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Review

Targeted drug delivery to mammalian mitochondria in living cells

Pages 89-102 | Published online: 22 Apr 2005

Keep up to date with the latest research on this topic with citation updates for this article.

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Abel Matondo & Sung Soo Kim. (2018) Targeted-mitochondria antioxidants therapeutic implications in inflammatory bowel disease. Journal of Drug Targeting 26:1, pages 1-8.
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Lei Liu, Li-Min Mu, Yan Yan, Jia-Shuan Wu, Ying-Jie Hu, Ying-Zi Bu, Jing-Ying Zhang, Rui Liu, Xue-Qi Li & Wan-Liang Lu. (2017) The use of functional epirubicin liposomes to induce programmed death in refractory breast cancer. International Journal of Nanomedicine 12, pages 4163-4176.
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Francesco Visioli, Catalina Alarcón De La Lastra, Cristina Andres-Lacueva, Michael Aviram, Conceição Calhau, Alfredo Cassano, Massimo D’Archivio, Ana Faria, Gaëlle Favé, Vincenzo Fogliano, Rafael Llorach, Paola Vitaglione, Mario Zoratti & Marvin Edeas. (2011) Polyphenols and Human Health: A Prospectus. Critical Reviews in Food Science and Nutrition 51:6, pages 524-546.
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Gerard GM D'Souza & Volkmar Weissig. (2009) Subcellular targeting: a new frontier for drug-loaded pharmaceutical nanocarriers and the concept of the magic bullet. Expert Opinion on Drug Delivery 6:11, pages 1135-1148.
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Volkmar Weissig, Sarathi V. Boddapati, Shing-Ming Cheng & Gerard G. M. D’souza. (2006) Liposomes and Liposome-like Vesicles for Drug and DNA Delivery to Mitochondria. Journal of Liposome Research 16:3, pages 249-264.
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Sarathi V. Boddapati, Pakamas Tongcharoensirikul, Robert N. Hanson, Gerard G. M. D'Souza, Vladimir P. Torchilin & Volkmar Weissig. (2005) Mitochondriotropic Liposomes. Journal of Liposome Research 15:1-2, pages 49-58.
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Articles from other publishers (29)

