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Microemulsions for oral administration and their therapeutic applications

, PhD PharmD &
Pages 937-951 | Published online: 05 Jun 2012

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Takayuki Yoshida, Hiroyuki Kojima, Kazuhiro Sako & Hiromu Kondo. (2022) Drug delivery to the intestinal lymph by oral formulations. Pharmaceutical Development and Technology 27:2, pages 175-189.
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Mandana Ohadi, Arash Shahravan, Negar Dehghannoudeh, Touba Eslaminejad, Ibrahim M Banat & Gholamreza Dehghannoudeh. (2020) Potential Use of Microbial Surfactant in Microemulsion Drug Delivery System: A Systematic Review. Drug Design, Development and Therapy 14, pages 541-550.
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Victor Hugo Sousa Araujo, Jonatas Lobato Duarte, Gabriela Corrêa Carvalho, Amanda Letícia Polli Silvestre, Bruno Fonseca-Santos, Gabriel Davi Marena, Tais de Cassia Ribeiro, Matheus Aparecido dos Santos Ramos, Taís Maria Bauab & Marlus Chorilli. (2020) Nanosystems against candidiasis: a review of studies performed over the last two decades. Critical Reviews in Microbiology 46:5, pages 508-547.
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Juntao Yin, Cuiyu Xiang, Peiqing Wang, Yuyun Yin & Yantao Hou. (2017) Biocompatible nanoemulsions based on hemp oil and less surfactants for oral delivery of baicalein with enhanced bioavailability. International Journal of Nanomedicine 12, pages 2923-2931.
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Aman Kumar Sharma, Tarun Garg, Amit K. Goyal & Goutam Rath. (2016) Role of microemuslsions in advanced drug delivery. Artificial Cells, Nanomedicine, and Biotechnology 44:4, pages 1177-1185.
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Articles from other publishers (45)

Meenu Mehta, Thuy Anh Bui, Xinpu Yang, Yagiz Aksoy, Ewa M. Goldys & Wei Deng. (2023) Lipid-Based Nanoparticles for Drug/Gene Delivery: An Overview of the Production Techniques and Difficulties Encountered in Their Industrial Development. ACS Materials Au 3:6, pages 600-619.
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Preeti, Sharda Sambhakar, Rohit Malik, Saurabh Bhatia, Ahmed Al Harrasi, Chanchal Rani, Renu Saharan, Suresh Kumar, Geeta & Renu Sehrawat. (2023) Nanoemulsion: An Emerging Novel Technology for Improving the Bioavailability of Drugs. Scientifica 2023, pages 1-25.
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Atsushi Kambayashi. (2023) In Silico Modeling Approaches Coupled with In Vitro Characterization in Predicting In Vivo Performance of Drug Delivery System Formulations. Molecular Pharmaceutics.
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Fernández R. Nathalie, Madrigal R. German, Chavarría R. Marianela, Matarrita B. Daniela, Baltodano V. Eleaneth, Carazo B. Gustavo & Pacheco M. Jorge. (2023) Microemulsion Systems: Generalities and Fields of Application. European Journal of Pharmaceutical Research 3:4, pages 14-22.
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L. Ya. Zakharova, F. I. Maganova, K. O. Sinyashin, G. A. Gaynanova, A. B. Mirgorodskaya, E. A. Vasilieva & O. G. Sinyashin. (2023) Supramolecular Strategy for the Design of Nanocarriers for Drugs and Natural Bioactives: Current State of the Art (A Review). Russian Journal of General Chemistry 93:7, pages 1867-1899.
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Lena Scheller, Stephanie Bachmann, Theresa Zorn, Simon Hanio, Uwe Gbureck, Dimitrios Fatouros, Ann-Christin Pöppler & Lorenz Meinel. (2023) Solid microemulsion preconcentrates on pH responsive metal-organic framework for tableting. European Journal of Pharmaceutics and Biopharmaceutics 186, pages 105-111.
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Thuy Chinh Nguyen & Hoang Thai. (2023) Review: emulsion techniques for producing polymer based drug delivery systems. Vietnam Journal of Science and Technology 61:1, pages 1-26.
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Nidhi Mishra, Neelu Singh & Poonam Parashar. 2023. Viral Drug Delivery Systems. Viral Drug Delivery Systems 119 139 .
Baoqi Dong, Jingbao Chen, Ye Cai, Wenqing Wu & Xiaoqin Chu. (2022) In vitro and in vivo evaluation of cinnamaldehyde Microemulsion–Mucus interaction . Journal of Food Biochemistry 46:10.
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Evren Algın Yapar, M.E. Durgun, I. Esentürk, S. Güngör & Y. Özsoy. 2022. Herbal Bioactive-Based Drug Delivery Systems. Herbal Bioactive-Based Drug Delivery Systems 25 61 .
