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Transport of drugs by proton-coupled peptide transporters: pearls and pitfalls

Pages 887-905 | Published online: 12 Jun 2009

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Shiyu Peng, Hongdong Song, Yaqiong Chen, Sen Li & Xiao Guan. (2022) Oral Delivery of Food-derived Bioactive Peptides: Challenges and Strategies. Food Reviews International 0:0, pages 1-29.
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Xiaoyun Bai, Trevor F. Moraes & Reinhart A. F. Reithmeier. (2017) Structural biology of solute carrier (SLC) membrane transport proteins. Molecular Membrane Biology 34:1-2, pages 1-32.
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Ursula Gundert-Remy, Ulrike Bernauer, Brunhilde Blömeke, Barbara Döring, Eric Fabian, Carsten Goebel, Stefanie Hessel, Christine Jäckh, Alfonso Lampen, Franz Oesch, Ernst Petzinger, Wolfgang Völkel & Peter H. Roos. (2014) Extrahepatic metabolism at the body's internal–external interfaces. Drug Metabolism Reviews 46:3, pages 291-324.
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Barbara Döring & Ernst Petzinger. (2014) Phase 0 and phase III transport in various organs: Combined concept of phases in xenobiotic transport and metabolism. Drug Metabolism Reviews 46:3, pages 261-282.
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Mariana R. B. Batista, Anthony Watts & Antonio José Costa-Filho. (2019) Exploring Conformational Transitions and Free-Energy Profiles of Proton-Coupled Oligopeptide Transporters. Journal of Chemical Theory and Computation 15:11, pages 6433-6443.
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C. Meier, S. M. Camargo, S. Hunziker, U. Moehrlen, S. J. Gros, P. Bode, S. Leu, M. Meuli, S. Holland-Cunz, F. Verrey & R. N. Vuille-dit-Bille. (2018) Intestinal IMINO transporter SIT1 is not expressed in human newborns. American Journal of Physiology-Gastrointestinal and Liver Physiology 315:5, pages G887-G895.
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Paul W. Smith, Fabio ZuccottoRobert H. Bates, Maria Santos Martinez-Martinez, Kevin D. Read, Caroline PeetOla Epemolu. (2018) Pharmacokinetics of β-Lactam Antibiotics: Clues from the Past To Help Discover Long-Acting Oral Drugs in the Future. ACS Infectious Diseases 4:10, pages 1439-1447.
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Anne M. Dolberg & Stephan Reichl. (2018) Expression analysis of human solute carrier (SLC) family transporters in nasal mucosa and RPMI 2650 cells. European Journal of Pharmaceutical Sciences 123, pages 277-294.
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Giulia Boscutti, Chiara Nardon, Luciano Marchiò, Marco Crisma, Barbara Biondi, Daniele Dalzoppo, Lisa Dalla Via, Fernando Formaggio, Angela Casini & Dolores Fregona. (2018) Anticancer Gold(III) Peptidomimetics: From Synthesis to in vitro and ex vivo Biological Evaluations. ChemMedChem 13:11, pages 1131-1145.
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Britta Spanier & Florian Rohm. 2011. Comprehensive Physiology. Comprehensive Physiology 843 869 .
Alessia Griglio, Enza Torre, Marta Serafini, Alice Bianchi, Roberta Schmid, Giulia Coda Zabetta, Alberto Massarotti, Giovanni Sorba, Tracey Pirali & Silvia Fallarini. (2018) A multicomponent approach in the discovery of indoleamine 2,3-dioxygenase 1 inhibitors: Synthesis, biological investigation and docking studies. Bioorganic & Medicinal Chemistry Letters 28:4, pages 651-657.
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Bei Yang & David E. Smith. (2017) In Silico Absorption Analysis of Valacyclovir in Wildtype and Pept1 Knockout Mice Following Oral Dose Escalation. Pharmaceutical Research 34:11, pages 2349-2361.
