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Dhiraj Bhavsar, Krishnakumar Subramanian, Swaminathan Sethuraman & Uma Maheswari Krishnan. (2016) EpCAM-targeted liposomal si-RNA delivery for treatment of epithelial cancer. Drug Delivery 23:4, pages 1101-1114.
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Sulaiman Mohammed Alnasser. (2023) Advances and Challenges in Cancer Stem Cells for Onco-Therapeutics. Stem Cells International 2023, pages 1-17.
Crossref
Crossref
Valentina Palacio-Castañeda, Bas van de Crommert, Elke Verploegen, Mike Overeem, Jenny van Oostrum & Wouter P.R. Verdurmen. (2023) Potent and selective eradication of tumor cells by an EpCAM-targeted Ras-degrading enzyme. Molecular Therapy - Oncolytics 30, pages 16-26.
Crossref
Crossref
Yi Zhang, Yiao Wang, Safak Uslu, Sneha Venkatachalapathy, Mohammad Rashidian, Jonas V. Schaefer, Andreas Plückthun & Mark D. Distefano. (2022) Enzymatic Construction of DARPin-Based Targeted Delivery Systems Using Protein Farnesyltransferase and a Capture and Release Strategy. International Journal of Molecular Sciences 23:19, pages 11537.
Crossref
Crossref
Maliheh Hasannia, Khalil Abnous, Seyed Mohammad Taghdisi, Sirous Nekooei, Mohammad Ramezani & Mona Alibolandi. (2022) Synthesis of doxorubicin-loaded peptosomes hybridized with gold nanorod for targeted drug delivery and CT imaging of metastatic breast cancer. Journal of Nanobiotechnology 20:1.
Crossref
Crossref
Tianqi Xu, Yongsheng Liu, Alexey Schulga, Elena Konovalova, Sergey Deyev, Vladimir Tolmachev & Anzhelika Vorobyeva. (2022) Epithelial cell adhesion molecule‑targeting designed ankyrin repeat protein‑toxin fusion Ec1‑LoPE exhibits potent cytotoxic action in prostate cancer cells. Oncology Reports 47:5.
Crossref
Crossref
Kevin Zhou, Xiaoqi Huo, Romario Nguyen, Sarah Da Won Bae, Shuanglin Han, Zhiqiang Zhang, Wei Duan, Lawrence Yuen, Vincent Lam, Jacob George & Liang Qiao. (2022) Aptamer-mediated doxorubicin delivery reduces HCC burden in 3D organoids model. Journal of Controlled Release 341, pages 341-350.
Crossref
Crossref
Rajeswari Raguraman, Santny Shanmugarama, Meghna Mehta, Jo Elle Peterson, Yan D. Zhao, Anupama Munshi & Rajagopal Ramesh. (2022) Drug delivery approaches for HuR-targeted therapy for lung cancer. Advanced Drug Delivery Reviews 180, pages 114068.
Crossref
Crossref
Meng Sun, Helin Zhang, Min Jiang, Yan Chai, Jianxun Qi, George F. Gao & Shuguang Tan. (2021) Structural insights into the cis and trans assembly of human trophoblast cell surface antigen 2. iScience 24:10, pages 103190.
Crossref
Crossref
Seong-Wook Park, Sei-Yong Jun, Ji-Sun Kim & Yong-Sung Kim. (2021) Engineering of an EpCAM-targeting cyclic peptide to improve the EpCAM-mediated cellular internalization and tumor accumulation of a peptide-fused antibody. Biochemical and Biophysical Research Communications 573, pages 35-41.
Crossref
Crossref
Tomaž Žagar, Miha Pavšič & Aljaž Gaber. (2021) Destabilization of EpCAM dimer is associated with increased susceptibility towards cleavage by TACE. PeerJ 9, pages e11484.
Crossref
Crossref
Mohammad Mashreghi, Parvin Zamani, Seyedeh Alia Moosavian & Mahmoud Reza Jaafari. (2020) Anti-Epcam Aptamer (Syl3c)-Functionalized Liposome for Targeted Delivery Of Doxorubicin: In Vitro And In Vivo Antitumor Studies in Mice Bearing C26 Colon Carcinoma. Nanoscale Research Letters 15:1.
