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Mucoadhesive in situ nasal gelling drug delivery systems for modulated drug delivery

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Pages 115-130 | Published online: 30 Nov 2012

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Read on this site (7)

Marzooka Kazi-Chishti, Javeed Shaikh, Nazimuddin Chishti & Mohamed Hassan Dehghan. (2023) Nasal mucoadhesive in situ gelling liquid crystalline fluid precursor system of polyene antibiotic for potential treatment of localized sinuses aspergillosis post COVID infection. Journal of Dispersion Science and Technology 0:0, pages 1-19.
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Saleha Rehman, Bushra Nabi, Ameeduzzafar Zafar, Sanjula Baboota & Javed Ali. (2019) Intranasal delivery of mucoadhesive nanocarriers: a viable option for Parkinson’s disease treatment?. Expert Opinion on Drug Delivery 16:12, pages 1355-1366.
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Forouhe Zahir-Jouzdani, Julian Dominik Wolf, Fatemeh Atyabi & Andreas Bernkop-Schnürch. (2018) In situ gelling and mucoadhesive polymers: why do they need each other?. Expert Opinion on Drug Delivery 15:10, pages 1007-1019.
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Juilee A. Kulkarni & Amelia M. Avachat. (2017) Pharmacodynamic and pharmacokinetic investigation of cyclodextrin-mediated asenapine maleate in situ nasal gel for improved bioavailability. Drug Development and Industrial Pharmacy 43:2, pages 234-245.
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Marwa Ahmed Sallam, Hala Mahmoud Helal & Sana Mohamed Mortada. (2016) Rationally designed nanocarriers for intranasaltherapy of allergic rhinitis: influence of carrier type on in vivo nasal deposition. International Journal of Nanomedicine 11, pages 2345-2357.
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Sonali S Bharate & Ram A Vishwakarma. (2013) Impact of preformulation on drug development. Expert Opinion on Drug Delivery 10:9, pages 1239-1257.
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Chandrakantsing Vijaysing Pardeshi & Veena Shailendra Belgamwar. (2013) Direct nose to brain drug delivery via integrated nerve pathways bypassing the blood–brain barrier: an excellent platform for brain targeting. Expert Opinion on Drug Delivery 10:7, pages 957-972.
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Articles from other publishers (48)

Surabhi V. Boraste & Dr. Sanjay B. Patil. (2023) FORMULATION DEVELOPMENT AND EVALUATION OF NASAL IN SITU GEL OF PROMETHAZINE HYDROCHLORIDE . Drug Development and Industrial Pharmacy, pages 1-20.
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Xiao Zhao, Shuting Ni, Yangjie Song & Kaili Hu. (2023) Intranasal delivery of Borneol/R8dGR peptide modified PLGA nanoparticles co-loaded with curcumin and cisplatin alleviate hypoxia in pediatric brainstem glioma which improves the synergistic therapy. Journal of Controlled Release 362, pages 121-137.
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Afroditi Kapourani, Katerina Kirimkiroglou, Konstantina Chachlioutaki, Maria Koromili, Christos Ritzoulis, Andreana N. Assimopoulou, Dimitrios A. Andreadis, Dimitrios G. Fatouros & Panagiotis Barmpalexis. (2023) Evaluation of pilocarpine in situ forming buccal gels as potential formulations for the management of xerostomia. Journal of Drug Delivery Science and Technology 86, pages 104698.
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Paramita Saha, Himanshu Kathuria & Murali Monohar Pandey. (2023) Intranasal nanotherapeutics for brain targeting and clinical studies in Parkinson's disease. Journal of Controlled Release 358, pages 293-318.
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Xiyue He, Xiaoyan Chen, Hairui Wang, Guangsheng Du & Xun Sun. (2023) Recent advances in respiratory immunization: A focus on COVID-19 vaccines. Journal of Controlled Release 355, pages 655-674.
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Elisa Corazza, Massimiliano Pio di Cagno, Annette Bauer-Brandl, Angela Abruzzo, Teresa Cerchiara, Federica Bigucci & Barbara Luppi. (2022) Drug delivery to the brain: In situ gelling formulation enhances carbamazepine diffusion through nasal mucosa models with mucin. European Journal of Pharmaceutical Sciences 179, pages 106294.
