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Jianxin Yang, Xue Bai, Guiqin Liu & Xiangyang Li. (2022) A transcriptional regulatory network of HNF4α and HNF1α involved in human diseases and drug metabolism. Drug Metabolism Reviews 54:4, pages 361-385.
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Frida Fart, Samira Salihović, Aidan McGlinchey, Melanie G. Gareau, Matej Orešič, Jonas Halfvarson, Tuulia Hyötyläinen & Ida Schoultz. (2021) Perfluoroalkyl substances are increased in patients with late-onset ulcerative colitis and induce intestinal barrier defects ex vivo in murine intestinal tissue. Scandinavian Journal of Gastroenterology 56:11, pages 1286-1295.
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Zhi-Xu He, Xiao-Wu Chen, Zhi-Wei Zhou & Shu-Feng Zhou. (2015) Impact of physiological, pathological and environmental factors on the expression and activity of human cytochrome P450 2D6 and implications in precision medicine. Drug Metabolism Reviews 47:4, pages 470-519.
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Bret D. Wallace & Matthew R. Redinbo. (2013) Xenobiotic-sensing nuclear receptors involved in drug metabolism: a structural perspective. Drug Metabolism Reviews 45:1, pages 79-100.
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Ai-Ming Yu. (2009) Role of microRNAs in the regulation of drug metabolism and disposition. Expert Opinion on Drug Metabolism & Toxicology 5:12, pages 1513-1528.
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Alberto Ruiz, Ignasi Sanahuja, Karl B. Andree, Dolors Furones, Paul G. Holhorea, Josep A. Calduch-Giner, Jose J. Pastor, Marc Viñas, Jaume Pérez-Sánchez, Sofia Morais & Enric Gisbert. (2024) Supplementation of gilthead seabream (Sparus aurata) diets with spices as a functional strategy to control excess adiposity through lipid, cholesterol and bile acid metabolism, and to induce an immunomodulatory intestinal regulation. Aquaculture 581, pages 740378.
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Rilu Feng, Chenhao Tong, Tao Lin, Hui Liu, Chen Shao, Yujia Li, Carsten Sticht, Kejia Kan, Xiaofeng Li, Rui Liu, Sai Wang, Shanshan Wang, Stefan Munker, Hanno Niess, Christoph Meyer, Roman Liebe, Matthias P. Ebert, Steven Dooley, Hua Wang, Huiguo Ding & Hong-Lei Weng. (2023) Insulin Determines Transforming Growth Factor β Effects on Hepatocyte Nuclear Factor 4α Transcription in Hepatocytes. The American Journal of Pathology.
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Marta Alonso-Peña, Ricardo Espinosa-Escudero, Heike M. Hermanns, Oscar Briz, Jose M. Herranz, Carmen Garcia-Ruiz, Jose C. Fernandez-Checa, Javier Juamperez, Matias Avila, Josepmaria Argemi, Ramon Bataller, Javier Crespo, Maria J. Monte, Andreas Geier, Elisa Herraez & Jose J. G. Marin. (2022) Impact of Liver Inflammation on Bile Acid Side Chain Shortening and Amidation. Cells 11:24, pages 3983.
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Crossref
Zongmei Zheng, Jiao Wei, Xinxin Hou, Fengjing Jia, Zhaozhou Zhang, Haidong Guo, Fuwen Yuan, Feng He, Zunji Ke, Yan Wang & Ling Zhao. (2022) A High Hepatic Uptake of Conjugated Bile Acids Promotes Colorectal Cancer—Associated Liver Metastasis. Cells 11:23, pages 3810.
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Ya Zhao, Jinqiu Wang, Lijuan Liu, Yayun Wu, Qiaohong Hu & Ruizhi Zhao. (2022) Vinegar-baked Radix Bupleuri enhances the liver-targeting effect of rhein on liver injury rats by regulating transporters. Journal of Pharmacy and Pharmacology 74:11, pages 1588-1597.