Crossref
Crossref
Reyhaneh Najafi Soulari, Majid Basafa, Masoumeh Rajabibazl & Atieh Hashemi. (2020) Effective Strategies to Overcome the Insolubility of Recombinant ScFv Antibody against EpCAM Extracellular Domain in E. coli. International Journal of Peptide Research and Therapeutics 26:4, pages 2465-2474.
Crossref
Crossref
Dirk van den Brand, Sanne A. M. van Lith, Jelske M. de Jong, Mark A. J. Gorris, Valentina Palacio-Castañeda, Stijn T. Couwenbergh, Mark R. G. Goldman, Inge Ebisch, Leon F. Massuger, William P. J. Leenders, Roland Brock & Wouter P. R. Verdurmen. (2020) EpCAM-Binding DARPins for Targeted Photodynamic Therapy of Ovarian Cancer. Cancers 12:7, pages 1762.
Crossref
Crossref
Aljaž Gaber, Brigita Lenarčič & Miha Pavšič. (2020) Current View on EpCAM Structural Biology. Cells 9:6, pages 1361.
Crossref
Crossref
David R. BellJeffrey K. WeberWang YinTien HuynhWei DuanRuhong Zhou. (2020) In silico design and validation of high-affinity RNA aptamers targeting epithelial cellular adhesion molecule dimers. Proceedings of the National Academy of Sciences 117:15, pages 8486-8493.
Crossref
Crossref
M. Mohtar, Saiful Syafruddin, Siti Nasir & Teck Yew Low. (2020) Revisiting the Roles of Pro-Metastatic EpCAM in Cancer. Biomolecules 10:2, pages 255.
Crossref
Crossref
Lina Zhu, Beibei Yang, Kun Qian, Liang Qiao, Yun Liu & Baohong Liu. (2020) Sensitive electrochemical aptasensor for detecting EpCAM with silica nanoparticles and quantum dots for signal amplification. Journal of Electroanalytical Chemistry 856, pages 113655.
Crossref
Crossref
M. Chernyavska, M. Schmid, P. C. Freitag, V. Palacio-Castañeda, A. Piruska, W. T. S. Huck, A. Plückthun & W. P. R. Verdurmen. (2019) Unravelling Receptor and RGD Motif Dependence of Retargeted Adenoviral Vectors using Advanced Tumor Model Systems. Scientific Reports 9:1.
Crossref
Crossref
Eva C. González Díaz, Sauradeep Sinha, Raffi S. Avedian & Fan Yang. (2019) Tissue-engineered 3D models for elucidating primary and metastatic bone cancer progression. Acta Biomaterialia 99, pages 18-32.
Crossref
Crossref
Miana Gabriela Pop. 2019. Basic Principles and Practice in Surgery. Basic Principles and Practice in Surgery.
Fabian Brandl, Hannes Merten, Martina Zimmermann, Martin Béhé, Uwe Zangemeister-Wittke & Andreas Plückthun. (2019) Influence of size and charge of unstructured polypeptides on pharmacokinetics and biodistribution of targeted fusion proteins. Journal of Controlled Release 307, pages 379-392.
Crossref
Crossref
Yong Luo, Tebo Hua, Xia You, Jinfeng Lou, Xuxiong Yang & Ningwen Tang. (2019) Effects of miR-107 on the Chemo-drug sensitivity of breast cancer cells. Open Medicine 14:1, pages 59-65.
Crossref
Crossref
Jakob C. Stüber, Florian Kast & Andreas Plückthun. (2019) High-Throughput Quantification of Surface Protein Internalization and Degradation. ACS Chemical Biology 14:6, pages 1154-1163.
Crossref
Crossref
Mi-Hyeon Jeong, Soo-Yeon Park, Seung-Hyun Lee, JaeSung Seo, Jung-Yoon Yoo, Seung-Ho Park, Mi Jeong Kim, SooYeon Lee, Subhin Jang, Hyo-Kyoung Choi, Jae Eun Lee, Su-Jin Shin, Kyung-Chul Choi, Jae-Ho Cheong & Ho-Geun Yoon. (2019) EPB41L5 Mediates TGFβ-Induced Metastasis of Gastric Cancer. Clinical Cancer Research 25:12, pages 3617-3629.
