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Non-invasive iontophoretic delivery of peptides and proteins across the skin

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Pages 645-663 | Published online: 24 Mar 2011

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Jayanaraian F. M. Andrade, Marcilio Cunha-Filho, Guilherme M. Gelfuso & Tais Gratieri. (2023) Iontophoresis for the cutaneous delivery of nanoentraped drugs. Expert Opinion on Drug Delivery 20:6, pages 785-798.
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Shubhangi Shukla, Ryan H. Huston, Blake D. Cox, Abhay R. Satoskar & Roger J. Narayan. (2022) Transdermal delivery via medical device technologies. Expert Opinion on Drug Delivery 19:11, pages 1505-1519.
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Hairui Li, Yuan Yu, Sara Faraji Dana, Bo Li, Chi-Ying Lee & Lifeng Kang. (2013) Novel engineered systems for oral, mucosal and transdermal drug delivery. Journal of Drug Targeting 21:7, pages 611-629.
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Articles from other publishers (37)

Thamires C. Miranda, Laudimar A. Oliveira, Leandro A. Hilgert, Marcilio Cunha-Filho, Guilherme M. Gelfuso & Tais Gratieri. (2023) Iontophoresis use for increasing drug penetration into root canals and dentinal tubules: a proof-of-concept study. Journal of Dentistry, pages 104797.
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Fernando A.P. de Sá, Jayanaraian F.M. Andrade, Thamires C. Miranda, Marcilio Cunha-Filho, Guilherme M. Gelfuso, Maria Lapteva, Yogeshvar N. Kalia & Taís Gratieri. (2023) Enhanced topical paromomycin delivery for cutaneous leishmaniasis treatment: Passive and iontophoretic approaches. International Journal of Pharmaceutics 648, pages 123617.
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Chunyi Xu, Yuyi Wu, Linxian Zhao, Weiling Zhou, Yanyan Li, Xin Yi, Youqin Wang, Qiankun Zhang, Huiling Hu & Zhanguo Wang. (2023) Transdermal hormone delivery: Strategies, application and modality selection. Journal of Drug Delivery Science and Technology 86, pages 104730.
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Koosha Ehtiati, Johannes Eiler, Agnieszka Bochynska, Louis Lech Nissen, Esben Strøbech, Lene Feldskov Nielsen & Esben Thormann. (2023) Skin and Artificial Skin Models in Electrical Sensing Applications. ACS Applied Bio Materials 6:8, pages 3033-3051.
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Prachi Vibhute, Akshaya Radhakrishnan & Sivakamavalli Jeyachandran. 2023. Marine Antioxidants. Marine Antioxidants 11 25 .
Priyanka Shaw, Patrick Vanraes, Naresh Kumar & Annemie Bogaerts. (2022) Possible Synergies of Nanomaterial-Assisted Tissue Regeneration in Plasma Medicine: Mechanisms and Safety Concerns. Nanomaterials 12:19, pages 3397.
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Patrick Vanraes & Annemie Bogaerts. (2021) The essential role of the plasma sheath in plasma–liquid interaction and its applications—A perspective. Journal of Applied Physics 129:22.
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Taís Gratieri, Rhita Zarhloule, Sachin Dubey & Yogeshvar N. Kalia. (2021) The influence of skin barrier impairment on the iontophoretic transport of low and high molecular weight permeants. International Journal of Pharmaceutics 602, pages 120607.
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Byel Kim, Hang-Eui Cho, Sun He Moon, Hyun-Jung Ahn, Seunghee Bae, Hyun-Dae Cho & Sungkwan An. (2020) Transdermal delivery systems in cosmetics. Biomedical Dermatology 4:1.
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Mingxin Ji, Guoliang Liu, Yunfeng Cui & Peng Zhao. (2020) Safety and efficacy concerns of modern strategies of local anesthetics delivery. 3 Biotech 10:8.
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Breno N. Matos, Maíra N. Pereira, Martha de O. Bravo, Marcilio Cunha-Filho, Felipe Saldanha-Araújo, Tais Gratieri & Guilherme M. Gelfuso. (2020) Chitosan nanoparticles loading oxaliplatin as a mucoadhesive topical treatment of oral tumors: Iontophoresis further enhances drug delivery ex vivo. International Journal of Biological Macromolecules 154, pages 1265-1275.
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Mayank Singhal, César E. S. Jimenez, Maria Lapteva & Yogeshvar N. Kalia. 2019. Innovative Dosage Forms. Innovative Dosage Forms 245 279 .
Song Li, Wei Li & Mark Prausnitz. (2018) Individually coated microneedles for co-delivery of multiple compounds with different properties. Drug Delivery and Translational Research 8:5, pages 1043-1052.
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Javier O. Morales, Kristin R. Fathe, Ashlee Brunaugh, Silvia Ferrati, Song Li, Miguel Montenegro-Nicolini, Zeynab Mousavikhamene, Jason T. McConville, Mark R. Prausnitz & Hugh D. C. Smyth. (2017) Challenges and Future Prospects for the Delivery of Biologics: Oral Mucosal, Pulmonary, and Transdermal Routes. The AAPS Journal 19:3, pages 652-668.
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Sergio del Río-Sancho, Cecile Cros, Bethsabée Coutaz, Muriel Cuendet & Yogeshvar N. Kalia. (2017) Cutaneous iontophoresis of μ-conotoxin CnIIIC—A potent Na V 1.4 antagonist with analgesic, anaesthetic and myorelaxant properties. International Journal of Pharmaceutics 518:1-2, pages 59-65.
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Michael N. Pastore & Michael S. Roberts. 2017. Skin Permeation and Disposition of Therapeutic and Cosmeceutical Compounds. Skin Permeation and Disposition of Therapeutic and Cosmeceutical Compounds 251 262 .
