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Review

Mini-tablets: a contemporary system for oral drug delivery in targeted patient groups

, M Pharm (PhD Student) , , M Pharm PhD (Assistant Professor) , , M Pharm PhD (Professor) & , M Pharm PhD (Professor)

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Maria Siiskonen, Rydvikha Govender, Johan Malmqvist & Staffan Folestad. (2023) Modelling the cost-benefit impact of integrated product modularisation and postponement in the supply chain for pharmaceutical mass customisation. Journal of Engineering Design 34:10, pages 865-896.
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Hanna Kotlowska, Joanna Krotka, Marta Szymanska, Bartlomiej Kubiak, Malgorzata Sznitowska & Buchi N. Nalluri. (2020) The use of novel tools for the assessment of powders and granules flow properties and for the analysis of minitablets compression process. Drug Development and Industrial Pharmacy 46:4, pages 547-556.
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Maja Szczepanska, Piotr Paduszynski, Hanna Kotlowska & Malgorzata Sznitowska. (2020) Optimization of the coating process of minitablets in two different lab-scale fluid bed systems. Drug Development and Industrial Pharmacy 46:1, pages 31-41.
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Ankit Parikh, Krishna Kathawala, Chun Chuan Tan, Sanjay Garg & Xin-Fu Zhou. (2018) Self-nanomicellizing solid dispersion of edaravone: part I – oral bioavailability improvement. Drug Design, Development and Therapy 12, pages 2051-2069.
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Ling Gong, Miao Yu, Yanyan Sun, Ying Gao, Tong An, Meijuan Zou & Gang Cheng. (2018) Design and optimization of gastric floating sustained-release mini-tablets of alfuzosin hydrochloride based on a factorial design: in vitro/in vivo evaluation. Drug Development and Industrial Pharmacy 44:12, pages 1990-1999.
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Lin Liu, WenDong Yao, YueFeng Rao, XiaoYang Lu & JianQing Gao. (2017) pH-Responsive carriers for oral drug delivery: challenges and opportunities of current platforms. Drug Delivery 24:1, pages 569-581.
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Veronika A. Eberle, Armella Häring, Joachim Schoelkopf, Patrick A. C. Gane, Jörg Huwyler & Maxim Puchkov. (2016) In silico and in vitro methods to optimize the performance of experimental gastroretentive floating mini-tablets. Drug Development and Industrial Pharmacy 42:5, pages 808-817.
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Felipe L Lopez, Terry B Ernest, Catherine Tuleu & Mine Orlu Gul. (2015) Formulation approaches to pediatric oral drug delivery: benefits and limitations of current platforms. Expert Opinion on Drug Delivery 12:11, pages 1727-1740.
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Articles from other publishers (60)

Drashti Maniyar, Pramod Kadu & Mirza Ilyas Rahim Baig. (2023) Critical variables affecting the layering method of pelletization. Future Journal of Pharmaceutical Sciences 9:1.
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SUSHMITA SANKESHWARI, GANGADHARAPPA H. V., ASHA SPANDANA K. M., ANU ELIYAS, SHAILESH THIRUMALESHWAR & PYDA VENKATA HARSHA VARDHAN. (2023) A REVIEW ON THE SOLID ORAL DOSAGE FORM FOR PEDIATRICS, REGULATORY ASPECTS, CHALLENGES INVOLVED DURING THE FORMULATION, AND TOXICITY OF THE EXCIPIENTS USED IN PEDIATRIC FORMULATION. International Journal of Applied Pharmaceutics, pages 12-27.
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Shang Jun Loo, Xin Yun Seah, Paul Wan Sia Heng & Lai Wah Chan. (2023) Study of diminutive granules as feed powders for manufacturability of high drug load minitablets. International Journal of Pharmaceutics 638, pages 122922.
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Klervi Golhen, Michael Buettcher, Jonas Kost, Jörg Huwyler & Marc Pfister. (2023) Meeting Challenges of Pediatric Drug Delivery: The Potential of Orally Fast Disintegrating Tablets for Infants and Children. Pharmaceutics 15:4, pages 1033.
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Rauf-ur-Rehman, Muhammad Harris Shoaib, Farrukh Rafiq Ahmed, Rabia Ismail Yousuf, Fahad Siddiqui, Muhammad Talha Saleem, Faaiza Qazi, Momina Zarish Khan, Asma Irshad, Lubna Bashir, Shazia Naz, Muhammad Farooq & Zafar Alam Mahmood. (2023) SeDeM expert system with I-optimal mixture design for oral multiparticulate drug delivery: An encapsulated floating minitablets of loxoprofen Na and its in silico physiologically based pharmacokinetic modeling. Frontiers in Pharmacology 14.
