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Original Research

The formulation of a nasal nanoemulsion zaleplon in situ gel for the treatment of insomnia

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Pages 1033-1041 | Published online: 25 Jun 2013

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (8)

Sarah A. Ali, Nabil A. Alhakamy, Khaled M. Hosny, Eman Alfayez, Deena M. Bukhary, Awaji Y. Safhi, Moutaz Y. Badr, Rayan Y. Mushtaq, Majed Alharbi, Bader Huwaimel, Mohammed Alissa, Sameer Alshehri, Ali H. Alamri & Taha Alqahtani. (2022) Rapid oral transmucosal delivery of zaleplon–lavender oil utilizing self-nanoemulsifying lyophilized tablets technology: development, optimization and pharmacokinetic evaluation. Drug Delivery 29:1, pages 2773-2783.
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Randa Latif, Rana R. Makar, Ehab A. Hosni & Omaima N. El Gazayerly. (2021) The potential of intranasal delivery of nanocrystals in powder form on the improvement of zaleplon performance: in-vitro, in-vivo assessment. Drug Development and Industrial Pharmacy 47:2, pages 268-279.
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Dalia M. N. Abouhussein, Dina Bahaa El Din Mahmoud & Ebtehal Mohammad F.. (2019) Design of a liquid nano-sized drug delivery system with enhanced solubility of rivaroxaban for venous thromboembolism management in paediatric patients and emergency cases. Journal of Liposome Research 29:4, pages 399-412.
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Dina Mahmoud Mostafa, Sameh Hosam Abd El-Alim, Marwa Hasanein Asfour, Sahar Youssef Al-Okbi, Doha Abdou Mohamed, Thanaa El-Sayed Hamed & Gamal Awad. (2019) Transdermal fennel essential oil nanoemulsions with promising hepatic dysfunction healing effect: in vitro and in vivo study. Pharmaceutical Development and Technology 24:6, pages 729-738.
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Bader Mubarak Aljaeid & Khaled Mohamed Hosny. (2018) Fabrication and evaluation of Phytomenadione as a nanostructure lipid carrier for enhancement of bioavailability. Pharmaceutical Development and Technology 23:4, pages 382-386.
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Juilee A. Kulkarni & Amelia M. Avachat. (2017) Pharmacodynamic and pharmacokinetic investigation of cyclodextrin-mediated asenapine maleate in situ nasal gel for improved bioavailability. Drug Development and Industrial Pharmacy 43:2, pages 234-245.
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Ali H. Hassan, Khaled M. Hosny, Zuahir A. Murshid, Adel Alhadlaq, Ahmed Yamani, Ghada Naguib, Hala M. Alkhalidi & Ahmed R. Afify. (2016) Controlled release of injectable liposomal in situ gel loaded with recombinant human bone morphogenetic protein-2 for the repair of alveolar bone clefts in rabbits. Journal of Liposome Research 26:2, pages 148-155.
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Prerna Verma, Jaya Gopal Meher, Shalini Asthana, Vivek K. Pawar, Mohini Chaurasia & Manish K. Chourasia. (2016) Perspectives of nanoemulsion assisted oral delivery of docetaxel for improved chemotherapy of cancer. Drug Delivery 23:2, pages 479-488.
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Krushna Shirsath & Yogeeta O. Agrawal. (2023) A Potential Strategy for Treating Parkinson's Disease Through Intranasal Nanoemulsions. CNS & Neurological Disorders - Drug Targets 22:8, pages 1137-1145.
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Shashi Kiran Misra & Kamla Pathak. (2023) Nose-to-Brain Targeting via Nanoemulsion: Significance and Evidence. Colloids and Interfaces 7:1, pages 23.
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Marwa Hasanein Asfour, Sameh Hosam Abd El-Alim, Ahmed Alaa Kassem, Abeer Salama, Amr Sobhi Gouda, Walaa Samy Nazim, Neveen Hassan Nashaat, Maha Hemimi & Nagwa Abdel Meguid. (2023) Vitamin D3-Loaded Nanoemulsions as a Potential Drug Delivery System for Autistic Children: Formulation Development, Safety, and Pharmacokinetic Studies. AAPS PharmSciTech 24:2.
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Shiv Bahadur & Kamla Pathak. 2023. Nasal Drug Delivery. Nasal Drug Delivery 59 82 .