Mayank Singhal & Yogeshvar N. Kalia. 2017. Skin Permeation and Disposition of Therapeutic and Cosmeceutical Compounds. Skin Permeation and Disposition of Therapeutic and Cosmeceutical Compounds 165 182 .
Virginia Merino, Alicia López Castellano & M. Begoña Delgado-Charro. 2017. Percutaneous Penetration Enhancers Physical Methods in Penetration Enhancement. Percutaneous Penetration Enhancers Physical Methods in Penetration Enhancement 77 101 .
Laurent Simon. 2017. Percutaneous Penetration Enhancers Physical Methods in Penetration Enhancement. Percutaneous Penetration Enhancers Physical Methods in Penetration Enhancement 391 398 .
Marianna Foldvari & P. Kumar. 2017. Percutaneous Penetration Enhancers Drug Penetration Into/Through the Skin. Percutaneous Penetration Enhancers Drug Penetration Into/Through the Skin 355 358 .
Daniela S. Bernardi, Claudia Bitencourt, Denise S.C. da Silveira, Estael L.C.M. da Cruz, Marcelo A. Pereira-da-Silva, Lúcia Helena Faccioli & Renata F.V. Lopez. (2016) Effective transcutaneous immunization using a combination of iontophoresis and nanoparticles. Nanomedicine: Nanotechnology, Biology and Medicine 12:8, pages 2439-2448.
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Renquan Ruan, Ming Chen, Lili Zou, Pengfei Wei, Juanjuan Liu, Weiping Ding & Longping Wen. (2016) Recent advances in peptides for enhancing transdermal macromolecular drug delivery. Therapeutic Delivery 7:2, pages 89-100.
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Ali Aghazadeh-Habashi, Yang Yang, Kathy Tang, Raimar Lőbenberg & Michael R. Doschak. (2015) Transdermal drug delivery: feasibility for treatment of superficial bone stress fractures. Drug Delivery and Translational Research 5:6, pages 540-551.
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John F. Peppin, Phillip J. Albrecht, Charles Argoff, Burkhard Gustorff, Marco Pappagallo, Frank L. Rice & Mark S. Wallace. (2015) Skin Matters: A Review of Topical Treatments for Chronic Pain. Part One: Skin Physiology and Delivery Systems. Pain and Therapy 4:1, pages 17-32.
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Changli Wang, Renquan Ruan, Li Zhang, Yunjiao Zhang, Wei Zhou, Jun Lin, Weiping Ding & Longping Wen. (2015) Role of the Na + /K + -ATPase Beta-Subunit in Peptide-Mediated Transdermal Drug Delivery . Molecular Pharmaceutics 12:4, pages 1259-1267.
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Takayuki Sato, Hiroyuki TakeuchiTakanobu SakuraiKensuke TanakaKota MatsukiKenjirou Higashi, Kunikazu Moribe & Keiji Yamamoto. (2015) Characterization of a Riboflavin Non-aqueous Nanosuspension Prepared by Bead Milling for Cutaneous Application. CHEMICAL & PHARMACEUTICAL BULLETIN Chemical and Pharmaceutical Bulletin 63:2, pages 88-94.
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Thiago Caon, Liang Jin, Cláudia M. O. Simões, Raymond S. Norton & Joseph A. Nicolazzo. (2014) Enhancing the Buccal Mucosal Delivery of Peptide and Protein Therapeutics. Pharmaceutical Research 32:1, pages 1-21.
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Renquan Ruan, Peipei Jin, Li Zhang, Changli Wang, Chuanjun Chen, Weiping Ding & Longping Wen. (2014) Peptide-Chaperone-Directed Transdermal Protein Delivery Requires Energy. Molecular Pharmaceutics 11:11, pages 4015-4022.
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Kristina Malinovskaja, Timo Laaksonen & Jouni Hirvonen. (2014) Controlled transdermal delivery of leuprorelin by pulsed iontophoresis and ion-exchange fiber. European Journal of Pharmaceutics and Biopharmaceutics 88:3, pages 594-601.
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Sandra Wiedersberg & Richard H. Guy. (2014) Transdermal drug delivery: 30+ years of war and still fighting!. Journal of Controlled Release 190, pages 150-156.
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Matthieu Roustit, Sophie Blaise & Jean-Luc Cracowski. (2014) Trials and tribulations of skin iontophoresis in therapeutics. British Journal of Clinical Pharmacology 77:1, pages 63-71.
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I.A. Aljuffali, C.-F. Lin & J.-Y. Fang. (2014) Skin ablation by physical techniques for enhancing dermal/transdermal drug delivery. Journal of Drug Delivery Science and Technology 24:3, pages 277-287.
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Taís Gratieri & Yogeshvar N. Kalia. 2014. Focal Controlled Drug Delivery. Focal Controlled Drug Delivery 263 284 .
Taís Gratieri & Yogeshvar N. Kalia. (2013) Mathematical models to describe iontophoretic transport in vitro and in vivo and the effect of current application on the skin barrier. Advanced Drug Delivery Reviews 65:2, pages 315-329.
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Gerard Marx & Chaim Gilon. (2012) The Molecular Basis of Memory. ACS Chemical Neuroscience 3:8, pages 633-642.
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Clara GómezMarta BenitoJosé Maria TeijónMaria Dolores Blanco. (2012) Novel methods and devices to enhance transdermal drug delivery: the importance of laser radiation in transdermal drug delivery. Therapeutic Delivery 3:3, pages 373-388.
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Edward A. Shipton. (2012) New Delivery Systems for Local Anaesthetics—Part 2. Anesthesiology Research and Practice 2012, pages 1-6.
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