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Review

Novel drug delivery strategies for the treatment of inflammatory bowel disease

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Pages 451-463 | Published online: 10 May 2005

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Read on this site (6)

M. Junaid Dar, Hussain Ali, Amjad Khan & Gul Majid Khan. (2017) Polymer-based drug delivery: the quest for local targeting of inflamed intestinal mucosa. Journal of Drug Targeting 25:7, pages 582-596.
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Jian-Xin Zhang, Kun Wang, Zheng-Fa Mao, Xin Fan, De-Li Jiang, Min Chen, Lei Cui, Kang Sun & Sheng-Chun Dang. (2013) Application of liposomes in drug development — focus on gastroenterological targets. International Journal of Nanomedicine 8, pages 1325-1334.
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Omri Wolk, Svetlana Epstein, Viktoriya Ioffe-Dahan, Shimon Ben-Shabat & Arik Dahan. (2013) New targeting strategies in drug therapy of inflammatory bowel disease: mechanistic approaches and opportunities. Expert Opinion on Drug Delivery 10:9, pages 1275-1286.
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Bo Xiao & Didier Merlin. (2012) Oral colon-specific therapeutic approaches toward treatment of inflammatory bowel disease. Expert Opinion on Drug Delivery 9:11, pages 1393-1407.
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Arik Dahan, Gordon L Amidon & Ellen M Zimmermann. (2010) Drug targeting strategies for the treatment of inflammatory bowel disease: a mechanistic update. Expert Review of Clinical Immunology 6:4, pages 543-550.
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Simon Mantell, Rhys Jones & Mike Trevethick. (2010) Design and application of locally delivered agonists of the adenosine A2A receptor. Expert Review of Clinical Pharmacology 3:1, pages 55-72.
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Articles from other publishers (28)