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Tsukasa Kobayashi, Yuko Takeba, Yuki Ohta, Masanori Ootaki, Keisuke Kida, Minoru Watanabe, Taroh Iiri & Naoki Matsumoto. (2022)
Prenatal glucocorticoid administration enhances bilirubin metabolic capacity and increases
Ugt1a
and
Abcc2
gene expression via glucocorticoid receptor and PXR in rat fetal liver
. Journal of Obstetrics and Gynaecology Research 48:7, pages 1591-1606.
Crossref
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Yulia Shulpekova, Elena Shirokova, Maria Zharkova, Pyotr Tkachenko, Igor Tikhonov, Alexander Stepanov, Alexandra Sinitsyna, Alexander Izotov, Tatyana Butkova, Nadezhda Shulpekova, Vladimir Nechaev, Igor Damulin, Alexey Okhlobystin & Vladimir Ivashkin. (2022) A Recent Ten-Year Perspective: Bile Acid Metabolism and Signaling. Molecules 27:6, pages 1983.
Crossref
Crossref
Tao Lin, Shanshan Wang, Stefan Munker, Kyounghwa Jung, Ricardo U. Macías‐Rodríguez, Astrid Ruiz‐Margáin, Robert Schierwagen, Hui Liu, Chen Shao, Chunlei Fan, Rilu Feng, Xiaodong Yuan, Sai Wang, Franziska Wandrer, Christoph Meyer, Ralf Wimmer, Roman Liebe, Jens Kroll, Long Zhang, Tobias Schiergens, Peter ten Dijke, Andreas Teufel, Alexander Marx, Peter R. Mertens, Hua Wang, Matthias P.A. Ebert, Heike Bantel, Enrico N. De Toni, Jonel Trebicka, Steven Dooley, Donghun Shin, Huiguo Ding & Hong‐Lei Weng. (2021) Follistatin‐controlled activin‐HNF4α‐coagulation factor axis in liver progenitor cells determines outcome of acute liver failure. Hepatology 75:2, pages 322-337.
Crossref
Crossref
María Gárate‐Rascón, Miriam Recalde, Maddalen Jimenez, María Elizalde, María Azkona, Iker Uriarte, M. Uxue Latasa, Raquel Urtasun, Idoia Bilbao, Bruno Sangro, Carmen Garcia‐Ruiz, José C. Fernandez‐Checa, Fernando J Corrales, Argitxu Esquivel, Antonio Pineda‐Lucena, Maite G. Fernández‐Barrena, Matías A. Ávila, María Arechederra & Carmen Berasain. (2021) Splicing Factor SLU7 Prevents Oxidative Stress‐Mediated Hepatocyte Nuclear Factor 4α Degradation, Preserving Hepatic Differentiation and Protecting From Liver Damage. Hepatology 74:5, pages 2791-2807.
Crossref
Crossref
Amal Essaouiba, Teru Okitsu, Rie Kinoshita, Rachid Jellali, Marie Shinohara, Mathieu Danoy, Cécile Legallais, Yasuyuki Sakai & Eric Leclerc. (2020) Development of a pancreas-liver organ-on-chip coculture model for organ-to-organ interaction studies. Biochemical Engineering Journal 164, pages 107783.
Crossref
Crossref
So-Young Choi, Tae Hyun Kim, Min-Wook Hong, Tae Sub Park, Hyojeong Lee & Sung-Jin Lee. (2020) Transcriptomic alterations induced by aflatoxin B1 and ochratoxin A in LMH cell line. Poultry Science 99:11, pages 5265-5274.
Crossref
Crossref
Liming Chen, Yifan Bao, Suzhen Jiang & Xiao-bo Zhong. (2020) The Roles of Long Noncoding RNAs HNF1α-AS1 and HNF4α-AS1 in Drug Metabolism and Human Diseases. Non-Coding RNA 6:2, pages 24.
Crossref
Crossref
Anne-Cathrin Behr, Anna Kwiatkowski, Marcus Ståhlman, Felix Florian Schmidt, Claudia Luckert, Albert Braeuning & Thorsten Buhrke. (2020) Impairment of bile acid metabolism by perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS) in human HepaRG hepatoma cells. Archives of Toxicology 94:5, pages 1673-1686.