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Mary B. McGuckin, Jiawen Wang, Rand Ghanma, Nuoya Qin, Santiago D. Palma, Ryan F. Donnelly & Alejandro J. Paredes. (2022) Nanocrystals as a master key to deliver hydrophobic drugs via multiple administration routes. Journal of Controlled Release 345, pages 334-353.
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E. O. Bakhrushina, N. B. Demina, M. M. Shumkova, P. S. Rodyuk, D. S. Shulikina & I. I. Krasnyuk. (2021) <i>In situ</i> Intranasal Delivery Systems: Application Prospects and Main Pharmaceutical Aspects of Development (Review). Drug development & registration 10:4, pages 54-63.
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N. N. Porfiryeva, I. I. Semina, R. I. Moustafine & V. V. Khutoryanskiy. (2021) Intranasal Administration as a Route to Deliver Drugs to the Brain (Review). Drug development & registration 10:4, pages 117-127.
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Barbara R. Conway & Muhammad U. Ghori. 2021. Fundamentals of Drug Delivery. Fundamentals of Drug Delivery 393 432 .
Jheel Dholakia, Bala Prabhakar & Pravin Shende. (2021) Strategies for the delivery of antidiabetic drugs via intranasal route. International Journal of Pharmaceutics 608, pages 121068.
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Haiyang Wu, Yan Zhou, Yulin Wang, Linjian Tong, Fanchen Wang, Sirong Song, Lixia Xu, Baolong Liu, Hua Yan & Zhiming Sun. (2021) Current State and Future Directions of Intranasal Delivery Route for Central Nervous System Disorders: A Scientometric and Visualization Analysis. Frontiers in Pharmacology 12.
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Marzia Cirri, Francesca Maestrelli, Giulia Nerli, Natascia Mennini, Mario D’Ambrosio, Cristina Luceri & Paola Angela Mura. (2021) Development of a Cyclodextrin-Based Mucoadhesive-Thermosensitive In Situ Gel for Clonazepam Intranasal Delivery. Pharmaceutics 13:7, pages 969.
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Ahmed A. El-Shenawy, Reda A. Mahmoud, Essam A. Mahmoud & Mohamed S. Mohamed. (2021) Intranasal In Situ Gel of Apixaban-Loaded Nanoethosomes: Preparation, Optimization, and In Vivo Evaluation. AAPS PharmSciTech 22:4.
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Roberta Cassano, Camilla Servidio & Sonia Trombino. (2021) Biomaterials for Drugs Nose–Brain Transport: A New Therapeutic Approach for Neurological Diseases. Materials 14:7, pages 1802.
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Hetal Thakkar, Darshan Vaghela & Brijesh Pradipkumar Patel. (2021) Brain targeted intranasal in-situ gelling spray of paroxetine: Formulation, characterization and in-vivo evaluation". Journal of Drug Delivery Science and Technology 62, pages 102317.
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Guiting Huang, Jin Xie, Shuyuan Shuai, Shaofeng Wei, Yingchong Chen, Zhiyu Guan, Qin Zheng, Pengfei Yue & Changhong Wang. (2021) Nose-to-brain delivery of drug nanocrystals by using Ca2+ responsive deacetylated gellan gum based in situ-nanogel. International Journal of Pharmaceutics 594, pages 120182.
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Masoumeh Moslemi. (2021) Reviewing the recent advances in application of pectin for technical and health promotion purposes: From laboratory to market. Carbohydrate Polymers 254, pages 117324.
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Serge Mignani, Xiangyang Shi, Andrii Karpus & Jean-Pierre Majoral. (2021) Non-invasive intranasal administration route directly to the brain using dendrimer nanoplatforms: An opportunity to develop new CNS drugs. European Journal of Medicinal Chemistry 209, pages 112905.
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Umesh D. Laddha & Amol A. Tagalpallewar. 2021. Direct Nose-to-Brain Drug Delivery. Direct Nose-to-Brain Drug Delivery 39 54 .
Mukta Agrawal, Shailendra Saraf, Swarnlata Saraf, Sunil K. Dubey, Anu Puri, Umesh Gupta, Prashant Kesharwani, V. Ravichandiran, Pramod Kumar, V.G.M. Naidu, Upadhyayula Suryanarayana Murty, Ajazuddin & Amit Alexander. (2020) Stimuli-responsive In situ gelling system for nose-to-brain drug delivery. Journal of Controlled Release 327, pages 235-265.
