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Review

Allosteric P450 mechanisms: multiple binding sites, multiple conformers or both?

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Pages 1523-1535 | Published online: 28 Nov 2008

Keep up to date with the latest research on this topic with citation updates for this article.

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Robert Valencia, Wesam Bassiouni, Ahmed M. Darwesh, Raj Bapuji & John M. Seubert. (2022) Cardiomyocyte-specific CYP2J2 and its therapeutic implications. Expert Opinion on Drug Metabolism & Toxicology 18:7-8, pages 423-439.
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Junmei Chen, Jinman Liu, Yueyue Huang, Ruoyu Li, Cuiru Ma, Beiping Zhang, Fanchang Wu, Wenqian Yu, Xue Zuo, Yong Liang & Qi Wang. (2021) Insights into oral bioavailability enhancement of therapeutic herbal constituents by cytochrome P450 3A inhibition. Drug Metabolism Reviews 53:4, pages 491-507.
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Bikash Dangi, Nadezhda Y. Davydova, Nikita E. Vavilov, Victor G. Zgoda & Dmitri R. Davydov. (2020) Nonadditivity in human microsomal drug metabolism revealed in a study with coumarin 152, a polyspecific cytochrome P450 substrate. Xenobiotica 50:12, pages 1393-1405.
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Pramod C. Nair, Ross A. McKinnon & John O. Miners. (2016) Cytochrome P450 structure–function: insights from molecular dynamics simulations. Drug Metabolism Reviews 48:3, pages 434-452.
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Tewes Tralau & Andreas Luch. (2013) The evolution of our understanding of endo-xenobiotic crosstalk and cytochrome P450 regulation and the therapeutic implications. Expert Opinion on Drug Metabolism & Toxicology 9:12, pages 1541-1554.
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Dong Dong, Baojian Wu, Diana Chow & Ming Hu. (2012) Substrate selectivity of drug-metabolizing cytochrome P450s predicted from crystal structures and in silico modeling. Drug Metabolism Reviews 44:2, pages 192-208.
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Violeta I Pérez-Nueno & David W Ritchie. (2012) Identifying and characterizing promiscuous targets: Implications for virtual screening. Expert Opinion on Drug Discovery 7:1, pages 1-17.
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Baojian Wu. (2011) Substrate inhibition kinetics in drug metabolism reactions. Drug Metabolism Reviews 43:4, pages 440-456.
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Dmitri R Davydov. (2011) Microsomal monooxygenase as a multienzyme system: the role of P450-P450 interactions. Expert Opinion on Drug Metabolism & Toxicology 7:5, pages 543-558.
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Harshica Fernando, Jessica A. O. Rumfeldt, Nadezhda Y. Davydova, James R. Halpert & Dmitri R. Davydov. (2011) Multiple substrate-binding sites are retained in cytochrome P450 3A4 mutants with decreased cooperativity. Xenobiotica 41:4, pages 281-289.
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Santosh Kumar. (2010) Engineering cytochrome P450 biocatalysts for biotechnology, medicine and bioremediation. Expert Opinion on Drug Metabolism & Toxicology 6:2, pages 115-131.
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