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Editorial

Coacervate delivery systems for proteins and small molecule drugs

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Read on this site (4)

Xiangquan Zeng, Weibo Jiang, Zhenjiao Du & Jozef L. Kokini. (2023) Encapsulation of tannins and tannin-rich plant extracts by complex coacervation to improve their physicochemical properties and biological activities: A review. Critical Reviews in Food Science and Nutrition 63:18, pages 3005-3018.
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Ashlee D. Brunaugh, Shivam Sharma & Hugh Smyth. (2021) Inhaled fixed-dose combination powders for the treatment of respiratory infections. Expert Opinion on Drug Delivery 18:8, pages 1101-1115.
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Guo-Qing Huang, Xiao-Na Han & Jun-Xia Xiao. (2017) Glutaraldehyde-crosslinked O-carboxymethyl chitosan–gum Arabic coacervates: Characteristics versus complexation acidity. Journal of Dispersion Science and Technology 38:11, pages 1607-1612.
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Antonella Bandiera. (2017) Elastin-like polypeptides: the power of design for smart cell encapsulation. Expert Opinion on Drug Delivery 14:1, pages 37-48.
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Articles from other publishers (82)

Thi Van Anh Bui, Jin-Ju Kim, Xin Huang, Aoyang Pu, Xin Li, Seok Beom Hong, Yeon-Jik Choi, Hae-Won Kim, Xi Yao, Hun-Jun Park & Kiwon Ban. (2023) Core–Shell Droplet-Based Angiogenic Patches for the Treatment of Ischemic Diseases: Ultrafast Processability, Physical Tunability, and Controlled Delivery of an Angiogenic Cocktail. ACS Applied Materials & Interfaces 15:44, pages 50693-50707.
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Jiabao Zheng, Paul Van der Meeren & Weizheng Sun. (2023) New insights into protein–polysaccharide complex coacervation: Dynamics, molecular parameters, and applications. Aggregate.
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Charles E. Sing & Jian Qin. (2023) Bridging Field Theory and Ion Pairing in the Modeling of Polyelectrolytes and Complex Coacervation. Macromolecules 56:15, pages 5941-5963.
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Michele Denise Illmann, Lea Schäfl, Felicitas Drees, Laura Hartmann & Stephan Schmidt. (2023) Glycan-Presenting Coacervates Derived from Charged Poly(active esters): Preparation, Phase Behavior, and Lectin Capture. Biomacromolecules 24:6, pages 2532-2540.
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Samaneh Montazeri, Ali Rastegari, Zohreh Mohammadi, Mahboobeh Nazari, Maryam Yousefi, Fatemeh Yazdi Samadi, Somayeh Najafzadeh & Mehdi Aghsami. (2023) Chitosan nanoparticle loaded by epidermal growth factor as a potential protein carrier for wound healing: In vitro and in vivo studies. IET Nanobiotechnology 17:3, pages 204-211.
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Bertrand Muhoza, Jean Damascene Harindintwali, Baokun Qi, Shuang Zhang & Yang Li. (2022) Conjugation Induced by Wet-Heating of Gelatin and Low Methoxyl Pectin Improves the Properties and Stability of Microcapsules Prepared by Complex Coacervation. Food Biophysics 18:1, pages 95-106.
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Wesam A. Hatem & Yakov Lapitsky. (2023) Accelerating Payload Release from Complex Coacervates through Mechanical Stimulation. Polymers 15:3, pages 586.
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Lilusi Ma, Xiaocui Fang & Chen Wang. (2023) Peptide-based coacervates in therapeutic applications. Frontiers in Bioengineering and Biotechnology 10.
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Hamid Gharanjig & Gholamali Farzi. 2023. Principles of Biomaterials Encapsulation : Volume One. Principles of Biomaterials Encapsulation : Volume One 323 376 .
Xiangxi Meng. (2022) A mini-review on bio-inspired polymer self-assembly: single-component and interactive polymer systems. Emerging Topics in Life Sciences 6:6, pages 593-607.