Crossref
Crossref
Debasmita Dutta, Apala Chakraborty, Biswajit Mukherjee & Sreya Gupta. (2018) Aptamer-Conjugated Apigenin Nanoparticles To Target Colorectal Carcinoma: A Promising Safe Alternative of Colorectal Cancer Chemotherapy. ACS Applied Bio Materials 1:5, pages 1538-1556.
Crossref
Crossref
Aljaž Gaber, Seung Joong Kim, Robyn M. Kaake, Mojca Benčina, Nevan Krogan, Andrej Šali, Miha Pavšič & Brigita Lenarčič. (2018) EpCAM homo-oligomerization is not the basis for its role in cell-cell adhesion. Scientific Reports 8:1.
Crossref
Crossref
Ji-sun Kim, Jae-Yeong Park, Seung-Min Shin, Seong-Wook Park, Sei-Yong Jun, Jin-Sun Hong, Dong-Ki Choi & Yong-Sung Kim. (2018) Engineering of a tumor cell–specific, cytosol-penetrating antibody with high endosomal escape efficacy. Biochemical and Biophysical Research Communications 503:4, pages 2510-2516.
Crossref
Crossref
Seyed-Ali Hosseinian, Aliakbar Haddad-Mashadrizeh & Samaneh Dolatabadi. (2018) Simulation and Stability Assessment of Anti-EpCAM Immunotoxin for Cancer Therapy. Advanced Pharmaceutical Bulletin 8:3, pages 447-455.
Crossref
Crossref
Leonardo do Prado Lima, Carla Jorge Machado, João Bernardo Sancio Rocha Rodrigues, Leonardo de Souza Vasconcellos, Eduardo Paulino Junior, Paula Vieira Teixeira Vidigal & Vivian Resende. (2018) Immunohistochemical Coexpression of Epithelial Cell Adhesion Molecule and Alpha-Fetoprotein in Hepatocellular Carcinoma. Canadian Journal of Gastroenterology and Hepatology 2018, pages 1-8.
Crossref
Crossref
Anna Cifuentes-Rius, Lisa M Butler & Nicolas H Voelcker. (2018) Precision nanomedicines for prostate cancer. Nanomedicine 13:8, pages 803-807.
Crossref
Crossref
Lin Xiao, Can Chen, Zhendong Li, Sumin Zhu, Johan Ck Tay, Xi Zhang, Shijun Zha, Jieming Zeng, Wee Kiat Tan, Xin Liu, Wee Joo Chng & Shu Wang. (2018) Large-scale expansion of Vγ9Vδ2 T cells with engineered K562 feeder cells in G-Rex vessels and their use as chimeric antigen receptor–modified effector cells. Cytotherapy 20:3, pages 420-435.
Crossref
Crossref
Valentina Kalichuk, Axelle Renodon-Cornière, Ghislaine Béhar, Federico Carrión, Gonzalo Obal, Mike Maillasson, Barbara Mouratou, Véronique Préat & Frédéric Pecorari. (2018) A novel, smaller scaffold for Affitins: Showcase with binders specific for EpCAM. Biotechnology and Bioengineering 115:2, pages 290-299.
Crossref
Crossref
Joanna Macdonald, Justin Henri, Kislay Roy, Emma Hays, Michelle Bauer, Rakesh Veedu, Normand Pouliot & Sarah Shigdar. (2018) EpCAM Immunotherapy versus Specific Targeted Delivery of Drugs. Cancers 10:1, pages 19.
Crossref
Crossref
Yunchao Xiao, Mingwu Shen & Xiangyang Shi. (2018) Design of functional electrospun nanofibers for cancer cell capture applications. Journal of Materials Chemistry B 6:10, pages 1420-1432.
Crossref
Crossref
Wouter P. R. Verdurmen, Marigona Mazlami & Andreas Plückthun. (2017) A quantitative comparison of cytosolic delivery via different protein uptake systems. Scientific Reports 7:1.
