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Dual delivery of an antibiotic and a growth factor addresses both the microbiological and biological challenges of contaminated bone fractures

, PhD & , PhD
Pages 1555-1569 | Published online: 22 Oct 2011

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Carmen Alvarez-Lorenzo, Carlos A. Garcia-Gonzalez, Emilio Bucio & Angel Concheiro. (2016) Stimuli-responsive polymers for antimicrobial therapy: drug targeting, contact-killing surfaces and competitive release. Expert Opinion on Drug Delivery 13:8, pages 1109-1119.
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Viviana Mouriño, Juan P Cattalini, Judith A Roether, Prachi Dubey, Ipsita Roy & Aldo R Boccaccini. (2013) Composite polymer-bioceramic scaffolds with drug delivery capability for bone tissue engineering. Expert Opinion on Drug Delivery 10:10, pages 1353-1365.
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Aldo R Boccaccini, Ulrich Kneser & Andreas Arkudas. (2012) Scaffolds for vascularized bone regeneration: advances and challenges. Expert Review of Medical Devices 9:5, pages 457-460.
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Lorena Castro Mariano, Maria Helena Raposo Fernandes & Pedro Sousa Gomes. (2022) Antimicrobial Biomaterials for the Healing of Infected Bone Tissue: A Systematic Review of Microtomographic Data on Experimental Animal Models. Journal of Functional Biomaterials 13:4, pages 193.
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Viviana Mouriño. 2022. Tissue Engineering Using Ceramics and Polymers. Tissue Engineering Using Ceramics and Polymers 817 840 .
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Feifei Liu, Xuewei Cheng, Lu Xiao, Qiang Wang, Kun Yan, Zhi Su, Lei Wang, Chuang Ma & Yingbo Wang. (2021) Inside-outside Ag nanoparticles-loaded polylactic acid electrospun fiber for long-term antibacterial and bone regeneration. International Journal of Biological Macromolecules 167, pages 1338-1348.
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Thomas J. Spoonmore, Caleb A. Ford, Jacob M. Curry, Scott A. Guelcher & James E. Cassat. (2020) Concurrent Local Delivery of Diflunisal Limits Bone Destruction but Fails To Improve Systemic Vancomycin Efficacy during Staphylococcus aureus Osteomyelitis. Antimicrobial Agents and Chemotherapy 64:7.
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Carmen Alvarez-Lorenzo & Angel Concheiro. (2019) Smart Drug Release from Medical Devices. Journal of Pharmacology and Experimental Therapeutics 370:3, pages 544-554.
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Yaping Chang, Mohit Bhandari, Kan Lun Zhu, Reza Donald Mirza, Melody Ren, Sean Alexander Kennedy, Ahmed Negm, Neera Bhatnagar, Faysal N. Naji, Lazar Milovanovic, Yutong Fei, Arnav Agarwal, Rakhshan Kamran, Sung Min Cho, Stefan Schandelmaier, Li Wang, Lin Jin, Shiyun Hu, Yanping Zhao, Luciane Cruz Lopes, Mei Wang, Brad Petrisor, Bill Ristevski, Reed A.C. Siemieniuk & Gordon H. Guyatt. (2019) Antibiotic Prophylaxis in the Management of Open Fractures. JBJS Reviews 7:2, pages e1-e1.
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Ju Liu, Weihu Yang, Bailong Tao, Tingting Shen, Ye He, Xinkun Shen & Kaiyong Cai. (2018) Preparing and immobilizing antimicrobial osteogenic growth peptide on titanium substrate surface. Journal of Biomedical Materials Research Part A 106:12, pages 3021-3033.
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Huiyong Xu, Ge Zhang, Kaige Xu, Leyu Wang, Lei Yu, Malcolm M.Q. Xing & Xiaozhong Qiu. (2018) Mussel-inspired dual-functional PEG hydrogel inducing mineralization and inhibiting infection in maxillary bone reconstruction. Materials Science and Engineering: C 90, pages 379-386.
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Matt E. Brown, Yuan Zou, Rebecca Peyyala, Sarandeep S. Huja, Larry L. Cunningham, Todd A. Milbrandt, Thomas D. Dziubla & David A. Puleo. (2018) Testing of a bioactive, moldable bone graft substitute in an infected, critically sized segmental defect model. Journal of Biomedical Materials Research Part B: Applied Biomaterials 106:5, pages 1878-1886.
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Krystle A. Blanchette, Ranjani Prabhakara, Mark E. Shirtliff & Joseph C. Wenke. (2017) Inhibition of fracture healing in the presence of contamination by Staphylococcus aureus : Effects of growth state and immune response . Journal of Orthopaedic Research 35:9, pages 1845-1854.
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