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Expert Opinion on Drug Delivery Volume 12, 2015 - Issue 8
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Review

Factors to consider when selecting a nebulizer for a new inhaled drug product development program

Mark ElphickRespironics, Inc., a Philips Healthcare Co., 200 Franklin Square Drive, Somerset, 08873 NJ, USA
, BSc,
Dirk von HollenRespironics, Inc., a Philips Healthcare Co., 200 Franklin Square Drive, Somerset, 08873 NJ, USA
, BSc,
John N PritchardRespironics Respiratory Drug Delivery (UK) Ltd, a business of Philips Electronics UK Limited, Chichester Business Park, City Fields Way, Tangmere, Chichester, PO20 2FT, West Sussex, UK+44 870 4231440; [email protected]
, PhD,
Kurt NikanderInDevCo AB, Handbollsvägen 1 B, SE-611 64 Nyköping, Sweden
, BA,
Lucy EA HardakerRespironics Respiratory Drug Delivery (UK) Ltd, a business of Philips Electronics UK Limited, Chichester Business Park, City Fields Way, Tangmere, Chichester, PO20 2FT, West Sussex, UK+44 870 4231440; [email protected]
, BSc &
Ross HM HatleyRespironics Respiratory Drug Delivery (UK) Ltd, a business of Philips Electronics UK Limited, Chichester Business Park, City Fields Way, Tangmere, Chichester, PO20 2FT, West Sussex, UK+44 870 4231440; [email protected]
, PhD
Pages 1375-1387 | Published online: 10 Mar 2015

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Sujit Kumar Debnath, Rohit Srivastava, Monalisha Debnath & Abdelwahab Omri. (2021) Status of inhalable antimicrobial agents for lung infection: progress and prospects. Expert Review of Respiratory Medicine 15:10, pages 1251-1270.
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John N Pritchard. (2015) Industry guidance for the selection of a delivery system for the development of novel respiratory products. Expert Opinion on Drug Delivery 12:11, pages 1755-1765.
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Articles from other publishers (15)

Cong Yi-Jun, Chen Wei-Ya, Wei Jia-Xing, Liu Chun-Yu, Yang Fei-Fei & Liao Yong-Hong. (2022) The pulmonary pharmacokinetics and anti-inflammatory effects after intratracheal and intravenous administration of Chuankezhi injection. Biomedicine & Pharmacotherapy 156, pages 113892.
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Mohammad H. Azhdari, Nima Goodarzi, Mohammad Doroudian & Ronan MacLoughlin. (2022) Molecular Insight into the Therapeutic Effects of Stem Cell-Derived Exosomes in Respiratory Diseases and the Potential for Pulmonary Delivery. International Journal of Molecular Sciences 23:11, pages 6273.
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Hui-Yun Tseng, Hui-Ling LinHan-Sun Chiang. (2022) In Vitro Evaluation of Aerosol Delivery by Hand-Held Mesh Nebulizers in an Adult Spontaneous Breathing Lung Model . Journal of Aerosol Medicine and Pulmonary Drug Delivery 35:2, pages 83-90.
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Sakshi V Khairnar, Divya D Jain, Srushti M Tambe, Yashashri R Chavan & Purnima D Amin. (2022) Nebulizer systems: a new frontier for therapeutics and targeted delivery. Therapeutic Delivery 13:1, pages 31-49.
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S.K. Katiyar, S.N. Gaur, R.N. Solanki, Nikhil Sarangdhar, J.C. Suri, Raj Kumar, G.C. Khilnani, Dhruva Chaudhary, Rupak Singla, Parvaiz A. Koul, Ashok A. Mahashur, A.G. Ghoshal, D. Behera, D.J. Christopher, Deepak Talwar, Dhiman Ganguly, H. Paramesh, K.B. Gupta, Mohan Kumar T, P.D. Motiani, P.S. Shankar, Rajesh Chawla, Randeep Guleria, S.K. Jindal, S.K. Luhadia, V.K. Arora, V.K. Vijayan, Abhishek Faye, Aditya Jindal, Amit K. Murar, Anand Jaiswal, Arunachalam M, A.K. Janmeja, Brijesh Prajapat, C. Ravindran, Debajyoti Bhattacharyya, George D'Souza, Inderpaul Singh Sehgal, J.K. Samaria, Jogesh Sarma, Lalit Singh, M.K. Sen, Mahendra K. Bainara, Mansi Gupta, Nilkanth T. Awad, Narayan Mishra, Naveed N. Shah, Neetu Jain, Prasanta R. Mohapatra, Parul Mrigpuri, Pawan Tiwari, R. Narasimhan, R. Vijai Kumar, Rajendra Prasad, Rajesh Swarnakar, Rakesh K. Chawla, Rohit Kumar, S. Chakrabarti, Sandeep Katiyar, Saurabh Mittal, Sonam Spalgais, Subhadeep Saha, Surya Kant, V.K. Singh, Vijay Hadda, Vikas Kumar, Virendra Singh, Vishal Chopra & Visweswaran B. (2022) Indian Guidelines on Nebulization Therapy. Indian Journal of Tuberculosis 69, pages S1-S191.
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Abigail A. Matthews, Pui Lai Rachel Ee & Ruowen Ge. (2020) Developing inhaled protein therapeutics for lung diseases. Molecular Biomedicine 1:1.
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Holly A. Maulhardt, Alyson M. Marin & Gere S. diZerega. (2020) Intratumoral submicron particle docetaxel inhibits syngeneic Renca renal cancer growth and increases CD4+, CD8+, and Treg levels in peripheral blood. Investigational New Drugs 38:5, pages 1618-1626.
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Moritz Beck-Broichsitter. (2020) Polymer-coated aperture plates for tailored atomization processes. Materials Science and Engineering: C 110, pages 110666.
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Moritz Beck-Broichsitter. (2019) Stability of Polymer Coatings on Nebulizer Membranes During Aerosol Generation. Journal of Pharmaceutical Sciences 108:11, pages 3750-3754.
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Yi Zhang, Brian Chi-Yan Cheng, Cui Li, Yonghua Tao, Chanjuan Yu, Xinyue Liu, Xiaoyan Gao & Gan Luo. (2019) Characterization and comparison of Re-Du-Ning aerosol particles generated by different jet nebulizers . RSC Advances 9:52, pages 30292-30301.
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María De Jesús Valle, Pablo Gil González, Maximiano Prata Ribeiro, André Araujo & Amparo Sánchez Navarro. (2018) Sildenafil Citrate Liposomes for Pulmonary Delivery by Ultrasonic Nebulization. Applied Sciences 8:8, pages 1291.
Crossref
John N Pritchard, Ross HM Hatley, John Denyer & Dirk von Hollen. (2018) Mesh nebulizers have become the first choice for new nebulized pharmaceutical drug developments. Therapeutic Delivery 9:2, pages 121-136.
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Moritz Beck-Broichsitter. (2017) Aerosol Production by Vibrating Membrane Technology: Analysis of the Electrolyte Effect on Generated Droplet Size and Nebulizer Output Rate. Journal of Pharmaceutical Sciences 106:8, pages 2168-2172.
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Moritz Beck-Broichsitter, Olga Samsonova, Juliane Nguyen, Thomas Schmehl, Werner Seeger & Thomas Kissel. (2016) Influence of amine-modified poly(vinyl alcohol)s on vibrating-membrane nebulizer performance and lung toxicity. European Journal of Pharmaceutical Sciences 86, pages 34-40.
Crossref
Mario Cazzola & Paola Rogliani. 2015. Controversies in COPD. Controversies in COPD 213 223 .

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