Crossref
Crossref
SAMIRA SADEGHI, ZOHREH HOJATI & HOSSEIN TABATABAEIAN. (2017) Cooverexpression of EpCAM and c-myc genes in malignant breast tumours. Journal of Genetics 96:1, pages 109-118.
Crossref
Crossref
Wei Xia Ang, Zhendong Li, Zhixia Chi, Shou-Hui Du, Can Chen, Johan C.K. Tay, Han Chong Toh, John E. Connolly, Xue Hu Xu & Shu Wang. (2017) Intraperitoneal immunotherapy with T cells stably and transiently expressing anti-EpCAM CAR in xenograft models of peritoneal carcinomatosis. Oncotarget 8:8, pages 13545-13559.
Crossref
Crossref
Zhi-Mei Liang, Yang Chen & Man-Li Luo. 2017. Translational Research in Breast Cancer. Translational Research in Breast Cancer
147
169
.
Anthony W. H. Chan & Ka-Fai To. 2017. Biomarkers in Liver Disease. Biomarkers in Liver Disease
349
372
.
Peyman Ranji, Tayyebali Salmani Kesejini, Sara Saeedikhoo & Ali Mohammad Alizadeh. (2016) Targeting cancer stem cell-specific markers and/or associated signaling pathways for overcoming cancer drug resistance. Tumor Biology 37:10, pages 13059-13075.
Crossref
Crossref
Kiki C. Andree, Ana M.C. Barradas, Ai T. Nguyen, Anouk Mentink, Ivan Stojanovic, Jacob Baggerman, Joost van Dalum, Cees J.M. van Rijn & Leon W.M.M. Terstappen. (2016) Capture of Tumor Cells on Anti-EpCAM-Functionalized Poly(acrylic acid)-Coated Surfaces. ACS Applied Materials & Interfaces 8:23, pages 14349-14356.
Crossref
Crossref
Ruben R. Bender, Anke Muth, Irene C. Schneider, Thorsten Friedel, Jessica Hartmann, Andreas Plückthun, Andrea Maisner & Christian J. Buchholz. (2016) Receptor-Targeted Nipah Virus Glycoproteins Improve Cell-Type Selective Gene Delivery and Reveal a Preference for Membrane-Proximal Cell Attachment. PLOS Pathogens 12:6, pages e1005641.
Crossref
Crossref
Jung Ho Kim, Jeong Mo Bae, Young Seok Song, Nam-Yun Cho, Hye Seung Lee & Gyeong Hoon Kang. (2015) Clinicopathologic, molecular, and prognostic implications of the loss of EPCAM expression in colorectal carcinoma. Oncotarget 7:12, pages 13372-13387.
Crossref
Crossref
Martin C. BoonstraSusanna W.L. De GeusHendrica A.J.M. PrevooLukas J.A.C. HawinkelsCornells J.H. Van De VeldePeter J.K. KuppenAlexander L. VahrmeijerCornelis F.M. Sier. (2016) Selecting Targets for Tumor Imaging: An Overview of Cancer-Associated Membrane Proteins. Biomarkers in Cancer 8, pages BIC.S38542.
Crossref
Crossref
Nithya Subramanian, Jagat R Kanwar, Prasanna kumar Athalya, Narayanan Janakiraman, Vikas Khetan, Rupinder K Kanwar, Sailaja Eluchuri & Subramanian Krishnakumar. (2015) EpCAM aptamer mediated cancer cell specific delivery of EpCAM siRNA using polymeric nanocomplex. Journal of Biomedical Science 22:1.
Crossref
Crossref
Martin Heubner, Pauline Wimberger, Sabine Kasimir-Bauer, Bernhard B. Singer, Peter Ruf, Rainer Kimmig & Winfried Siffert. (2015) Single nucleotide polymorphisms of the EpCAM-coding gene TACSTD1 in patients with ovarian cancer and their potential translational aspects. Archives of Gynecology and Obstetrics 292:6, pages 1367-1372.