Junshan Wang, Min Yao, Jiafeng Zou, Wenxing Ding, Mingyue Sun, Ying Zhuge & Feng Gao. (2023) pH-Sensitive Nanoparticles for Colonic Delivery Anti-miR-301a in Mouse Models of Inflammatory Bowel Diseases. Nanomaterials 13:20, pages 2797.
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Samet Özdemir, Burcu Üner, Juste Baranauskaite, Engin Sümer, Ecem Yıldırım & Aylin Yaba. (2023) Design and characterization of dexamethasone loaded microsponges for the management of ulcerative colitis. European Journal of Pharmaceutics and Biopharmaceutics 187, pages 34-45.
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Ibrahim M Ibrahim. (2023) Advances in Polysaccharide-Based Oral Colon-Targeted Delivery Systems: The Journey So Far and the Road Ahead. Cureus.
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Farah Yasmin, Hala Najeeb, Shehryar Shaikh, Muhammad Hasanain, Unaiza Naeem, Abdul Moeed, Thoyaja Koritala, Syedadeel Hasan & Salim Surani. (2022) Novel drug delivery systems for inflammatory bowel disease. World Journal of Gastroenterology 28:18, pages 1922-1933.
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Wunan Zhang, Cecilia Bohns Michalowski & Ana Beloqui. (2021) Oral Delivery of Biologics in Inflammatory Bowel Disease Treatment. Frontiers in Bioengineering and Biotechnology 9.
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Yun-Chu Chen, Sheryhan F. Gad, Dhawal Chobisa, Yongzhe Li & Yoon Yeo. (2021) Local drug delivery systems for inflammatory diseases: Status quo, challenges, and opportunities. Journal of Controlled Release 330, pages 438-460.
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Denish Bardoliwala, Dipesh Baradia, Jitendra Amrutiya & Ambikanandan Misra. 2021. Applications of Polymers in Drug Delivery. Applications of Polymers in Drug Delivery 187 220 .
Jagadeesh Nagendra Manda, Milica Markovic, Ellen M. Zimmermann, Shimon Ben‐Shabat, Arik Dahan & Aaron Aponick. (2020) Phospholipid Cyclosporine Prodrugs Targeted at Inflammatory Bowel Disease (IBD) Treatment: Design, Synthesis, and in Vitro Validation. ChemMedChem 15:17, pages 1639-1644.
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Xin Li, Chao Lu, Yanyan Yang, Chaohui Yu & Yuefeng Rao. (2020) Site-specific targeted drug delivery systems for the treatment of inflammatory bowel disease. Biomedicine & Pharmacotherapy 129, pages 110486.
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Giulia Auriemma, Andrea Cerciello, Rita P. Aquino, Pasquale Del Gaudio, Bruno M. Fusco & Paola Russo. (2020) Pectin and Zinc Alginate: The Right Inner/Outer Polymer Combination for Core-Shell Drug Delivery Systems. Pharmaceutics 12:2, pages 87.
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Milica Markovic, Arik Dahan, Shahar Keinan, Igor Kurnikov, Aaron Aponick, Ellen M. Zimmermann & Shimon Ben-Shabat. (2019) Phospholipid-Based Prodrugs for Colon-Targeted Drug Delivery: Experimental Study and In-Silico Simulations. Pharmaceutics 11:4, pages 186.
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Murtada A. Oshi, Muhammad Naeem, Junhwan Bae, Jihyun Kim, Juho Lee, Nurhasni Hasan, Wooseong Kim, Eunok Im, Yunjin Jung & Jin-Wook Yoo. (2018) Colon-targeted dexamethasone microcrystals with pH-sensitive chitosan/alginate/Eudragit S multilayers for the treatment of inflammatory bowel disease. Carbohydrate Polymers 198, pages 434-442.
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Arik Dahan, Milica Markovic, Shahar Keinan, Igor Kurnikov, Aaron Aponick, Ellen M. Zimmermann & Shimon Ben-Shabat. (2017) Computational modeling and in-vitro/in-silico correlation of phospholipid-based prodrugs for targeted drug delivery in inflammatory bowel disease. Journal of Computer-Aided Molecular Design 31:11, pages 1021-1028.
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. 2016. Biodrug Delivery Systems. Biodrug Delivery Systems 154 187 .
Amit Singh, Meghna Talekar, Ankita Raikar & Mansoor Amiji. (2014) Macrophage-targeted delivery systems for nucleic acid therapy of inflammatory diseases. Journal of Controlled Release 190, pages 515-530.
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Anette Müllertz, Dimitrios G Fatouros, Maria Vertzoni & Christos Reppas. (2013) Unravelling the ultrastructure of ascending colon fluids from patients with ulcerative colitis by cryogenic transmission electron microscopy. Journal of Pharmacy and Pharmacology 65:10, pages 1482-1487.
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Raj Kumar Shukla & Akanksha Tiwari. (2012) Carbohydrate polymers: Applications and recent advances in delivering drugs to the colon. Carbohydrate Polymers 88:2, pages 399-416.
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Xiao-Lai Yang, Tian-Kang Guo, Yan-Hong Wang, Yan-Hui Huang, Xia Liu, Xiao-Xia Wang, Wan Li, Xin Zhao, Li-Ping Wang, Shuai Yan, Di Wu & Yong-Jie Wu. (2012) Ginsenoside Rd attenuates the inflammatory response via modulating p38 and JNK signaling pathways in rats with TNBS-induced relapsing colitis. International Immunopharmacology 12:2, pages 408-414.
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Brian K. Reuter, Luca Pastorelli, Marco Brogi, Rekha R. Garg, James A. McBride, Robert M. Rowlett, Marie C. Arrieta, Xiao–Ming Wang, Erik J. Keller, Sanford H. Feldman, James R. Mize, Fabio Cominelli, Jonathan B. Meddings & Theresa T. Pizarro. (2011) Spontaneous, Immune-Mediated Gastric Inflammation in SAMP1/YitFc Mice, a Model of Crohn's-Like Gastritis. Gastroenterology 141:5, pages 1709-1719.
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Efrat Harel, Abraham Rubinstein, Aviram Nissan, Elena Khazanov, Mirela Nadler Milbauer, Yechezkel Barenholz & Boaz Tirosh. (2011) Enhanced Transferrin Receptor Expression by Proinflammatory Cytokines in Enterocytes as a Means for Local Delivery of Drugs to Inflamed Gut Mucosa. PLoS ONE 6:9, pages e24202.
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Mirela Nadler Milabuer, Yossi Kam & Abraham Rubinstein. 2010. Oral Controlled Release Formulation Design and Drug Delivery. Oral Controlled Release Formulation Design and Drug Delivery 225 243 .
Xiangshang Xu, Zhixin Cao, Xiaolan Li, Deding Tao, Junbo Hu, Chuanyong Yang & Jianping Gong. (2010) Injecting drugs by a tube from appendix stump to colon may be a good method for dealing with refractory ulcerative colitis. Medical Hypotheses 74:4, pages 631-633.
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Boaz TiroshNadine KhatibYechezkel BarenholzAviram NissanAbraham Rubinstein. (2009) Transferrin as a Luminal Target for Negatively Charged Liposomes in the Inflamed Colonic Mucosa. Molecular Pharmaceutics 6:4, pages 1083-1091.
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Zunwu Zhang & Hugh Kennedy. (2009) Ulcerative colitis: current medical therapy and strategies for improving medication adherence. European Journal of Gastroenterology & Hepatology 21:1, pages 1-8.
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Hiraku Onishi, Tomoko Oosegi & Yoshiharu Machida. (2008) Efficacy and toxicity of Eudragit-coated chitosan–succinyl-prednisolone conjugate microspheres using rats with 2,4,6-trinitrobenzenesulfonic acid-induced colitis. International Journal of Pharmaceutics 358:1-2, pages 296-302.
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M. Astegiano, N. Pagano, N. Sapone, D. Simondi, L. Bertolusso, F. Bresso, B. Demarchi, R. Pellicano, R. Bonardi, S. Marconi & M. Rizzetto. (2007) Efficacy and safety of oral beclomethasone dipropionate for ileal or ileal-right colon Crohn's disease of mild-to-moderate activity or in remission: Retrospective study. Biomedicine & Pharmacotherapy 61:6, pages 370-376.
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Kristiina M. Huttunen, Niina Mähönen, Jukka Leppänen, Jouko Vepsäläinen, Risto O. Juvonen, Hannu Raunio, Hanna Kumpulainen, Tomi Järvinen & Jarkko Rautio. (2007) Novel Cyclic Phosphate Prodrug Approach for Cytochrome P450-activated Drugs Containing an Alcohol Functionality. Pharmaceutical Research 24:4, pages 679-687.
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D AMRE, RD AMRE & S PRAKASH. 2007. Artificial Cells, Cell Engineering and Therapy. Artificial Cells, Cell Engineering and Therapy 454 468 .

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