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Review

Drug nanosuspensions: a ZIP tool between traditional and innovative pharmaceutical formulations

(PhD Student in Material Science and Technology) & (Associated Professor in Pharmaceutical Technology)

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Qing Xia, Jiaqi Shen, Huining Ding, Siyi Liu, Fei Li, Fengqian Li & Nianping Feng. (2023) Intravenous nanocrystals: fabrication, solidification, in vivo fate, and applications for cancer therapy. Expert Opinion on Drug Delivery 0:0, pages 1-22.
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Tingting Meng, Fangxia Qiao, Shijie Ma, Ting Gao, Li Li, Yanhui Hou & Jianhong Yang. (2021) Exploring the influence factors and improvement strategies of drug polymorphic transformation combined kinetic and thermodynamic perspectives during the formation of nanosuspensions. Drug Development and Industrial Pharmacy 47:12, pages 1867-1880.
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Azadeh Haeri, Mahraz Osouli, Fereshteh Bayat, Sonia Alavi & Simin Dadashzadeh. (2018) Nanomedicine approaches for sirolimus delivery: a review of pharmaceutical properties and preclinical studies. Artificial Cells, Nanomedicine, and Biotechnology 46:sup1, pages 1-14.
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David Lembo, Manuela Donalisio, Andrea Civra, Monica Argenziano & Roberta Cavalli. (2018) Nanomedicine formulations for the delivery of antiviral drugs: a promising solution for the treatment of viral infections. Expert Opinion on Drug Delivery 15:1, pages 93-114.
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Linjie Yang, Jingyi Hong, Jing Di, Yifei Guo, Meihua Han, Meifeng Liu & Xiangtao Wang. (2017) 10-Hydroxycamptothecin (HCPT) nanosuspensions stabilized by mPEG1000-HCPT conjugate: high stabilizing efficiency and improved antitumor efficacy. International Journal of Nanomedicine 12, pages 3681-3695.
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Sophia Yui Kau Fong, Annette Bauer-Brandl & Martin Brandl. (2017) Oral bioavailability enhancement through supersaturation: an update and meta-analysis. Expert Opinion on Drug Delivery 14:3, pages 403-426.
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Articles from other publishers (32)