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Neslihan Üstündağ Okur, Ayşe Pınar Yağcılar & Panoraia I. Siafaka. (2020) Promising Polymeric Drug Carriers for Local Delivery: The Case of in situ Gels. Current Drug Delivery 17:8, pages 675-693.
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Gul’nur Tatykhanova, Vladimir Aseyev & Sarkyt E. Kudaibergenov. (2021) Mucoadhesive Properties of Gellan and Its Modified Derivatives. Reviews and Advances in Chemistry 10:3-4, pages 140-157.
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Foziyah Zakir, Adil Ahmad, Uzma Farooq, Mohd Aamir Mirza, Alok Tripathi, Divya Singh, Faiyaz Shakeel, Sradhanjali Mohapatra, Farhan J Ahmad & Kanchan Kohli. (2020) Design and development of a commercially viable in situ nanoemulgel for the treatment of postmenopausal osteoporosis . Nanomedicine 15:12, pages 1167-1187.
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Daisuke Inoue, Tomoyuki Furubayashi, Akiko Tanaka, Toshiyasu Sakane & Kiyohiko Sugano. (2020) Quantitative estimation of drug permeation through nasal mucosa using in vitro membrane permeability across Calu-3 cell layers for predicting in vivo bioavailability after intranasal administration to rats. European Journal of Pharmaceutics and Biopharmaceutics 149, pages 145-153.
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Yifan Chen, Gang Cheng, Rongfeng Hu, Shengqi Chen, Wenjie Lu, Song Gao, Hongmei Xia, Bin Wang, Chaojie Sun, Xiangjiang Nie, Qiang Shen & Wenyou Fang. (2019) A Nasal Temperature and pH Dual-Responsive In Situ Gel Delivery System Based on Microemulsion of Huperzine A: Formulation, Evaluation, and In Vivo Pharmacokinetic Study. AAPS PharmSciTech 20:7.
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Tingwang Guo, Yuanyuan Guo, Yuhua Gong, Jingou Ji, Shilei Hao, Jia Deng & Bochu Wang. (2019) An enhanced charge-driven intranasal delivery of nicardipine attenuates brain injury after intracerebral hemorrhage. International Journal of Pharmaceutics 566, pages 46-56.
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Amarjitsing P. Rajput & Shital B. Butani. (2019) Resveratrol anchored nanostructured lipid carrier loaded in situ gel via nasal route: Formulation, optimization and in vivo characterization. Journal of Drug Delivery Science and Technology 51, pages 214-223.
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Qianwen Wang, Zhong Zuo, Cheuk Kit Chucky Cheung & Sharon Shui Yee Leung. (2019) Updates on thermosensitive hydrogel for nasal, ocular and cutaneous delivery. International Journal of Pharmaceutics 559, pages 86-101.
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Huichao Xie, Lingjun Li, Yue Sun, Yuzhen Wang, Shuang Gao, Yuan Tian, Xuemei Ma, Chengcheng Guo, Fumin Bo & Li Zhang. (2019) An Available Strategy for Nasal Brain Transport of Nanocomposite Based on PAMAM Dendrimers via In Situ Gel. Nanomaterials 9:2, pages 147.
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Yu-Jung Lin, Fwu-Long Mi, Po-Yen Lin, Yang-Bao Miao, Tringyo Huang, Kuan-Hung Chen, Chiung-Tong Chen, Yen Chang & Hsing-Wen Sung. (2019) Strategies for improving diabetic therapy via alternative administration routes that involve stimuli-responsive insulin-delivering systems. Advanced Drug Delivery Reviews 139, pages 71-82.
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Javed Iqbal, Gautam Behl, Gavin Walker, Chris Edin, Parveen Kumar, Niall O’Reilly, Rohit Bhatia, Laurence Fitzhenry & Taruna Arora. 2019. Nanoparticles in Pharmacotherapy. Nanoparticles in Pharmacotherapy 147 193 .
