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Original Research

Optimization of niosomes for enhanced antibacterial activity and reduced bacterial resistance: in vitro and in vivo evaluation

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Mehrnoush Mehrarya, Behnaz Gharehchelou, Samin Haghighi Poodeh, Elham Jamshidifar, Sara Karimifard, Bahareh Farasati Far, Iman Akbarzadeh & Alexander Seifalian. (2022) Niosomal formulation for antibacterial applications. Journal of Drug Targeting 30:5, pages 476-493.
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Mohammed M. Mehanna, Amina Tarek Mneimneh & Khaled Abed El Jalil. (2020) Levofloxacin-loaded naturally occurring monoterpene-based nanoemulgel: a feasible efficient system to circumvent MRSA ocular infections. Drug Development and Industrial Pharmacy 46:11, pages 1787-1799.
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Mona T Kashef, Nehal M Saleh, Nouran H Assar & Mohammed A Ramadan. (2020) The Antimicrobial Activity of Ciprofloxacin-Loaded Niosomes against Ciprofloxacin-Resistant and Biofilm-Forming Staphylococcus aureus. Infection and Drug Resistance 13, pages 1619-1629.
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Suresh Maddila, Sridevi Gorle & Sreekantha B Jonnalagadda. (2020) Drug screening of rhodanine derivatives for antibacterial activity. Expert Opinion on Drug Discovery 15:2, pages 203-229.
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Sara Salatin, Farzaneh Lotfipour & Mitra Jelvehgari. (2019) A brief overview on nano-sized materials used in the topical treatment of skin and soft tissue bacterial infections. Expert Opinion on Drug Delivery 16:12, pages 1313-1331.
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Rania K. Eid, Ebtessam A. Essa & Gamal M. El Maghraby. (2019) Essential oils in niosomes for enhanced transdermal delivery of felodipine. Pharmaceutical Development and Technology 24:2, pages 157-165.
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Amal A. Sultan, Sanaa A. El-Gizawy, Mohamed A. Osman & Gamal M. El Maghraby. (2018) Niosomes for oral delivery of nateglinide: in situ–in vivo correlation. Journal of Liposome Research 28:3, pages 209-217.
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Articles from other publishers (41)

Jaber Hemmati, Zahra Chegini & Mohammad Reza Arabestani. (2023) Niosomal-Based Drug Delivery Platforms: A Promising Therapeutic Approach to Fight Staphylococcus aureus Drug Resistance. Journal of Nanomaterials 2023, pages 1-18.
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Kawthar K. Abla, Soumaya M. Hijazi & Mohammed M. Mehanna. (2023) Augmented efficiency of azithromycin for MRSA ocular infections management: Limonene-based nanostructured lipid carriers in-situ approach. Journal of Drug Delivery Science and Technology 87, pages 104764.
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Mahmood Barani, Fatemeh Paknia, Maryam Roostaee, Batoul Kavyani, Davood Kalantar-Neyestanaki, Narges Ajalli & Alireza Amirbeigi. (2023) Niosome as an Effective Nanoscale Solution for the Treatment of Microbial Infections. BioMed Research International 2023, pages 1-18.
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Hamideh Karbalaeiheidar & Fatemeh Ashrafi. (2023) Vancomycin-gingerol encapsulated niosomal formulation against carbapenem-resistant Klebsiella pneumoniae. Biomedical Materials 18:4, pages 045015.
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Hemangi Ramesh Trivedi & Prashant Keshao Puranik. (2023) Chlorogenic acid loaded niosomes and proniosomes: in vitro antioxidant and antibacterial activities with efficacy in wound healing. Digital Chinese Medicine 6:2, pages 170-188.
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Iman Akbarzadeh, Niloufar Rezaei, Saina Bazzazan, Maryam Naderi Mezajin, Afsoun Mansouri, Hamideh Karbalaeiheidar, Shamim Ashkezari, Zahra Salehi Moghaddam, Zahra Asghari Lalami & Ebrahim Mostafavi. (2023) In silico and in vitro studies of GENT-EDTA encapsulated niosomes: A novel approach to enhance the antibacterial activity and biofilm inhibition in drug-resistant Klebsiella pneumoniae. Biomaterials Advances 149, pages 213384.