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Ching-Shuen Wang, Shen-Dean Luo, Shihai Jia, Wilfred Wu, Shwu-Fen Chang, Sheng-Wei Feng, Chieh-Hsiang Yang, Jiann-Her Lin & Yinshen Wee. (2022) Balance of Macrophage Activation by a Complex Coacervate-Based Adhesive Drug Carrier Facilitates Diabetic Wound Healing. Antioxidants 11:12, pages 2351.
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Anna R. Johnston, Gregory M. Pitch, Eris D. Minckler, Ivette G. Mora, Vitor H. Balasco Serrão, Eric A. Dailing & Alexander L. Ayzner. (2022) Excitonically Coupled Simple Coacervates via Liquid/Liquid Phase Separation. The Journal of Physical Chemistry Letters 13:44, pages 10275-10281.
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Ju-Fang Liu, Yinshen Wee, Shen-Dean Luo, Shwu-Fen Chang, Shihai Jia, Sheng-Wei Feng, Huei-Mei Huang, Jiann-Her Lin & Ching-Shuen Wang. (2022) Proanthocyanidins-loaded complex coacervates-based drug delivery attenuates oral squamous cell carcinoma cells metastatic potential through down-regulating the Akt signaling pathway. Frontiers in Oncology 12.
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Heyi Liang & Juan J. de Pablo. (2022) A Coarse-Grained Molecular Dynamics Study of Strongly Charged Polyelectrolyte Coacervates: Interfacial, Structural, and Dynamical Properties. Macromolecules 55:10, pages 4146-4158.
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Anna R. Johnston, Eris D. Minckler, Mia C. J. Shockley, Levi N. Matsushima, Sarah L. Perry & Alexander L. Ayzner. (2022) Conjugated Polyelectrolyte‐Based Complex Fluids as Aqueous Exciton Transport Networks. Angewandte Chemie International Edition 61:20.
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Anna R. Johnston, Eris D. Minckler, Mia C. J. Shockley, Levi N. Matsushima, Sarah L. Perry & Alexander L. Ayzner. (2022) Conjugated Polyelectrolyte‐Based Complex Fluids as Aqueous Exciton Transport Networks. Angewandte Chemie 134:20.
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Juanfeng Sun, Jessica D. Schiffman & Sarah L. Perry. (2022) Linear Viscoelasticity and Time–Alcohol Superposition of Chitosan/Hyaluronic Acid Complex Coacervates. ACS Applied Polymer Materials 4:3, pages 1617-1625.
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Joseph J. Pearson & Johnna S. Temenoff. (2022) Growth Factor Immobilization Strategies for Musculoskeletal Disorders. Current Osteoporosis Reports 20:1, pages 13-25.
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Shin-nosuke Nishimura, Kei Nishida, Tomoya Ueda, Shohei Shiomoto & Masaru Tanaka. (2022) Biocompatible poly( N -(ω-acryloyloxy- n -alkyl)-2-pyrrolidone)s with widely-tunable lower critical solution temperatures (LCSTs): a promising alternative to poly( N -isopropylacrylamide) . Polymer Chemistry.
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Yanwen Zhang, Yu Yao, Songyang Liu, Yufeng Chen, Shaohong Zhou, Kemin Wang, Xiaohai Yang & Jianbo Liu. (2021) Coacervate microdroplet protocell-mediated gene transfection for nitric oxide production and induction of cell apoptosis. Journal of Materials Chemistry B 9:47, pages 9784-9793.
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Özge Karabıyık Acar, Seden Bedir, A. Basak Kayitmazer & Gamze Torun Kose. (2021) Chondro-inductive hyaluronic acid/chitosan coacervate-based scaffolds for cartilage tissue engineering. International Journal of Biological Macromolecules 188, pages 300-312.
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Nisal Wanasingha, Naba K. Dutta & Namita Roy Choudhury. (2021) Emerging bioadhesives: from traditional bioactive and bioinert to a new biomimetic protein-based approach. Advances in Colloid and Interface Science 296, pages 102521.