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Deepak Sarangi, Chandra Sekhar Patro, Ch. Niranjan Patra, Gurudutta Pattnaik & Jnyanranjan Panda. (2023) Basic Formulation Semblance and Contemporary Approach of Mini Tablets. International Journal of Pharmaceutical Sciences and Nanotechnology(IJPSN) 16:1, pages 6325-6336.
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Jie Lou, Hongli Duan, Qin Qin, Zhipeng Teng, Fengxu Gan, Xiaofang Zhou & Xing Zhou. (2023) Advances in Oral Drug Delivery Systems: Challenges and Opportunities. Pharmaceutics 15:2, pages 484.
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Liang Chen, Yiqing Lin, Erwin Irdam, Nicole Madden & Frederick Osei-Yeboah. (2022) Improving the Manufacturability of Cohesive and Poorly Compactable API for Direct Compression of Mini-tablets at High Drug Loading via Particle Engineering. Pharmaceutical Research 39:12, pages 3185-3195.
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Smita Salunke, Fiona O'Brien, David Cheng Thiam Tan, David Harris, Marie-Christine Math, Tina Ariën, Sandra Klein & Carsten Timpe. (2022) Oral drug delivery strategies for development of poorly water soluble drugs in paediatric patient population. Advanced Drug Delivery Reviews 190, pages 114507.
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Guluzar Gorkem Buyukgoz, Christopher G. Kossor, Shen Ji, Murat Guvendiren & Rajesh N. Davé. (2022) Dose Titration of Solid Dosage Forms via FDM 3D-Printed Mini-Tablets. Pharmaceutics 14:11, pages 2305.
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Luz Nadiezda Naranjo Gómez, Thomas De Beer & Ashish Kumar. (2022) Finite Element Modeling of Powder Compaction: Mini-Tablets in Comparison with Conventionally Sized Tablets. Pharmaceutical Research 39:9, pages 2109-2118.
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Maja Frankiewicz & Małgorzata Sznitowska. (2022) Design of Experiments as a Tool to Optimize the Process of Coating Minitablets with Commercial Gastro-Resistant Coating Mixtures. Pharmaceutics 14:9, pages 1816.
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Shang Jun Loo, Paul Wan Sia Heng & Lai Wah Chan. (2022) Charge reduction assisted production of diminutive fluid bed granules for high drug load minitablets. International Journal of Pharmaceutics 623, pages 121965.
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Gaia Colombo, Stavros Politis & Alessandra Rossi. 2022. Oral Drug Delivery for Modified Release Formulations. Oral Drug Delivery for Modified Release Formulations 119 136 .
P. Zarmpi & N. Fotaki. 2022. The ADME Encyclopedia. The ADME Encyclopedia 499 503 .
Supratim Das, Sukhbir Kaur & Vineet Kumar Rai. (2021) Gastro-retentive drug delivery systems: a recent update on clinical pertinence and drug delivery. Drug Delivery and Translational Research 11:5, pages 1849-1877.
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Saikishore Meruva, Prajwal Thool, Yuchuan Gong, Anjali Agrawal, Shyam Karki, William Bowen, Biplob Mitra & Sumit Kumar. (2021) A Novel Use of Nanocrystalline Suspensions to Develop Sub-Microgram Dose Micro-Tablets. Journal of Pharmaceutical Sciences 110:9, pages 3276-3288.
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Maria Siiskonen, Johan Malmqvist & Staffan Folestad. (2021) Pharmaceutical Product Modularization as a Mass Customization Strategy to Increase Patient Benefit Cost-Efficiently. Systems 9:3, pages 59.
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Maithri S. Handattu, Shailesh Thirumaleshwar, Gowrav M. Prakash, Hemanth K. Somareddy & Gangadharappa H. Veerabhadrappa. (2021) A Comprehensive Review on Pellets as a Dosage Form in Pharmaceuticals. Current Drug Targets 22:10, pages 1183-1195.
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Cheol-Hee Cho, Ju-Young Kim & Eun-Seok Park. (2021) Utilization of a compaction simulator to formulate mini-tablets containing high dose of acyclovir. Journal of Drug Delivery Science and Technology 64, pages 102602.
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Bret BernerMelanie A. Felmlee & Xiaoling Li. 2021. Drug Delivery Approaches. Drug Delivery Approaches 407 422 .
Magdalena Turk, Rok Šibanc, Rok Dreu, Maja Frankiewicz & Małgorzata Sznitowska. (2021) Assessment of Mini-Tablets Coating Uniformity as a Function of Fluid Bed Coater Inlet Conditions. Pharmaceutics 13:5, pages 746.