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Susanne Johansson, David P. Rosenbaum, Johan Palm, Bergur Stefansson, Mikael Knutsson, Eleanor A. Lisbon & Constanze Hilgendorf. (2017) Tenapanor administration and the activity of the H + -coupled transporter PepT1 in healthy volunteers . British Journal of Clinical Pharmacology 83:9, pages 2008-2014.
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Ayman F. El‐Kattan. 2017. Oral Bioavailability Assessment. Oral Bioavailability Assessment 269 307 .
Michele Azzolini, Andrea Mattarei, Martina La Spina, Michele Fanin, Giacomo Chiodarelli, Matteo Romio, Mario Zoratti, Cristina Paradisi & Lucia Biasutto. (2017) New natural amino acid-bearing prodrugs boost pterostilbene’s oral pharmacokinetic and distribution profile. European Journal of Pharmaceutics and Biopharmaceutics 115, pages 149-158.
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Xiaomei Chen, Richard F. Keep, Yan Liang, Hao-Jie Zhu, Margareta Hammarlund-Udenaes, Yongjun Hu & David E. Smith. (2017) Influence of peptide transporter 2 (PEPT2) on the distribution of cefadroxil in mouse brain: A microdialysis study. Biochemical Pharmacology 131, pages 89-97.
Crossref
Tiziano Verri, Amilcare Barca, Paola Pisani, Barbara Piccinni, Carlo Storelli & Alessandro Romano. (2016) Di- and tripeptide transport in vertebrates: the contribution of teleost fish models. Journal of Comparative Physiology B 187:3, pages 395-462.
Crossref
Esben M. Quistgaard, Maria Martinez Molledo & Christian Löw. (2017) Structure determination of a major facilitator peptide transporter: Inward facing PepTSt from Streptococcus thermophilus crystallized in space group P3121. PLOS ONE 12:3, pages e0173126.
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Kenji Kitamura, Eldaa Zefany Banami Kinsui & Fumiyoshi Abe. (2017) Critical role of the proton-dependent oligopeptide transporter (POT) in the cellular uptake of the peptidyl nucleoside antibiotic, blasticidin S. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1864:2, pages 393-398.
Crossref
Souzan B. Yanni. 2015. Translational ADMET for Drug Therapy. Translational ADMET for Drug Therapy 1 36 .
Jian-Xiang Yang, Cai-Hong Wang, Qing-Biao Xu, Feng-Qi Zhao, Jian-Xin Liu & Hong-Yun Liu. (2015) Methionyl-Methionine Promotes α-s1 Casein Synthesis in Bovine Mammary Gland Explants by Enhancing Intracellular Substrate Availability and Activating JAK2-STAT5 and mTOR-Mediated Signaling Pathways. The Journal of Nutrition 145:8, pages 1748-1753.
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Jamshed Warsi, Zohreh Hosseinzadeh, Bernat Elvira, Lisann Pelzl, Ekaterina Shumilina, Dong-Er Zhang, Karl S. Lang, Philipp A. Lang & Florian Lang. (2015) USP18 Sensitivity of Peptide Transporters PEPT1 and PEPT2. PLOS ONE 10:6, pages e0129365.
Crossref
Keith K. Burkhart, Darrell Abernethy & David Jackson. (2015) Data Mining FAERS to Analyze Molecular Targets of Drugs Highly Associated with Stevens-Johnson Syndrome. Journal of Medical Toxicology 11:2, pages 265-273.
Crossref
Raphael N. Vuille-dit-Bille, Simone M. Camargo, Luca Emmenegger, Tom Sasse, Eva Kummer, Julia Jando, Qeumars M. Hamie, Chantal F. Meier, Schirin Hunziker, Zsofia Forras-Kaufmann, Sena Kuyumcu, Mark Fox, Werner Schwizer, Michael Fried, Maja Lindenmeyer, Oliver Götze & François Verrey. (2014) Human intestine luminal ACE2 and amino acid transporter expression increased by ACE-inhibitors. Amino Acids 47:4, pages 693-705.