Nazneen Sultana, Juber Akhtar, Badruddeen, Mohammad Irfan Khan, Usama Ahmad, Muhammad Arif, Mohammad Ahmad & Tanmay Upadhyay. 2022. Drug Development Life Cycle. Drug Development Life Cycle.
Bakr Ahmed, Md Rizwanullah, Showkat Rasool Mir, M Shaheer Akhtar & Saima Amin. (2022) Development of cannabidiol nanoemulsion for direct nose to brain delivery: statistical optimization, in vitro and in vivo evaluation. Biomedical Materials 17:6, pages 065009.
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Saeid Moghassemi, Arezoo Dadashzadeh, Ricardo Bentes Azevedo & Christiani A. Amorim. (2022) Nanoemulsion applications in photodynamic therapy. Journal of Controlled Release 351, pages 164-173.
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Rana Abu‐Huwaij, Sarah F. Al‐Assaf & Rania Hamed. (2021) Recent exploration of nanoemulsions for drugs and cosmeceuticals delivery. Journal of Cosmetic Dermatology 21:9, pages 3729-3740.
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Tobeka Naki & Blessing A. Aderibigbe. (2022) Efficacy of Polymer-Based Nanomedicine for the Treatment of Brain Cancer. Pharmaceutics 14:5, pages 1048.
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S. Cunha, M. Swedrowska, Y. Bellahnid, Z. Xu, J.M. Sousa Lobo, Ben Forbes & A.C. Silva. (2022) Thermosensitive in situ hydrogels of rivastigmine-loaded lipid-based nanosystems for nose-to-brain delivery: characterisation, biocompatibility, and drug deposition studies. International Journal of Pharmaceutics 620, pages 121720.
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Anas Tarik Alhamdany, Ashti M.H. Saeed & Maryam Alaayedi. (2021) Nanoemulsion and Solid Nanoemulsion for Improving Oral Delivery of a Breast Cancer Drug: Formulation, Evaluation, and a Comparison Study. Saudi Pharmaceutical Journal.
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Muhammad Usama Ashhar, Shobhit Kumar, Javed Ali & Sanjula Baboota. (2021) CCRD based development of bromocriptine and glutathione nanoemulsion tailored ultrasonically for the combined anti-parkinson effect. Chemistry and Physics of Lipids 235, pages 105035.
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Yusuf A. Haggag, Ahmed Kh. Abosalha, Murtaza M. Tambuwala, Enass Y. Osman, Sanaa A. El‐Gizawy, Ebtessam A. Essa & Ahmed A. Donia. (2021) Polymeric nanoencapsulation of zaleplon into PLGA nanoparticles for enhanced pharmacokinetics and pharmacological activity. Biopharmaceutics & Drug Disposition 42:1, pages 12-23.
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Shiv Bahadur, Dinesh M. Pardhi, Jarkko Rautio, Jessica M. Rosenholm & Kamla Pathak. (2020) Intranasal Nanoemulsions for Direct Nose-to-Brain Delivery of Actives for CNS Disorders. Pharmaceutics 12:12, pages 1230.
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Tamilvanan ShunmugaperumalOly Katari & Tamilvanan Shunmugaperumal. 2020. Oil‐in‐Water Nanosized Emulsions for Drug Delivery and Targeting. Oil‐in‐Water Nanosized Emulsions for Drug Delivery and Targeting 259 285 .
Khaled M. Hosny, Rahaf H. Bahmdan, Nabil A. Alhakamy, Mohamed A. Alfaleh, Osama A. Ahmed & Mohammed H. Elkomy. (2020) Physically Optimized Nano-Lipid Carriers Augment Raloxifene and Vitamin D Oral Bioavailability in Healthy Humans for Management of Osteoporosis. Journal of Pharmaceutical Sciences 109:7, pages 2145-2155.
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Randa Latif, Rana R. Makar, Ehab A. Hosni & Omaima N. El Gazayerly. (2020) The impact of bioceramic nanocarriers on the intranasal delivery of zaleplon nanoscale powder through new adsorption techniques: Improvement in bioavailability and hypnotic effect. Journal of Drug Delivery Science and Technology 55, pages 101375.
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Areen Alshweiat, Rita Ambrus & IIdikó Csóka. (2019) Intranasal Nanoparticulate Systems as Alternative Route of Drug Delivery. Current Medicinal Chemistry 26:35, pages 6459-6492.
