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Intranasal delivery: circumventing the iron curtain to treat neurological disorders

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Carlotta Marianecci, Federica Rinaldi, Patrizia Nadia Hanieh, Luisa Di Marzio, Donatella Paolino & Maria Carafa. (2017) Drug delivery in overcoming the blood–brain barrier: role of nasal mucosal grafting. Drug Design, Development and Therapy 11, pages 325-335.
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Adryana Clementino, Mellissa Batger, Gabriela Garrastazu, Michele Pozzoli, Elena Del Favero, Valeria Rondelli, Bianca Gutfilen, Thiago Barboza, Maria B Sukkar, Sergio A L Souza, Laura Cantù & Fabio Sonvico. (2016) The nasal delivery of nanoencapsulated statins – an approach for brain delivery. International Journal of Nanomedicine 11, pages 6575-6590.
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Articles from other publishers (31)

Shuyu Zheng, Yuanyuan Guo, Furong Yan, Feng Yan, Ruogu Qi & Jianliang Shen. (2023) Chances and challenges in intranasal administration delivery for brain disease treatment. Clinical and Translational Discovery 3:6.
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Yuxing Liu & Dawei Wu. (2023) Bi‐directional nasal drug delivery systems: A scoping review of nasal particle deposition patterns and clinical application. Laryngoscope Investigative Otolaryngology.
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Shijie Duan, Shuhang Wang, Lei Qiao, Xinbo Yu, Nan Wang, Liting Chen, Xinyuan Zhang, Xu Zhao, Hongyu Liu, Tianye Wang, Ying Wu, Ning Li & Funan Liu. (2023) Oncolytic Virus‐Driven Biotherapies from Bench to Bedside. Small 19:23.
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Farzad Salehpour, Saeed Sadigh-Eteghad, Javad Mahmoudi, Farzin Kamari, Paolo Cassano & Michael Richard HamblinFarzad Salehpour, Saeed Sadigh-Eteghad, Javad Mahmoudi, Farzin Kamari, Paolo Cassano & Michael Richard Hamblin. 2023. Photobiomodulation for the Brain. Photobiomodulation for the Brain 103 136 .
Meenakshi Bose, Gabriela Farias Quipildor, Michelle E. Ehrlich & Stephen R. Salton. (2022) Intranasal Peptide Therapeutics: A Promising Avenue for Overcoming the Challenges of Traditional CNS Drug Development. Cells 11:22, pages 3629.
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Matthew Upcott, Kirill D. Chaprov & Vladimir L. Buchman. (2021) Toward a Disease-Modifying Therapy of Alpha-Synucleinopathies: New Molecules and New Approaches Came into the Limelight. Molecules 26:23, pages 7351.
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Coad Thomas Dow. (2021) Warm, Sweetened Milk at the Twilight of Immunity - Alzheimer’s Disease - Inflammaging, Insulin Resistance, M. paratuberculosis and Immunosenescence. Frontiers in Immunology 12.
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Yunbo Sun, Lina Du, Meiyan Yang, Qi Li, Xueli Jia, Qian Li, Lin Zhu, Yuanyuan Zhang, Yijing Liu & Shuchen Liu. (2021) Brain-targeted drug delivery assisted by physical techniques and its potential applications in traditional Chinese medicine. Journal of Traditional Chinese Medical Sciences 8:3, pages 186-197.
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Svetlana G. Belokoskova, Darya V. Krytskaya, Gleb V. Beznin, Marina N. Karpenko & Sergey G. Tsikunov. (2021) 1-desamino-8-D-arginin-vasopressin, DDAVP, increases the content of brain-derived neurotrophic factor (BDNF) in blood plasma of rats in model of post-traumatic stress disorder. Medical academic journal 20:4, pages 27-34.
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Michael C. Veronesi, Brian D. Graner, Shih-Hsun Cheng, Marta Zamora, Hamideh Zarrinmayeh, Chin-Tu Chen, Sudip K. Das & Michael W. Vannier. (2021) Aerosolized In Vivo 3D Localization of Nose-to-Brain Nanocarrier Delivery Using Multimodality Neuroimaging in a Rat Model—Protocol Development. Pharmaceutics 13:3, pages 391.
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Siqing Zhu, Shouguo Zhang, Lulu Pang, Ge Ou, Lin Zhu, Jinqiu Ma, Ruiteng Li, Yijing Liu, Lin Wang, Lifeng Wang, Lina Du & Yiguang Jin. (2021) Effects of armodafinil nanocrystal nasal hydrogel on recovery of cognitive function in sleep-deprived rats. International Journal of Pharmaceutics 597, pages 120343.
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Huachao Shen, Xiaohuan Gu, Zheng Zachory Wei, Anika Wu, Xinfeng Liu & Ling Wei. (2021) Combinatorial intranasal delivery of bone marrow mesenchymal stem cells and insulin-like growth factor-1 improves neurovascularization and functional outcomes following focal cerebral ischemia in mice. Experimental Neurology 337, pages 113542.
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Hawley Helmbrecht, Andrea Joseph, Michael McKenna, Mengying Zhang & Elizabeth Nance. (2020) Governing transport principles for nanotherapeutic application in the brain. Current Opinion in Chemical Engineering 30, pages 112-119.
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Farzad Salehpour, Sevda Gholipour-Khalili, Fereshteh Farajdokht, Farzin Kamari, Tomasz Walski, Michael R. Hamblin, Joseph O. DiDuro & Paolo Cassano. (2020) Therapeutic potential of intranasal photobiomodulation therapy for neurological and neuropsychiatric disorders: a narrative review. Reviews in the Neurosciences 31:3, pages 269-286.
