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Expert Opinion on Drug Metabolism & Toxicology Volume 5, 2009 - Issue 4
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Drug Evaluations

Biochemical properties, pharmacokinetics and pharmacological response of tiotropium in chronic obstructive pulmonary disease patients

David Price General Practice Airways Group Professor of Primary Care Respiratory Medicine University of Aberdeen, Foresterhill Health Centre, Department of General Practice and Primary Care, Westburn Road, Aberdeen AB25 2AY, UK +44 1224 554588; +44 1224 550683; [email protected]
, FRCGP,
Ashish Sharma Clinical Pharmacokineticist Boehringer Ingelheim Pharma GmbH & Co. KG, Department of Drug Metabolism and Pharmacokinetics, Biberach, Germany
, PhD &
Frank Cerasoli Senior Director, NY and Adjunct Professor of Medicine Mount Sinai School of Medicine, Allergy and Respiratory, Global Medical Department, Department of Pulmonary and Critical Care Medicine, Pfizer Inc, New York, USA
, PhD
Pages 417-424 | Published online: 17 Mar 2009

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Maria Gabriella Matera, Barbara Rinaldi, Clive Page, Paola Rogliani & Mario Cazzola. (2018) Pharmacokinetic considerations concerning the use of bronchodilators in the treatment of chronic obstructive pulmonary disease. Expert Opinion on Drug Metabolism & Toxicology 14:10, pages 1101-1111.
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Nicola A Hanania, Suzanne C. Lareau & Barbara P. Yawn. (2017) Safety of inhaled long-acting anti-muscarinic agents in COPD. Postgraduate Medicine 129:5, pages 500-512.
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Articles from other publishers (18)

Tianjing Ren, Xu Zhu, Natalie M. Jusko, Wojciech Krzyzanski & William J. Jusko. (2022) Pharmacodynamic model of slow reversible binding and its applications in pharmacokinetic/pharmacodynamic modeling: review and tutorial. Journal of Pharmacokinetics and Pharmacodynamics 49:5, pages 493-510.
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Sandra Anderson, Paul Atkins, Per Bäckman, David Cipolla, Andrew Clark, Evangelia Daviskas, Bernd Disse, Plamena Entcheva-Dimitrov, Rick Fuller, Igor Gonda, Hans Lundbäck, Bo Olsson & Jeffry Weers. (2022) Inhaled Medicines: Past, Present, and Future. Pharmacological Reviews 74:1, pages 48-118.
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Dave Singh, Arjun Ravi, Katie Kane, Tess Schmalbach & David L. Hava. (2018) The pharmacokinetics, pharmacodynamics and tolerability of PUR0200, a novel tiotropium formulation, in chronic obstructive pulmonary disease. British Journal of Clinical Pharmacology 84:9, pages 2097-2105.
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David M. Halpin, Alan G. Kaplan & Richard K. Russell. (2017) Why choose tiotropium for my patient? A comprehensive review of actions and outcomes versus other bronchodilators. Respiratory Medicine 128, pages 28-41.
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Jaime Algorta. (2017) Response to Sharma et al.: Long Pulmonary Residence Time and Plasma Half-Life of Tiotropium: Implications for Pharmacokinetic Bioequivalence Studies. Clinical Drug Investigation 37:7, pages 709-710.
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Ashish Sharma, Benjamin Weber & Bernd Meibohm. (2017) Long Pulmonary Residence Time and Plasma Half-Life of Tiotropium: Implications for Pharmacokinetic Bioequivalence Studies. Clinical Drug Investigation 37:7, pages 705-707.
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Jaime Algorta, Laura Andrade, Marta Medina, Valentin Kirkov, Sacha Arsova, Fumin Li & Jingduan Chi. (2016) Pharmacokinetic Bioequivalence of Two Inhaled Tiotropium Bromide Formulations in Healthy Volunteers. Clinical Drug Investigation 36:9, pages 753-762.
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Ashish Sharma, Benjamin Weber, Martina Wein, Christoph Hallmann & Bernd Meibohm. (2016) Essential criteria for pharmacokinetic studies supporting bioequivalence of inhaled tiotropium bromide products. Clinical Pharmacology in Drug Development 5:1, pages 52-56.
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Stephen T. Horhota, Jan A. van Noord, Cynthia B. Verkleij, Loek J. Bour, Ashish Sharma, Michael Trunk & Piet J. G. Cornelissen. (2015) In Vitro, Pharmacokinetic, Pharmacodynamic, and Safety Comparisons of Single and Combined Administration of Tiotropium and Salmeterol in COPD Patients Using Different Dry Powder Inhalers. The AAPS Journal 17:4, pages 871-880.
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Felix Schiele, Pelin Ayaz & Anke Müller‐Fahrnow. 2015. Thermodynamics and Kinetics of Drug Binding. Thermodynamics and Kinetics of Drug Binding 237 256 .
Michael W. KonstanAshish SharmaPetra Moroni-ZentgrafFei WangPaul Koker. (2015) Safety, Tolerability, and Plasma Exposure of Tiotropium Respimat ® in Children and Adults with Cystic Fibrosis . Journal of Aerosol Medicine and Pulmonary Drug Delivery 28:2, pages 137-144.
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Ashish Sharma, David E. Geller, Petra Moroni-Zentgraf, Sabine Kattenbeck, Marion Schmid, Katja Boland, Barbara Rapp, Michael W. Konstan, Felix Ratjen, J. Stuart Elborn & Paul Koker. (2014) Pooled analysis of tiotropium Respimat? pharmacokinetics in cystic fibrosis. Pulmonary Pharmacology & Therapeutics 29:2, pages 217-223.
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J.M. Hohlfeld, A. Sharma, J.A. van Noord, P.J.G. Cornelissen, E. Derom, L. Towse, V. Peterkin & B. Disse. (2013) Pharmacokinetics and pharmacodynamics of tiotropium solution and tiotropium powder in chronic obstructive pulmonary disease. The Journal of Clinical Pharmacology 54:4, pages 405-414.
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Göran Dahl & Tomas Akerud. (2013) Pharmacokinetics and the drug–target residence time concept. Drug Discovery Today 18:15-16, pages 697-707.
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Amit S. Kalgutkar, Deepak Dalvie, R. Scott Obach & Dennis A. Smith. 2012. Reactive Drug Metabolites. Reactive Drug Metabolites 269 312 .
Michael L. Schulte & Craig W. Lindsley. 2012. Bioactive Heterocyclic Compound Classes. Bioactive Heterocyclic Compound Classes 21 36 .
Antonia F. Stepan, Daniel P. Walker, Jonathan Bauman, David A. Price, Thomas A. Baillie, Amit S. Kalgutkar & Michael D. Aleo. (2011) Structural Alert/Reactive Metabolite Concept as Applied in Medicinal Chemistry to Mitigate the Risk of Idiosyncratic Drug Toxicity: A Perspective Based on the Critical Examination of Trends in the Top 200 Drugs Marketed in the United States. Chemical Research in Toxicology 24:9, pages 1345-1410.
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Bart C Moulton & Allison D Fryer. (2011) Muscarinic receptor antagonists, from folklore to pharmacology; finding drugs that actually work in asthma and COPD. British Journal of Pharmacology 163:1, pages 44-52.
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