Advanced search
Publication Cover
Expert Opinion on Drug Metabolism & Toxicology Volume 5, 2009 - Issue 11
Submit an article Journal homepage
212
Views
28
CrossRef citations to date
0
Altmetric
Reviews

The effect of oral lipids and circulating lipoproteins on the metabolism of drugs

Jigar P Patel Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, 3118 Dentistry/Pharmacy Centre, Edmonton, AB, T6G 2N8, Canada +001 780 492 2953; +001 780 492 1217; [email protected]
&
Dion R Brocks Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, 3118 Dentistry/Pharmacy Centre, Edmonton, AB, T6G 2N8, Canada +001 780 492 2953; +001 780 492 1217; [email protected]
, PhD (Professor)
Pages 1385-1398 | Published online: 10 Aug 2009

Citations (28)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (5)

Unji Lee, Mi Hye Kwon & Hee Eun Kang. (2019) Pharmacokinetic alterations in poloxamer 407-induced hyperlipidemic rats. Xenobiotica 49:5, pages 611-625.
Read now
Tewes Tralau & Andreas Luch. (2013) The evolution of our understanding of endo-xenobiotic crosstalk and cytochrome P450 regulation and the therapeutic implications. Expert Opinion on Drug Metabolism & Toxicology 9:12, pages 1541-1554.
Read now
Dion R Brocks, Mohamed Ben-Eltriki, Raniah Q Gabr & Raj S Padwal. (2012) The effects of gastric bypass surgery on drug absorption and pharmacokinetics. Expert Opinion on Drug Metabolism & Toxicology 8:12, pages 1505-1519.
Read now
Young Sun Lee, Ji Na Yoon, In-Soo Yoon, Myung Gull Lee & Hee Eun Kang. (2012) Pharmacokinetics of verapamil and its metabolite norverapamil in rats with hyperlipidaemia induced by poloxamer 407. Xenobiotica 42:8, pages 766-774.
Read now
Dalia A. Hamdy & Dion R. Brocks. (2011) The effect of increased lipoprotein levels on the pharmacokinetics of ketoconazole enantiomers in the rat. Xenobiotica 41:2, pages 137-143.
Read now

Articles from other publishers (23)