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Tony Z Jia, Po-Hsiang Wang, Tatsuya Niwa & Irena Mamajanov. (2021) Connecting primitive phase separation to biotechnology, synthetic biology, and engineering. Journal of Biosciences 46:3.
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Takahiro Iwata, Hisaaki Hirose, Kentarou Sakamoto, Yusuke Hirai, Jan Vincent V. Arafiles, Misao Akishiba, Miki Imanishi & Shiroh Futaki. (2021) Liquid Droplet Formation and Facile Cytosolic Translocation of IgG in the Presence of Attenuated Cationic Amphiphilic Lytic Peptides. Angewandte Chemie International Edition 60:36, pages 19804-19812.
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Takahiro Iwata, Hisaaki Hirose, Kentarou Sakamoto, Yusuke Hirai, Jan Vincent V. Arafiles, Misao Akishiba, Miki Imanishi & Shiroh Futaki. (2021) Liquid Droplet Formation and Facile Cytosolic Translocation of IgG in the Presence of Attenuated Cationic Amphiphilic Lytic Peptides. Angewandte Chemie 133:36, pages 19957-19965.
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Niki Baccile, Chloé Seyrig, Alexandre Poirier, Silvia Alonso-de Castro, Sophie L. K. W. Roelants & Stéphane Abel. (2021) Self-assembly, interfacial properties, interactions with macromolecules and molecular modelling and simulation of microbial bio-based amphiphiles (biosurfactants). A tutorial review. Green Chemistry 23:11, pages 3842-3944.
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Hui-Hui Zhang, Guo-Qing Huang, Xin Geng, Jing Teng & Jun-Xia Xiao. (2021) Interaction between ovalbumin and pectin and coacervate characterization. Colloid and Polymer Science 299:6, pages 943-953.
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Samira Mohammadalinejhad & Marcin Andrzej Kurek. (2021) Microencapsulation of Anthocyanins—Critical Review of Techniques and Wall Materials. Applied Sciences 11:9, pages 3936.
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Aditya N. Singh & Arun Yethiraj. (2021) Liquid–Liquid Phase Separation As the Second Step of Complex Coacervation. The Journal of Physical Chemistry B 125:12, pages 3023-3031.
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Marleen H. M. E. van Stevendaal, Laurynas Vasiukas, N. Amy Yewdall, Alexander F. Mason & Jan C. M. van Hest. (2021) Engineering of Biocompatible Coacervate-Based Synthetic Cells. ACS Applied Materials & Interfaces 13:7, pages 7879-7889.
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Frances J. Morin, Marissa L. Puppo & Jennifer E. Laaser. (2021) Decoupling salt- and polymer-dependent dynamics in polyelectrolyte complex coacervates via salt addition . Soft Matter 17:5, pages 1223-1231.
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Nao Ikeuchi, Takuya Komachi, Keiji Murayama, Hiroyuki Asanuma, Atsushi Maruyama & Naohiko Shimada. (2021) Light-Regulated Liquid–Liquid Phase Separation for Spatiotemporal Protein Recruitment and Cell Aggregation. ACS Applied Materials & Interfaces 13:4, pages 5652-5659.
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Elisa Floris, Andrea Piras, Luca Dall’Asta, Andrea Gamba, Emilio Hirsch & Carlo C. Campa. (2021) Physics of compartmentalization: How phase separation and signaling shape membrane and organelle identity. Computational and Structural Biotechnology Journal 19, pages 3225-3233.
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Whitney C. Blocher McTigue & Sarah L. Perry. 2021. Liquid-Liquid Phase Coexistence and Membraneless Organelles. Liquid-Liquid Phase Coexistence and Membraneless Organelles 277 306 .
Preeti Tiwari, Indu Bharti, Himadri B Bohidar, Shabina Quadir, Mohan C Joshi & Najmul Arfin. (2020) Complex Coacervation and Overcharging during Interaction between Hydrophobic Zein and Hydrophilic Laponite in Aqueous Ethanol Solution. ACS Omega 5:51, pages 33064-33074.
