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Laser microporation of the skin: prospects for painless application of protective and therapeutic vaccines

, PhD, , PhD & , PhD
Pages 761-773 | Published online: 21 Feb 2013

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Md Kamal Hossain, Taksim Ahmed, Prabhat Bhusal, Robhash Kusam Subedi, Iman Salahshoori, M Soltani & Majid Hassanzadeganroudsari. (2020) Microneedle Systems for Vaccine Delivery: the story so far. Expert Review of Vaccines 19:12, pages 1153-1166.
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Sandra Scheiblhofer, Yoan Machado, Andrea Feinle, Josef Thalhamer, Nicola Hüsing & Richard Weiss. (2016) Potential of nanoparticles for allergen-specific immunotherapy – use of silica nanoparticles as vaccination platform. Expert Opinion on Drug Delivery 13:12, pages 1777-1788.
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Satoshi Kashiwagi, Timothy Brauns, Jeffrey Gelfand & Mark C Poznansky. (2014) Laser vaccine adjuvants. Human Vaccines & Immunotherapeutics 10:7, pages 1892-1907.
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Xinyuan Chen, Ji Wang, Dilip Shah & Mei X Wu. (2013) An update on the use of laser technology in skin vaccination. Expert Review of Vaccines 12:11, pages 1313-1323.
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Articles from other publishers (35)

