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Review

Perfluorocarbon compounds as vehicles for pulmonary drug delivery

Pages 247-262 | Published online: 09 May 2007

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Charalambos Tsagogiorgas, Friedrich Anger, Grietje Beck, Annette Breedijk, Benito Yard & Simone Hoeger. (2019) Impact of different emulsifiers on biocompatibility and inflammatory potential of Perfluorohexyloctane (F6H8) emulsions for new intravenous drug delivery systems. Drug Design, Development and Therapy 13, pages 2097-2110.
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Rolf Dembinski, Ralf Bensberg, Gernot Marx, Rolf Rossaint, Michael Quintel & Ralf Kuhlen. (2010) Semi-fluorinated alkanes as carriers for drug targeting in acute respiratory failure. Experimental Lung Research 36:8, pages 499-507.
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Hans-Joachim Lehmler. (2008) Anti-inflammatory effects of perfluorocarbon compounds. Expert Review of Respiratory Medicine 2:2, pages 273-289.
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Articles from other publishers (31)

Charalambos Tsagogiorgas & Matthias Otto. (2023) Semifluorinated Alkanes as New Drug Carriers—An Overview of Potential Medical and Clinical Applications. Pharmaceutics 15:4, pages 1211.
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Genrikh A. Sofronov, Elena V. Murzina, Diana Yu. Lazarenko, Lyudmila V. Buryakova & Tat'yana G. Krylova. (2022) The possibility of using perfluorocarbon compounds for virus-associated pneumonia treatment. Bulletin of the Russian Military Medical Academy 24:3, pages 567-580.
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Giulia Kassab, Johan Sebastian Diaz Tovar, Lucas Miguel Pereira Souza, Rayla Kelly Magalhães Costa, Rudielson Santos Silva, André Silva Pimentel, Cristina Kurachi & Vanderlei Salvador Bagnato. (2022) Lung surfactant negatively affects the photodynamic inactivation of bacteria—in vitro and molecular dynamic simulation analyses. Proceedings of the National Academy of Sciences 119:25.
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Travis Kotzur, Samantha Tilden & Emily A. Partridge. (2021) Liquid Ventilation in the Management of Preterm Infants. Current Stem Cell Reports 7:3, pages 121-127.
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Xichun Qin, Yeqing Zhou, Yuzhuo Wang, Ziyao Wang, Yun Wang, Jiali Chen, Lidong Zhu, Xiaoyu Quan, Zhiwei Liu, Hao Zhang, Liqun Jiang, Hongyan Dong & Zhongming Zhang. (2021) Preparation and Characterization of Protein-loaded PFC Nanoemulsions for the Treatment of Heart Diseases by Pulmonary Administration. European Journal of Pharmaceutical Sciences 158, pages 105690.
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Elambalassery G. Jayasree, Chinthu Sukumar & Suseeladevi Asha. (2020) A theoretical insight into the reducing properties of bicyclic dithia hydrocarbons and hetero-bicyclic dithiolopyrrolone compounds with rotation-restricted planar disulfide linkage. Structural Chemistry 32:1, pages 107-113.
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Ryan D. Larochelle, Ryan A. Shields, Benjamin P. Erickson & A. Ruwan Silva. (2020) Periorbital Subcutaneous Perfluoron Is Well Tolerated Following Intravitreal Surgery. Journal of VitreoRetinal Diseases 4:4, pages 337-339.
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Pascal Detampel, Anutosh Ganguly, Sara Tehranian, Francis Green, Santiswarup Singha, Pere Santamaria, Ayodeji A. Jeje, Clifford S. Cho, Björn Petri & Matthias W. Amrein. (2019) In vivo clearance of nanoparticles by transcytosis across alveolar epithelial cells. PLOS ONE 14:9, pages e0223339.