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Shamim Ashkezari, Maryam Sadat Abtahi, Zahra Sattari, Mohammad Tavakkoli Yaraki, Fatemeh Hosseini, Raheleh Inanloo Salehi, Elham Afzali, Saeedeh Hajihosseini & Neda Mousavi-Niri. (2023) Antibiotic and inorganic nanoparticles co-loaded into carboxymethyl chitosan-functionalized niosome: Synergistic enhanced antibacterial and anti-biofilm activities. Journal of Drug Delivery Science and Technology 83, pages 104386.
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Rania K. Eid, Mona F. Arafa, Dalia S. Ashour, Ebtessam A. Essa, Eman S. El-Wakil, Salwa S. Younis & Gamal M. El Maghraby. (2023) Surfactant vesicles for enhanced antitoxoplasmic effect of norfloxacin: In vitro and in vivo evaluations. International Journal of Pharmaceutics 638, pages 122912.
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Amal M. Abo Kamer, Noha M. Amer, Ahmed A. Abdelmegeed, Gamal M. El Maghraby & Noha M. Gamaleldin. (2023) Surfactant nanovesicles for augmented antibacterial activity against carbapenemase resistant enterobacteriaceae and extended spectrum beta-lactamases producing bacteria: in vitro and in vivo evaluation. BMC Microbiology 23:1.
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Ghada Ahmed El-Emam, Ahmed M. El-Baz, Ahmed Shata, Ahmed A. Shaaban, Mohamed M. Adel El-Sokkary & Amira Motawea. (2023) Formulation and microbiological ancillary studies of gemifloxacin proniosomes for exploiting its role against LPS acute pneumonia model. Journal of Drug Delivery Science and Technology 81, pages 104053.
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Qian Pang, Zilian Jiang, Kaihao Wu, Ruixia Hou & Yabin Zhu. (2023) Nanomaterials-Based Wound Dressing for Advanced Management of Infected Wound. Antibiotics 12:2, pages 351.
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Abbas Haddadian, Farnoush Falahi Robattorki, Hedieh Dibah, Ali Soheili, Erfan Ghanbarzadeh, Nasrin Sartipnia, Shadi Hajrasouliha, Kamal Pasban, Romina Andalibi, Mojtaba Hedayati Ch, Arezou Azari, Arman Chitgarzadeh, Aliasghar Bagheri Kashtali, Fatemeh Mastali, Hassan Noorbazargan & Amir Mirzaie. (2022) Niosomes-loaded selenium nanoparticles as a new approach for enhanced antibacterial, anti-biofilm, and anticancer activities. Scientific Reports 12:1.
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Mohamad Rahmati, Ebrahim Babapoor & Mehrouz Dezfulian. (2022) Amikacin-loaded niosome nanoparticles improve amikacin activity against antibiotic-resistant Klebsiella pneumoniae strains. World Journal of Microbiology and Biotechnology 38:12.
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Linda Maurizi, Jacopo Forte, Maria Grazia Ammendolia, Patrizia Nadia Hanieh, Antonietta Lucia Conte, Michela Relucenti, Orlando Donfrancesco, Caterina Ricci, Federica Rinaldi, Carlotta Marianecci, Maria Carafa & Catia Longhi. (2022) Effect of Ciprofloxacin-Loaded Niosomes on Escherichia coli and Staphylococcus aureus Biofilm Formation. Pharmaceutics 14:12, pages 2662.
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Reem Binsuwaidan, Amal A. Sultan, Walaa A. Negm, Nashwah G. M. Attallah, Moneerah J. Alqahtani, Ismail A. Hussein, Moataz A. Shaldam, Suzy A. El-Sherbeni & Engy Elekhnawy. (2022) Bilosomes as Nanoplatform for Oral Delivery and Modulated In Vivo Antimicrobial Activity of Lycopene. Pharmaceuticals 15:9, pages 1043.
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Milad MansouriBoroujeniBoroujeni, Seyed Mahmoud Barzi, Mahdi Zafari, Mohsen Chiani, Mojtaba Chehrazi, Hamed Nosrati, Mohammad Sadegh Shams Nosrati, Sara Nayyeri, Mohammad Khodaei, Shahin Bonakdar & Morvarid Shafiei. (2022) Electrosprayed cefazolin‐loaded niosomes onto electrospun chitosan nanofibrous membrane for wound healing applications. Journal of Biomedical Materials Research Part B: Applied Biomaterials 110:8, pages 1814-1826.