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Mojiz Abbas Trimzi & Young-Bog Ham. (2021) A Needle-Free Jet Injection System for Controlled Release and Repeated Biopharmaceutical Delivery. Pharmaceutics 13:11, pages 1770.
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Devyani Joshi, Rikhav P. Gala, Mohammad N. Uddin & Martin J. D'Souza. (2021) Novel ablative laser mediated transdermal immunization for microparticulate measles vaccine. International Journal of Pharmaceutics 606, pages 120882.
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Pierre Marschall, Ruicheng Wei, Justine Segaud, Wenjin Yao, Pierre Hener, Beatriz Falcon German, Pierre Meyer, Cecile Hugel, Grace Ada Da Silva, Reinhard Braun, Daniel H. Kaplan & Mei Li. (2021) Dual function of Langerhans cells in skin TSLP-promoted TFH differentiation in mouse atopic dermatitis. Journal of Allergy and Clinical Immunology 147:5, pages 1778-1794.
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Prateek Kakar, Zhuofan Li, Yibo Li, Yan Cao & Xinyuan Chen. (2020) Laser facilitates week-long sustained transdermal drug delivery at high doses. Journal of Controlled Release 319, pages 428-437.
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Jonas Pielenhofer, Julian Sohl, Maike Windbergs, Peter Langguth & Markus P. Radsak. (2020) Current Progress in Particle-Based Systems for Transdermal Vaccine Delivery. Frontiers in Immunology 11.
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Mayank Singhal, César E. S. Jimenez, Maria Lapteva & Yogeshvar N. Kalia. 2019. Innovative Dosage Forms. Innovative Dosage Forms 245 279 .
Sergey Nikonov, Danila Chernopyatov, Oleg Shumkov, Mikhail Soluyanov & Mikhail Smagin. (2019) Theoretical Substantiation for the Original Technique of Photodynamic Fractional Laser Photothermolysis (PFLP) for Dermatology, based on Intradermal Transport of Photosensibilisers. Theoretical Substantiation for the Original Technique of Photodynamic Fractional Laser Photothermolysis (PFLP) for Dermatology, based on Intradermal Transport of Photosensibilisers.
Xiaoyi Sun, Linghui Zeng & Yongzhuo Huang. (2019) Transcutaneous delivery of DNA/mRNA for cancer therapeutic vaccination. The Journal of Gene Medicine 21:7.
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Heather A.E. Benson, Jeffrey E. Grice, Yousuf Mohammed, Sarika Namjoshi & Michael S. Roberts. (2019) Topical and Transdermal Drug Delivery: From Simple Potions to Smart Technologies. Current Drug Delivery 16:5, pages 444-460.
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Pierre-Louis Hervé, Véronique Dhelft, Camille Plaquet, Anaïs Rousseaux, Adeline Bouzereau, Laetitia Gaulme, Sylvain Tilleul, Mélanie Ligouis, Nathalie Donne, Paul-Henri Lambert, Pham Hong-Thai, Wassana Wijagkanalan, Hugh A. Sampson & Lucie Mondoulet. (2019) Epidermal micro-perforation potentiates the efficacy of epicutaneous vaccination. Journal of Controlled Release 298, pages 12-26.
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Laura Engelke, Gerhard Winter & Julia Engert. (2018) Application of water-soluble polyvinyl alcohol-based film patches on laser microporated skin facilitates intradermal macromolecule and nanoparticle delivery. European Journal of Pharmaceutics and Biopharmaceutics 128, pages 119-130.
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Thomas Hunziker. 2018. Vitiligo. Vitiligo 357 361 .
Moniba Rahim, Syed M.D. Rizvi, Sana Iram, Salman Khan, Paramdeep S. Bagga & Mohd S. Khan. 2018. Inorganic Frameworks as Smart Nanomedicines. Inorganic Frameworks as Smart Nanomedicines 185 237 .
Yoan Machado, Sanne Duinkerken, Veronika Hoepflinger, Melissa Mayr, Evgeniia Korotchenko, Almedina Kurtaj, Isabel Pablos, Markus Steiner, Angelika Stoecklinger, Joyce Lübbers, Maximillian Schmid, Uwe Ritter, Sandra Scheiblhofer, Michael Ablinger, Verena Wally, Sarah Hochmann, Anna M. Raninger, Dirk Strunk, Yvette van Kooyk, Josef Thalhamer & Richard Weiss. (2017) Synergistic effects of dendritic cell targeting and laser-microporation on enhancing epicutaneous skin vaccination efficacy. Journal of Controlled Release 266, pages 87-99.
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Esther Moreno, Juana Schwartz, Alba Calvo, Laura Blanco, Esther Larrea, Juan M. Irache, Carmen Sanmartín, Sion A. Coulman, Manuel Soto, James C. Birchall & Socorro Espuelas. (2017) Skin vaccination using microneedles coated with a plasmid DNA cocktail encoding nucleosomal histones of Leishmania spp.. International Journal of Pharmaceutics 533:1, pages 236-244.
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Sandra Scheiblhofer, Anna Strobl, Veronika Hoepflinger, Theresa Thalhamer, Martin Steiner, Josef Thalhamer & Richard Weiss. (2017) Skin vaccination via fractional infrared laser ablation - Optimization of laser-parameters and adjuvantation. Vaccine 35:14, pages 1802-1809.
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Yan Cao, Prateek Kakar, Md. Nazir Hossen, Mei X. Wu & Xinyuan Chen. (2017) Sustained epidermal powder drug delivery via skin microchannels. Journal of Controlled Release 249, pages 94-102.
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Bhupinder Singh, Rajneet K. Khurana, Atul Jain, Ripandeep Kaur & Rajendra Kumar. 2017. Nanotechnology-Based Approaches for Targeting and Delivery of Drugs and Genes. Nanotechnology-Based Approaches for Targeting and Delivery of Drugs and Genes 485 514 .
DJ Jordan, P Mafi, R Mafi, M Malahias & A El Gawad. (2016) The Use of LASER and its Further Development in Varying Aspects of Surgery. Open Medicine Journal 3:1, pages 288-299.
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Gabriela Senti & Thomas M. Kündig. (2016) Novel Delivery Routes for Allergy Immunotherapy. Immunology and Allergy Clinics of North America 36:1, pages 25-37.
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Hazel Garvie-Cook, James M. Stone, Fei Yu, Richard H. Guy & Sergey N. Gordeev. (2016) Femtosecond pulsed laser ablation to enhance drug delivery across the skin. Journal of Biophotonics 9:1-2, pages 144-154.
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Dorothea Terhorst, Even Fossum, Anna Baranska, Samira Tamoutounour, Camille Malosse, Mattia Garbani, Reinhard Braun, Elmira Lechat, Reto Crameri, Bjarne Bogen, Sandrine Henri & Bernard Malissen. (2015) Laser-Assisted Intradermal Delivery of Adjuvant-Free Vaccines Targeting XCR1+ Dendritic Cells Induces Potent Antitumoral Responses. The Journal of Immunology 194:12, pages 5895-5902.
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G. Senti, S. Moos, F. Tay, N. Graf, P. Johansen & T. M. Kündig. (2015) Determinants of efficacy and safety in epicutaneous allergen immunotherapy: summary of three clinical trials. Allergy 70:6, pages 707-710.
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Daniele Bani, Andrea Bencini, Maria Camilla Bergonzi, Anna Rita Bilia, Clizia Guccione, Mirko Severi, Roberto Udisti & Barbara Valtancoli. (2015) Enhanced intra-cutaneous delivery of a Mn-containing antioxidant drug by high-frequency ultrasounds. Journal of Pharmaceutical and Biomedical Analysis 106, pages 197-203.
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Teerawan Rattanapak, Camilla Foged & Sarah Hook. 2015. Subunit Vaccine Delivery. Subunit Vaccine Delivery 347 369 .
Sandra Wiedersberg & Richard H. Guy. (2014) Transdermal drug delivery: 30+ years of war and still fighting!. Journal of Controlled Release 190, pages 150-156.
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Matthias A Oberli, Carl M Schoellhammer, Robert Langer & Daniel Blankschtein. (2014) Ultrasound-enhanced transdermal delivery: recent advances and future challenges. Therapeutic Delivery 5:7, pages 843-857.
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S. Siebeneicher, S. Reuter, M. Krause, A. Wangorsch, J. Maxeiner, S. Wolfheimer, S. Schülke, S. Naito, A. Heinz, C. Taube, S. Vieths, S. Scheurer & M. Toda. (2014) Epicutaneous immune modulation with Bet v 1 plus R848 suppresses allergic asthma in a murine model. Allergy 69:3, pages 328-337.
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Gabriela Senti, Seraina von Moos & Thomas M. Kündig. (2013) Epicutaneous Immunotherapy for Aeroallergen and Food Allergy. Current Treatment Options in Allergy 1:1, pages 68-78.
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Karl-Josef Kallen & Andreas Theß. (2013) A development that may evolve into a revolution in medicine: mRNA as the basis for novel, nucleotide-based vaccines and drugs. Therapeutic Advances in Vaccines 2:1, pages 10-31.
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Shariq Ali & Erik Rytting. 2014. Nanomaterial. Nanomaterial 45 54 .
Richard Weiss, Sandra Scheiblhofer, Yoan Machado & Josef Thalhamer. (2013) New approaches to transcutaneous immunotherapy. Current Opinion in Allergy & Clinical Immunology 13:6, pages 669-676.
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Bernhard Ortel & Edward V. Maytin. (2013) Progress in dermatology. Photonics & Lasers in Medicine 2:4.
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