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Review

Pharmacokinetic/pharmacodynamic evaluation of inhalation drugs: application to targeted pulmonary delivery systems

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Pages 519-532 | Published online: 10 May 2005

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Ali Keshavarz, Hossam Kadry, Ahmed Alobaida & Fakhrul Ahsan. (2020) Newer approaches and novel drugs for inhalational therapy for pulmonary arterial hypertension. Expert Opinion on Drug Delivery 17:4, pages 439-461.
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Luigino Calzetta, Barbara Rinaldi, Mario Cazzola & Maria Gabriella Matera. (2016) Pharmacodynamic and pharmacokinetic assessment of fluticasone furoate + vilanterol for the treatment of asthma. Expert Opinion on Drug Metabolism & Toxicology 12:7, pages 813-822.
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Simon Mantell, Rhys Jones & Mike Trevethick. (2010) Design and application of locally delivered agonists of the adenosine A2A receptor. Expert Review of Clinical Pharmacology 3:1, pages 55-72.
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Jennifer Padden, David Skoner & Gunther Hochhaus. (2008) Pharmacokinetics and Pharmacodynamics of Inhaled Glucocorticoids. Journal of Asthma 45:sup1, pages 13-24.
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Neil A. Miller. (2023) Modeling. Journal of Aerosol Medicine and Pulmonary Drug Delivery.
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Sandra Anderson, Paul Atkins, Per Bäckman, David Cipolla, Andrew Clark, Evangelia Daviskas, Bernd Disse, Plamena Entcheva-Dimitrov, Rick Fuller, Igor Gonda, Hans Lundbäck, Bo Olsson & Jeffry Weers. (2022) Inhaled Medicines: Past, Present, and Future. Pharmacological Reviews 74:1, pages 48-118.
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Elisa Pasqua, Nicole Hamblin, Christine Edwards, Charles Baker-Glenn & Chris Hurley. (2022) Developing inhaled drugs for respiratory diseases: A medicinal chemistry perspective. Drug Discovery Today 27:1, pages 134-150.
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Ali Keshavarz, Hossam Kadry, Ahmed Alobaida, Md Nurunnabi & Taslim A. Al-Hilal. 2021. Bioinspired and Biomimetic Materials for Drug Delivery. Bioinspired and Biomimetic Materials for Drug Delivery 241 276 .
Julia Johansson, Marie H. Larsson & Jorrit J. Hornberg. (2019) Predictive in vitro toxicology screening to guide chemical design in drug discovery. Current Opinion in Toxicology 15, pages 99-108.
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Jens Markus Borghardt, Charlotte Kloft & Ashish Sharma. (2018) Inhaled Therapy in Respiratory Disease: The Complex Interplay of Pulmonary Kinetic Processes. Canadian Respiratory Journal 2018, pages 1-11.
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Richard S. Roberts, Sara Sevilla, Manel Ferrer, Joan Taltavull, Begoña Hernández, Victor Segarra, Jordi Gràcia, Martin D. Lehner, Amadeu Gavaldà, Miriam Andrés, Judit Cabedo, Dolors Vilella, Peter Eichhorn, Elena Calama, Carla Carcasona & Montserrat Miralpeix. (2018) 4-Amino-7,8-dihydro-1,6-naphthyridin-5(6 H )-ones as Inhaled Phosphodiesterase Type 4 (PDE4) Inhibitors: Structural Biology and Structure–Activity Relationships . Journal of Medicinal Chemistry 61:6, pages 2472-2489.
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Ramon Hendrickx, Eva Lamm Bergström, David L. I. Janzén, Markus Fridén, Ulf Eriksson, Ken Grime & Douglas Ferguson. (2017) Translational Model to Predict Pulmonary Pharmacokinetics and Efficacy in Man for Inhaled Bronchodilators. CPT: Pharmacometrics & Systems Pharmacology 7:3, pages 147-157.
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A. M. Puga, T. Partearroyo & G. Varela-Moreiras. (2017) Hydration status, drug interactions, and determinants in a Spanish elderly population: a pilot study. Journal of Physiology and Biochemistry 74:1, pages 139-151.
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Martin Hemmerling, Stinabritt Nilsson, Karl Edman, Stefan Eirefelt, Wayne Russell, Ramon Hendrickx, Eskil Johnsson, Carina Kärrman Mårdh, Markus Berger, Hartmut Rehwinkel, Anna Abrahamsson, Jan Dahmén, Anders R. Eriksson, Balint Gabos, Krister Henriksson, Nafizal Hossain, Svetlana Ivanova, Anne-Helene Jansson, Tina J. Jensen, Anders Jerre, Henrik Johansson, Tomas Klingstedt, Matti Lepistö, Martin Lindsjö, Irene Mile, Grigorios Nikitidis, John Steele, Ulrika Tehler, Lisa Wissler & Thomas Hansson. (2017) Selective Nonsteroidal Glucocorticoid Receptor Modulators for the Inhaled Treatment of Pulmonary Diseases. Journal of Medicinal Chemistry 60:20, pages 8591-8605.
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Jayne E. Hastedt, Per Bäckman, Andrew R. Clark, William Doub, Anthony Hickey, Guenther Hochhaus, Phil J. Kuehl, Claus-Michael Lehr, Peter Mauser, Jason McConville, Ralph Niven, Masahiro Sakagimi & Jeffry G. Weers. (2016) Scope and relevance of a pulmonary biopharmaceutical classification system AAPS/FDA/USP Workshop March 16-17th, 2015 in Baltimore, MD. AAPS Open 2:1.