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Mohamed Nasr, Sameh Saber, Alaa Y. Bazeed, Heba A. Ramadan, Asmaa Ebada, Adela Laura Ciorba, Simona Cavalu & Heba I. Elagamy. (2022) Advantages of Cubosomal Formulation for Gatifloxacin Delivery in the Treatment of Bacterial Keratitis: In Vitro and In Vivo Approach Using Clinical Isolate of Methicillin-Resistant Staphylococcus aureus. Materials 15:9, pages 3374.
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Tohid Piri-Gharaghie, Neda Jegargoshe-Shirin, Sara Saremi-Nouri, Seyed-hossein Khademhosseini, Eskandar Hoseinnezhad-lazarjani, Aezam Mousavi, Hamidreza Kabiri, Negin Rajaei, Anali Riahi, Ali Farhadi-Biregani & Sadegh Fatehi-Ghahfarokhi. (2022) Effects of Imipenem-containing Niosome nanoparticles against high prevalence methicillin-resistant Staphylococcus Epidermidis biofilm formed. Scientific Reports 12:1.
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Engy A. Elekhnawy, Fatma I. Sonbol, Tarek E. Elbanna & Ahmed A. Abdelaziz. (2021) Evaluation of the impact of adaptation of Klebsiella pneumoniae clinical isolates to benzalkonium chloride on biofilm formation. Egyptian Journal of Medical Human Genetics 22:1.
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Noha D. Fayed, Ahmed E. Goda, Ebtesam A. Essa & Gamal M. El Maghraby. (2021) Chitosan-encapsulated niosomes for enhanced oral delivery of atorvastatin. Journal of Drug Delivery Science and Technology 66, pages 102866.
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Arefeh Abolhassani Targhi, Ali Moammeri, Elham Jamshidifar, Koorosh Abbaspour, Somayeh Sadeghi, Lida Lamakani & Iman Akbarzadeh. (2021) Synergistic effect of curcumin-Cu and curcumin-Ag nanoparticle loaded niosome: Enhanced antibacterial and anti-biofilm activities. Bioorganic Chemistry 115, pages 105116.
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Maha A. Khalil, Gamal M. El Maghraby, Fatma I. Sonbol, Nanis G. Allam, Perihan S. Ateya & Sameh S. Ali. (2021) Enhanced Efficacy of Some Antibiotics in Presence of Silver Nanoparticles Against Multidrug Resistant Pseudomonas aeruginosa Recovered From Burn Wound Infections. Frontiers in Microbiology 12.
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Mahla Behyari, Rana Imani & Hamid Keshvari. (2021) Evaluation of Silk Fibroin Nanofibrous Dressing Incorporating Niosomal Propolis, for Potential Use in Wound Healing. Fibers and Polymers 22:8, pages 2090-2101.
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Dalia A. Elmehy, Marwa A. Hasby Saad, Gamal M. El Maghraby, Mona F. Arafa, Nema A. Soliman, Heba H Elkaliny & Dina I. Elgendy. (2021) Niosomal versus nano-crystalline ivermectin against different stages of Trichinella spiralis infection in mice. Parasitology Research 120:7, pages 2641-2658.
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Mojtaba Hedayati Ch, Arefeh Abolhassani Targhi, Farzaneh Shamsi, Fatemeh Heidari, Zahra Salehi Moghadam, Amir Mirzaie, Reyhaneh Behdad, Maryam Moghtaderi & Iman Akbarzadeh. (2020) Niosome‐encapsulated tobramycin reduced antibiotic resistance and enhanced antibacterial activity against multidrug‐resistant clinical strains of Pseudomonas aeruginosa . Journal of Biomedical Materials Research Part A 109:6, pages 966-980.
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Mahdi Zafari, Mahsa Adibi, Mohsen Chiani, Negin Bolourchi, Seyed Mahmoud Barzi, Mohammad Sadegh Shams Nosrati, Zeinab Bahari, Parisa Shirvani, Kambiz Akbari Noghabi, Mojgan Ebadi, Nazanin Rahimirad & Morvarid Shafiei. (2021) Effects of cefazolin-containing niosome nanoparticles against methicillin-resistant Staphylococcus aureus biofilm formed on chronic wounds. Biomedical Materials 16:3, pages 035001.
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Dina E. Bali, Mona F. Arafa, Noha M. Gamaleldin & Gamal M. El Maghraby. (2021) Nanographene oxide for enhanced dissolution rate and antibacterial activity of cefdinir. Journal of Drug Delivery Science and Technology 62, pages 102411.