Crossref
Crossref
Jennifer Bolleyn, Matthias Rombaut, Nisha Nair, Steven Branson, Anja Heymans, Marinee Chuah, Thierry VandenDriessche, Vera Rogiers, Joery De Kock & Tamara Vanhaecke. (2020) Genetic and Epigenetic Modification of Rat Liver Progenitor Cells via HNF4α Transduction and 5’ Azacytidine Treatment: An Integrated miRNA and mRNA Expression Profile Analysis. Genes 11:5, pages 486.
Crossref
Crossref
Anca D. Petrescu, Jessica Kain, Victoria Liere, Trace Heavener & Sharon DeMorrow. (2018) Hypothalamus-Pituitary-Adrenal Dysfunction in Cholestatic Liver Disease. Frontiers in Endocrinology 9.
Crossref
Crossref
Marwa Zahra, Hassan Azzazy & Ahmed Moustafa. (2018) Transcriptional Regulatory Networks in Hepatitis C Virus-induced Hepatocellular Carcinoma. Scientific Reports 8:1.
Crossref
Crossref
Yuanyuan Zhang, Jonathan P. Jackson, Robert L. St. ClaireIIIIII, Kimberly Freeman, Kenneth R. Brouwer & Jeffrey E. Edwards. (2017) Obeticholic acid, a selective farnesoid X receptor agonist, regulates bile acid homeostasis in sandwich-cultured human hepatocytes. Pharmacology Research & Perspectives 5:4, pages e00329.
Crossref
Crossref
Ramani Gopal, Karthikeyan Selvarasu, Ponmathi Panneer Pandian & Kumaresan Ganesan. (2017) Integrative transcriptome analysis of liver cancer profiles identifies upstream regulators and clinical significance of ACSM3 gene expression. Cellular Oncology 40:3, pages 219-233.
Crossref
Crossref
David Q.-H. Wang, Brent A. Neuschwander-Tetri & Piero Portincasa. (2016) The Biliary System, Second Edition. Colloquium Series on Integrated Systems Physiology: From Molecule to Function 8:5, pages i-178.
Crossref
Crossref
Frank J. Gonzalez, Changtao Jiang & Andrew D. Patterson. (2016) An Intestinal Microbiota–Farnesoid X Receptor Axis Modulates Metabolic Disease. Gastroenterology 151:5, pages 845-859.
Crossref
Crossref
Kayoung Lee, Grace Ying Shyen Goh, Marcus Andrew Wong, Tara Leah Klassen & Stefan Taubert. (2016) Gain-of-Function Alleles in Caenorhabditis elegans Nuclear Hormone Receptor nhr-49 Are Functionally Distinct. PLOS ONE 11:9, pages e0162708.
Crossref
Crossref
Martin Krøyer Rasmussen, Peter Kappel Theil & Niels Oksbjerg. (2016) Constitutive expression of cytochrome P450 in foetal and adult porcine livers—Effects of body weight. Toxicology Letters 258, pages 87-92.
Crossref
Crossref
Julia Yue Cui & Curtis D. Klaassen. (2016) RNA-Seq reveals common and unique PXR- and CAR-target gene signatures in the mouse liver transcriptome. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1859:9, pages 1198-1217.
Crossref
Crossref
Hong Lu. (2016) Crosstalk of HNF4 α with extracellular and intracellular signaling pathways in the regulation of hepatic metabolism of drugs and lipids. Acta Pharmaceutica Sinica B 6:5, pages 393-408.
Crossref
Crossref
Yongfeng Song, Chao Xu, Shanshan Shao, Jun Liu, Wanjia Xing, Jin Xu, Chengkun Qin, Chunyou Li, Baoxiang Hu, Shounan Yi, Xuefeng Xia, Haiqing Zhang, Xiujuan Zhang, Tingting Wang, Wenfei Pan, Chunxiao Yu, Qiangxiu Wang, Xiaoyan Lin, Laicheng Wang, Ling Gao & Jiajun Zhao. (2015) Thyroid-stimulating hormone regulates hepatic bile acid homeostasis via SREBP-2/HNF-4α/CYP7A1 axis. Journal of Hepatology 62:5, pages 1171-1179.
Crossref
Crossref
Joana Torres, Silvio Danese & Jean-Frédéric Colombel. (2013) New therapeutic avenues in ulcerative colitis: thinking out of the box. Gut 62:11, pages 1642-1652.
