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Editorial

Emerging methods for identifying monoclonal antibodies with low propensity to self-associate during the early discovery process

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Monica L. Fernández-Quintero, Anne Ljungars, Franz Waibl, Victor Greiff, Jan Terje Andersen, Torleif T. Gjølberg, Timothy P. Jenkins, Bjørn Gunnar Voldborg, Lise Marie Grav, Sandeep Kumar, Guy Georges, Hubert Kettenberger, Klaus R. Liedl, Peter M. Tessier, John McCafferty & Andreas H. Laustsen. (2023) Assessing developability early in the discovery process for novel biologics. mAbs 15:1.
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Marie R.G. Kopp, Adriana-Michelle Wolf Pérez, Marta Virginia Zucca, Umberto Capasso Palmiero, Brigitte Friedrichsen, Nikolai Lorenzen & Paolo Arosio. (2020) An accelerated surface-mediated stress assay of antibody instability for developability studies. mAbs 12:1.
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Patricia Estep, Isabelle Caffry, Yao Yu, Tingwan Sun, Yuan Cao, Heather Lynaugh, Tushar Jain, Maximiliano Vásquez, Peter M Tessier & Yingda Xu. (2015) An alternative assay to hydrophobic interaction chromatography for high-throughput characterization of monoclonal antibodies. mAbs 7:3, pages 553-561.
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Articles from other publishers (19)

Carl Mieczkowski, Alan Cheng, Thierry Fischmann, Mark Hsieh, Jeanne Baker, Makiko Uchida, Gopalan Raghunathan, Corey Strickland & Laurence Fayadat-Dilman. (2021) Characterization and Modeling of Reversible Antibody Self-Association Provide Insights into Behavior, Prediction, and Correction. Antibodies 10:1, pages 8.
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Steven A. Berkowitz. 2020. Biophysical Characterization of Proteins in Developing Biopharmaceuticals. Biophysical Characterization of Proteins in Developing Biopharmaceuticals 459 479 .
Steven A. Berkowitz. 2020. Biophysical Characterization of Proteins in Developing Biopharmaceuticals. Biophysical Characterization of Proteins in Developing Biopharmaceuticals 431 456 .
Illarion V. Turko. 2020. Immunoinformatics. Immunoinformatics 245 254 .
Laila Shehata, Daniel P. Maurer, Anna Z. Wec, Asparouh Lilov, Elizabeth Champney, Tingwan Sun, Kimberly Archambault, Irina Burnina, Heather Lynaugh, Xiaoyong Zhi, Yingda Xu & Laura M. Walker. (2019) Affinity Maturation Enhances Antibody Specificity but Compromises Conformational Stability. Cell Reports 28:13, pages 3300-3308.e4.
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Arathi Kizhedath, Micael Karlberg & Jarka Glassey. (2019) Cross‐Interaction Chromatography‐Based QSAR Model for Early‐Stage Screening to Facilitate Enhanced Developability of Monoclonal Antibody Therapeutics. Biotechnology Journal 14:8, pages 1800696.
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Nazlı Eda Kaleli, Murat Karadag & Sibel Kalyoncu. (2019) Phage display derived therapeutic antibodies have enriched aliphatic content: Insights for developability issues. Proteins: Structure, Function, and Bioinformatics 87:7, pages 607-618.
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Lilia A Rabia, Yulei Zhang, Seth D Ludwig, Mark C Julian & Peter M Tessier. (2018) Net charge of antibody complementarity-determining regions is a key predictor of specificity. Protein Engineering, Design and Selection 31:11, pages 409-418.
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Neal Whitaker, Jian Xiong, Samantha E. Pace, Vineet Kumar, C. Russell Middaugh, Sangeeta B. Joshi & David B. Volkin. (2017) A Formulation Development Approach to Identify and Select Stable Ultra–High-Concentration Monoclonal Antibody Formulations With Reduced Viscosities. Journal of Pharmaceutical Sciences 106:11, pages 3230-3241.
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Crystal S. F. Cheung, Kyle W. Anderson, Pooja M. Patel, Keale L. Cade, Karen W. Phinney & Illarion V. Turko. (2017) A new approach to quantification of mAb aggregates using peptide affinity probes. Scientific Reports 7:1.
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Vladimir I. Razinkov & Gerd R. Kleemann. 2017. High-Throughput Formulation Development of Biopharmaceuticals. High-Throughput Formulation Development of Biopharmaceuticals 45 74 .
Steven B. Geng, Jiemin Wu, Magfur E. Alam, Jason S. Schultz, Craig D. Dickinson, Carly R. Seminer & Peter M. Tessier. (2016) Facile Preparation of Stable Antibody–Gold Conjugates and Application to Affinity-Capture Self-Interaction Nanoparticle Spectroscopy. Bioconjugate Chemistry 27:10, pages 2287-2300.
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Lilian Lam Josephson, Eric M. Furst & William J. Galush. (2016) Particle tracking microrheology of protein solutions. Journal of Rheology 60:4, pages 531-540.
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B. Frka-Petesic, D. Zanchi, N. Martin, S. Carayon, S. Huille & C. Tribet. (2016) Aggregation of Antibody Drug Conjugates at Room Temperature: SAXS and Light Scattering Evidence for Colloidal Instability of a Specific Subpopulation. Langmuir 32:19, pages 4848-4861.
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Jiemin Wu, Jason S. Schultz, Caroline L. Weldon, Shantanu V. Sule, Qing Chai, Steven B. Geng, Craig D. Dickinson & Peter M. Tessier. (2015) Discovery of highly soluble antibodies prior to purification using affinity-capture self-interaction nanoparticle spectroscopy. Protein Engineering Design and Selection 28:10, pages 403-414.
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Nasir Hussain, Angeliki Siapkara & Sarah Branch. (2015) Quality considerations of paediatric investigation plans for monoclonal antibodies: A regulatory perspective from the MHRA. International Journal of Pharmaceutics 492:1-2, pages 338-340.
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Alexander Jarasch, Hans Koll, Joerg T. Regula, Martin Bader, Apollon Papadimitriou & Hubert Kettenberger. (2015) Developability Assessment During the Selection of Novel Therapeutic Antibodies. Journal of Pharmaceutical Sciences 104:6, pages 1885-1898.
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Xiaoning Li, Steven B. Geng, Mark L. Chiu, Dorina Saro & Peter M. Tessier. (2015) High-Throughput Assay for Measuring Monoclonal Antibody Self-Association and Aggregation in Serum. Bioconjugate Chemistry 26:3, pages 520-528.
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Steven D. Hudson, Prasad Sarangapani, Jai A. Pathak & Kalman B. Migler. (2015) A Microliter Capillary Rheometer for Characterization of Protein Solutions. Journal of Pharmaceutical Sciences 104:2, pages 678-685.
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