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Oral insulin delivery systems using chitosan-based formulation: a review

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Simin Feng, Liling Wang, Ping Shao, Peilong Sun & Chung S. Yang. (2022) A review on chemical and physical modifications of phytosterols and their influence on bioavailability and safety. Critical Reviews in Food Science and Nutrition 62:20, pages 5638-5657.
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Shiming He, Wenliang Fu, Minji Zou, Weiwei Xing, Zhongcheng Liu & Donggang Xu. (2019) Construction and evaluation of SAK-HV protein oral dosage form based on chitosan quaternary ammonium salt-PLGA microsphere. Journal of Drug Targeting 27:10, pages 1108-1117.
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Shiming He, Zhongcheng Liu & Donggang Xu. (2019) Advance in oral delivery systems for therapeutic protein. Journal of Drug Targeting 27:3, pages 283-291.
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Sahar Gooneh-Farahani, M. Reza Naimi-Jamal & Seyed Morteza Naghib. (2019) Stimuli-responsive graphene-incorporated multifunctional chitosan for drug delivery applications: a review. Expert Opinion on Drug Delivery 16:1, pages 79-99.
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Lily Ellysa Hashim, Akmal Hidayat Sabri, Malihah Athirah Mohamad, Qonita Kurnia Anjani, Mohd Faiz Mustaffa & Khuriah Abdul Hamid. (2024) Circumventing the Gastrointestinal Barrier for Oral Delivery of Therapeutic Proteins and Peptides (PPTS): Current Trends and Future Trajectories. Current Drug Delivery 21:2, pages 211-235.
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Obaid Afzal, Md Rizwanullah, Abdulmalik S.A. Altamimi, Manal A. Alossaimi, Mehnaz Kamal & Javed Ahmad. (2023) Harnessing natural polysaccharides-based nanoparticles for oral delivery of phytochemicals: Knocking down the barriers. Journal of Drug Delivery Science and Technology 82, pages 104368.
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Jingyi XueChristopher BlessoYangchao Luo. (2023) A Comprehensive Review of Nanoparticles for Oral Delivery in Food: Biological Fate, Evaluation Models, and Gut Microbiota Influences. Annual Review of Food Science and Technology 14:1, pages 1-33.
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Ujjawal Rawat, Ambika Choudhary, Piyush Mittal & Anurag Verma. (2023) The hidden obstacles to intranasal insulin delivery: A narrative review. Journal of Diabetology 14:1, pages 14.
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Sadikalmahdi Abdella, Fatima Abid, Souha H. Youssef, Sangseo Kim, Franklin Afinjuomo, Constance Malinga, Yunmei Song & Sanjay Garg. (2023) pH and its applications in targeted drug delivery. Drug Discovery Today 28:1, pages 103414.
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Aijun Qiu, Yunyun Wang, Genlin Zhang & Hebin Wang. (2022) Natural Polysaccharide-Based Nanodrug Delivery Systems for Treatment of Diabetes. Polymers 14:15, pages 3217.
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Eman I. Hassanen, Yasmin A. Ebedy, Marwa A. Ibrahim, Khaled Y. Farroh & M.O. Elshazly. (2022) Insights overview on the possible protective effect of chitosan nanoparticles encapsulation against neurotoxicity induced by carbendazim in rats. NeuroToxicology 91, pages 31-43.
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Gayatri Iyer, Sathish Dyawanapelly, Ratnesh Jain & Prajakta Dandekar. (2022) An overview of oral insulin delivery strategies (OIDS). International Journal of Biological Macromolecules 208, pages 565-585.
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Adel Abdel‐Moneim & Hanaa Ramadan. (2021) Novel strategies to oral delivery of insulin: Current progress of nanocarriers for diabetes management. Drug Development Research 83:2, pages 301-316.
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Maximilian George Dindelegan, Cristina Blebea, Maria Perde-Schrepler, Anca Dana Buzoianu & Alma Aurelia Maniu. (2022) Recent Advances and Future Research Directions for Hearing Loss Treatment Based on Nanoparticles. Journal of Nanomaterials 2022, pages 1-15.
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Rian Harriman & Jamal S. Lewis. (2021) Bioderived materials that disarm the gut mucosal immune system: Potential lessons from commensal microbiota. Acta Biomaterialia 133, pages 187-207.
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Jiang Song, Yanni Zhang, Siew Yin Chan, Zhaoyi Du, Yinjia Yan, Tengjiao Wang, Peng Li & Wei Huang. (2021) Hydrogel-based flexible materials for diabetes diagnosis, treatment, and management. npj Flexible Electronics 5:1.
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Sandra Musu Jusu, John David Obayemi, Ali Azeko Salifu, Chukwudalu Clare Nwazojie, Vanessa Obiageli Uzonwanne, Olushola Segun Odusanya & Winnston Oluwole Soboyejo. (2021) PLGA-CS-PEG Microparticles for Controlled Drug Delivery in the Treatment of Triple Negative Breast Cancer Cells. Applied Sciences 11:15, pages 7112.
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Fatemah Bahman, Khaled Greish & Sebastien Taurin. 2021. Theory and Applications of Nonparenteral Nanomedicines. Theory and Applications of Nonparenteral Nanomedicines 409 443 .