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Jung-Min Kim, Tae-Young Heo & Soo-Hyung Choi. (2020) Structure and Relaxation Dynamics for Complex Coacervate Hydrogels Formed by ABA Triblock Copolymers. Macromolecules 53:21, pages 9234-9243.
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Wenjin Xiao, Monika D. Jakimowicz, Ioannis Zampetakis, Sarah Neely, Fabrizio Scarpa, Sean A. Davis, David S. Williams & Adam W. Perriman. (2020) Biopolymeric Coacervate Microvectors for the Delivery of Functional Proteins to Cells. Advanced Biosystems 4:11, pages 2000101.
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Hadi M. Fares, Alexander E. Marras, Jeffrey M. Ting, Matthew V. Tirrell & Christine D. Keating. (2020) Impact of wet-dry cycling on the phase behavior and compartmentalization properties of complex coacervates. Nature Communications 11:1.
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Yalin Liu, Cristiam F. Santa Chalarca, R. Nicholas Carmean, Rebecca A. Olson, Jason Madinya, Brent S. Sumerlin, Charles E. Sing, Todd Emrick & Sarah L. Perry. (2020) Effect of Polymer Chemistry on the Linear Viscoelasticity of Complex Coacervates. Macromolecules 53:18, pages 7851-7864.
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Chloé Seyrig, Gertrude Kignelman, Wim Thielemans, Patrick Le Griel, Nathan Cowieson, Javier Perez & Niki Baccile. (2020) Stimuli-Induced Nonequilibrium Phase Transitions in Polyelectrolyte–Surfactant Complex Coacervates. Langmuir 36:30, pages 8839-8857.
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Zhi Wei Lim, Vijaykumar B. Varma, Raju V. Ramanujan & Ali Miserez. (2020) Magnetically responsive peptide coacervates for dual hyperthermia and chemotherapy treatments of liver cancer. Acta Biomaterialia 110, pages 221-230.
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Whitney C. Blocher McTigue & Sarah L. Perry. (2020) Protein Encapsulation Using Complex Coacervates: What Nature Has to Teach Us. Small 16:27, pages 1907671.
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Charles E. Sing & Sarah L. Perry. (2020) Recent progress in the science of complex coacervation. Soft Matter 16:12, pages 2885-2914.
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Aditya N. Singh & Arun Yethiraj. (2020) Driving Force for the Complexation of Charged Polypeptides. The Journal of Physical Chemistry B 124:7, pages 1285-1292.
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Giulia Auriemma, Andrea Cerciello, Rita P. Aquino, Pasquale Del Gaudio, Bruno M. Fusco & Paola Russo. (2020) Pectin and Zinc Alginate: The Right Inner/Outer Polymer Combination for Core-Shell Drug Delivery Systems. Pharmaceutics 12:2, pages 87.
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Bartosz Gabryelczyk, Hao Cai, Xiangyan Shi, Yue Sun, Piet J. M. Swinkels, Stefan Salentinig, Konstantin Pervushin & Ali Miserez. (2019) Hydrogen bond guidance and aromatic stacking drive liquid-liquid phase separation of intrinsically disordered histidine-rich peptides. Nature Communications 10:1.
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Kurt D. Ristroph & Robert K. Prud'homme. (2019) Hydrophobic ion pairing: encapsulating small molecules, peptides, and proteins into nanocarriers. Nanoscale Advances 1:11, pages 4207-4237.
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Seonghee Jeong, ByungWook Kim, Hui-Chong Lau & Aeri Kim. (2019) Gelatin-Alginate Complexes for EGF Encapsulation: Effects of H-Bonding and Electrostatic Interactions. Pharmaceutics 11:10, pages 530.
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Xiaochu Ding, Paula G. Miller, Mintai Peter Hwang, Jiayin Fu & Yadong Wang. (2019) Scale-up synthesis of a polymer designed for protein therapy. European Polymer Journal 117, pages 353-362.
