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Expert Opinion on Drug Delivery Volume 13, 2016 - Issue 7
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Original Research

Development of oral self nano-emulsifying delivery system(s) of lanreotide with improved stability against presystemic thiol-disulfide exchange reactions

Muhammad IjazCenter for Chemistry and Biomedicine, Department of Pharmaceutical Technology, Institute of Pharmacy, University of Innsbruck, Innsbruck, Austria
,
Sonja BonengelCenter for Chemistry and Biomedicine, Department of Pharmaceutical Technology, Institute of Pharmacy, University of Innsbruck, Innsbruck, Austria
,
Ožbej ZupančičCenter for Chemistry and Biomedicine, Department of Pharmaceutical Technology, Institute of Pharmacy, University of Innsbruck, Innsbruck, Austria
,
Muhammad YaqoobCenter for Chemistry and Biomedicine, Department of Pharmaceutical Technology, Institute of Pharmacy, University of Innsbruck, Innsbruck, Austria
,
Markus HartlCenter for Chemistry and Biomedicine, Institute of Biochemistry, University of Innsbruck, Innsbruck, Austria
,
Shah HussainCenter for Chemistry and Biomedicine, Institute of Analytical Chemistry and Radiochemistry, Leopold-Franzens University, Innsbruck, Austria
,
Christian W. HuckCenter for Chemistry and Biomedicine, Institute of Analytical Chemistry and Radiochemistry, Leopold-Franzens University, Innsbruck, Austria
&
Andreas Bernkop-SchnürchCenter for Chemistry and Biomedicine, Department of Pharmaceutical Technology, Institute of Pharmacy, University of Innsbruck, Innsbruck, AustriaCorrespondence[email protected]
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Pages 923-929 | Received 10 Dec 2015, Accepted 14 Mar 2016, Published online: 07 Apr 2016

