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Expert Opinion on Drug Delivery Volume 10, 2013 - Issue 3
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Current options for drug delivery to the spinal cord

Filippo RossiDipartimento di Neuroscienze, Istituto di Ricerche Farmacologiche Mario Negri, via La Masa 19, 20156 Milano, Italy+39 02 3901 4205; +39 02 354 6277; [email protected];Dipartimento di Chimica, Materiali e Ingegneria Chimica ‘Giulio Natta', Politecnico di Milano, via Mancinelli 7, 20131 Milano, Italy
, PhD,
Giuseppe PeraleDipartimento di Neuroscienze, Istituto di Ricerche Farmacologiche Mario Negri, via La Masa 19, 20156 Milano, Italy+39 02 3901 4205; +39 02 354 6277; [email protected];Dipartimento di Chimica, Materiali e Ingegneria Chimica ‘Giulio Natta', Politecnico di Milano, via Mancinelli 7, 20131 Milano, Italy
, PhD,
Simonetta PapaDipartimento di Neuroscienze, Istituto di Ricerche Farmacologiche Mario Negri, via La Masa 19, 20156 Milano, Italy+39 02 3901 4205; +39 02 354 6277; [email protected]
, MS,
Gianluigi ForloniDipartimento di Neuroscienze, Istituto di Ricerche Farmacologiche Mario Negri, via La Masa 19, 20156 Milano, Italy+39 02 3901 4205; +39 02 354 6277; [email protected]
, PhD &
Pietro VeglianeseDipartimento di Neuroscienze, Istituto di Ricerche Farmacologiche Mario Negri, via La Masa 19, 20156 Milano, Italy+39 02 3901 4205; +39 02 354 6277; [email protected]
, PhD
Pages 385-396 | Published online: 06 Jan 2013

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Simonetta Papa, Fabio Pizzetti, Giuseppe Perale, Pietro Veglianese & Filippo Rossi. (2020) Regenerative medicine for spinal cord injury: focus on stem cells and biomaterials. Expert Opinion on Biological Therapy 20:10, pages 1203-1213.
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Emanuele Mauri, Simonetta Papa, Maurizio Masi, Pietro Veglianese & Filippo Rossi. (2017) Novel functionalization strategies to improve drug delivery from polymers. Expert Opinion on Drug Delivery 14:11, pages 1305-1313.
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Simonetta Papa, Ilaria Caron, Filippo Rossi & Pietro Veglianese. (2016) Modulators of microglia: a patent review. Expert Opinion on Therapeutic Patents 26:4, pages 427-437.
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Articles from other publishers (53)

Ying-Chuan Kuan, Shinn-Zong Lin, Tsung-Lang Chiu & Hsiang-Yi Hung. (2023) Improved neurological function in a patient with complete spinal cord injury through bone marrow mesenchymal stem cells implantation: a case report. Regenerative Medicine.
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Eiki Kanemaru, Yusuke Miyazaki, Eizo Marutani, Mariko Ezaka, Shunsaku Goto, Etsuo Ohshima, Donald B. Bloch & Fumito Ichinose. (2023) Intranasal administration of polysulfide prevents neurodegeneration in spinal cord and rescues mice from delayed paraplegia after spinal cord ischemia. Redox Biology 60, pages 102620.
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Haichuan Peng, Yongkang Liu, Fengfeng Xiao, Limei Zhang, Wenting Li, Binghan Wang, Zhijian Weng, Yu Liu & Gang Chen. (2023) Research progress of hydrogels as delivery systems and scaffolds in the treatment of secondary spinal cord injury. Frontiers in Bioengineering and Biotechnology 11.
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Filippo Pinelli, Fabio Pizzetti, Valeria Veneruso, Emilia Petillo, Michael Raghunath, Giuseppe Perale, Pietro Veglianese & Filippo Rossi. (2022) Biomaterial-Mediated Factor Delivery for Spinal Cord Injury Treatment. Biomedicines 10:7, pages 1673.
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Johra Khan, Mithun Rudrapal, Eijaz Ahmed Bhat, Ahmad Ali, Mohammad Alaidarous, Bader Alshehri, Saeed Banwas, Randa Ismail & Chukwuebuka Egbuna. (2021) Perspective Insights to Bio-Nanomaterials for the Treatment of Neurological Disorders. Frontiers in Bioengineering and Biotechnology 9.