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K. A. Volianiuk, O. L. Paiuk, N. Ye. Mitina, A. S. Zaichenko & N. I. Kinash. (2019) LUMINESCENT OLIGONUCLEOTIDE CONTAINING BLOCK-COPOLYMERS AS MARKERS OF BACTERIA AND CELLS BASED ON TELECHELATIC POLY (N-VINYLPYRROLIDONE) WITH THE TERMINAL EPOXY AND FLUOROALKYL FRAGMENT. Chemistry, Technology and Application of Substances 2:1, pages 166-172.
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K. Sykłowska-Baranek, W. Rymaszewski, M. Gaweł, P. Rokicki, M. Pilarek, M. Grech-Baran, J. Hennig & A. Pietrosiuk. (2018) Comparison of elicitor-based effects on metabolic responses of Taxus × media hairy roots in perfluorodecalin-supported two-phase culture system. Plant Cell Reports 38:1, pages 85-99.
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Martyna Horochowska, Katarzyna Cieślik-Boczula & Maria Rospenk. (2018) Ethanol- and trifluoroethanol-induced changes in phase states of DPPC membranes. Prodan emission-excitation fluorescence spectroscopy supported by PARAFAC analysis. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 192, pages 16-22.
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Chen Zhang, Kangqiang Qiu, Chaofeng Liu, Huaiyi Huang, Thomas W. Rees, Liangnian Ji, Qianling Zhang & Hui Chao. (2018) Tracking mitochondrial dynamics during apoptosis with phosphorescent fluorinated iridium( iii ) complexes . Dalton Transactions 47:37, pages 12907-12913.
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M. Skrzypiec, G.As. Georgiev, M. Rojewska & K. Prochaska. (2017) Interaction of polyhedral oligomeric silsesquioxanes and dipalmitoylphosphatidylcholine at the air/water interface: Thermodynamic and rheological study. Biochimica et Biophysica Acta (BBA) - Biomembranes 1859:10, pages 1838-1850.
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Ting Wu, Longhai Wang, Shenggang Ding & Yezi You. (2017) Fluorinated PEG-Polypeptide Polyplex Micelles Have Good Serum-Resistance and Low Cytotoxicity for Gene Delivery. Macromolecular Bioscience 17:8, pages 1700114.
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Charalambos Tsagogiorgas, Sonja Theisinger, Elisabeth Heesch, Jörg Krebs, René Holm, Grietje Beck & Benito Yard. (2015) Evaluation of pharmacokinetic properties and anaesthetic effects of propofol in a new perfluorohexyloctane (F6H8) emulsion in rats – A comparative study. International Journal of Pharmaceutics 486:1-2, pages 69-76.
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K. Sykłowska-Baranek, M. Pilarek, M. Bonfill, K. Kafel & A. Pietrosiuk. (2014) Perfluorodecalin-supported system enhances taxane production in hairy root cultures of Taxus x media var. Hicksii carrying a taxadiene synthase transgene. Plant Cell, Tissue and Organ Culture (PCTOC) 120:3, pages 1051-1059.
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Olivier Humblet, Ledif Grisell Diaz-Ramirez, John R. Balmes, Susan M. Pinney & Robert A. Hiatt. (2014) Perfluoroalkyl Chemicals and Asthma among Children 12–19 Years of Age: NHANES (1999–2008). Environmental Health Perspectives 122:10, pages 1129-1133.
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Phuc Nghia Nguyen, Mariam Veschgini, Motomu Tanaka, Gilles Waton, Thierry Vandamme & Marie Pierre Krafft. (2014) Counteracting the inhibitory effect of proteins towards lung surfactant substitutes: a fluorocarbon gas helps displace albumin at the air/water interface. Chem. Commun. 50:78, pages 11576-11579.
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Mei-Jy Jeng, Wen-Jue Soong, Shr-Yun Chiou, Yu-Tse Wu, Tung-Hu Tsai, Chia-Chun Lin, Chia-Feng Yang, Pei-Chen Tsao & Yu-Sheng Lee. (2012) Efficacy of intratracheal instillation of a meropenem/perfluorochemical suspension in acute lung injury. Pediatric Pulmonology 47:2, pages 189-198.