Crossref
Crossref
Thanos Tsaktanis, Heidi Kremling, Miha Pavšič, Ricarda von Stackelberg, Brigitte Mack, Akio Fukumori, Harald Steiner, Franziska Vielmuth, Volker Spindler, Zhe Huang, Jasmine Jakubowski, Nikolas H. Stoecklein, Elke Luxenburger, Kirsten Lauber, Brigita Lenarčič & Olivier Gires. (2015) Cleavage and Cell Adhesion Properties of Human Epithelial Cell Adhesion Molecule (HEPCAM). Journal of Biological Chemistry 290:40, pages 24574-24591.
Crossref
Crossref
Mei-Ying Liao, Jun-Kai Lai, Mark Yen-Ping Kuo, Ruei-Min Lu, Cheng-Wei Lin, Ping-Chang Cheng, Kang-Hao Liang & Han-Chung Wu. (2015) An anti-EpCAM antibody EpAb2-6 for the treatment of colon cancer. Oncotarget 6:28, pages 24947-24968.
Crossref
Crossref
Nithya Subramanian, Jagat R. Kanwar, Rupinder K. Kanwar, JagadeeshBabu Sreemanthula, Jyotirmay Biswas, Vikas Khetan & Subramanian Krishnakumar. (2015) EpCAM Aptamer-siRNA Chimera Targets and Regress Epithelial Cancer. PLOS ONE 10:7, pages e0132407.
Crossref
Crossref
MEI-YING LIAO, MARK YEN-PING KUO, TUNG-YING LU, YI-PING WANG & HAN-CHUNG WU. (2015) Generation of an anti-EpCAM antibody and epigenetic regulation of EpCAM in colorectal cancer. International Journal of Oncology 46:4, pages 1788-1800.
Crossref
Crossref
Cornelia Lorenzer, Mehrdad Dirin, Anna-Maria Winkler, Volker Baumann & Johannes Winkler. (2015) Going beyond the liver: Progress and challenges of targeted delivery of siRNA therapeutics. Journal of Controlled Release 203, pages 1-15.
Crossref
Crossref
Jiujiao Gao, Qiu Yan, Jiao Wang, Shuai Liu & Xuesong Yang. (2015) Epithelial-to-Mesenchymal Transition Induced by TGF-?1 Is Mediated by AP1-Dependent EpCAM Expression in MCF-7 Cells. Journal of Cellular Physiology 230:4, pages 775-782.
Crossref
Crossref
Jasmeet Assi, Gunjan Srivastava, Ajay Matta, Christina MacMillan, Ranju Ralhan & Paul G. Walfish. (2015) Nuclear Ep-ICD Expression Is a Predictor of Poor Prognosis in ?Low Risk? Prostate Adenocarcinomas. PLOS ONE 10:2, pages e0107586.
Crossref
Crossref
Laurent DolléNeil D. TheiseEva SchmelzerLuke Boulter, Olivier Gires & Leo A. van Grunsven. (2015) EpCAM and the biology of hepatic stem/progenitor cells. American Journal of Physiology-Gastrointestinal and Liver Physiology 308:4, pages G233-G250.
Crossref
Crossref
Manasi Das, Wei Duan & Sanjeeb K. Sahoo. (2015) Multifunctional nanoparticle?EpCAM aptamer bioconjugates: A paradigm for targeted drug delivery and imaging in cancer therapy. Nanomedicine: Nanotechnology, Biology and Medicine 11:2, pages 379-389.
Crossref
Crossref
Anthony W. H. Chan & Ka-Fai To. 2016. Biomarkers in Liver Disease. Biomarkers in Liver Disease
1
24
.
Nikolas Stefan, Martina Zimmermann, Manuel Simon, Uwe Zangemeister-Wittke & Andreas Plückthun. (2014) Novel Prodrug-Like Fusion Toxin with Protease-Sensitive Bioorthogonal PEGylation for Tumor Targeting. Bioconjugate Chemistry 25:12, pages 2144-2156.
Crossref
Crossref
Olivier Gires & Nikolas H. Stoecklein. (2014) Dynamic EpCAM expression on circulating and disseminating tumor cells: causes and consequences. Cellular and Molecular Life Sciences 71:22, pages 4393-4402.