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Sajad Fakhri, Fatemeh Abbaszadeh & Masoumeh Jorjani. (2021) On the therapeutic targets and pharmacological treatments for pain relief following spinal cord injury: A mechanistic review. Biomedicine & Pharmacotherapy 139, pages 111563.
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Amina T. Mneimneh & Mohammed M. Mehanna. (2021) Collagen-based scaffolds: An auspicious tool to support repair, recovery, and regeneration post spinal cord injury. International Journal of Pharmaceutics 601, pages 120559.
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Simonetta Papa, Valeria Veneruso, Emanuele Mauri, Giada Cremonesi, Xhuljana Mingaj, Alessandro Mariani, Massimiliano De Paola, Arianna Rossetti, Alessandro Sacchetti, Filippo Rossi, Gianluigi Forloni & Pietro Veglianese. (2021) Functionalized nanogel for treating activated astrocytes in spinal cord injury. Journal of Controlled Release 330, pages 218-228.
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Irma Vismara, Simonetta Papa, Valeria Veneruso, Emanuele Mauri, Alessandro Mariani, Massimiliano De Paola, Roberta Affatato, Arianna Rossetti, Mattia Sponchioni, Davide Moscatelli, Alessandro Sacchetti, Filippo Rossi, Gianluigi Forloni & Pietro Veglianese. (2019) Selective Modulation of A1 Astrocytes by Drug-Loaded Nano-Structured Gel in Spinal Cord Injury. ACS Nano 14:1, pages 360-371.
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Nikunj K. Agrawal, Peter Allen, Young Hye Song, Rebecca A. Wachs, Yan Du, Andrew D. Ellington & Christine E. Schmidt. (2020) Oligonucleotide-functionalized hydrogels for sustained release of small molecule (aptamer) therapeutics. Acta Biomaterialia 102, pages 315-325.
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Šárka Kubinová. 2020. Spinal Cord Injury (SCI) Repair Strategies. Spinal Cord Injury (SCI) Repair Strategies 105 127 .
Simonetta Papa, Emanuele Mauri, Filippo Rossi, Giuseppe Perale & Pietro Veglianese. 2020. Spinal Cord Injury (SCI) Repair Strategies. Spinal Cord Injury (SCI) Repair Strategies 1 12 .
Nureddin AshammakhiHan-Jun KimArshia EhsanipourRebecca D. BiermanOuti KaarelaChengbin XueAli KhademhosseiniStephanie K. Seidlits. (2019) Regenerative Therapies for Spinal Cord Injury. Tissue Engineering Part B: Reviews 25:6, pages 471-491.
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Filippo Rossi & Maurizio Masi. (2019) On the ability of chromatographic mass balance to predict solute diffusivity in drug delivery systems. AIChE Journal 65:10.
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Sam Parittotokkaporn, Anusha Dravid, Mahima Bansal, Zaid Aqrawe, Darren Svirskis, Vinod Suresh & Simon J. O’Carroll. (2019) Make it simple: long-term stable gradient generation in a microfluidic microdevice. Biomedical Microdevices 21:3.
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Fabio Cofano, Marina Boido, Matteo Monticelli, Francesco Zenga, Alessandro Ducati, Alessandro Vercelli & Diego Garbossa. (2019) Mesenchymal Stem Cells for Spinal Cord Injury: Current Options, Limitations, and Future of Cell Therapy. International Journal of Molecular Sciences 20:11, pages 2698.
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V. Veneruso, F. Rossi, A. Villella, A. Bena, G. Forloni & P. Veglianese. (2019) Stem cell paracrine effect and delivery strategies for spinal cord injury regeneration. Journal of Controlled Release 300, pages 141-153.
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Simonetta Papa, Filippo Rossi, Irma Vismara, Gianluigi Forloni & Pietro Veglianese. (2019) Nanovector-Mediated Drug Delivery in Spinal Cord Injury: A Multitarget Approach. ACS Chemical Neuroscience 10:3, pages 1173-1182.
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Fernando L. Esteban Florez, Yashwant Pathak & Charles Preuss. 2019. Nanobiomaterials in Clinical Dentistry. Nanobiomaterials in Clinical Dentistry 595 616 .
Emanuele Mauri, Giuseppe Perale & Filippo Rossi. (2018) Nanogel Functionalization: A Versatile Approach To Meet the Challenges of Drug and Gene Delivery. ACS Applied Nano Materials 1:12, pages 6525-6541.
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Stecia-Marie P. Fletcher & Meaghan A. O'Reilly. (2018) Analysis of Multifrequency and Phase Keying Strategies for Focusing Ultrasound to the Human Vertebral Canal. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control 65:12, pages 2322-2331.