Crossref
Simon Newstead. (2015) Molecular insights into proton coupled peptide transport in the PTR family of oligopeptide transporters. Biochimica et Biophysica Acta (BBA) - General Subjects 1850:3, pages 488-499.
Crossref
Philip W. Fowler, Marcella Orwick-Rydmark, Sebastian Radestock, Nicolae Solcan, Patricia M. Dijkman, Joseph A. Lyons, Jane Kwok, Martin Caffrey, Anthony Watts, Lucy R. Forrest & Simon Newstead. (2015) Gating Topology of the Proton-Coupled Oligopeptide Symporters. Structure 23:2, pages 290-301.
Crossref
Anita Emmerstorfer, Tamara Wriessnegger, Melanie Hirz & Harald Pichler. (2014) Overexpression of membrane proteins from higher eukaryotes in yeasts. Applied Microbiology and Biotechnology 98:18, pages 7671-7698.
Crossref
Stephen M. Carl, Dea Herrera‐Ruiz, Rajinder K. Bhardwaj, Olafur Gudmundsson & Gregory T. Knipp. 2014. Drug Transporters. Drug Transporters 67 90 .
Fatma Guettou, Esben M Quistgaard, Michael Raba, Per Moberg, Christian Löw & Pär Nordlund. (2014) Selectivity mechanism of a bacterial homolog of the human drug-peptide transporters PepT1 and PepT2. Nature Structural & Molecular Biology 21:8, pages 728-731.
Crossref
Marta Celegato, Dolores Fregona, Maurizio Mongiat, Luca Ronconi, Cinzia Borghese, Vincenzo Canzonieri, Naike Casagrande, Chiara Nardon, Alfonso Colombatti & Donatella Aldinucci. (2014) Preclinical activity of multiple-target gold(III)-dithiocarbamato peptidomimetics in prostate cancer cells and xenografts. Future Medicinal Chemistry 6:11, pages 1249-1263.
Crossref
Alessandro Romano, Amilcare Barca, Carlo Storelli & Tiziano Verri. (2014) Teleost fish models in membrane transport research: the PEPT1(SLC15A1) H + -oligopeptide transporter as a case study . The Journal of Physiology 592:5, pages 881-897.
Crossref
Chiara Nardon, Sara M. Schmitt, Huanjie Yang, Jian Zuo, Dolores Fregona & Q. Ping Dou. (2014) Gold(III)-Dithiocarbamato Peptidomimetics in the Forefront of the Targeted Anticancer Therapy: Preclinical Studies against Human Breast Neoplasia. PLoS ONE 9:1, pages e84248.
Crossref
Jamshed Warsi, Bernat Elvira, Rosi Bissinger, Ekaterina Shumilina, Zohreh Hosseinzadeh & Florian Lang. (2014) Downregulation of Peptide Transporters PEPT1 and PEPT2 by Oxidative Stress Responsive Kinase OSR1. Kidney and Blood Pressure Research 39:6, pages 591-599.
Crossref
Jamshed Warsi, Luo Dong, Bernat Elvira, Madhuri S. Salker, Ekaterina Shumilina, Zohreh Hosseinzadeh & Florian Lang. (2014) SPAK Dependent Regulation of Peptide Transporters PEPT1 and PEPT2. Kidney and Blood Pressure Research 39:4, pages 388-398.
Crossref
Simon Newstead. 2014. Membrane Transport Mechanism. Membrane Transport Mechanism 159 179 .
Ikumi Tamai & Takeo Nakanishi. (2013) OATP transporter-mediated drug absorption and interaction. Current Opinion in Pharmacology 13:6, pages 859-863.
Crossref
Matthias Brandsch. (2013) Drug transport via the intestinal peptide transporter PepT1. Current Opinion in Pharmacology 13:6, pages 881-887.
