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Expert Opinion on Drug Delivery Volume 7, 2010 - Issue 8
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Gastric emptying of non-disintegrating solid drug delivery systems in fasted state: relevance to drug dissolution

Igor Locatelli University of Ljubljana, Faculty of Pharmacy, Aškerčeva cesta 7, SI-1000 Ljubljana, Slovenia
, MPharm PhD,
Nataša Nagelj Kovačič University of Ljubljana, Faculty of Pharmacy, Aškerčeva cesta 7, SI-1000 Ljubljana, Slovenia
, MPharm,
Aleš Mrhar University of Ljubljana, Faculty of Pharmacy, Aškerčeva cesta 7, SI-1000 Ljubljana, Slovenia
, MPharm PhD &
Marija Bogataj University of Ljubljana, Faculty of Pharmacy, Aškerčeva cesta 7, SI-1000 Ljubljana, Slovenia +386 1 4769 500; +386 1 4258 031; [email protected]
, MPharm PhD
Pages 967-976 | Published online: 30 Jun 2010

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Božena Bürmen, Igor Locatelli, Aleš Mrhar & Marija Bogataj. (2015) Analysis of factors influencing gastric emptying of pellets in a fed state. Expert Opinion on Drug Delivery 12:8, pages 1225-1238.
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Khosro Adibkia, Sanaz Hamedeyazdan & Yousef Javadzadeh. (2011) Drug release kinetics and physicochemical characteristics of floating drug delivery systems. Expert Opinion on Drug Delivery 8:7, pages 891-903.
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M. M. Gurova. (2022) Goat Milk Formula. To whom, why, how. Meditsinskiy sovet = Medical Council:1, pages 128-133.
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Miklós Tamás Katona, Melinda Kakuk, Réka Szabó, Péter Tonka-Nagy, Krisztina Takács-Novák & Enikő Borbás. (2022) Towards a Better Understanding of the Post-Gastric Behavior of Enteric-Coated Formulations. Pharmaceutical Research 39:1, pages 201-211.
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P. Zarmpi & N. Fotaki. 2022. The ADME Encyclopedia. The ADME Encyclopedia 499 503 .
PAIROTE SATIRACOO & ANDREA DE GAETANO. (2021) PARAMETER ESTIMATION OF A SIMPLE, REALISTIC STOCHASTIC MODEL OF GASTRIC EMPTYING OF PELLETS UNDER FASTING CONDITIONS. Journal of Biological Systems 29:03, pages 561-576.
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P. Zarmpi & N. Fotaki. 2021. The ADME Encyclopedia. The ADME Encyclopedia 1 5 .
Erik Wollmer, Greg Neal, Martin J. Whitaker, Daniel Margetson & Sandra Klein. (2018) Biorelevant in vitro assessment of dissolution and compatibility properties of a novel paediatric hydrocortisone drug product following exposure of the drug product to child-appropriate administration fluids. European Journal of Pharmaceutics and Biopharmaceutics 133, pages 277-284.
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Jozef Al-Gousous, Yasuhiro Tsume, Maoqi Fu, Isam I. Salem & Peter Langguth. (2017) Unpredictable Performance of pH-Dependent Coatings Accentuates the Need for Improved Predictive in Vitro Test Systems . Molecular Pharmaceutics 14:12, pages 4209-4219.
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Annet Maathuis, Robert Havenaar, Tao He & Susann Bellmann. (2017) Protein Digestion and Quality of Goat and Cow Milk Infant Formula and Human Milk Under Simulated Infant Conditions. Journal of Pediatric Gastroenterology & Nutrition 65:6, pages 661-666.
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Sandra Klein. 2017. Multiparticulate Drug Delivery. Multiparticulate Drug Delivery 169 212 .
Kyung Soo Kim, Sung Giu Jin, Omer Mustapha, Abid Mehmood Yousaf, Dong Wuk Kim, Young Hun Kim, Jong Oh Kim, Chul Soon Yong, Jong Soo Woo & Han-Gon Choi. (2015) Novel fenofibric acid-loaded controlled release pellet bioequivalent to choline fenofibrate-loaded commercial product in beagle dogs. International Journal of Pharmaceutics 490:1-2, pages 273-280.
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Aleksandar Aleksovski, Matevž Luštrik, Rok Šibanc & Rok Dreu. (2015) Design and evaluation of a specific, bi-phase extended release system based on differently coated mini-tablets. European Journal of Pharmaceutical Sciences 75, pages 114-122.
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Nata?a Nagelj Kova?i?Mitja Pi?lar, Ilija Ili?Ale? Mrhar & Marija Bogataj. (2014) Influence of the physiological variability of fasted gastric pH and tablet retention time on the variability of in vitro dissolution and simulated plasma profiles. International Journal of Pharmaceutics 473:1-2, pages 552-559.
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Sandra Klein, Grzegorz Garbacz, Mitja Pišlar, Igor Locatelli, Chong Liu, Werner Weitschies, Werner Siegmund, Aleš Mrhar & Marija Bogataj. (2013) The role of individual gastric emptying of pellets in the prediction of diclofenac in vivo dissolution. Journal of Controlled Release 166:3, pages 286-293.
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Uroš Klančar, Boštjan Markun, Saša Baumgartner & Igor Legen. (2012) A Novel Beads-Based Dissolution Method for the In Vitro Evaluation of Extended Release HPMC Matrix Tablets and the Correlation with the In Vivo Data. The AAPS Journal 15:1, pages 267-277.
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Tobias Hahn, Sebastian Kozerke, Werner Schwizer, Michael Fried, Peter Boesiger & Andreas Steingoetter. (2012) 19 F MR Imaging Golden Angle–based Capsule Tracking for Intestinal Transit and Catheter Tracking: Initial in Vivo Experience . Radiology 265:3, pages 917-925.
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M. Štefanič, I. Locatelli, F. Vrečer, T. Sever, A. Mrhar & M. Bogataj. (2012) The influence of gastric emptying kinetics on the drug release from enteric coated pellets in fasted state: An in vitro/in vivo correlation. European Journal of Pharmaceutics and Biopharmaceutics 82:2, pages 376-382.
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Tobias Hahn, Sebastian Kozerke, Werner Schwizer, Michael Fried, Peter Boesiger & Andreas Steingoetter. (2011) Visualization and quantification of intestinal transit and motor function by real-time tracking of 19 F labeled capsules in humans . Magnetic Resonance in Medicine 66:3, pages 812-820.
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