488
Views
32
CrossRef citations to date
0
Altmetric
Reviews

Interactions between human cytochrome P450 enzymes and steroids: physiological and pharmacological implications

&
Pages 621-629 | Published online: 28 May 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Jui-Tai Chen, Li Wei, Ta-Liang Chen, Chun-Jen Huang & Ruei-Ming Chen. (2018) Regulation of cytochrome P450 gene expression by ketamine: a review. Expert Opinion on Drug Metabolism & Toxicology 14:7, pages 709-720.
Read now
Jing Ning, Jie Hou, Ping Wang, Jing-Jing Wu, Zi-Ru Dai, Li-Wei Zou, Wei Li, Guang-Bo Ge, Xiao-Chi Ma & Ling Yang. (2015) Interspecies variation in phase I metabolism of bufalin in hepatic microsomes from mouse, rat, dog, minipig, monkey, and human. Xenobiotica 45:11, pages 954-960.
Read now
Jui-Tai Chen & Ruei-Ming Chen. (2010) Mechanisms of ketamine-involved regulation of cytochrome P450 gene expression. Expert Opinion on Drug Metabolism & Toxicology 6:3, pages 273-281.
Read now
Y.-F. Cao, Y.-Y. Zhang, J. Li, G.-B. Ge, D. Hu, H.-X. Liu, T. Huang, Y.-C. Wang, Z.-Z. Fang, D.-X. Sun, H. Huo, J. Yin & L. Yang. (2010) CYP3A catalyses schizandrin biotransformation in human, minipig and rat liver microsomes. Xenobiotica 40:1, pages 38-47.
Read now

Articles from other publishers (28)