Crossref
Jamshed Warsi, Zohreh Hosseinzadeh, Luo Dong, Tatsiana Pakladok, Anja T. Umbach, Shefalee K. Bhavsar, Ekaterina Shumilina & Florian Lang. (2013) Effect of Janus Kinase 3 on the Peptide Transporters PEPT1 and PEPT2. The Journal of Membrane Biology 246:12, pages 885-892.
Crossref
Christian A. BippesLin GeMarcel Meury, Daniel Harder, Zöhre Ucurum, Hannelore Daniel, Dimitrios Fotiadis & Daniel J. Müller. (2013) Peptide transporter DtpA has two alternate conformations, one of which is promoted by inhibitor binding. Proceedings of the National Academy of Sciences 110:42.
Crossref
Fatma Guettou, Esben M Quistgaard, Lionel Trésaugues, Per Moberg, Caroline Jegerschöld, Lin Zhu, Agnes Jin Oi Jong, Pär Nordlund & Christian Löw. (2013) Structural insights into substrate recognition in proton‐dependent oligopeptide transporters. EMBO reports 14:9, pages 804-810.
Crossref
Rebecca Fransson, Christian Sköld, Jadel M. Kratz, Richard Svensson, Per Artursson, Fred Nyberg, Mathias Hallberg & Anja Sandström. (2013) Constrained H-Phe-Phe-NH 2 Analogues with High Affinity to the Substance P 1–7 Binding Site and with Improved Metabolic Stability and Cell Permeability . Journal of Medicinal Chemistry 56:12, pages 4953-4965.
Crossref
Valerie Voigt, Linda Laug, Katja Zebisch, Iris Thondorf, Fritz Markwardt & Matthias Brandsch. (2013) Transport of the areca nut alkaloid arecaidine by the human proton-coupled amino acid transporter 1 (hPAT1). Journal of Pharmacy and Pharmacology 65:4, pages 582-590.
Crossref
Kenta YoshidaKazuya MaedaYuichi Sugiyama. (2013) Hepatic and Intestinal Drug Transporters: Prediction of Pharmacokinetic Effects Caused by Drug-Drug Interactions and Genetic Polymorphisms. Annual Review of Pharmacology and Toxicology 53:1, pages 581-612.
Crossref
Bente Steffansen, Carsten Uhd Nielsen & Birger Brodin. 2013. Transporters in Drug Development. Transporters in Drug Development 1 22 .
Tamima Ashraf, Olena Kis, Nilasha Banerjee & Reina Bendayan. 2013. Biology and Regulation of Blood-Tissue Barriers. Biology and Regulation of Blood-Tissue Barriers 20 69 .
Morelle Negom Kouodom, Giulia Boscutti, Marta Celegato, Marco Crisma, Sergio Sitran, Donatella Aldinucci, Fernando Formaggio, Luca Ronconi & Dolores Fregona. (2012) Rational design of gold(III)-dithiocarbamato peptidomimetics for the targeted anticancer chemotherapy. Journal of Inorganic Biochemistry 117, pages 248-260.
Crossref
Nicolae Solcan, Jane Kwok, Philip W Fowler, Alexander D Cameron, David Drew, So Iwata & Simon Newstead. (2012) Alternating access mechanism in the POT family of oligopeptide transporters. The EMBO Journal 31:16, pages 3411-3421.
Crossref
Feng Cao, Jinghao Jia, Zhi Yin, Yahan Gao, Lei Sha, Yisheng Lai, Qineng Ping & Yihua Zhang. (2012) Ethylene Glycol-Linked Amino Acid Diester Prodrugs of Oleanolic Acid for PepT1-Mediated Transport: Synthesis, Intestinal Permeability and Pharmacokinetics. Molecular Pharmaceutics 9:8, pages 2127-2135.
