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Paracellular drug absorption enhancement through tight junction modulation

& , PhD
Pages 103-114 | Published online: 20 Nov 2012

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Joël Brunner & Gerrit Borchard. (2023) Structure–activity relationship of a peptide permeation enhancer. Tissue Barriers 11:1.
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Wee Ling Koh, Thomas Foster, Armin Mooranian & Hani Al-Salami. (2022) Applications of bile acids as biomaterials-based modulators, in biomedical science and microfluidics. Therapeutic Delivery 13:12, pages 591-604.
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Zaihua Wang & Yan Li. (2018) Raloxifene/SBE-β-CD Inclusion Complexes Formulated into Nanoparticles with Chitosan to Overcome the Absorption Barrier for Bioavailability Enhancement. Pharmaceutics 10:3, pages 76.
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Deepali Verma, Neha Gulati, Shreya Kaul, Siddhartha Mukherjee & Upendra Nagaich. (2018) Protein Based Nanostructures for Drug Delivery. Journal of Pharmaceutics 2018, pages 1-18.
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Wenji Deng, Qian Xie, Huan Wang, Zhiguo Ma, Baojian Wu & Xingwang Zhang. (2017) Selenium nanoparticles as versatile carriers for oral delivery of insulin: Insight into the synergic antidiabetic effect and mechanism. Nanomedicine: Nanotechnology, Biology and Medicine 13:6, pages 1965-1974.
Crossref
David Julian McClements, Hang Xiao & Philip Demokritou. (2017) Physicochemical and colloidal aspects of food matrix effects on gastrointestinal fate of ingested inorganic nanoparticles. Advances in Colloid and Interface Science 246, pages 165-180.
Crossref
Tarianna Stewart, William T. Koval, Samuel A. Molina, Suzanne M. Bock, James W. LillardJr.Jr., Russell F. Ross, Tejal A. Desai & Michael Koval. (2017) Calibrated flux measurements reveal a nanostructure-stimulated transcytotic pathway. Experimental Cell Research 355:2, pages 153-161.
Crossref
Pierre-André Billat, Emilie Roger, Sébastien Faure & Frédéric Lagarce. (2017) Models for drug absorption from the small intestine: where are we and where are we going?. Drug Discovery Today 22:5, pages 761-775.
Crossref
Sandra Bowles, Elizabeth Joubert, Dalene de Beer, Johan Louw, Christel Brunschwig, Mathew Njoroge, Nina Lawrence, Lubbe Wiesner, Kelly Chibale & Christo Muller. (2017) Intestinal Transport Characteristics and Metabolism of C-Glucosyl Dihydrochalcone, Aspalathin. Molecules 22:4, pages 554.
Crossref
E. Thomas Danielsen & E. Michael Danielsen. (2017) Glycol chitosan: A stabilizer of lipid rafts in the intestinal brush border. Biochimica et Biophysica Acta (BBA) - Biomembranes 1859:3, pages 360-367.
Crossref
Sonia Alavi, Azadeh Haeri & Simin Dadashzadeh. (2017) Utilization of chitosan-caged liposomes to push the boundaries of therapeutic delivery. Carbohydrate Polymers 157, pages 991-1012.
Crossref
Claudio D. Schteingart & Jolene L. Lau. 2017. Platform Technologies in Drug Discovery and Validation. Platform Technologies in Drug Discovery and Validation 543 586 .
Raje Chouhan, Shilpi Goswami & Anil Kumar Bajpai. 2017. Nanostructures for Oral Medicine. Nanostructures for Oral Medicine 435 465 .
Ruojie Zhang & David Julian McClements. (2016) Enhancing nutraceutical bioavailability by controlling the composition and structure of gastrointestinal contents: Emulsion-based delivery and excipient systems. Food Structure 10, pages 21-36.
Crossref