Abdulrahman A. Balhaddad, Yang Xia, Yucheng Lan, Lamia Mokeem, Maria S. Ibrahim, Michael D. Weir, Hockin H. K. Xu & Mary Anne S. Melo. (2021) Magnetic-Responsive Photosensitizer Nanoplatform for Optimized Inactivation of Dental Caries-Related Biofilms: Technology Development and Proof of Principle. ACS Nano 15:12, pages 19888-19904.
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Nida Suhail, A. Khuzaim Alzahrani, W. Jamith Basha, Nadeem Kizilbash, Arsalan Zaidi, Jaweria Ambreen & Hassan M. Khachfe. (2021) Microemulsions: Unique Properties, Pharmacological Applications, and Targeted Drug Delivery. Frontiers in Nanotechnology 3.
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Sya’ban Putra Adiguna, Jonathan Ardhianto Panggabean, Akhirta Atikana, Febriana Untari, Fauzia Izzati, Asep Bayu, A’liyatur Rosyidah, Siti Irma Rahmawati & Masteria Yunovilsa Putra. (2021) Antiviral Activities of Andrographolide and Its Derivatives: Mechanism of Action and Delivery System. Pharmaceuticals 14:11, pages 1102.
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Takashi Kuroiwa, Yuto Kawauchi, Ryutaro Moriyoshi, Hiroki Shino, Tatsuhito Suzuki, Sosaku Ichikawa, Isao Kobayashi, Kunihiko Uemura & Akihiko Kanazawa. (2021) Biocompatible homogeneous particle formation via the self-complexation of chitosan with oleic acid and its application as an encapsulation material for a water-insoluble compound. Colloids and Surfaces A: Physicochemical and Engineering Aspects 624, pages 126808.
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Matheus Aparecido dos Santos Ramos, Luciani Gaspar de Toledo, Larissa Spósito, Gabriel Davi Marena, Laura Caminitti de Lima, Giovanna Capaldi Fortunato, Victor Hugo Sousa Araújo, Taís Maria Bauab & Marlus Chorilli. (2021) Nanotechnology-based lipid systems applied to resistant bacterial control: A review of their use in the past two decades. International Journal of Pharmaceutics 603, pages 120706.
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Johanna Zech, Nadeen Salaymeh, Nicholas H. Hunt, Karsten Mäder & Jacob Golenser. (2021) Efficient Treatment of Experimental Cerebral Malaria by an Artemisone-SMEDDS System: Impact of Application Route and Dosing Frequency. Antimicrobial Agents and Chemotherapy 65:4.
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Yunhong Wang, Rong Hu, Yanlei Guo, Weihan Qin, Xiaomei Zhang, Lei Hua & Yong Yang. (2020) Preparation, evaluation, and in vitro release of chitosan-alginate tanshinone self-microemulsifying sustained-release microcapsules. Technology and Health Care, pages 1-9.
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Agnieszka Ewa Wiącek, Małgorzata Jurak, Agata Ładniak, Kacper Przykaza & Klaudia Szafran. (2020) Cyclosporine CsA—The Physicochemical Characterization of Liposomal and Colloidal Systems. Colloids and Interfaces 4:4, pages 46.
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Delaram Babadi, Simin Dadashzadeh, Mahraz Osouli, Maryam Sadat Daryabari & Azadeh Haeri. (2020) Nanoformulation strategies for improving intestinal permeability of drugs: A more precise look at permeability assessment methods and pharmacokinetic properties changes. Journal of Controlled Release 321, pages 669-709.
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Ioanna Theochari, Aristotelis Xenakis & Vassiliki Papadimitriou. 2020. Smart Nanocontainers. Smart Nanocontainers 315 341 .
Anna Froelich & Tomasz Osmałek. 2020. Emulsion‐based Encapsulation of Antioxidants. Emulsion‐based Encapsulation of Antioxidants 197 224 .
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Selin S. Timur, Diğdem Yöyen-Ermiş, Güldal Esendağlı, Selcen Yonat, Utku Horzum, Güneş Esendağlı & R. Neslihan Gürsoy. (2019) Efficacy of a novel LyP-1-containing self-microemulsifying drug delivery system (SMEDDS) for active targeting to breast cancer. European Journal of Pharmaceutics and Biopharmaceutics 136, pages 138-146.
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Ching-Yun Hsu, Pei-Wen Wang, Ahmed Alalaiwe, Zih-Chan Lin & Jia-You Fang. (2019) Use of Lipid Nanocarriers to Improve Oral Delivery of Vitamins. Nutrients 11:1, pages 68.