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Sean J. Nagel, Chandan G. Reddy, Leonardo A. Frizon, Marshall T. Holland, Andre G. Machado, George T. Gillies & Matthew A. Howard III. (2018) Intrathecal Therapeutics: Device Design, Access Methods, and Complication Mitigation. Neuromodulation: Technology at the Neural Interface 21:7, pages 625-640.
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Emanuele Mauri, Anna Negri, Erica Rebellato, Maurizio Masi, Giuseppe Perale & Filippo Rossi. (2018) Hydrogel-Nanoparticles Composite System for Controlled Drug Delivery. Gels 4:3, pages 74.
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Irma Vismara, Simonetta Papa, Filippo Rossi, Gianluigi Forloni & Pietro Veglianese. (2017) Current Options for Cell Therapy in Spinal Cord Injury. Trends in Molecular Medicine 23:9, pages 831-849.
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Angela Faccendini, Barbara Vigani, Silvia Rossi, Giuseppina Sandri, Maria Bonferoni, Carla Caramella & Franca Ferrari. (2017) Nanofiber Scaffolds as Drug Delivery Systems to Bridge Spinal Cord Injury. Pharmaceuticals 10:3, pages 63.
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Emanuele Mauri, Giulia M.F. Chincarini, Riccardo Rigamonti, Luca Magagnin, Alessandro Sacchetti & Filippo Rossi. (2017) Modulation of electrostatic interactions to improve controlled drug delivery from nanogels. Materials Science and Engineering: C 72, pages 308-315.
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Lei Xie, Zhenfei Wang, Changwei Li, Kai Yang & Yu Liang. (2017) Protective effect of nicotinamide adenine dinucleotide (NAD+) against spinal cord ischemia?reperfusion injury via reducing oxidative stress-induced neuronal apoptosis. Journal of Clinical Neuroscience 36, pages 114-119.
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Emanuele Mauri, Pietro Veglianese, Simonetta Papa, Alessandro Mariani, Massimiliano De Paola, Riccardo Rigamonti, Giulia M. F. Chincarini, Irma Vismara, Stefano Rimondo, Alessandro Sacchetti & Filippo Rossi. (2017) Double conjugated nanogels for selective intracellular drug delivery. RSC Advances 7:48, pages 30345-30356.
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Farideh Ordikhani, Saahil Sheth & Silviya Petrova Zustiak. (2017) Polymeric particle-mediated molecular therapies to treat spinal cord injury. International Journal of Pharmaceutics 516:1-2, pages 71-81.
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S. Papa & P. Veglianese. 2017. Bioresorbable Polymers for Biomedical Applications. Bioresorbable Polymers for Biomedical Applications 285 302 .
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Hjalte H. Andersen, Kasper B. Johnsen & Lars Arendt-Nielsen. (2016) On the prospect of clinical utilization of microRNAs as biomarkers or treatment of chronic pain. Experimental Neurology 284, pages 63-66.
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Raymond J. Colello, Woon N. Chow, John W. Bigbee, Charles Lin, Dustin Dalton, Damien Brown, Balendu Shekhar Jha, Bruce E. Mathern, Kangmin D. Lee & David G. Simpson. (2016) The incorporation of growth factor and chondroitinase ABC into an electrospun scaffold to promote axon regrowth following spinal cord injury. Journal of Tissue Engineering and Regenerative Medicine 10:8, pages 656-668.
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Filippo Rossi, Franca Castiglione, Monica Ferro, Marta Moioli, Andrea Mele & Maurizio Masi. (2016) The Role of Drug-Drug Interactions in Hydrogel Delivery Systems: Experimental and Model Study. ChemPhysChem 17:11, pages 1615-1622.
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Thomas Trimaille, Vincent Pertici & Didier Gigmes. (2016) Recent advances in synthetic polymer based hydrogels for spinal cord repair. Comptes Rendus Chimie 19:1-2, pages 157-166.
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Ilaria Caron, Filippo Rossi, Simonetta Papa, Rossella Aloe, Marika Sculco, Emanuele Mauri, Alessandro Sacchetti, Eugenio Erba, Nicolò Panini, Valentina Parazzi, Mario Barilani, Gianluigi Forloni, Giuseppe Perale, Lorenza Lazzari & Pietro Veglianese. (2016) A new three dimensional biomimetic hydrogel to deliver factors secreted by human mesenchymal stem cells in spinal cord injury. Biomaterials 75, pages 135-147.