Tong Tong, Liying Wang, Xinru You & Jun Wu. (2020) Nano and microscale delivery platforms for enhanced oral peptide/protein bioavailability. Biomaterials Science 8:21, pages 5804-5823.
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Jeong Un Kim, Hafiz Muhammad Shahbaz, Hyunah Lee, Taehyung Kim, Kyungjik Yang, Young Hoon Roh & Jiyong Park. (2020) Optimization of phytic acid-crosslinked chitosan microspheres for oral insulin delivery using response surface methodology. International Journal of Pharmaceutics 588, pages 119736.
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Xuqian Lang, Ting Wang, Mengjie Sun, Xiguang Chen & Ya Liu. (2020) Advances and applications of chitosan-based nanomaterials as oral delivery carriers: A review. International Journal of Biological Macromolecules 154, pages 433-445.
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Svenja Sladek, Fiona McCartney, Mena Eskander, David J. Dunne, Maria Jose Santos-Martinez, Federico Benetti, Lidia Tajber & David J. Brayden. (2020) An Enteric-Coated Polyelectrolyte Nanocomplex Delivers Insulin in Rat Intestinal Instillations When Combined with a Permeation Enhancer. Pharmaceutics 12:3, pages 259.
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Cíntia Marques, Claudia Som, Mélanie Schmutz, Olga Borges & Gerrit Borchard. (2020) How the Lack of Chitosan Characterization Precludes Implementation of the Safe-by-Design Concept. Frontiers in Bioengineering and Biotechnology 8.
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Sandra Jesus, Ana Patrícia Marques, Alana Duarte, Edna Soares, João Panão Costa, Mariana Colaço, Mélanie Schmutz, Claudia Som, Gerrit Borchard, Peter Wick & Olga Borges. (2020) Chitosan Nanoparticles: Shedding Light on Immunotoxicity and Hemocompatibility. Frontiers in Bioengineering and Biotechnology 8.
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Ana Macedo, Patrícia Filipe, Natália G. Thomé, João Vieira, Carolina Oliveira, Catarina Teodósio, Raquel Ferreira, Luís Roque & Pedro Fonte. (2020) A Brief Overview of the Oral Delivery of Insulin as an Alternative to the Parenteral Delivery. Current Molecular Medicine 20:2, pages 134-143.
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Awanish Kumar, Shraddha Gupta & Dhakshinamoorthy Vasanth. 2020. Advanced Biopolymeric Systems for Drug Delivery. Advanced Biopolymeric Systems for Drug Delivery 183 193 .
Dongdong Yuan, E. Dolores O'Riordan & Jean Christophe Jacquier. (2019) Development of a first order derivative spectrophotometry method to rapidly quantify protein in the presence of chitosan and its application in protein encapsulation systems. Food Chemistry 289, pages 1-6.
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Fatemah Bahman, Khaled Greish & Sebastien Taurin. (2019) Nanotechnology in Insulin Delivery for Management of Diabetes. Pharmaceutical Nanotechnology 7:2, pages 113-128.
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Qiaobin Hu & Yangchao Luo. (2018) Recent advances of polysaccharide-based nanoparticles for oral insulin delivery. International Journal of Biological Macromolecules 120, pages 775-782.
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Thanaa I. Shalaby & Wessam M. El-Refaie. (2018) Bioadhesive Chitosan-Coated Cationic Nanoliposomes With Improved Insulin Encapsulation and Prolonged Oral Hypoglycemic Effect in Diabetic Mice. Journal of Pharmaceutical Sciences 107:8, pages 2136-2143.
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Mokhamad Nur & Todor Vasiljevic. (2017) Can natural polymers assist in delivering insulin orally?. International Journal of Biological Macromolecules 103, pages 889-901.
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Mar Oroval, Paula Díez, Elena Aznar, Carmen Coll, María Dolores Marcos, Félix Sancenón, Reynaldo Villalonga & Ramón Martínez-Máñez. (2017) Self-Regulated Glucose-Sensitive Neoglycoenzyme-Capped Mesoporous Silica Nanoparticles for Insulin Delivery. Chemistry - A European Journal 23:6, pages 1353-1360.
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Daojiang Yu, Shan Li, Shuai Wang, Xiujie Li, Minsheng Zhu, Shai Huang, Li Sun, Yongsheng Zhang, Yanli Liu & Shouli Wang. (2016) Development and Characterization of VEGF165-Chitosan Nanoparticles for the Treatment of Radiation-Induced Skin Injury in Rats. Marine Drugs 14:10, pages 182.
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Jong Hyun Lee, Abhishek Sahu, Won Il Choi, Jae Young Lee & Giyoong Tae. (2016) ZOT-derived peptide and chitosan functionalized nanocarrier for oral delivery of protein drug. Biomaterials 103, pages 160-169.
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Ignacio Insua, Andrew Wilkinson & Francisco Fernandez-Trillo. (2016) Polyion complex (PIC) particles: Preparation and biomedical applications. European Polymer Journal 81, pages 198-215.
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Sruthi Ravindranathan, Bhanu Koppolu, Sean Smith & David Zaharoff. (2016) Effect of Chitosan Properties on Immunoreactivity. Marine Drugs 14:5, pages 91.
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