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Kumar Anand, Subhabrata Ray, Mahfoozur Rahman, Adil Shaharyar, Rudranil Bhowmik, Rammohan Bera & Sanmoy Karmakar. (2019) Nano-emulgel: Emerging as a Smarter Topical Lipidic Emulsion-based Nanocarrier for Skin Healthcare Applications. Recent Patents on Anti-Infective Drug Discovery 14:1, pages 16-35.
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Niyaz Ahmad, Farhan Jalees Ahmad, Sumit Bedi, Sonali Sharma, Sadiq Umar & Mohammad Azam Ansari. (2019) A novel Nanoformulation Development of Eugenol and their treatment in inflammation and periodontitis. Saudi Pharmaceutical Journal 27:6, pages 778-790.
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Bappaditya Chatterjee, Bapi Gorain, Keithanchali Mohananaidu, Pinaki Sengupta, Uttam Kumar Mandal & Hira Choudhury. (2019) Targeted drug delivery to the brain via intranasal nanoemulsion: Available proof of concept and existing challenges. International Journal of Pharmaceutics 565, pages 258-268.
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Ramsha Iqbal, Shakeeb Ahmed, Gaurav K. Jain & Divya Vohora. (2019) Design and development of letrozole nanoemulsion: A comparative evaluation of brain targeted nanoemulsion with free letrozole against status epilepticus and neurodegeneration in mice. International Journal of Pharmaceutics 565, pages 20-32.
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Nabil Abdulhafiz Alhakamy & Khaled Mohamed Hosny. (2019) Nano-vesicular delivery system loaded by Bifonazole: Preparation, optimization, and assessment of pharmacokinetic and antifungal activity. Journal of Drug Delivery Science and Technology 49, pages 316-322.
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Maha E. Elmataeeshy, Magda S. Sokar, Mohammed Bahey-El-Din & Dalia S. Shaker. (2018) Enhanced transdermal permeability of Terbinafine through novel nanoemulgel formulation; Development, in vitro and in vivo characterization. Future Journal of Pharmaceutical Sciences 4:1, pages 18-28.
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Shakeeb Ahmed, Azka Gull, Mahtab Alam, Mohd. Aqil & Yasmin Sultana. (2018) Ultrasonically tailored, chemically engineered and “QbD” enabled fabrication of agomelatine nanoemulsion; optimization, characterization, ex-vivo permeation and stability study. Ultrasonics Sonochemistry 41, pages 213-226.
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Khaled M. Hosny, Osama A.A. Ahmed, Usama A. Fahmy & Hala M. Alkhalidi. (2018) Nanovesicular systems loaded with a recently approved second generation type-5 phospodiesterase inhibitor (avanafil): I. Plackett-Burman screening and characterization. Journal of Drug Delivery Science and Technology 43, pages 154-159.
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Parichehr Hassanzadeh, Fatemeh Atyabi & Rassoul Dinarvand. (2017) Application of modelling and nanotechnology-based approaches: The emergence of breakthroughs in theranostics of central nervous system disorders. Life Sciences 182, pages 93-103.
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Hira Choudhury, Bapi Gorain, Manisha Pandey, Lipika Alok Chatterjee, Pinaki Sengupta, Arindam Das, Nagashekhara Molugulu & Prashant Kesharwani. (2017) Recent Update on Nanoemulgel as Topical Drug Delivery System. Journal of Pharmaceutical Sciences 106:7, pages 1736-1751.
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Ahmed Alaa Kassem, Amira Mohamed Mohsen, Reham Samir Ahmed & Tamer Mohamed Essam. (2016) Self-nanoemulsifying drug delivery system (SNEDDS) with enhanced solubilization of nystatin for treatment of oral candidiasis: Design, optimization, in vitro and in vivo evaluation. Journal of Molecular Liquids 218, pages 219-232.
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Shital Lungare, James Bowen & Raj Badhan. (2016) Development and Evaluation of a Novel Intranasal Spray for the Delivery of Amantadine. Journal of Pharmaceutical Sciences 105:3, pages 1209-1220.
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Usama A. Fahmy, Osama A. A. Ahmed & Khaled M. Hosny. (2014) Development and Evaluation of Avanafil Self-nanoemulsifying Drug Delivery System with Rapid Onset of Action and Enhanced Bioavailability. AAPS PharmSciTech 16:1, pages 53-58.
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Khaled Mohamed Hosny & Ali Habiballah Hassan. (2014) Intranasal in situ gel loaded with saquinavir mesylate nanosized microemulsion: Preparation, characterization, and in vivo evaluation. International Journal of Pharmaceutics 475:1-2, pages 191-197.
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