David Julian McClements, Laura Saliva-Trujillo, Ruojie Zhang, Zipei Zhang, Liqiang Zou, Mingfei Yao & Hang Xiao. (2016) Boosting the bioavailability of hydrophobic nutrients, vitamins, and nutraceuticals in natural products using excipient emulsions. Food Research International 88, pages 140-152.
Crossref
Hiraku Onishi & Ayako Tokuyasu. (2016) Preparation and Evaluation of Enteric-Coated Chitosan Derivative-Based Microparticles Loaded with Salmon Calcitonin as an Oral Delivery System. International Journal of Molecular Sciences 17:9, pages 1546.
Crossref
Salvatore V. Pizzo, Roger L. Lundblad & Monte S. Willis. 2016. Proteolysis in the Interstitial Space. Proteolysis in the Interstitial Space 1 42 .
Laura Salvia-Trujillo, Olga Martín-Belloso & David McClements. (2016) Excipient Nanoemulsions for Improving Oral Bioavailability of Bioactives. Nanomaterials 6:1, pages 17.
Crossref
Jinfeng Liu, Kebo Wang, Jie Li, Chengchuan Che, Ge Yang & Kejian Wang. (2015) Targeted Delivery of Superoxide Dismutase by Chemical Modification with Quaternary Ammonium Chitosan and Pharmacokinetic Analysis. Journal of Pharmaceutical Innovation 10:4, pages 348-356.
Crossref
Suma Gopinathan. 2015. New Horizons in Predictive Drug Metabolism and Pharmacokinetics. New Horizons in Predictive Drug Metabolism and Pharmacokinetics 348 358 .
David Julian McClements, Liqiang Zou, Ruojie Zhang, Laura Salvia-Trujillo, Taha Kumosani & Hang Xiao. (2015) Enhancing Nutraceutical Performance Using Excipient Foods: Designing Food Structures and Compositions to Increase Bioavailability. Comprehensive Reviews in Food Science and Food Safety 14:6, pages 824-847.
Crossref
Gecioni Loch-Neckel, Lorena Santos-Bubniak, Letícia Mazzarino, Amanda V. Jacques, Bárbara Moccelin, Maria Claúdia Santos-Silva & Elenara Lemos-Senna. (2015) Orally Administered Chitosan-Coated Polycaprolactone Nanoparticles Containing Curcumin Attenuate Metastatic Melanoma in the Lungs. Journal of Pharmaceutical Sciences 104:10, pages 3524-3534.
Crossref
Isabelle George, Grégoire Naudin, Sonja Boland, Stéphane Mornet, Vincent Contremoulins, Karine Beugnon, Laurent Martinon, Olivier Lambert & Armelle Baeza-Squiban. (2015) Metallic oxide nanoparticle translocation across the human bronchial epithelial barrier. Nanoscale 7:10, pages 4529-4544.
Crossref
Anna Karewicz, Krzysztof Szczubiałka & Maria Nowakowska. 2014. Cationic Polymers in Regenerative Medicine. Cationic Polymers in Regenerative Medicine 296 320 .
David Julian McClements & Hang Xiao. (2014) Excipient foods: designing food matrices that improve the oral bioavailability of pharmaceuticals and nutraceuticals. Food Funct. 5:7, pages 1320-1333.
Crossref
Hanne Mørck Nielsen. 2014. Mucosal Delivery of Biopharmaceuticals. Mucosal Delivery of Biopharmaceuticals 99 122 .
Camilla Sander, Hanne Mørck Nielsen & Jette Jacobsen. (2013) Buccal delivery of metformin: TR146 cell culture model evaluating the use of bioadhesive chitosan discs for drug permeability enhancement. International Journal of Pharmaceutics 458:2, pages 254-261.
Crossref
Maelíosa TC McCrudden, Thakur Raghu Raj Singh, Katarzyna Migalska & Ryan F Donnelly. (2013) Strategies for enhanced peptide and protein delivery. Therapeutic Delivery 4:5, pages 593-614.
Crossref
M. Boegh, C. Foged, A. Müllertz & H. Mørck Nielsen. (2013) Mucosal drug delivery: barriers, in vitro models and formulation strategies. Journal of Drug Delivery Science and Technology 23:4, pages 383-391.
Crossref

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