Crossref
Crossref
Gerhard Moldenhauer. 2014. Handbook of Therapeutic Antibodies. Handbook of Therapeutic Antibodies
15
42
.
Miha Pavšič, Gregor Gunčar, Kristina Djinović-Carugo & Brigita Lenarčič. (2014) Crystal structure and its bearing towards an understanding of key biological functions of EpCAM. Nature Communications 5:1.
Crossref
Crossref
Sawitree Nangola, Weeraya Thongkum, Somphot Saoin, Aftab A. Ansari & Chatchai Tayapiwatana. (2014) An application of capsid-specific artificial ankyrin repeat proteinproduced in E. coli for immunochromatographic assay as a surrogate for antibody. Applied Microbiology and Biotechnology 98:13, pages 6095-6103.
Crossref
Crossref
Anthony W H Chan, Joanna H M Tong, Stephen L Chan, Paul B S Lai & Ka-Fai To. (2014) Expression of stemness markers (CD133 and EpCAM) in prognostication of hepatocellular carcinoma. Histopathology 64:7, pages 935-950.
Crossref
Crossref
Yuming Guo, Xiaoman Shi, Qilong Fang, Jie Zhang, Hui Fang, Weili Jia, Gai Yang & Lin Yang. (2014) Facile preparation of hydroxyapatite?chondroitin sulfate hybrid mesoporous microrods for controlled and sustained release of antitumor drugs. Materials Letters 125, pages 111-115.
Crossref
Crossref
Travis McMurphy, Run Xiao, Daniel Magee, Andrew Slater, Lennart Zabeau, Jan Tavernier & Lei Cao. (2014) The Anti-Tumor Activity of a Neutralizing Nanobody Targeting Leptin Receptor in a Mouse Model of Melanoma. PLoS ONE 9:2, pages e89895.
Crossref
Crossref
Manuel Simon, Nikolas Stefan, Lubor Borsig, Andreas Plückthun & Uwe Zangemeister-Wittke. (2014) Increasing the Antitumor Effect of an EpCAM-Targeting Fusion Toxin by Facile Click PEGylation. Molecular Cancer Therapeutics 13:2, pages 375-385.
Crossref
Crossref
Klervi Even-Desrumeaux, Damien Nevoltris, Marie Noelle Lavaut, Karima Alim, Jean-Paul Borg, Stéphane Audebert, Brigitte Kerfelec, Daniel Baty & Patrick Chames. (2014) Masked Selection: A Straightforward and Flexible Approach for the Selection of Binders Against Specific Epitopes and Differentially Expressed Proteins by Phage Display. Molecular & Cellular Proteomics 13:2, pages 653-665.
Crossref
Crossref
Suneetha Nunna, Richard Reinhardt, Sergey Ragozin & Albert Jeltsch. (2014) Targeted Methylation of the Epithelial Cell Adhesion Molecule (EpCAM) Promoter to Silence Its Expression in Ovarian Cancer Cells. PLoS ONE 9:1, pages e87703.
Crossref
Crossref
Willam Sterlacci, Spasenija Savic, Michael Fiegl, Ellen Obermann & Alexandar Tzankov. (2014) Putative Stem Cell Markers in Non–Small-Cell Lung Cancer: A Clinicopathologic Characterization. Journal of Thoracic Oncology 9:1, pages 41-49.
Crossref
Crossref
Nithya SubramanianJagadeesh Babu Sreemanthula, Baghavathi Balaji, Jagat R. Kanwar, Jyotirmay Biswas & Subramanian Krishnakumar. (2014) A strain-promoted alkyne–azide cycloaddition (SPAAC) reaction of a novel EpCAM aptamer–fluorescent conjugate for imaging of cancer cells. Chem. Commun. 50:80, pages 11810-11813.
Crossref
Crossref
Manuel Simon, Raphael Frey, Uwe Zangemeister-Wittke & Andreas Plückthun. (2013) Orthogonal Assembly of a Designed Ankyrin Repeat Protein–Cytotoxin Conjugate with a Clickable Serum Albumin Module for Half-Life Extension. Bioconjugate Chemistry 24:11, pages 1955-1966.
Crossref
Crossref