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Michael J. StocksLilian AlcarazAndrew BaileyRoger BonnertElaine CadoganJadeen ChristieJohn DixonStephen ConnollyAnthony CookAdrian FisherAlice FlahertyAlexander HumphriesAnthony IngallStephen JordanMandy LawsonAlex MullenDavid NichollsStuart PaineGarry PairaudeauAlan Young. (2014) Discovery of AZD3199, An Inhaled Ultralong Acting β 2 Receptor Agonist with Rapid Onset of Action . ACS Medicinal Chemistry Letters 5:4, pages 416-421.
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Eung-Seok Lee, Jong-min Han, Min-Hee Kim, Uk Namgung, Yoon Yeo & Yang-Chun Park. (2013) Effects of Inhalable Microparticles of on Chronic Obstructive Pulmonary Disease in a Mouse Model. Journal of Korean Medicine 34:3, pages 54-68.
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Johanna Jessica Salomon & Carsten Ehrhardt. (2012) Organic cation transporters in the blood–air barrier: expression and implications for pulmonary drug delivery. Therapeutic Delivery 3:6, pages 735-747.
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Lilian Alcaraz, Andrew Bailey, Elaine Cadogan, Stephen Connolly, Robert Jewell, Stephen Jordan, Nicholas Kindon, Andrew Lister, Mandy Lawson, Alexander Mullen, Ian Dainty, David Nicholls, Stuart Paine, Garry Pairaudeau, Michael J. Stocks, Phillip Thorne & Alan Young. (2012) From libraries to candidate: The discovery of new ultra long-acting dibasic β2-adrenoceptor agonists. Bioorganic & Medicinal Chemistry Letters 22:1, pages 689-695.
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Mirjam Gnadt. (2011) Pharmakologie der Betasympathomimetika. Pharmazie in unserer Zeit 40:5, pages 385-389.
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Jin Xie, Gennadiy I. Poda, Yiding Hu, Natalie X. Chen, Richard F. Heier, Serge G. Wolfson, Matthew T. Reding, Patrick J. Lennon, Ravi G. Kurumbail, Shaun R. Selness, Xiong Li, Nandini N. Kishore, Cynthia D. Sommers, Lori Christine, Sheri L. Bonar, Neetu Venkatraman, Sumathy Mathialagan, Sarah J. Brustkern & Horng-Chih Huang. (2011) Aminopyridinecarboxamide-based inhaled IKK-2 inhibitors for asthma and COPD: Structure–activity relationship. Bioorganic & Medicinal Chemistry 19:3, pages 1242-1255.
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Ben Forbes, Bahman Asgharian, Lea Ann Dailey, Douglas Ferguson, Per Gerde, Mark Gumbleton, Lena Gustavsson, Colin Hardy, David Hassall, Rhys Jones, Ruth Lock, Janet Maas, Tim McGovern, Gary R. Pitcairn, Graham Somers & Ron K. Wolff. (2011) Challenges in inhaled product development and opportunities for open innovation. Advanced Drug Delivery Reviews 63:1-2, pages 69-87.
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Po-Chang Chiang, Yiding Hu, Jason D. Blom & David C. Thompson. (2010) Evaluating the Suitability of Using Rat Models for Preclinical Efficacy and Side Effects with Inhaled Corticosteroids Nanosuspension Formulations. Nanoscale Research Letters 5:6, pages 1010-1019.
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Po-Chang Chiang, Yiding Hu, Archie Thurston, Cynthia D. Sommers, Julia A. Guzova, Larry E. Kahn, Yurong Lai & Jason D. Blom. (2009) Pharmacokinetic and Pharmacodynamic Evaluation of the Suitability of Using Fluticasone and an Acute Rat Lung Inflammation Model to Differentiate Lung Versus Systemic Efficacy. Journal of Pharmaceutical Sciences 98:11, pages 4354-4364.
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Dramane I. Lainé, Zehong Wan, Hongxing Yan, Chongjie Zhu, Haibo Xie, Wei Fu, Jakob Busch-Petersen, Christopher Neipp, Roderick Davis, Katherine L. Widdowson, Frank E. Blaney, James Foley, Alicia M. Bacon, Edward F. Webb, Mark A. Luttmann, Miriam Burman, Henry M. Sarau, Michael Salmon, Michael R. Palovich & Kristen Belmonte. (2009) Design, Synthesis, and Structure−Activity Relationship of Tropane Muscarinic Acetylcholine Receptor Antagonists. Journal of Medicinal Chemistry 52:16, pages 5241-5252.
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Dramane I. Lainé, Brent McCleland, Sonia Thomas, Christopher Neipp, Brian Underwood, Jeremy Dufour, Katherine L. Widdowson, Michael R. Palovich, Frank E. Blaney, James J. Foley, Edward F. Webb, Mark A. Luttmann, Miriam Burman, Kristen Belmonte & Michael Salmon. (2009) Discovery of Novel 1-Azoniabicyclo[2.2.2]octane Muscarinic Acetylcholine Receptor Antagonists. Journal of Medicinal Chemistry 52:8, pages 2493-2505.
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Jasper Dingemanse & Silke Appel-Dingemanse. (2007) Integrated??Pharmacokinetics??and Pharmacodynamics in??Drug??Development. Clinical Pharmacokinetics 46:9, pages 713-737.
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Melanie Hübner, Günther Hochhaus & Hartmut Derendorf. (2005) Comparative Pharmacology, Bioavailability, Pharmacokinetics, and Pharmacodynamics of Inhaled Glucocorticosteroids. Immunology and Allergy Clinics of North America 25:3, pages 469-488.
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