Crossref
Agnès Poirier, Sara Belli, Christoph Funk, Michael B. Otteneder, Renée Portmann, Katja Heinig, Eric Prinssen, Stanley E. Lazic, Craig R. Rayner, Gerhard Hoffmann, Thomas Singer, David E. Smith & Franz Schuler. (2012) Role of the Intestinal Peptide Transporter PEPT1 in Oseltamivir Absorption: In Vitro and In Vivo Studies. Drug Metabolism and Disposition 40:8, pages 1556-1565.
Crossref
Morelle Negom Kouodom, Luca Ronconi, Marta Celegato, Chiara Nardon, Luciano Marchiò, Q. Ping Dou, Donatella Aldinucci, Fernando Formaggio & Dolores Fregona. (2012) Toward the Selective Delivery of Chemotherapeutics into Tumor Cells by Targeting Peptide Transporters: Tailored Gold-Based Anticancer Peptidomimetics. Journal of Medicinal Chemistry 55:5, pages 2212-2226.
Crossref
Kenji Kitamura, Mai Nakase, Hideki Tohda & Kaoru Takegawa. (2012) The Ubiquitin Ligase Ubr11 Is Essential for Oligopeptide Utilization in the Fission Yeast Schizosaccharomyces pombe. Eukaryotic Cell 11:3, pages 302-310.
Crossref
Alexander V. LyubimovFran Berlioz‐Seux. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 25 .
Vadivel Ganapathy. 2012. Physiology of the Gastrointestinal Tract. Physiology of the Gastrointestinal Tract 1595 1623 .
Jean-Pierre Gillet, Junbai WangAnna Maria Calcagno, Lisa J. Green, Sudhir Varma, Mari Bunkholt Elstrand, Claes G. Trope, Suresh V. Ambudkar, Ben Davidson & Michael M. Gottesman. (2011) Clinical Relevance of Multidrug Resistance Gene Expression in Ovarian Serous Carcinoma Effusions. Molecular Pharmaceutics 8:6, pages 2080-2088.
Crossref
David J. Lindley, Stephen M. Carl, Dea Herrera‐Ruiz, Li F. Pan, Lori B. Karpes, Jonathan M. E. Goole, Olafur S. Gudmundsson & Gregory T. Knipp. 2011. Oral Bioavailability. Oral Bioavailability 291 308 .
Alessandro Pedretti, Laura De Luca, Cristina Marconi, Luca Regazzoni, Giancarlo Aldini & Giulio Vistoli. (2011) Fragmental modeling of hPepT2 and analysis of its binding features by docking studies and pharmacophore mapping. Bioorganic & Medicinal Chemistry 19:15, pages 4544-4551.
Crossref
Michael Hellwig, Stefanie Geissler, René Matthes, Anett Peto, Christoph Silow, Matthias Brandsch & Thomas Henle. (2011) Transport of Free and Peptide-Bound Glycated Amino Acids: Synthesis, Transepithelial Flux at Caco-2 Cell Monolayers, and Interaction with Apical Membrane Transport Proteins. ChemBioChem 12:8, pages 1270-1279.
Crossref
Takehito Yamamoto, Hiroshi Suzuki & Akihiro Hisaka. 2011. Mass Spectrometry in Drug Metabolism and Disposition. Mass Spectrometry in Drug Metabolism and Disposition 197 228 .
Bruno Stieger & Peter J Meier. (2011) Pharmacogenetics of drug transporters in the enterohepatic circulation. Pharmacogenomics 12:5, pages 611-631.
Crossref
Stefanie Geissler, Michael Hellwig, Fritz Markwardt, Thomas Henle & Matthias Brandsch. (2011) Synthesis and intestinal transport of the iron chelator maltosine in free and dipeptide form. European Journal of Pharmaceutics and Biopharmaceutics 78:1, pages 75-82.