Geumbit Hwang, Hyejin Seo & Joo-Cheol Park. (2023) Copine7 deficiency leads to hepatic fat accumulation via mitochondrial dysfunction. Heliyon 9:11, pages e21676.
Crossref
Tuan Xu, Md Kabir, Srilatha Sakamuru, Pranav Shah, Elias C. Padilha, Deborah K. Ngan, Menghang Xia, Xin Xu, Anton Simeonov & Ruili Huang. (2023) Predictive Models for Human Cytochrome P450 3A7 Selective Inhibitors and Substrates. Journal of Chemical Information and Modeling 63:3, pages 846-855.
Crossref
Mohamad Jemain Mohamad Ridhwan, Syahrul Imran Abu Bakar, Normala Abd Latip, Nurunajah Ab Ghani & Nor Hadiani Ismail. (2022) A Comprehensive Analysis of Human CYP3A4 Crystal Structures as a Potential Tool for Molecular Docking-Based Site of Metabolism and Enzyme Inhibition Studies. Journal of Computational Biophysics and Chemistry 21:03, pages 259-285.
Crossref
Prangtip Uthaiwat, Aroonsri Priprem, Sirinart Chio-Srichan, Chatri Settasatian, Yao-Chang Lee, Pramote Mahakunakorn, Patcharee Boonsiri, Chanvit Leelayuwat, Patcharaporn Tippayawat, Ploenthip Puthongking & Jureerut Daduang. (2021) Oral Administration of Melatonin or Succinyl Melatonin Niosome Gel Benefits 5-FU-Induced Small Intestinal Mucositis Treatment in Mice. AAPS PharmSciTech 22:5.
Crossref
Fabian Wolpert & Patrick Roth. 2020. Central Nervous System Metastases. Central Nervous System Metastases 127 137 .
Fatima Al-Khelaifi, Ilhame Diboun, Francesco Donati, Francesco Botrè, David Abraham, Aroon Hingorani, Omar Albagha, Costas Georgakopoulos, Karsten Suhre, Noha A. Yousri & Mohamed A. Elrayess. (2019) Metabolic GWAS of elite athletes reveals novel genetically-influenced metabolites associated with athletic performance. Scientific Reports 9:1.
Crossref
Julie Ducharme, Vanja Polic & Karine Auclair. (2019) A Covalently Attached Progesterone Molecule Outcompetes the Binding of Free Progesterone at an Allosteric Site of Cytochrome P450 3A4. Bioconjugate Chemistry 30:6, pages 1629-1635.
Crossref
Bagavathy Shanmugam Karthikeyan, Suvaiyarasan Suvaithenamudhan, Mohammad Abdulkader Akbarsha & Subbiah Parthasarathy. (2017) Analysis of Species-Selectivity of Human, Mouse and Rat Cytochrome P450 1A and 2B Subfamily Enzymes using Molecular Modeling, Docking and Dynamics Simulations. Cell Biochemistry and Biophysics 76:1-2, pages 91-110.
Crossref
Nikhat Saba & Alpana Seal. (2018) Identification of a less toxic vinca alkaloid derivative for use as a chemotherapeutic agent, based on in silico structural insights and metabolic interactions with CYP3A4 and CYP3A5. Journal of Molecular Modeling 24:4.
Crossref
Freddyson J. Martínez-Rivera, Juliana Pérez-Laspiur, María E. Santiago-Gascot, Abner G. Alemán-Reyes, Emanuel García-Santiago, Yolanda Rodríguez-Pérez, Cristhian Calo-Guadalupe, Inelia Otero-Pagán, Roxsana N. Ayala-Pagán, Magdiel Martínez, Yisel M. Cantres-Rosario, Loyda M. Meléndez & Jennifer L. Barreto-Estrada. (2017) Differential protein expression profile in the hypothalamic GT1-7 cell line after exposure to anabolic androgenic steroids. PLOS ONE 12:7, pages e0180409.
Crossref
Jing-Jing Wu, Yun-Feng Cao, Liang Feng, Yu-Qi He, James Y. Hong, Tong-Yi Dou, Ping Wang, Da-Cheng Hao, Guang-Bo Ge & Ling Yang. (2017) A Naturally Occurring Isoform-Specific Probe for Highly Selective and Sensitive Detection of Human Cytochrome P450 3A5. Journal of Medicinal Chemistry 60:9, pages 3804-3813.
Crossref
Kimberly C Tu, Li-Chun Cheng, Hanh TK Vu, Jeffrey J Lange, Sean A McKinney, Chris W Seidel & Alejandro Sánchez Alvarado. (2015) Egr-5 is a post-mitotic regulator of planarian epidermal differentiation. eLife 4.
Crossref
Yune-Fang Ueng, Chien-Chih Chen, Yu-Ling Huang, I-Jung Lee, Chul-Ho Yun, Yu-Hsuan Chen & Chiung-Chiao Huang. (2015) Effects of aqueous extract of Ruta graveolens and its ingredients on cytochrome P450, uridine diphosphate (UDP)-glucuronosyltransferase, and reduced nicotinamide adenine dinucleotide (phosphate) (NAD(P)H)-quinone oxidoreductase in mice. Journal of Food and Drug Analysis 23:3, pages 516-528.
Crossref
Markus Storvik, Pasi Huuskonen, Petri Pehkonen & Markku Pasanen. (2014) The unique characteristics of the placental transcriptome and the hormonal metabolism enzymes in placenta. Reproductive Toxicology 47, pages 9-14.
Crossref
William J. Trickler, Xiaoqing Guo, Elvis Cuevas, Syed F. Ali, Merle G. Paule & Jyotshna Kanungo. (2014) Ketamine attenuates cytochrome p450 aromatase gene expression and estradiol-17β levels in zebrafish early life stages. Journal of Applied Toxicology 34:5, pages 480-488.
Crossref
Mercè Canta, David Font, Laura Gómez, Xavi Ribas & Miquel Costas. (2014) The Iron(II) Complex [Fe(CF 3 SO 3 ) 2 (mcp)] as a Convenient, Readily Available Catalyst for the Selective Oxidation of Methylenic Sites in Alkanes . Advanced Synthesis & Catalysis 356:4, pages 818-830.
Crossref
Ju-Yeon Moon, Myeong Hee Moon, Ki Tae Kim, Dae Hoon Jeong, Young Nam Kim, Bong Chul Chung & Man Ho Choi. (2014) Cytochrome P450-mediated metabolic alterations in preeclampsia evaluated by quantitative steroid signatures. The Journal of Steroid Biochemistry and Molecular Biology 139, pages 182-191.
Crossref
Lazaros Mavridis & John BO Mitchell. (2013) Predicting the protein targets for athletic performance-enhancing substances. Journal of Cheminformatics 5:1.
Crossref
Slavko Komarnytsky, Debora Esposito, Alexander Poulev & Ilya Raskin. (2013) Pregnane glycosides interfere with steroidogenic enzymes to down-regulate corticosteroid production in human adrenocortical H295R cells. Journal of Cellular Physiology 228:5, pages 1120-1126.
Crossref
Zengxiang Pan, Jinbi Zhang, Fei Lin, Xueshan Ma, Xuguang Wang & Honglin Liu. (2012) Expression profiles of key candidate genes involved in steroidogenesis during follicular atresia in the pig ovary. Molecular Biology Reports 39:12, pages 10823-10832.
Crossref
David W. Piotrowski. (2012) Mineralocorticoid Receptor Antagonists for the Treatment of Hypertension and Diabetic Nephropathy. Journal of Medicinal Chemistry 55:18, pages 7957-7966.
Crossref
Jessica A. Morgan, Satish B. Cheepala, Yao Wang, Geoff Neale, Masashi Adachi, Deepa Nachagari, Mark Leggas, Wenchen Zhao, Kelli Boyd, Raman Venkataramanan & John D. Schuetz. (2012) Deregulated Hepatic Metabolism Exacerbates Impaired Testosterone Production in Mrp4-deficient Mice. Journal of Biological Chemistry 287:18, pages 14456-14466.
Crossref
Hamed I. Ali, Morio Yamada, Yukihisa Fujita, Mitsuko Maeda & Eiichi Akaho. (2011) Studies on 16 -Hydroxylation of Steroid Molecules and Regioselective Binding Mode in Homology-Modeled Cytochrome P450-2C11 . International Journal of Medicinal Chemistry 2011, pages 1-11.
Crossref
Sigmund Brabrand, Sophie D. Fosså, Milada Cvancarova & Gustav Lehne. (2011) Androgen substitution with testosterone undecanoate in survivors of bilateral testicular cancer requires individually-adjusted injection intervals. BJU International 107:7, pages 1080-1087.
Crossref
Ami Oguro, Koichi Sakamoto, Yoshihiko Funae & Susumu Imaoka. (2011) Overexpression of CYP3A4, but not of CYP2D6, Promotes Hypoxic Response and Cell Growth of Hep3B Cells. Drug Metabolism and Pharmacokinetics 26:4, pages 407-415.
Crossref
Gareth J. VealChristine M. HartfordClinton F. Stewart. (2010) Clinical Pharmacology in the Adolescent Oncology Patient. Journal of Clinical Oncology 28:32, pages 4790-4799.
Crossref
Sandrine Meylan, Claudy Haussy & Yann Voituron. (2010) Physiological actions of corticosterone and its modulation by an immune challenge in reptiles. General and Comparative Endocrinology 169:2, pages 158-166.
Crossref
Dong‐Xue Sun, Zhong‐Ze Fang, Yan‐Yan Zhang, Yun‐Feng Cao, Ling Yang & Jun Yin. (2010) Inhibitory effects of curcumenol on human liver cytochrome P450 enzymes. Phytotherapy Research 24:8, pages 1213-1216.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.