Raquel Fernández-Ginés, José Antonio Encinar, John D. Hayes, Baldo Oliva, Maria Isabel Rodríguez-Franco, Ana I. Rojo & Antonio Cuadrado. (2022) An inhibitor of interaction between the transcription factor NRF2 and the E3 ubiquitin ligase adapter β-TrCP delivers anti-inflammatory responses in mouse liver. Redox Biology 55, pages 102396.
Crossref
Muhammad Ahsan Khan, Kaleem Ullah, Nisar ur Rahman, Arshad Mahmood, Anette Müllertz, Abdul Mannan, Ghulam Murtaza & Shujaat Ali Khan. (2022) Formulation, characterization and in-vitro evaluation of self-nanoemulsifying drug delivery system containing rhamnolipid biosurfactant. Journal of Drug Delivery Science and Technology 75, pages 103673.
Crossref
Daniel A. DavisJr.Jr., Han-Hsuan Peng & Robert O. WilliamsIIIIII. 2022. Formulating Poorly Water Soluble Drugs. Formulating Poorly Water Soluble Drugs 253 285 .
Yousef A. Bin Jardan, Abdul Ahad, Mohammad Raish, Ajaz Ahmad, Mohd Aftab Alam, Abdullah M. Al-Mohizea & Fahad I. Al-Jenoobi. (2021) Assessment of glibenclamide pharmacokinetics in poloxamer 407-induced hyperlipidemic rats. Saudi Pharmaceutical Journal 29:7, pages 719-723.
Crossref
Harriet Bennett-Lenane, Joseph P. O'Shea, Caitriona M. O'Driscoll & Brendan T. Griffin. (2020) A Retrospective Biopharmaceutical Analysis of >800 Approved Oral Drug Products: Are Drug Properties of Solid Dispersions and Lipid-Based Formulations Distinctive?. Journal of Pharmaceutical Sciences 109:11, pages 3248-3261.
Crossref
Harshita, Md. Abul Barkat, Sabya S. Das, Faheem H. Pottoo, Sarwar Beg & Ziyaur Rahman. (2020) Lipid-Based Nanosystem As Intelligent Carriers for Versatile Drug Delivery Applications. Current Pharmaceutical Design 26:11, pages 1167-1180.
Crossref
Mirko Koziolek, Stefano Alcaro, Patrick Augustijns, Abdul W. Basit, Michael Grimm, Bart Hens, Caroline L. Hoad, Philipp Jedamzik, Christine M. Madla, Marc Maliepaard, Luca Marciani, Annalisa Maruca, Neil Parrott, Petr Pávek, Christopher J.H. Porter, Christos Reppas, Diana van Riet-Nales, Jari Rubbens, Marina Statelova, Natalie L. Trevaskis, Kateřina Valentová, Maria Vertzoni, Dubravka Vitali Čepo & Maura Corsetti. (2019) The mechanisms of pharmacokinetic food-drug interactions – A perspective from the UNGAP group. European Journal of Pharmaceutical Sciences 134, pages 31-59.
Crossref
Vojtech Novohradsky, Ilaria Zanellato, Cristina Marzano, Jitka Pracharova, Jana Kasparkova, Dan Gibson, Valentina Gandin, Domenico Osella & Viktor Brabec. (2017) Epigenetic and antitumor effects of platinum(IV)-octanoato conjugates. Scientific Reports 7:1.
Crossref
Ali Abdussalam, Osama H. Elshenawy, Yousef A. bin Jardan, Ayman O.S. El-Kadi & Dion R. Brocks. (2017) The Obesogenic Potency of Various High-Caloric Diet Compositions in Male Rats, and Their Effects on Expression of Liver and Kidney Proteins Involved in Drug Elimination. Journal of Pharmaceutical Sciences 106:6, pages 1650-1658.
Crossref
Raniah Q. GabrAhmed A. El-SherbeniMohamed Ben-EltrikiAyman O. El-KadiDion R. Brocks. (2017) Pharmacokinetics of metformin in the rat: assessment of the effect of hyperlipidemia and evidence for its metabolism to guanylurea. Canadian Journal of Physiology and Pharmacology 95:5, pages 530-538.
Crossref
Hadeel A. Khalil, Tarek S. Belal, Ahmed F. El-Yazbi & Dalia A. Hamdy. (2016) The effect of increased lipoproteins levels on the disposition of vincristine in rat. Lipids in Health and Disease 15:1.
Crossref
Orlagh M. Feeney, Matthew F. Crum, Claire L. McEvoy, Natalie L. Trevaskis, Hywel D. Williams, Colin W. Pouton, William N. Charman, Christel A.S. Bergström & Christopher J.H. Porter. (2016) 50 years of oral lipid-based formulations: Provenance, progress and future perspectives. Advanced Drug Delivery Reviews 101, pages 167-194.
Crossref
Thuy Tran, Xi Xi, Thomas Rades & Anette M?llertz. (2016) Formulation and characterization of self-nanoemulsifying drug delivery systems containing monoacyl phosphatidylcholine. International Journal of Pharmaceutics 502:1-2, pages 151-160.
Crossref
Justin LaFountaine, Ping Gao & Robert O. WilliamsIIIIII. 2016. Formulating Poorly Water Soluble Drugs. Formulating Poorly Water Soluble Drugs 295 327 .
Jean-Claude Bakala-N’Goma, Hywel D. Williams, Philip J. Sassene, Karen Kleberg, Marilyn Calderone, Vincent Jannin, Annabel Igonin, Anette Partheil, Delphine Marchaud, Eduardo Jule, Jan Vertommen, Mario Maio, Ross Blundell, Hassan Benameur, Anette Müllertz, Colin W. Pouton, Christopher J. H. Porter & Frédéric Carrière. (2014) Toward the Establishment of Standardized In Vitro Tests for Lipid-Based Formulations. 5. Lipolysis of Representative Formulations by Gastric Lipase. Pharmaceutical Research 32:4, pages 1279-1287.
Crossref
Hywel D. Williams, Philip Sassene, Karen Kleberg, Marilyn Calderone, Annabel Igonin, Eduardo Jule, Jan Vertommen, Ross Blundell, Hassan Benameur, Anette Müllertz, Colin W. Pouton & Christopher J. H. Porter. (2013) Toward the Establishment of Standardized In Vitro Tests for Lipid-Based Formulations, Part 3: Understanding Supersaturation Versus Precipitation Potential During the In Vitro Digestion of Type I, II, IIIA, IIIB and IV Lipid-Based Formulations. Pharmaceutical Research 30:12, pages 3059-3076.
Crossref
Hywel D. Williams, Natalie L. Trevaskis, Susan A. Charman, Ravi M. Shanker, William N. Charman, Colin W. Pouton & Christopher J. H. Porter. (2013) Strategies to Address Low Drug Solubility in Discovery and Development. Pharmacological Reviews 65:1, pages 315-499.
Crossref
Hywel D. Williams, Mette U. Anby, Philip Sassene, Karen Kleberg, Jean-Claude Bakala-N’Goma, Marilyn Calderone, Vincent Jannin, Annabel Igonin, Anette Partheil, Delphine Marchaud, Eduardo Jule, Jan Vertommen, Mario Maio, Ross Blundell, Hassan Benameur, Frédéric Carrière, Anette Müllertz, Colin W. Pouton & Christopher J. H. Porter. (2012) Toward the Establishment of Standardized in Vitro Tests for Lipid-Based Formulations. 2. The Effect of Bile Salt Concentration and Drug Loading on the Performance of Type I, II, IIIA, IIIB, and IV Formulations during in Vitro Digestion . Molecular Pharmaceutics 9:11, pages 3286-3300.
Crossref
Alexander V. LyubimovBill Gurley, Kim E. Fifer & Zöe Gardner. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 79 .
Edgar Acosta, Levente Diosady, A. Venketeshwer Rao, Dérick Rousseau & Christopher Yip. 2012. Lipids in Nanotechnology. Lipids in Nanotechnology 135 170 .
Franziska Kramer Birkved, Alicja Mortensen, José L. Peñalvo, Rikke H. Lindecrona & Ilona Kryspin Sørensen. (2011) Investigation into the cancer protective effect of flaxseed in Tg.NK (MMTV/c-neu) mice, a murine mammary tumor model. Genes & Nutrition 6:4, pages 403-411.
Crossref
Dalia A. Hamdy & Dion R. Brocks. (2011) Effect of hyperlipidemia on ketoconazole–midazolam drug–drug interaction in rat. Journal of Pharmaceutical Sciences 100:11, pages 4986-4992.
Crossref
Leonid (Leo) Kirkovsky & Anup Zutshi. 2011. ADMET for Medicinal Chemists. ADMET for Medicinal Chemists 201 285 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.