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Simonetta Papa, Ilaria Caron, Eugenio Erba, Nicolò Panini, Massimiliano De Paola, Alessandro Mariani, Claudio Colombo, Raffaele Ferrari, Diego Pozzer, Elisa R. Zanier, Francesca Pischiutta, Jacopo Lucchetti, Andrea Bassi, Gianluca Valentini, Giulio Simonutti, Filippo Rossi, Davide Moscatelli, Gianluigi Forloni & Pietro Veglianese. (2016) Early modulation of pro-inflammatory microglia by minocycline loaded nanoparticles confers long lasting protection after spinal cord injury. Biomaterials 75, pages 13-24.
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Filippo Rossi, Giuseppe Perale & Maurizio MasiFilippo Rossi, Giuseppe Perale & Maurizio Masi. 2016. Controlled Drug Delivery Systems. Controlled Drug Delivery Systems 35 59 .
Shushi Kabu, Yue Gao, Brian K. Kwon & Vinod Labhasetwar. (2015) Drug delivery, cell-based therapies, and tissue engineering approaches for spinal cord injury. Journal of Controlled Release 219, pages 141-154.
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Filippo Rossi, Franca Castiglione, Monica Ferro, Paolo Marchini, Emanuele Mauri, Marta Moioli, Andrea Mele & Maurizio Masi. (2015) Drug-Polymer Interactions in Hydrogel-based Drug-Delivery Systems: An Experimental and Theoretical Study. ChemPhysChem 16:13, pages 2818-2825.
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Daniel T. Simon, Karin C. Larsson, David Nilsson, Gustav Burström, Dagmar Galter, Magnus Berggren & Agneta Richter-Dahlfors. (2015) An organic electronic biomimetic neuron enables auto-regulated neuromodulation. Biosensors and Bioelectronics 71, pages 359-364.
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Tobias F?hrmann, Mousumi Ghosh, Anthony Otero, Ben Goss, Tim R. Dargaville, Damien D. Pearse & Paul D. Dalton. (2015) Peptide-functionalized polymeric nanoparticles for active targeting of damaged tissue in animals with experimental autoimmune encephalomyelitis. Neuroscience Letters 602, pages 126-132.
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Claudio Colombo, Laura Galletti, Maddalena Lepri, Ilaria Caron, Luca Magagnin, Pietro Veglianese, Filippo Rossi & Davide Moscatelli. (2015) Multidrug encapsulation within self-assembled 3D structures formed by biodegradable nanoparticles. European Polymer Journal 68, pages 216-225.
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Florentia Papastefanaki & Rebecca Matsas. (2015) From demyelination to remyelination : The road toward therapies for spinal cord injury . Glia 63:7, pages 1101-1125.
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Paul Z. Elias, Gary W. Liu, Hua Wei, Michael C. Jensen, Philip J. Horner & Suzie H. Pun. (2015) A functionalized, injectable hydrogel for localized drug delivery with tunable thermosensitivity: Synthesis and characterization of physical and toxicological properties. Journal of Controlled Release 208, pages 76-84.
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Filippo Rossi, Raffaele Ferrari, Franca Castiglione, Andrea Mele, Giuseppe Perale & Davide Moscatelli. (2015) Polymer hydrogel functionalized with biodegradable nanoparticles as composite system for controlled drug delivery. Nanotechnology 26:1, pages 015602.
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Alessandro Sacchetti, Emanuele Mauri, Monica Sani, Maurizio Masi & Filippo Rossi. (2014) Microwave-assisted synthesis and click chemistry as simple and efficient strategy for RGD functionalized hydrogels. Tetrahedron Letters 55:50, pages 6817-6820.
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Ilaria Caron, Simonetta Papa, Filippo Rossi, Gianluigi Forloni & Pietro Veglianese. (2014) Nanovector‐mediated drug delivery for spinal cord injury treatment. WIREs Nanomedicine and Nanobiotechnology 6:5, pages 506-515.
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Filippo RossiMartijn van Griensven. (2014) Polymer Functionalization as a Powerful Tool to Improve Scaffold Performances. Tissue Engineering Part A 20:15-16, pages 2043-2051.
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Roger Y Tam, Tobias Fuehrmann, Nikolaos Mitrousis & Molly S Shoichet. (2013) Regenerative Therapies for Central Nervous System Diseases: a Biomaterials Approach. Neuropsychopharmacology 39:1, pages 169-188.
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