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Nisha Tiwari, A. Sivakumar, Amitava Mukherjee & N. Chandrasekaran. (2018) Enhanced antifungal activity of Ketoconazole using rose oil based novel microemulsion formulation. Journal of Drug Delivery Science and Technology 47, pages 434-444.
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Megumi Nishitani Yukuyama, Pedro Leonidas Filho Oseliero, Edna Tomiko Myiake Kato, Raimar Lobënberg, Cristiano Luis Pinto de Oliveira, Gabriel Lima Barros de Araujo & Nadia Araci Bou-Chacra. (2018) High internal vegetable oil nanoemulsion: D-phase emulsification as a unique low energy process. Colloids and Surfaces A: Physicochemical and Engineering Aspects 554, pages 296-305.
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Ziyaur Rahman, Naseem A. Charoo, Sohail Akhter, Sarwar Beg, Indra K. Reddy & Mansoor A. Khan. 2018. Nanoscale Fabrication, Optimization, Scale-Up and Biological Aspects of Pharmaceutical Nanotechnology. Nanoscale Fabrication, Optimization, Scale-Up and Biological Aspects of Pharmaceutical Nanotechnology 619 655 .
Peter van Hoogevest. (2017) Review – An update on the use of oral phospholipid excipients. European Journal of Pharmaceutical Sciences 108, pages 1-12.
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Mohammad Rejaul Kaiser, Zhaohui Ma, Xiwen Wang, Fudong Han, Tao Gao, Xiulin Fan, Jia-Zhao Wang, Hua Kun Liu, Shixue Dou & Chunsheng Wang. (2017) Reverse Microemulsion Synthesis of Sulfur/Graphene Composite for Lithium/Sulfur Batteries. ACS Nano 11:9, pages 9048-9056.
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Heibatullah Kalantari, Anayatollah Salimi, Eisa Motaharitabar, Azin Samimi & Annahita Rezai. (2017) Hepatoprotective Effect of Microemulsion-Based System of Prunus Cerasus Kernel Extract on CCL4-induced Liver Damage in Mice. Jundishapur Journal of Natural Pharmaceutical Products In Press:In Press.
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Silvia Stotani & Fabrizio Giordanetto. 2017. Practical Medicinal Chemistry with Macrocycles. Practical Medicinal Chemistry with Macrocycles 411 499 .
Shannon P. Callender, Jessica A. Mathews, Katherine Kobernyk & Shawn D. Wettig. (2017) Microemulsion utility in pharmaceuticals: Implications for multi-drug delivery. International Journal of Pharmaceutics 526:1-2, pages 425-442.
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Francisco Humberto Xavier-Junior, Nicolas Huang, Jean-Jacques Vachon, Vera Lucia Garcia Rehder, Eryvaldo Sócrates Tabosa do Egito & Christine Vauthier. (2016) Match of Solubility Parameters Between Oil and Surfactants as a Rational Approach for the Formulation of Microemulsion with a High Dispersed Volume of Copaiba Oil and Low Surfactant Content. Pharmaceutical Research 33:12, pages 3031-3043.
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Harivardhan Reddy Lakkireddy, Matthias Urmann, Melissa Besenius, Ulrich Werner, Torsten Haack, Priscilla Brun, Jean Alié, Brigitte Illel, Laurent Hortala, Rachel Vogel & Didier Bazile. (2016) Oral delivery of diabetes peptides — Comparing standard formulations incorporating functional excipients and nanotechnologies in the translational context. Advanced Drug Delivery Reviews 106, pages 196-222.
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Krishna Sanka, Deepthi Suda & Vasudha Bakshi. (2016) Optimization of solid-self nanoemulsifying drug delivery system for solubility and release profile of clonazepam using simplex lattice design. Journal of Drug Delivery Science and Technology 33, pages 114-124.
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Yanghuan Ye, Tianpeng Zhang, Wan Li, Hua Sun, Danyi Lu, Baojian Wu & Xingwang Zhang. (2015) Glucose-Based Mesoporous Carbon Nanospheres as Functional Carriers for Oral Delivery of Amphiphobic Raloxifene: Insights into the Bioavailability Enhancement and Lymphatic Transport. Pharmaceutical Research 33:3, pages 792-803.
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Marko Krstić, Miljana Popović, Vladimir Dobričić & Svetlana Ibrić. (2015) Influence of Solid Drug Delivery System Formulation on Poorly Water-Soluble Drug Dissolution and Permeability. Molecules 20:8, pages 14684-14698.
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Xiaojin Liu, Ruiming Han, Yueh Wang, Xiuxia Li, Min Zhang & Yu Yan. (2014) Fungicidal Activity of a Medium-chain Fatty Acids Mixture Comprising Caprylic, Pelargonic and Capric Acids. Plant Pathology Journal 13:1, pages 65-70.
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