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Dunia Rassy, Brandon Bárcena, Iván Nicolás Pérez-Osorio, Alejandro Espinosa, Alberto N Peón, Luis I Terrazas, Gabriela Meneses, Hugo O Besedovsky, Gladis Fragoso & Edda Sciutto. (2020) Intranasal Methylprednisolone Effectively Reduces Neuroinflammation in Mice With Experimental Autoimmune Encephalitis. Journal of Neuropathology & Experimental Neurology 79:2, pages 226-237.
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Maksymilian Nowak, Matthew E. Helgeson & Samir Mitragotri. (2019) Delivery of Nanoparticles and Macromolecules across the Blood–Brain Barrier. Advanced Therapeutics 3:1.
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Gabriela Meneses, Graciela Cárdenas, Alejandro Espinosa, Dunia Rassy, Ivan Nicolás Pérez‐Osorio, Brandon Bárcena, Agnes Fleury, Hugo Besedovsky, Gladis Fragoso & Edda Sciutto. (2018) Sepsis: developing new alternatives to reduce neuroinflammation and attenuate brain injury. Annals of the New York Academy of Sciences 1437:1, pages 43-56.
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Christian Alzheimer. (2018) Nasal Spray to the Rescue of Neurons in Stroke. Molecular Therapy 26:10, pages 2333-2334.
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Douglas M. BennionU. Muscha Steckelings & Colin Sumners. (2018) Neuroprotection via AT2 receptor agonists in ischemic stroke. Clinical Science 132:10, pages 1055-1067.
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Quanguo He, Jun Liu, Jing Liang, Xiaopeng Liu, Wen Li, Zhi Liu, Ziyu Ding & Du Tuo. (2018) Towards Improvements for Penetrating the Blood–Brain Barrier—Recent Progress from a Material and Pharmaceutical Perspective. Cells 7:4, pages 24.
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Douglas M. BennionChad H. JonesAlex N. DangJacob IsenbergJustin T. GrahamLena Lindblad, Oliver Domenig, Michael F. WatersMarko Poglitsch, Colin SumnersUlrike Muscha Steckelings. (2018) Protective effects of the angiotensin II AT2 receptor agonist compound 21 in ischemic stroke: a nose-to-brain delivery approach. Clinical Science 132:5, pages 581-593.
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Sehrish Sayed, Nicholas T Van Dam, Sarah R Horn, Marin M Kautz, Michael Parides, Sara Costi, Katherine A Collins, Brian Iacoviello, Dan V Iosifescu, Aleksander A Mathé, Steven M Southwick, Adriana Feder, Dennis S Charney & James W Murrough. (2018) A Randomized Dose-Ranging Study of Neuropeptide Y in Patients with Posttraumatic Stress Disorder. International Journal of Neuropsychopharmacology 21:1, pages 3-11.
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Yelena Y. Grinberg, Lois A. Zitzow & Richard P. Kraig. (2017) Intranasally administered IGF-1 inhibits spreading depression in vivo. Brain Research 1677, pages 47-57.
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Judit Meyer-Kovac, Isa Kolbe, Lea Ehrhardt, Alexei Leliavski, Jana Husse, Gabriela Salinas, Thomas Lingner, Anthony H. Tsang, Johanna L. Barclay & Henrik Oster. (2017) Hepatic gene therapy rescues high-fat diet responses in circadian Clock mutant mice. Molecular Metabolism 6:6, pages 512-523.
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Suzanne Craft, Amy Claxton, Laura D. Baker, Angela J. Hanson, Brenna Cholerton, Emily H. Trittschuh, Deborah Dahl, Erin Caulder, Bryan Neth, Thomas J. Montine, Youngkyoo Jung, Joseph Maldjian, Christopher Whitlow & Seth Friedman. (2017) Effects of Regular and Long-Acting Insulin on Cognition and Alzheimer’s Disease Biomarkers: A Pilot Clinical Trial. Journal of Alzheimer's Disease 57:4, pages 1325-1334.
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Fredrik Clausen, Hans-Arne Hansson, Johan Raud & Niklas Marklund. (2017) Intranasal Administration of the Antisecretory Peptide AF-16 Reduces Edema and Improves Cognitive Function Following Diffuse Traumatic Brain Injury in the Rat. Frontiers in Neurology 8.
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Evgenia Salta & Bart De Strooper. (2017) microRNA‐132: a key noncoding RNA operating in the cellular phase of Alzheimer's disease. The FASEB Journal 31:2, pages 424-433.
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Xiaohui Wang, Li Wang, Yunyun Xu, Qianqian Yu, Lin Li & Yanlin Guo. (2016) Intranasal administration of Exendin-4 antagonizes Aβ31–35-induced disruption of circadian rhythm and impairment of learning and memory. Aging Clinical and Experimental Research 28:6, pages 1259-1266.
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Thomas Chen, Clovis Da Fonseca & Axel Schönthal. (2016) Perillyl Alcohol and Its Drug-Conjugated Derivatives as Potential Novel Methods of Treating Brain Metastases. International Journal of Molecular Sciences 17:9, pages 1463.
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Mahua Dey, Dou Yu, Deepak Kanojia, Gina Li, Madina Sukhanova, Drew A. Spencer, Katatzyna C. Pituch, Lingjiao Zhang, Yu Han, Atique U. Ahmed, Karen S. Aboody, Maciej S. Lesniak & Irina V. Balyasnikova. (2016) Intranasal Oncolytic Virotherapy with CXCR4-Enhanced Stem Cells Extends Survival in Mouse Model of Glioma. Stem Cell Reports 7:3, pages 471-482.
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D S Quintana, A J Guastella, L T Westlye & O A Andreassen. (2015) The promise and pitfalls of intranasally administering psychopharmacological agents for the treatment of psychiatric disorders. Molecular Psychiatry 21:1, pages 29-38.
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