Linda N. Kekani & Bwalya A. Witika. (2023) Current advances in nanodrug delivery systems for malaria prevention and treatment. Discover Nano 18:1.
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Lixue Ma, Zhaohua Li, Jiancheng Fei, Mo Li, Bingyang Liu, Baocheng Tian, Yanhua Liu & Qiang Fu. (2023) In vivo behaviors of meloxicam nanocrystals by intravenous administration are not significantly affected by stabilizers. Journal of Drug Delivery Science and Technology 82, pages 104380.
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Pegah Cheshmehnoor, Noushin Bolourchian, Erfan Abdollahizad, Arash Derakhshi, Simin Dadashzadeh & Azadeh Haeri. (2023) Particle Size Tailoring of Quercetin Nanosuspensions by Wet Media Milling Technique: A Study on Processing and Formulation Parameters. Iranian Journal of Pharmaceutical Research 21:1.
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Pegah Cheshmehnoor, Shahram Rabbani & Azadeh Haeri. (2023) Quercetin nanocrystals prepared by a novel technique improve the dissolution rate and antifibrotic activity of quercetin. Nanomedicine 18:2, pages 89-107.
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Nazish Jabeen, Muhammad Sohail, Syed Ahmed Shah, Arshad Mahmood, Shahzeb Khan, Mehboob ur Rehman Kashif & Touba Khaliq. (2022) Silymarin nanocrystals-laden chondroitin sulphate-based thermoreversible hydrogels; A promising approach for bioavailability enhancement. International Journal of Biological Macromolecules 218, pages 456-472.
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Mahtab Rashed, Simin Dadashzadeh & Noushin Bolourchian. (2022) The Impact of Process and Formulation Parameters on the Fabrication of Efavirenz Nanosuspension to Improve Drug Solubility and Dissolution. Iranian Journal of Pharmaceutical Research 21:1.
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Monica Argenziano, Irfan Aamer Ansari, Elisabetta Muntoni, Rita Spagnolo, Anna Scomparin & Roberta Cavalli. (2022) Lipid-Coated Nanocrystals as a Tool for Improving the Antioxidant Activity of Resveratrol. Antioxidants 11:5, pages 1007.
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Huijuan Chen, Mao Deng, Long Xie, Kai Liu, Xumin Zhang & Xiaofang Li. (2022) Preparation and characterization of quercetin nanosuspensions using gypenosides as novel stabilizers. Journal of Drug Delivery Science and Technology 67, pages 102962.
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Gita Rani & Anu Bala. 2022. Industrial Applications of Nanocrystals. Industrial Applications of Nanocrystals 43 52 .
Lili Ren, Lirong Qiu, Binbin Huang, Jun Yin, Yaning Li, Xiaolong Yang & Guoguang Chen. (2021) Preparation and Characterization of Anti-Cancer Crystal Drugs Based on Erythrocyte Membrane Nanoplatform. Nanomaterials 11:10, pages 2513.
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Jiaying Long, Jiawen Song, Xumin Zhang, Mao Deng, Long Xie, Linlin Zhang & Xiaofang Li. (2020) Tea saponins as natural stabilizers for the production of hesperidin nanosuspensions. International Journal of Pharmaceutics 583, pages 119406.
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Hayley B. Schultz, Tahlia R. Meola, Nicky Thomas & Clive A. Prestidge. (2020) Oral formulation strategies to improve the bioavailability and mitigate the food effect of abiraterone acetate. International Journal of Pharmaceutics 577, pages 119069.
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Xinyue Lu, Xiaoyu Lu, Zhenhai Zhang & Huixia Lv. (2020) Preparation and Characterization of Honokiol Nanosuspensions and Preliminary Evaluation of Anti-Inflammatory Effect. AAPS PharmSciTech 21:2.
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Djordje Medarević, Svetlana Ibrić, Elisavet Vardaka, Miodrag Mitrić, Ioannis Nikolakakis & Kyriakos Kachrimanis. (2020) Insight into the Formation of Glimepiride Nanocrystals by Wet Media Milling. Pharmaceutics 12:1, pages 53.
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Serena Bertoni, Nadia Passerini & Beatrice Albertini. 2020. Nanotechnology for Oral Drug Delivery. Nanotechnology for Oral Drug Delivery 27 76 .
Vikas Pandey & Seema Kohli. 2020. Nanoformulations in Human Health. Nanoformulations in Human Health 13 42 .
Bibhu Prasad Panda, Rachna Krishnamoorthy, Subrat Kumar Bhattamisra, Naveen Kumar Hawala Shivashekaregowda, Low Bin Seng & Sujata Patnaik. (2019) Fabrication of Second Generation Smarter PLGA Based Nanocrystal Carriers for Improvement of Drug Delivery and Therapeutic Efficacy of Gliclazide in Type-2 Diabetes Rat Model. Scientific Reports 9:1.
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Massella, Argenziano, Ferri, Guan, Giraud, Cavalli, Barresi & Salaün. (2019) Bio-Functional Textiles: Combining Pharmaceutical Nanocarriers with Fibrous Materials for Innovative Dermatological Therapies. Pharmaceutics 11:8, pages 403.
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Alfonso Di Costanzo & Ruggero Angelico. (2019) Formulation Strategies for Enhancing the Bioavailability of Silymarin: The State of the Art. Molecules 24:11, pages 2155.
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Satya Sankar Sahoo & Chandu Babu Rao. (2019) Design, Optimization and Evaluation of Lurasidone Hydrochloride Nanocrystals as Fast Disintegrating Tablets. Asian Journal of Organic & Medicinal Chemistry 4:2, pages 121-129.
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D. Massella, A. Ancona, N. Garino, V. Cauda, J. Guan, F. Salaun, A. A. Barresi & A. Ferri. (2018) Preparation of bio-functional textiles by surface functionalization of cellulose fabrics with caffeine loaded nanoparticles.. IOP Conference Series: Materials Science and Engineering 460, pages 012044.
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Abhishek Chandra, Ankita D. Chondkar, Rupesh Shirodkar & Shaila A. Lewis. (2018) Rapidly dissolving lacidipine nanoparticle strips for transbuccal administration. Journal of Drug Delivery Science and Technology 47, pages 259-267.
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Eknath Ahire, Shreya Thakkar, Mahesh Darshanwad & Manju Misra. (2018) Parenteral nanosuspensions: a brief review from solubility enhancement to more novel and specific applications. Acta Pharmaceutica Sinica B 8:5, pages 733-755.
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Tian Zhou, Zhiyi Lin, Pavan Puligujja, Diana Palandri, James Hilaire, Mariluz Araínga, Nathan Smith, Nagsen Gautam, JoEllyn McMillan, Yazen Alnouti, Xinming Liu, Benson Edagwa & Howard E Gendelman. (2018) Optimizing the preparation and stability of decorated antiretroviral drug nanocrystals. Nanomedicine 13:8, pages 871-885.
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Pinar Erkekoglu & Belma Kocer-Gumusel. 2018. Inorganic Frameworks as Smart Nanomedicines. Inorganic Frameworks as Smart Nanomedicines 565 603 .
Monica Argenziano, Chiara Dianzani, Benedetta Ferrara, Shankar Swaminathan, Amedea Manfredi, Elisabetta Ranucci, Roberta Cavalli & Paolo Ferruti. (2017) Cyclodextrin-Based Nanohydrogels Containing Polyamidoamine Units: A New Dexamethasone Delivery System for Inflammatory Diseases. Gels 3:2, pages 22.
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Jing Zhang, Tianqi Wang, Shengjun Mu, Livesey D Olerile, Xiaoyue Yu & Na Zhang. (2017) Biomacromolecule/lipid hybrid nanoparticles for controlled delivery of sorafenib in targeting hepatocellular carcinoma therapy. Nanomedicine 12:8, pages 911-925.
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Lulu Wang, Juan Du, Yuqi Zhou & Yancai Wang. (2017) Safety of nanosuspensions in drug delivery. Nanomedicine: Nanotechnology, Biology and Medicine 13:2, pages 455-469.
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Qiang Fu, Minchao Ma, Mo Li, Guishan Wang, Mengran Guo, Jingru Li, Yanxian Hou & Mingming Fang. (2017) Improvement of oral bioavailability for nisoldipine using nanocrystals. Powder Technology 305, pages 757-763.
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Sunny Shah, Bhavin Parmar, Moinuddin Soniwala & Jayant Chavda. (2015) Design, Optimization, and Evaluation of Lurasidone Hydrochloride Nanocrystals. AAPS PharmSciTech 17:5, pages 1150-1158.
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Sung Min Pyo, Martina Meinke, Anja F. Klein, Tanja C. Fischer & Rainer H. Müller. (2016) A novel concept for the treatment of couperosis based on nanocrystals in combination with solid lipid nanoparticles (SLN). International Journal of Pharmaceutics 510:1, pages 9-16.
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Igor Elkin, Jean-Michel Rabanel & Patrice Hildgen. (2015) Influence of Hydrophobic Dendrimer Core Structure on the Itraconazole Encapsulation Efficiency. Macromolecular Chemistry and Physics 216:24, pages 2356-2367.
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