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Haisheng Peng, Jiahe Wang, Jiayu Chen, Yanbo Peng, Xiaoxian Wang, Ying Chen, David L. Kaplan & Qun Wang. (2023) Challenges and opportunities in delivering oral peptides and proteins. Expert Opinion on Drug Delivery 20:10, pages 1349-1369.
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Jinghan Xin, Mengdi Qin, Genyang Ye, Haonan Gong, Mo Li, Xiaofan Sui, Bingyang Liu, Qiang Fu & Zhonggui He. (2023) Hydrophobic ion pairing-based self-emulsifying drug delivery systems: a new strategy for improving the therapeutic efficacy of water-soluble drugs. Expert Opinion on Drug Delivery 20:1, pages 1-11.
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Ožbej Zupančič, Martin Spoerk & Amrit Paudel. (2022) Lipid-based solubilization technology via hot melt extrusion: promises and challenges. Expert Opinion on Drug Delivery 19:9, pages 1013-1032.
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Chen Jianxian, Kalsoom Saleem, Muhammad Ijaz, Masood Ur-Rehman, Ghulam Murtaza & Mulazim Hussain Asim. (2020) Development and in vitro Evaluation of Gastro-protective Aceclofenac-loaded Self-emulsifying Drug Delivery System. International Journal of Nanomedicine 15, pages 5217-5226.
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Ožbej Zupančič, Julia Rohrer, Hung Thanh Lam, Julia Anita Grießinger & Andreas Bernkop-Schnürch. (2017) Development and in vitro characterization of self-emulsifying drug delivery system (SEDDS) for oral opioid peptide delivery. Drug Development and Industrial Pharmacy 43:10, pages 1694-1702.
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Rosa Maria Paragliola, Alessandro Prete, Giampaolo Papi, Francesco Torino, Andrea Corsello, Alfredo Pontecorvi & Salvatore Maria Corsello. (2016) Clinical utility of lanreotide Autogel® in gastroenteropancreatic neuroendocrine tumors. Drug Design, Development and Therapy 10, pages 3459-3470.
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Ožbej Zupančič, Varun Kushwah & Amrit Paudel. (2023) Pancreatic lipase digestion: The forgotten barrier in oral administration of lipid-based delivery systems?. Journal of Controlled Release 362, pages 381-395.
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Leonie I. Weber & Markus Hartl. (2023) Strategies to target the cancer driver MYC in tumor cells. Frontiers in Oncology 13.
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Staffan Berg, Helena Edlund, William R. F. Goundry, Christel A. S. Bergström & Nigel M. Davies. (2022) Considerations in the developability of peptides for oral administration when formulated together with transient permeation enhancers. International Journal of Pharmaceutics 628, pages 122238.
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Soheil Haddadzadegan, Farid Dorkoosh & Andreas Bernkop-Schnürch. (2022) Oral delivery of therapeutic peptides and proteins: Technology landscape of lipid-based nanocarriers. Advanced Drug Delivery Reviews 182, pages 114097.
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Gyubin Noh, Taekwang Keum, Santosh Bashyal, Jo-Eun Seo, Lamichhane Shrawani, Jeong Hwan Kim & Sangkil Lee. (2021) Recent progress in hydrophobic ion-pairing and lipid-based drug delivery systems for enhanced oral delivery of biopharmaceuticals. Journal of Pharmaceutical Investigation 52:1, pages 75-93.
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Aristote B. Buya, Ana Beloqui, Patrick B. Memvanga & Véronique Préat. (2020) Self-Nano-Emulsifying Drug-Delivery Systems: From the Development to the Current Applications and Challenges in Oral Drug Delivery. Pharmaceutics 12:12, pages 1194.
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Iram Shahzadi, Imran Nazir, Thi Nhu Quynh Phan & Andreas Bernkop-Schnürch. (2020) About the impact of superassociation of hydrophobic ion pairs on membrane permeability. European Journal of Pharmaceutics and Biopharmaceutics 151, pages 1-8.
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Khaled AboulFotouh, Ayat A. Allam & Mahmoud El-Badry. 2020. Current and Future Aspects of Nanomedicine. Current and Future Aspects of Nanomedicine.
Kuldeep Rajpoot, Muktika Tekade, Vikas Pandey, SreeHarsha Nagaraja, Susanne R. Youngren-Ortiz & Rakesh K. Tekade. 2020. Drug Delivery Systems. Drug Delivery Systems 393 454 .
Kurt D. Ristroph & Robert K. Prud'homme. (2019) Hydrophobic ion pairing: encapsulating small molecules, peptides, and proteins into nanocarriers. Nanoscale Advances 1:11, pages 4207-4237.
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Muthanna Abdulkarim, Peeyush Kumar Sharma & Mark Gumbleton. (2019) Self-emulsifying drug delivery system: Mucus permeation and innovative quantification technologies. Advanced Drug Delivery Reviews 142, pages 62-74.
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Arshad Mahmood & Andreas Bernkop-Schnürch. (2019) SEDDS: A game changing approach for the oral administration of hydrophilic macromolecular drugs. Advanced Drug Delivery Reviews 142, pages 91-101.
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Julia Rohrer, Noemi Lupo & Andreas Bernkop-Schnürch. (2018) Advanced formulations for intranasal delivery of biologics. International Journal of Pharmaceutics 553:1-2, pages 8-20.
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Khaled AboulFotouh, Ayat A. Allam, Mahmoud El-Badry & Ahmed M. El-Sayed. (2018) Role of self-emulsifying drug delivery systems in optimizing the oral delivery of hydrophilic macromolecules and reducing interindividual variability. Colloids and Surfaces B: Biointerfaces 167, pages 82-92.
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Hanh Thuy Nguyen, Cao Dai Phung, Raj Kumar Thapa, Tung Thanh Pham, Tuan Hiep Tran, Jee-Heon Jeong, Sae Kwang Ku, Han-Gon Choi, Chul Soon Yong & Jong Oh Kim. (2018) Multifunctional nanoparticles as somatostatin receptor-targeting delivery system of polyaniline and methotrexate for combined chemo–photothermal therapy. Acta Biomaterialia 68, pages 154-167.
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Ožbej Zupančič & Andreas Bernkop-Schnürch. (2017) Lipophilic peptide character – What oral barriers fear the most. Journal of Controlled Release 255, pages 242-257.
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Ožbej Zupančič, Julia Anita Grießinger, Hung Thanh Lam & Andreas Bernkop-Schnürch. (2017) Storage Stability of Bivalirudin: Hydrophilic Versus Lipophilic Solutions. Journal of Pharmaceutical Sciences 106:5, pages 1322-1330.
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Janine Griesser, Gergely Hetényi, Michael Moser, Frédéric Demarne, Vincent Jannin & Andreas Bernkop-Schnürch. (2017) Hydrophobic ion pairing: Key to highly payloaded self-emulsifying peptide drug delivery systems. International Journal of Pharmaceutics 520:1-2, pages 267-274.
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Wongsakorn Suchaoin & Andreas Bernkop-Schnürch. (2017) Nanocarriers protecting toward an intestinal pre-uptake metabolism. Nanomedicine 12:3, pages 255-269.
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