Crossref
Crossref
Patricio Godoy, Nicola J. Hewitt, Ute Albrecht, Melvin E. Andersen, Nariman Ansari, Sudin Bhattacharya, Johannes Georg Bode, Jennifer Bolleyn, Christoph Borner, Jan Böttger, Albert Braeuning, Robert A. Budinsky, Britta Burkhardt, Neil R. Cameron, Giovanni Camussi, Chong-Su Cho, Yun-Jaie Choi, J. Craig Rowlands, Uta Dahmen, Georg Damm, Olaf Dirsch, María Teresa Donato, Jian Dong, Steven Dooley, Dirk Drasdo, Rowena Eakins, Karine Sá Ferreira, Valentina Fonsato, Joanna Fraczek, Rolf Gebhardt, Andrew Gibson, Matthias Glanemann, Chris E. P. Goldring, María José Gómez-Lechón, Geny M. M. Groothuis, Lena Gustavsson, Christelle Guyot, David Hallifax, Seddik Hammad, Adam Hayward, Dieter Häussinger, Claus Hellerbrand, Philip Hewitt, Stefan Hoehme, Hermann-Georg Holzhütter, J. Brian Houston, Jens Hrach, Kiyomi Ito, Hartmut Jaeschke, Verena Keitel, Jens M. Kelm, B. Kevin Park, Claus Kordes, Gerd A. Kullak-Ublick, Edward L. LeCluyse, Peng Lu, Jennifer Luebke-Wheeler, Anna Lutz, Daniel J. Maltman, Madlen Matz-Soja, Patrick McMullen, Irmgard Merfort, Simon Messner, Christoph Meyer, Jessica Mwinyi, Dean J. Naisbitt, Andreas K. Nussler, Peter Olinga, Francesco Pampaloni, Jingbo Pi, Linda Pluta, Stefan A. Przyborski, Anup Ramachandran, Vera Rogiers, Cliff Rowe, Celine Schelcher, Kathrin Schmich, Michael Schwarz, Bijay Singh, Ernst H. K. Stelzer, Bruno Stieger, Regina Stöber, Yuichi Sugiyama, Ciro Tetta, Wolfgang E. Thasler, Tamara Vanhaecke, Mathieu Vinken, Thomas S. Weiss, Agata Widera, Courtney G. Woods, Jinghai James Xu, Kathy M. Yarborough & Jan G. Hengstler. (2013) Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. Archives of Toxicology 87:8, pages 1315-1530.
Crossref
Crossref
Frank J. Gonzalez. 2011. Comprehensive Physiology. Comprehensive Physiology
2811
2828
.
David Q.-H. Wang, Brent A. Neuschwander-Tetri & Piero Portincasa. (2012) The Biliary System. Colloquium Series on Integrated Systems Physiology: From Molecule to Function 4:2, pages 1-148.
Crossref
Crossref
Aneta Novotna, Aneta Doricakova, Radim Vrzal, Petr Pavek & Zdenek Dvorak. (2011) Construction and characterization of hepatocyte nuclear factor HNF4alpha1 over-expressing cell line derived from human hepatoma HepG2 cells. European Journal of Pharmacology 669:1-3, pages 45-50.
Crossref
Crossref
Yoon Mee Yang, Kyoung Noh, Chang Yeob Han & Sang Geon Kim. (2010) Transactivation of Genes Encoding for Phase II Enzymes and Phase III Transporters by Phytochemical Antioxidants. Molecules 15:9, pages 6332-6348.
Crossref
Crossref
Yu-Kun Jennifer Zhang, Kurt W. Saupe & Curtis D. Klaassen. (2010) Energy Restriction Does Not Compensate for the Reduced Expression of Hepatic Drug-Processing Genes in Mice with Aging. Drug Metabolism and Disposition 38:7, pages 1122-1131.
Crossref
Crossref
Shuxin Han, Tiangang Li, Ewa Ellis, Stephen Strom & John Y. L. Chiang. (2010) A Novel Bile Acid-Activated Vitamin D Receptor Signaling in Human Hepatocytes. Molecular Endocrinology 24:6, pages 1151-1164.
Crossref
Crossref