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Jun Huang, Frances J. Morin & Jennifer E. Laaser. (2019) Charge-Density-Dominated Phase Behavior and Viscoelasticity of Polyelectrolyte Complex Coacervates. Macromolecules 52:13, pages 4957-4967.
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Laura Marvin, Wynter Paiva, Nicole Gill, Marissa A. Morales, Jeffrey Mark Halpern, James Vesenka & Eva Rose M. Balog. (2019) Flow imaging microscopy as a novel tool for high-throughput evaluation of elastin-like polymer coacervates. PLOS ONE 14:5, pages e0216406.
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Junzhe Lou, Sean Friedowitz, Jian Qin & Yan Xia. (2019) Tunable Coacervation of Well-Defined Homologous Polyanions and Polycations by Local Polarity. ACS Central Science 5:3, pages 549-557.
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Arianna Ferrini, Molly M. Stevens, Susanne Sattler & Nadia Rosenthal. (2019) Toward Regeneration of the Heart: Bioengineering Strategies for Immunomodulation. Frontiers in Cardiovascular Medicine 6.
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Sara Tabandeh & Lorraine Leon. (2019) Engineering Peptide-Based Polyelectrolyte Complexes with Increased Hydrophobicity. Molecules 24:5, pages 868.
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Like Mao, Qiuyue Pan, Fang Yuan & Yanxiang Gao. (2019) Formation of soy protein isolate-carrageenan complex coacervates for improved viability of Bifidobacterium longum during pasteurization and in vitro digestion. Food Chemistry 276, pages 307-314.
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Xiangxi Meng, Jessica D. Schiffman & Sarah L. Perry. (2018) Electrospinning Cargo-Containing Polyelectrolyte Complex Fibers: Correlating Molecular Interactions to Complex Coacervate Phase Behavior and Fiber Formation. Macromolecules 51:21, pages 8821-8832.
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James D. Tang, Steven R. Caliari & Kyle J. Lampe. (2018) Temperature-Dependent Complex Coacervation of Engineered Elastin-like Polypeptide and Hyaluronic Acid Polyelectrolytes. Biomacromolecules 19:10, pages 3925-3935.
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Jun-Xia Xiao, Cui-Ping Zhu, Ling-Yun Cheng, Jian Yang & Guo-Qing Huang. (2018) pH-Dependent intestine-targeted delivery potency of the O-carboxymethyl chitosan – gum Arabic coacervates. International Journal of Biological Macromolecules 117, pages 315-322.
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Fawzi G. Hamad, Quan Chen & Ralph H. Colby. (2018) Linear Viscoelasticity and Swelling of Polyelectrolyte Complex Coacervates. Macromolecules 51:15, pages 5547-5555.
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Zhi Wei Lim, Yuan Ping & Ali Miserez. (2018) Glucose-Responsive Peptide Coacervates with High Encapsulation Efficiency for Controlled Release of Insulin. Bioconjugate Chemistry 29:7, pages 2176-2180.
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Kenta Morita, Takahiro Suzuki, Yuya Nishimura, Kazuhisa Matsumoto, Chiya Numako, Kazuyoshi Sato, Masao Nakayama, Ryohei Sasaki, Chiaki Ogino & Akihiko Kondo. (2018) In vivo tissue distribution and safety of polyacrylic acid-modified titanium peroxide nanoparticles as novel radiosensitizers. Journal of Bioscience and Bioengineering 126:1, pages 119-125.
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Werner E. G. Müller, Shunfeng Wang, Emad Tolba, Meik Neufurth, Maximilian Ackermann, Rafael Muñoz-Espí, Ingo Lieberwirth, Gunnar Glasser, Heinz C. Schröder & Xiaohong Wang. (2018) Transformation of Amorphous Polyphosphate Nanoparticles into Coacervate Complexes: An Approach for the Encapsulation of Mesenchymal Stem Cells. Small 14:27, pages 1801170.