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Massimo Cametti, Benoit Crousse, Pierangelo Metrangolo, Roberto Milani & Giuseppe Resnati. (2012) The fluorous effect in biomolecular applications. Chem. Soc. Rev. 41:1, pages 31-42.
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C. Tsagogiorgas, T. Jung, J. Krebs, B. Theisinger, G. Beck, B.A. Yard & M. Quintel. (2012) Aerosolized semifluorinated alkanes as excipients are suitable for inhalative drug delivery—A pilot study. International Journal of Pharmaceutics 422:1-2, pages 194-201.
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Pieter Hindryckx, Lindsey Devisscher, Debby Laukens, Koen Venken, Harald Peeters & Martine De Vos. (2011) Intrarectal administration of oxygenated perfluorodecalin promotes healing of murine colitis by targeting inflammatory hypoxia. Laboratory Investigation 91:9, pages 1266-1276.
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Maria Carmelita Z. Kasuya, Shinya Nakano, Ruriko Katayama & Kenichi Hatanaka. (2011) Evaluation of the hydrophobicity of perfluoroalkyl chains in amphiphilic compounds that are incorporated into cell membrane. Journal of Fluorine Chemistry 132:3, pages 202-206.
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C. Tsagogiorgas, J. Krebs, M. Pukelsheim, G. Beck, B. Yard, B. Theisinger, M. Quintel & T. Luecke. (2010) Semifluorinated alkanes – A new class of excipients suitable for pulmonary drug delivery. European Journal of Pharmaceutics and Biopharmaceutics 76:1, pages 75-82.
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Vivian Ojogun, Barbara L. Knutson, Sandhya Vyas & Hans-Joachim Lehmler. (2010) Fluorophilicity of alkyl and polyfluoroalkyl nicotinic acid ester prodrugs. Journal of Fluorine Chemistry 131:7, pages 784-790.
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Vivian Ojogun, Sandhya M. Vyas, Hans-Joachim Lehmler & Barbara L. Knutson. (2010) Partitioning of homologous nicotinic acid ester prodrugs (nicotinates) into dipalmitoylphosphatidylcholine (DPPC) membrane bilayers. Colloids and Surfaces B: Biointerfaces 78:1, pages 75-84.
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Nu Xiao & Y. Bruce Yu. (2010) Separation of fluorinated amino acids and oligopeptides from their non-fluorinated counterparts using high-performance liquid chromatography. Journal of Fluorine Chemistry 131:3, pages 439-445.
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Xueshu Li, Jaroslav Turánek, Pavlína Knötigová, Hana Kudláčková, Josef Mašek, Sean Parkin, Stephen E. Rankin, Barbara L. Knutson & Hans-Joachim Lehmler. (2009) Hydrophobic tail length, degree of fluorination and headgroup stereochemistry are determinants of the biocompatibility of (fluorinated) carbohydrate surfactants. Colloids and Surfaces B: Biointerfaces 73:1, pages 65-74.
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Jean G. Riess. (2009) Highly fluorinated amphiphilic molecules and self-assemblies with biomedical potential. Current Opinion in Colloid & Interface Science 14:5, pages 294-304.
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Berenice Venegas, Marla R. Wolfson, Peter H. Cooke & Parkson Lee-Gau Chong. (2008) High Vapor Pressure Perfluorocarbons Cause Vesicle Fusion and Changes in Membrane Packing. Biophysical Journal 95:10, pages 4737-4747.
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Xueshu Li, Jaroslav Turánek, Pavlína Knötigová, Hana Kudláčková, Josef Mašek, D. Brant Pennington, Stephen E. Rankin, Barbara L. Knutson & Hans-Joachim Lehmler. (2008) Synthesis and biocompatibility evaluation of fluorinated, single-tailed glucopyranoside surfactants. New Journal of Chemistry 32:12, pages 2169.
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