (2021) Synthesis of quercetin based self-assembling supramolecular amphiphiles for amphotericin B delivery. Journal of Molecular Liquids 333, pages 115941.
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Jiao Liu, Ping Leng & Yujun Liu. (2020) Oral drug delivery with nanoparticles into the gastrointestinal mucosa. Fundamental & Clinical Pharmacology 35:1, pages 86-96.
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Wei Zhu, Wenquan Huang, Liping Ye, Yuehua Deng, Qiuling Xie & Yanbin Jiang. (2020) Facile preparation of succinylated-zein-ZIF-8 hybrid for enhanced stability and pH-responsive drug delivery. Chemical Engineering Science 228, pages 115981.
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Kishor M. Wasan, Ellen K. Wasan & Peter Hnik. (2020) Assessing the Safety, Tolerability, Pharmacokinetics, and Biodistribution of Novel Oral Formulations of Amphotericin B following Single- and Multiple-Dose Administration to Beagle Dogs. Antimicrobial Agents and Chemotherapy 64:11.
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Kishor M. Wasan. (2020) Development of an Oral Amphotericin B Formulation as an Alternative Approach to Parenteral Amphotericin B Administration in the Treatment of Blood-Borne Fungal Infections. Current Pharmaceutical Design 26:14, pages 1521-1523.
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Rana Khafagy, Sumit Gupta, Paolo Campisi & Valerie Waters. (2020) Treatment of localized mucormycosis using nasal amphotericin B irrigation in pediatric oncology. Pediatric Blood & Cancer.
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Laura Machín, Beatriz Tamargo, Abel Piñón, Regla C. Atíes, Ramón Scull, William N. Setzer & Lianet Monzote. (2019) Bixa orellana L. (Bixaceae) and Dysphania ambrosioides (L.) Mosyakin & Clemants (Amaranthaceae) Essential Oils Formulated in Nanocochleates against Leishmania amazonensis. Molecules 24:23, pages 4222.
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Jinhua Zhang, Jie Ma, Yuanzhen Dong, Wenjie Zhao & Jun Feng. (2019) Synthesis and characterization of NH2-(AEEA)n-amphotericin B derivatives. The Journal of Antibiotics 72:4, pages 210-217.
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Grace Cuddihy, Ellen Wasan, Yunyun Di & Kishor Wasan. (2019) The Development of Oral Amphotericin B to Treat Systemic Fungal and Parasitic Infections: Has the Myth Been Finally Realized?. Pharmaceutics 11:3, pages 99.
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T.C. Moraes Moreira Carraro, C. Altmeyer, N. Maissar Khalil & R. Mara Mainardes. (2017) Assessment of in vitro antifungal efficacy and in vivo toxicity of Amphotericin B-loaded PLGA and PLGA-PEG blend nanoparticles. Journal de Mycologie Médicale 27:4, pages 519-529.
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J. M. Falcón-González, G. Jiménez-Domínguez, I. Ortega-Blake & M. Carrillo-Tripp. (2017) Multi-Phase Solvation Model for Biological Membranes: Molecular Action Mechanism of Amphotericin B. Journal of Chemical Theory and Computation 13:7, pages 3388-3397.
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Min Liu, Xiaoming Zhong & Zhiwen Yang. (2017) Chitosan functionalized nanocochleates for enhanced oral absorption of cyclosporine A. Scientific Reports 7:1.
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Abhijit A. Date, Justin Hanes & Laura M. Ensign. (2016) Nanoparticles for oral delivery: Design, evaluation and state-of-the-art. Journal of Controlled Release 240, pages 504-526.
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Bushra T. AL-Quadeib, Mahasen A. Radwan, Lidija Siller, Benjamin Horrocks & Matthew C. Wright. (2015) Stealth Amphotericin B nanoparticles for oral drug delivery: In vitro optimization. Saudi Pharmaceutical Journal 23:3, pages 290-302.
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A.C.O. Souza, A.L. Nascimento, N.M. de Vasconcelos, M.S. Jerônimo, I.M. Siqueira, L. R-Santos, D.O.S. Cintra, L.L. Fuscaldi, O.R. Pires Júnior, R. Titze-de-Almeida, M.F. Borin, S.N. Báo, O.P. Martins, V.N. Cardoso, S.O. Fernandes, M.R. Mortari, A.C. Tedesco, A.C. Amaral, M.S.S. Felipe & A.L. Bocca. (2015) Activity and in vivo tracking of Amphotericin B loaded PLGA nanoparticles. European Journal of Medicinal Chemistry 95, pages 267-276.