Mengbi Yang, Qian Zhang, Qianwen Wang, Kasper K. Sørensen, Josephine T. Boesen, Sum Yi Ma, Knud J. Jensen, Kin Ming Kwan, Jacky Chi Ki Ngo, Ho Yin Edwin Chan & Zhong Zuo. (2018) Brain-Targeting Delivery of Two Peptidylic Inhibitors for Their Combination Therapy in Transgenic Polyglutamine Disease Mice via Intranasal Administration. Molecular Pharmaceutics 15:12, pages 5781-5792.
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Karishma Khan, Mohd Aqil, Syed Sarim Imam, Abdul Ahad, Thasleem Moolakkadath, Yasmin Sultana & Mohd Mujeeb. (2018) Ursolic acid loaded intra nasal nano lipid vesicles for brain tumour: Formulation, optimization, in-vivo brain/plasma distribution study and histopathological assessment. Biomedicine & Pharmacotherapy 106, pages 1578-1585.
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Amarjitsing Rajput, Aditi Bariya, Ahmed Allam, Sarah Othman & Shital B. Butani. (2018) In situ nanostructured hydrogel of resveratrol for brain targeting: in vitro-in vivo characterization. Drug Delivery and Translational Research 8:5, pages 1460-1470.
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Elena Giuliano, Donatella Paolino, Massimo Fresta & Donato Cosco. (2018) Mucosal Applications of Poloxamer 407-Based Hydrogels: An Overview. Pharmaceutics 10:3, pages 159.
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Mohammed Hassan Elkomy, Shahira F. El-Menshawe, Adel Ahmed Ali, Abdelkhalik Ali Halawa & Ahmed S. G. Srag El-Din. (2017) Betahistine dihydrochloride transdermal delivery via optimized thermosensitive gels: percutaneous absorption evaluation using rat growth as a biomarker. Drug Delivery and Translational Research 8:1, pages 165-177.
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Ji Eun Choi, Ki Ryung Kim, Yangseop Noh, Won-Ho Chung, Yang-Sun Cho, Seung-Kyu Chung, Hun-Jong Dhong & Hyo Yeol Kim. (2017) Intranasal distribution and clearance of thermoreversible gel in an animal model. International Forum of Allergy & Rhinology 7:7, pages 705-711.
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Irawan Pramudya, Catalina G. Rico, Choogon Lee & Hoyong Chung. (2016) POSS-Containing Bioinspired Adhesives with Enhanced Mechanical and Optical Properties for Biomedical Applications. Biomacromolecules 17:12, pages 3853-3861.
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Li Liu, Qi Gao, Xuemin Lu & Huifang Zhou. (2016) In situ forming hydrogels based on chitosan for drug delivery and tissue regeneration. Asian Journal of Pharmaceutical Sciences 11:6, pages 673-683.
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Santosh Shelke, Sadhana Shahi, Kiran Jadhav, Dinesh Dhamecha, Roshan Tiwari & Hemlata Patil. (2016) Thermoreversible nanoethosomal gel for the intranasal delivery of Eletriptan hydrobromide. Journal of Materials Science: Materials in Medicine 27:6.
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Tomotaka Shingaki, Yumiko Katayama, Takayoshi Nakaoka, Satsuki Irie, Kayo Onoe, Takashi Okauchi, Emi Hayashinaka, Masataka Yamaguchi, Nobuyoshi Tanki, Takayuki Ose, Takuya Hayashi, Yasuhiro Wada, Tomoyuki Furubayashi, Yilong Cui, Toshiyasu Sakane & Yasuyoshi Watanabe. (2016) Visualization of drug translocation in the nasal cavity and pharmacokinetic analysis on nasal drug absorption using positron emission tomography in the rat. European Journal of Pharmaceutics and Biopharmaceutics 99, pages 45-53.
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Xiaofeng Xu, Yan Shen, Wei Wang, Chunmeng Sun, Chang Li, Yerong Xiong & Jiasheng Tu. (2014) Preparation and in vitro characterization of thermosensitive and mucoadhesive hydrogels for nasal delivery of phenylephrine hydrochloride. European Journal of Pharmaceutics and Biopharmaceutics 88:3, pages 998-1004.
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Abeer Ahmed Kassem, Fatma Ahmed Ismail, Vivian Fahim Naggar & Elsayed Aboulmagd. (2014) Comparative Study to Investigate the Effect of Meloxicam or Minocycline HCl In Situ Gel System on Local Treatment of Periodontal Pockets. AAPS PharmSciTech 15:4, pages 1021-1028.
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