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Julius Krause, Laura Müller, Dorota Sarwinska, Anne Seidlitz, Malgorzata Sznitowska & Werner Weitschies. (2021) 3D Printing of Mini Tablets for Pediatric Use. Pharmaceuticals 14:2, pages 143.
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Emma Hellberg, Annica Westberg, Patrik Appelblad & Sofia Mattsson. (2021) Evaluation of dissolution techniques for orally disintegrating mini-tablets. Journal of Drug Delivery Science and Technology 61, pages 102191.
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Nélio Drumond & Sven Stegemann. (2020) Better Medicines for Older Patients: Considerations between Patient Characteristics and Solid Oral Dosage Form Designs to Improve Swallowing Experience. Pharmaceutics 13:1, pages 32.
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Ki Hyun Kim, Minju Jun & Mi-Kyung Lee. (2020) Bioavailability of the Common Cold Medicines in Jellies for Oral Administration. Pharmaceutics 12:11, pages 1073.
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Lisa Freerks, Jana Sommerfeldt, Pia C. Löper & Sandra Klein. (2020) Safe, swallowable and palatable paediatric mini-tablet formulations for a WHO model list of essential medicines for children compound – A promising starting point for future PUMA applications. European Journal of Pharmaceutics and Biopharmaceutics 156, pages 11-19.
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Homare KurashimaShinya Uchida, Yasuharu Kashiwagura, Shimako Tanaka & Noriyuki Namiki. (2020) Evaluation of Weight Variation in Mini-Tablets Manufactured by a Multiple-Tip Tool. Chemical and Pharmaceutical Bulletin 68:10, pages 981-988.
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Fúlvio G. Corazza, Julia V. Ernesto, Felipe A. N. Nambu, Leandro A. Calixto, Gustavo H. C. Varca, Daniel P. Vieira, Vânia R. Leite-Silva, Newton Andréo-Filho & Patricia S. Lopes. (2020) Enhancing the Furosemide Permeability by Papain Minitablets Through a Triple Co-culture In Vitro Intestinal Cell Model. AAPS PharmSciTech 21:7.
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Maria Siiskonen, Johan Malmqvist & Staffan Folestad. (2020) Integrated product and manufacturing system platforms supporting the design of personalized medicines. Journal of Manufacturing Systems 56, pages 281-295.
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Katarzyna Wasilewska, Patrycja Ciosek-Skibińska, Joanna Lenik, Stanko Srčič, Anna Basa & Katarzyna Winnicka. (2020) Utilization of Ethylcellulose Microparticles with Rupatadine Fumarate in Designing Orodispersible Minitablets with Taste Masking Effect. Materials 13:12, pages 2715.
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Xian Sun, Li Wu, Abi Maharjan, Hongyu Sun, Xiaoxiao Hu, Peter York, Huimin Sun, Jiwen Zhang & Xianzhen Yin. (2020) Static and dynamic structural features of single pellets determine the release behaviors of metoprolol succinate sustained-release tablets. European Journal of Pharmaceutical Sciences 149, pages 105324.
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Cheol-Hee Cho, Ju-Young Kim & Eun-Seok Park. (2020) Effects of process parameters of rotary tablet press on die filling behavior during mini-tablet production: Comparison with conventional tablet. Powder Technology 362, pages 90-100.
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Venkat Tumuluri. 2020. Drug Delivery Trends. Drug Delivery Trends 123 139 .
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Muhammad Sohail, Mudassir, Muhammad Usman Minhas, Shahzeb Khan, Zahid Hussain, Marcel de Matas, Syed Ahmed Shah, Samiullah Khan, Mubeen Kousar & Kaleem Ullah. (2018) Natural and synthetic polymer-based smart biomaterials for management of ulcerative colitis: a review of recent developments and future prospects. Drug Delivery and Translational Research 9:2, pages 595-614.
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Hui Ping Goh, Paul Wan Sia Heng & Celine Valeria Liew. (2019) The Effects of Feed Frame Parameters and Turret Speed on Mini-Tablet Compression. Journal of Pharmaceutical Sciences 108:3, pages 1161-1171.
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Jennifer Walsh, Sejal R. Ranmal, Terry B. Ernest & Fang Liu. (2018) Patient acceptability, safety and access: A balancing act for selecting age-appropriate oral dosage forms for paediatric and geriatric populations. International Journal of Pharmaceutics 536:2, pages 547-562.
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Hui Ping Goh, Paul Wan Sia Heng & Celine Valeria Liew. (2017) Understanding die fill variation during mini-tablet production. International Journal of Pharmaceutics 534:1-2, pages 279-286.
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