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Brad A. Haubrich, Ujjal K. Singha, Matthew B. Miller, Craigen R. Nes, Hosanna Anyatonwu, Laurence Lecordier, Presheet Patkar, David J. Leaver, Fernando Villalta, Benoit Vanhollebeke, Minu Chaudhuri & W. David Nes. (2015) Discovery of an ergosterol-signaling factor that regulates Trypanosoma brucei growth. Journal of Lipid Research 56:2, pages 331-341.
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Neeradi Dinesh, Preet Kamal Kaur, Kayala Kambagiri Swamy & Sushma Singh. (2014) Mianserin, an antidepressant kills Leishmania donovani by depleting ergosterol levels. Experimental Parasitology 144, pages 84-90.
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Leonid Kagan, Pavel Gershkovich, Kishor M. Wasan & Donald E. Mager. (2013) Dual Physiologically Based Pharmacokinetic Model of Liposomal and Nonliposomal Amphotericin B Disposition. Pharmaceutical Research 31:1, pages 35-45.
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Zhiwen Yang, Yinhe Tan, Meiwan Chen, Linghui Dian, Ziyun Shan, Xinsheng Peng & Chuanbin Wu. (2012) Development of Amphotericin B-Loaded Cubosomes Through the SolEmuls Technology for Enhancing the Oral Bioavailability. AAPS PharmSciTech 13:4, pages 1483-1491.
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Sanyog Jain, Pankaj U. Valvi, Nitin K. Swarnakar & Kaushik Thanki. (2012) Gelatin Coated Hybrid Lipid Nanoparticles for Oral Delivery of Amphotericin B. Molecular Pharmaceutics 9:9, pages 2542-2553.
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Fady Ibrahim, Pavel Gershkovich, Olena Sivak, Ellen K. Wasan & Kishor M. Wasan. (2012) Assessment of novel oral lipid-based formulations of amphotericin B using an in vitro lipolysis model. European Journal of Pharmaceutical Sciences 46:5, pages 323-328.
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M. Alsaadi, J.L. Italia, A.B. Mullen, M.N.V. Ravi Kumar, A.A. Candlish, R.A.M. Williams, C.D. Shaw, F. Al Gawhari, G.H. Coombs, M. Wiese, A.H. Thomson, M. Puig-Sellart, J. Wallace, A. Sharp, L. Wheeler, P. Warn & K.C. Carter. (2012) The efficacy of aerosol treatment with non-ionic surfactant vesicles containing amphotericin B in rodent models of leishmaniasis and pulmonary aspergillosis infection. Journal of Controlled Release 160:3, pages 685-691.
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Alexander V. LyubimovBenny M. Amore. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 39 .
Carlos G Leon, Jinkyung Lee, Karen Bartlett, Pavel Gershkovich, Ellen K Wasan, Jinying Zhao, John G Clement & Kishor M Wasan. (2011) In vitro cytotoxicity of two novel oral formulations of Amphotericin B (iCo-009 and iCo-010) against Candida albicans, human monocytic and kidney cell lines. Lipids in Health and Disease 10:1.
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Olena Sivak, Pavel Gershkovich, Molly Lin, Ellen K Wasan, Jinying Zhao, David Owen, John G Clement & Kishor M Wasan. (2011) Tropically stable novel oral lipid formulation of amphotericin B (iCo-010): biodistribution and toxicity in a mouse model. Lipids in Health and Disease 10:1.
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Qamar Zia, Mohammad Farzuddin, Mairaj Ahmad Ansari, Maroof Alam, Azmat Ali, Iqbal Ahmad & Mohammad Owais. 2010. Combating Fungal Infections. Combating Fungal Infections 485 528 .
Samusi A. Adediran, Timothy P. Day, Diptesh Sil, Matthew R. Kimbrell, Hemamali J. Warshakoon, Subbalakshmi S. Malladi & Sunil A. David. (2009) Synthesis of a Highly Water-Soluble Derivative of Amphotericin B with Attenuated Proinflammatory Activity. Molecular Pharmaceutics 6:5, pages 1582-1590.
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Rafael Laniado-Laborín & Maria Noemí Cabrales-Vargas. (2009) Amphotericin B: side effects and toxicity. Revista Iberoamericana de Micología 26:4, pages 223-227.
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Subhashis Chakraborty, Dali Shukla, Brahmeshwar Mishra & Sanjay Singh. (2009) Lipid – An emerging platform for oral delivery of drugs with poor bioavailability. European Journal of Pharmaceutics and Biopharmaceutics 73:1, pages 1-15.
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