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Fatemeh Heidari, Iman Akbarzadeh, Dariush Nourouzian, Amir Mirzaie & Haleh Bakhshandeh. (2020) Optimization and characterization of tannic acid loaded niosomes for enhanced antibacterial and anti-biofilm activities. Advanced Powder Technology 31:12, pages 4768-4781.
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Tarek El-Banna, Ahmed Abd El-Aziz, Fatma Sonbol & Engy El-Ekhnawy. (2019) Adaptation of Pseudomonas aeruginosa clinical isolates to benzalkonium chloride retards its growth and enhances biofilm production. Molecular Biology Reports 46:3, pages 3437-3443.
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Hager S. Zoghroban, Samy I. El-Kowrany, Ibrahim A. Aboul Asaad, Gamal M. El Maghraby, Kholoud A. El-Nouby & Mona A. Abd Elazeem. (2018) Niosomes for enhanced activity of praziquantel against Schistosoma mansoni: in vivo and in vitro evaluation. Parasitology Research 118:1, pages 219-234.
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Danford Mhule, Rahul S. Kalhapure, Mahantesh Jadhav, Calvin A. Omolo, Sanjeev Rambharose, Chunderika Mocktar, Sanil Singh, Ayman Y. Waddad, Valence M.K. Ndesendo & Thirumala Govender. (2018) Synthesis of an oleic acid based pH-responsive lipid and its application in nanodelivery of vancomycin. International Journal of Pharmaceutics 550:1-2, pages 149-159.
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Amal A. Sultan, Sanaa A. El-Gizawy, Mohamed A. Osman & Gamal M. El Maghraby. (2017) Peceosomes for oral delivery of glibenclamide: In vitro in situ correlation. Journal of Drug Delivery Science and Technology 41, pages 303-309.
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Rita Muzzalupo, Lourdes Pérez, Aurora Pinazo & Lorena Tavano. (2017) Pharmaceutical versatility of cationic niosomes derived from amino acid-based surfactants: Skin penetration behavior and controlled drug release. International Journal of Pharmaceutics 529:1-2, pages 245-252.
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Haiyue Long, Xiaoling Li, Zitai Sang, Lan Mei, Tao Yang, Zicheng Li, Liangxue Zhou, Yu Zheng, Gu He, Gang Guo, Zhenling Wang, Yong Deng & Youfu Luo. (2017) Improving the pharmacokinetics and tissue distribution of pyrinezolid by self-assembled polymeric micelles. Colloids and Surfaces B: Biointerfaces 156, pages 149-156.
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Faeze Mahdiun, Shahla Mansouri, Payam Khazaeli & Rasoul Mirzaei. (2017) The effect of tobramycin incorporated with bismuth-ethanedithiol loaded on niosomes on the quorum sensing and biofilm formation of Pseudomonas aeruginosa. Microbial Pathogenesis 107, pages 129-135.
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Abbas Pardakhty. 2017. Pharmaceutical Sciences. Pharmaceutical Sciences 154 184 .
Abbas Pardakhty. 2017. Novel Approaches for Drug Delivery. Novel Approaches for Drug Delivery 89 119 .
Amal A Sultan, Sanaa A El-Gizawy, Mohamed A Osman & Gamal M El Maghraby. (2016) Colloidal carriers for extended absorption window of furosemide. Journal of Pharmacy and Pharmacology 68:3, pages 324-332.
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George Dan Mogoşanu, Alexandru Mihai Grumezescu, Ludovic Everard Bejenaru & Cornelia Bejenaru. 2016. Nanobiomaterials in Drug Delivery. Nanobiomaterials in Drug Delivery 229 284 .
Neeru Singh, Saurabh Manaswita Verma, Sandeep Kumar Singh & Priya Ranjan Prasad Verma. (2015) Evidence for bactericidal activities of lipidic nanoemulsions against Pseudomonas aeruginosa. Antonie van Leeuwenhoek 107:6, pages 1555-1568.
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Nawras Osman, Calvin A. Omolo, Nikita Devnarain, Chunderika Mocktar, Sanjeev Rambharose, Usri H. Ibrahim, Victoria O. Fasiku & Thirumala Govender. (2022) Niosomes Modified with a Novel pH-Responsive Coating (mPEG-OA) Enhance the Antibacterial and Anti-Biofilm Activity of Vancomycin Against Methicillin-Resistant <i>Staphylococcus aureus</i>. SSRN Electronic Journal.
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