Crossref
Gøril Eide Flaten, Gabor Kottra, Wenche Stensen, Geir Isaksen, Rasmus Karstad, John S. Svendsen, Hannelore Daniel & Johan Svenson. (2011) In Vitro Characterization of Human Peptide Transporter hPEPT1 Interactions and Passive Permeation Studies of Short Cationic Antimicrobial Peptides. Journal of Medicinal Chemistry 54:7, pages 2422-2432.
Crossref
Werner Kramer. (2011) Transporters, Trojan horses and therapeutics: suitability of bile acid and peptide transporters for drug delivery. Biological Chemistry 392:1-2.
Crossref
Simon Newstead, David Drew, Alexander D Cameron, Vincent L G Postis, Xiaobing Xia, Philip W Fowler, Jean C Ingram, Elisabeth P Carpenter, Mark S P Sansom, Michael J McPherson, Stephen A Baldwin & So Iwata. (2011) Crystal structure of a prokaryotic homologue of the mammalian oligopeptide-proton symporters, PepT1 and PepT2. The EMBO Journal 30:2, pages 417-426.
Crossref
Catia Marzolini, Manuel Battegay & David Back. 2011. Drug Interactions in Infectious Diseases. Drug Interactions in Infectious Diseases 43 72 .
Catriona M. H. Anderson & David T. Thwaites. (2010) Hijacking Solute Carriers for Proton-Coupled Drug Transport. Physiology 25:6, pages 364-377.
Crossref
Tomoko Sugiura, Sayaka Kato, Takuya Shimizu, Tomohiko Wakayama, Noritaka Nakamichi, Yoshiyuki Kubo, Daisuke Iwata, Kazuhiro Suzuki, Tomoyoshi Soga, Masahide Asano, Shoichi Iseki, Ikumi Tamai, Akira Tsuji & Yukio Kato. (2010) Functional Expression of Carnitine/Organic Cation Transporter OCTN1/SLC22A4 in Mouse Small Intestine and Liver. Drug Metabolism and Disposition 38:10, pages 1665-1672.
Crossref
Diana Højmark Omkvist, Simon Birksø Larsen, Carsten Uhd Nielsen, Bente Steffansen, Lars Olsen, Flemming Steen Jørgensen & Birger Brodin. (2010) A Quantitative Structure–Activity Relationship for Translocation of Tripeptides via the Human Proton-Coupled Peptide Transporter, hPEPT1 (SLC15A1). The AAPS Journal 12:3, pages 385-396.
Crossref
Kiyohiko Sugano, Manfred Kansy, Per Artursson, Alex Avdeef, Stefanie Bendels, Li Di, Gerhard F. Ecker, Bernard Faller, Holger Fischer, Grégori Gerebtzoff, Hans Lennernaes & Frank Senner. (2010) Coexistence of passive and carrier-mediated processes in drug transport. Nature Reviews Drug Discovery 9:8, pages 597-614.
Crossref
Stefanie Geissler, Michael Hellwig, Madlen Zwarg, Fritz Markwardt, Thomas Henle & Matthias Brandsch. (2010) Transport of the Advanced Glycation End Products Alanylpyrraline and Pyrralylalanine by the Human Proton-Coupled Peptide Transporter hPEPT1. Journal of Agricultural and Food Chemistry 58:4, pages 2543-2547.
Crossref
Stefanie Geissler, Madlen Zwarg, Ilka Knütter, Fritz Markwardt & Matthias Brandsch. (2010) The bioactive dipeptide anserine is transported by human proton‐coupled peptide transporters. The FEBS Journal 277:3, pages 790-795.
Crossref
Reynold Spector. (2010) Nature and consequences of mammalian brain and CSF efflux transporters: four decades of progress. Journal of Neurochemistry 112:1, pages 13-23.
Crossref
Hui-Po Wang & Chun-Li Wang. (2009) Biological Transporters as Targets for New Drug Design. Journal of Experimental & Clinical Medicine 1:1, pages 31-38.
Crossref

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