Senta M. Kapnick, Corinne A. Martin & Christopher M. Jewell. (2024) Engineering metabolism to modulate immunity. Advanced Drug Delivery Reviews 204, pages 115122.
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Dayene de Assis Fernandes Caldeira, Dahienne Ferreira de Oliveira, João Paulo Cavalcanti-de-Albuquerque, Jose Hamilton Matheus Nascimento, Walter Araujo Zin & Leonardo Maciel. (2021) Isolation of Mitochondria From Fresh Mice Lung Tissue. Frontiers in Physiology 12.
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Parisa K. Kargaran, Jared M. Evans, Sara E. Bodbin, James G. W. Smith, Timothy J. Nelson, Chris Denning & Diogo Mosqueira. (2020) Mitochondrial DNA: Hotspot for Potential Gene Modifiers Regulating Hypertrophic Cardiomyopathy. Journal of Clinical Medicine 9:8, pages 2349.
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Shulei Zhu, Xumeng Yu, Yang He, Mingliang Ma & Wei Lu. (2020) Synthesis and fluorescent studies of a low molecular weight rotor for living cancer cell imaging. Dyes and Pigments 178, pages 108353.
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Kinfemichael Geressu Asfaw, Qiong Liu, Jan Maisch, Stephan W. Münch, Ilona Wehl, Stefan Bräse, Ivan Bogeski, Ute Schepers & Peter Nick. (2019) A Peptoid Delivers CoQ-derivative to Plant Mitochondria via Endocytosis. Scientific Reports 9:1.
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Xun Ji, Omar M Khdour & Sidney M Hecht. (2019) Multifunctional radical quenchers as potential therapeutic agents for the treatment of mitochondrial dysfunction. Future Medicinal Chemistry 11:13, pages 1605-1624.
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Christian Foster, Andre Watson, Joseph Kaplinsky & Nazila Kamaly. 2017. Cancer Nanotechnology. Cancer Nanotechnology 13 37 .
. 2016. Bio-Targets and Drug Delivery Approaches. Bio-Targets and Drug Delivery Approaches 259 289 .
Aleš Prokop & Volkmar Weissig. 2016. Intracellular Delivery III. Intracellular Delivery III 3 36 .
Silvia Grancara, Francesca Zonta, Shinji Ohkubo, Anna Maria Brunati, Enzo Agostinelli & Antonio Toninello. (2015) Pathophysiological implications of mitochondrial oxidative stress mediated by mitochondriotropic agents and polyamines: the role of tyrosine phosphorylation. Amino Acids 47:5, pages 869-883.
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Jimmy Pham, Oliver Grundmann & Tamer Elbayoumi. 2015. Mitochondrial Medicine. Mitochondrial Medicine 85 101 .
Sae Rin Jean, David V. Tulumello, Simon P. Wisnovsky, Eric K. Lei, Mark P. Pereira & Shana O. Kelley. (2014) Molecular Vehicles for Mitochondrial Chemical Biology and Drug Delivery. ACS Chemical Biology 9:2, pages 323-333.
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C. George Priya Doss, C. Debajyoti & S. Debottam. (2013) Disruption of Mitochondrial Complexes in Cancer Stem Cells Through Nano-based Drug Delivery: A Promising Mitochondrial Medicine. Cell Biochemistry and Biophysics 67:3, pages 1075-1079.
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Jimmy Pham, Bill Brownlow & Tamer Elbayoumi. (2013) Mitochondria-Specific Pro-Apoptotic Activity of Genistein Lipidic Nanocarriers. Molecular Pharmaceutics 10:10, pages 3789-3800.
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Jaime H. Gibbs, Larry T. Robins, Zehua Zhou, Petia Bobadova-Parvanova, Michael Cottam, Gregory T. McCandless, Frank R. Fronczek & M. Graça H. Vicente. (2013) Spectroscopic, computational modeling and cytotoxicity of a series of meso-phenyl and meso-thienyl-BODIPYs. Bioorganic & Medicinal Chemistry 21:18, pages 5770-5781.
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Dominik Kölmel, Daniel Fürniss, Steven Susanto, Andrea Lauer, Clemens Grabher, Stefan Bräse & Ute Schepers. (2012) Cell Penetrating Peptoids (CPPos): Synthesis of a Small Combinatorial Library by Using IRORI MiniKans. Pharmaceuticals 5:12, pages 1265-1281.
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Hani Atamna, Jeanette Mackey & Joseph M. Dhahbi. (2012) Mitochondrial pharmacology: Electron transport chain bypass as strategies to treat mitochondrial dysfunction. BioFactors 38:2, pages 158-166.
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Nazila Kamaly, Zeyu Xiao, Pedro M. Valencia, Aleksandar F. Radovic-Moreno & Omid C. Farokhzad. (2012) Targeted polymeric therapeutic nanoparticles: design, development and clinical translation. Chemical Society Reviews 41:7, pages 2971.
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Mayura A. Wagle, Laura E. Martinville & Gerard G. M. D’Souza. (2011) The Utility of an Isolated Mitochondrial Fraction in the Preparation of Liposomes for the Specific Delivery of Bioactives to Mitochondria in Live Mammalian Cells. Pharmaceutical Research 28:11, pages 2790-2796.
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Gerard G.M. D'Souza, Mayura A Wagle, Vaibhav Saxena & Anee Shah. (2011) Approaches for targeting mitochondria in cancer therapy. Biochimica et Biophysica Acta (BBA) - Bioenergetics 1807:6, pages 689-696.
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Melani Solomon & Gerard G. M. D’Souza. 2011. Intracellular Delivery. Intracellular Delivery 57 72 .
Gerard G. M. D'Souza & Volkmar Weissig. 2010. Organelle-Specific Pharmaceutical Nanotechnology. Organelle-Specific Pharmaceutical Nanotechnology 1 13 .
Lucia Biasutto, Nicola Sassi, Andrea Mattarei, Ester Marotta, Paola Cattelan, Antonio Toninello, Spiridione Garbisa, Mario Zoratti & Cristina Paradisi. (2010) Impact of mitochondriotropic quercetin derivatives on mitochondria. Biochimica et Biophysica Acta (BBA) - Bioenergetics 1797:2, pages 189-196.
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Martha Sibrian-Vazquez, Irina V. Nesterova, Timothy J. Jensen & M. Graça H. Vicente. (2008) Mitochondria Targeting by Guanidine− and Biguanidine−Porphyrin Photosensitizers. Bioconjugate Chemistry 19:3, pages 705-713.
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Huaizhong Pan & Jindrich Kopecek. 2008. Multifunctional Pharmaceutical Nanocarriers. Multifunctional Pharmaceutical Nanocarriers 81 142 .
Padmaja Magadala, Lilian E. van Vlerken, Aliasgar Shahiwala & Mansoor M. Amiji. 2008. Multifunctional Pharmaceutical Nanocarriers. Multifunctional Pharmaceutical Nanocarriers 33 66 .
Yon Ju-Nam, David W. Allen, Philip H.E. Gardiner, Mark E. Light, Michael B. Hursthouse & Neil Bricklebank. (2007) The synthesis and characterisation of masked phosphonioalkyl selenoates: Potential ligands for the production of functionalised gold nanoparticles. Journal of Organometallic Chemistry 692:22, pages 5065-5070.
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Richard W. Horobin, Stefan Trapp & Volkmar Weissig. (2007) Mitochondriotropics: A review of their mode of action, and their applications for drug and DNA delivery to mammalian mitochondria. Journal of Controlled Release 121:3, pages 125-136.
Crossref
Volkmar Weissig, Sarathi Boddapati, Shing-Ming Cheng, Gerard D’Souza & Vladimir Torchilin. 2006. Liposome Technology, Volume II. Liposome Technology, Volume II 317 339 .

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