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Kei Nishida, Atsushi Tamura & Nobuhiko Yui. (2018) pH-Responsive Coacervate Droplets Formed from Acid-Labile Methylated Polyrotaxanes as an Injectable Protein Carrier. Biomacromolecules 19:6, pages 2238-2247.
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Willem Kasper Spoelstra, Siddharth Deshpande & Cees Dekker. (2018) Tailoring the appearance: what will synthetic cells look like?. Current Opinion in Biotechnology 51, pages 47-56.
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Ghazi Ben Messaoud, Lyndsay Promeneur, Martha Brennich, Sophie L. K. W. Roelants, Patrick Le Griel & Niki Baccile. (2018) Complex coacervation of natural sophorolipid bolaamphiphile micelles with cationic polyelectrolytes. Green Chemistry 20:14, pages 3371-3385.
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Jose C. Rodríguez-Cabello, Israel González de Torre, Sergio Acosta, Soraya Salinas & Marcos Herrero. 2018. Self-assembling Biomaterials. Self-assembling Biomaterials 49 78 .
Guo-Qing Huang, Li-Na Liu, Xiao-Na Han & Jun-Xia Xiao. (2017) Intestine-targeted delivery potency of the O-carboxymethyl chitosan–gum Arabic coacervate: Effects of coacervation acidity and possible mechanism. Materials Science and Engineering: C 79, pages 423-429.
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Whitney C. Blocher & Sarah L. Perry. (2016) Complex coacervate‐based materials for biomedicine. WIREs Nanomedicine and Nanobiotechnology 9:4.
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Sean E. ReichheldLisa D. MuiznieksFred W. Keeley & Simon Sharpe. (2017) Direct observation of structure and dynamics during phase separation of an elastomeric protein. Proceedings of the National Academy of Sciences 114:22.
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Brandon M. Johnston, Cameron W. Johnston, Rachel A. Letteri, Tyler K. Lytle, Charles E. Sing, Todd Emrick & Sarah L. Perry. (2017) The effect of comb architecture on complex coacervation. Organic & Biomolecular Chemistry 15:36, pages 7630-7642.
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Xiaochu Ding & Yadong Wang. (2017) Weak bond-based injectable and stimuli responsive hydrogels for biomedical applications. Journal of Materials Chemistry B 5:5, pages 887-906.
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Chaeyeon Son, Sun Young Kim, So Yeong Bahn, Hyung Joon Cha & Yoo Seong Choi. (2017) CaCO 3 thin-film formation mediated by a synthetic protein-lysozyme coacervate . RSC Advances 7:25, pages 15302-15308.
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Yalin Liu, H. Henning Winter & Sarah L. Perry. (2017) Linear viscoelasticity of complex coacervates. Advances in Colloid and Interface Science 239, pages 46-60.
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A. Basak Kayitmazer. (2017) Thermodynamics of complex coacervation. Advances in Colloid and Interface Science 239, pages 169-177.
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Liangfei Tian, Nicolas Martin, Philip G. Bassindale, Avinash J. Patil, Mei Li, Adrian Barnes, Bruce W. Drinkwater & Stephen Mann. (2016) Spontaneous assembly of chemically encoded two-dimensional coacervate droplet arrays by acoustic wave patterning. Nature Communications 7:1.
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Hassan K. Awada, Louis A. Johnson, T. Kevin Hitchens, Lesley M. Foley & Yadong Wang. (2016) Factorial Design of Experiments to Optimize Multiple Protein Delivery for Cardiac Repair. ACS Biomaterials Science & Engineering 2:5, pages 879-886.
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Hassan K. Awada, Mintai P. Hwang & Yadong Wang. (2016) Towards comprehensive cardiac repair and regeneration after myocardial infarction: Aspects to consider and proteins to deliver. Biomaterials 82, pages 94-112.
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Yuhao Wang & Svetlana A. Sukhishvili. (2016) Hydrogen-bonded polymer complexes and nanocages of weak polyacids templated by a Pluronic® block copolymer. Soft Matter 12:42, pages 8744-8754.
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