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Structure–activity relationships of the glucuronidation of flavonoids by human glucuronosyltransferases

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Pages 1399-1419 | Published online: 11 Aug 2009

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Petra Jančová, Michal Šiller, Eva Anzenbacherová, Vladimír Křen, Pavel Anzenbacher & Vilím Šimánek. (2011) Evidence for differences in regioselective and stereoselective glucuronidation of silybin diastereomers from milk thistle (Silybum marianum) by human UDP-glucuronosyltransferases. Xenobiotica 41:9, pages 743-751.
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Sophia Yui Kau Fong, Chenrui Li, Yiu Cheong Ho, Rui Li, Qian Wang, Yin Cheong Wong, Hong Xue & Zhong Zuo. (2017) Brain Uptake of Bioactive Flavones in Scutellariae Radix and Its Relationship to Anxiolytic Effect in Mice. Molecular Pharmaceutics 14:9, pages 2908-2916.
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Yu Cai, Sai Li, Ting Li, Ruina Zhou, Alfred Tai-Seng Wai & Ru Yan. (2016) Oral pharmacokinetics of baicalin, wogonoside, oroxylin A 7- O -β- d -glucuronide and their aglycones from an aqueous extract of Scutellariae Radix in the rat. Journal of Chromatography B 1026, pages 124-133.
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Jianbo Xiao, Tamar S. Muzashvili & Milen I. Georgiev. (2014) Advances in the biotechnological glycosylation of valuable flavonoids. Biotechnology Advances 32:6, pages 1145-1156.
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Jian-Qing Ruan & Ru Yan. (2014) Regioselective glucuronidation of the isoflavone calycosin by human liver microsomes and recombinant human UDP-glucuronosyltransferases. Chemico-Biological Interactions 220, pages 231-240.
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Sophia Yui Kau Fong, Yin Cheong Wong & Zhong Zuo. (2014) Development of a SPE-LC/MS/MS method for simultaneous quantification of baicalein, wogonin, oroxylin A and their glucuronides baicalin, wogonoside and oroxyloside in rats and its application to brain uptake and plasma pharmacokinetic studies. Journal of Pharmaceutical and Biomedical Analysis 97, pages 9-23.
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Jianbo Xiao, Tingting Chen & Hui Cao. (2014) WITHDRAWN: Flavonoid glycosylation and biological benefits. Biotechnology Advances.
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Ah-Ng KongWing Lam, Scott Bussom, Zaoli Jiang, Wei Zhang, Fulan Guan, Shwu-Huey Liu & Yung-Chi Cheng. 2013. Inflammation, Oxidative Stress, and Cancer. Inflammation, Oxidative Stress, and Cancer 549 562 .
Emily D. Niemeyer & Jennifer S. Brodbelt. (2013) Regiospecificity of Human UDP-glucuronosyltransferase Isoforms in Chalcone and Flavanone Glucuronidation Determined by Metal Complexation and Tandem Mass Spectrometry. Journal of Natural Products 76:6, pages 1121-1132.
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Scott A. Robotham & Jennifer S. Brodbelt. (2013) Identification of Flavone Glucuronide Isomers by Metal Complexation and Tandem Mass Spectrometry: Regioselectivity of Uridine 5′-Diphosphate–Glucuronosyltransferase Isozymes in the Biotransformation of Flavones. Journal of Agricultural and Food Chemistry 61:7, pages 1457-1463.
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Yin Cheong Wong & Zhong Zuo. (2012) Comment on Uridine Diphosphate Glucuronosyltransferase Isoform-Dependent Regiospecificity of Glucuronidation of Flavonoids: Applicability of UV Spectrum Shifts in Identification of Glucuronidation Position in Flavones and Flavonols. Journal of Agricultural and Food Chemistry 60:17, pages 4416-4419.
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J. Debora van der Merwe, Elizabeth Joubert, Marena Manley, Dalene de Beer, Christiaan J. Malherbe & Wentzel C.A. Gelderblom. (2012) Mangiferin glucuronidation: Important hepatic modulation of antioxidant activity. Food and Chemical Toxicology 50:3-4, pages 808-815.
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Wen Jiang & Ming Hu. (2012) Mutual interactions between flavonoids and enzymatic and transporter elements responsible for flavonoid disposition via phase II metabolic pathways. RSC Advances 2:21, pages 7948.
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Scott A. Robotham & Jennifer S. Brodbelt. (2011) Regioselectivity of human UDP-glucuronosyltransferase isozymes in flavonoid biotransformation by metal complexation and tandem mass spectrometry. Biochemical Pharmacology 82:11, pages 1764-1770.
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Baojian Wu, Kaustubh Kulkarni, Sumit Basu, Shuxing Zhang & Ming Hu. (2011) First-Pass Metabolism via UDP-Glucuronosyltransferase: a Barrier to Oral Bioavailability of Phenolics. Journal of Pharmaceutical Sciences 100:9, pages 3655-3681.
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Baojian Wu, Beibei Xu & Ming Hu. (2011) Regioselective Glucuronidation of Flavonols by Six Human UGT1A Isoforms. Pharmaceutical Research 28:8, pages 1905-1918.
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Jacques Yves Gauthier, Michel Belley, Denis Deschênes, Jean-François Fournier, Sébastien Gagné, Yves Gareau, Martine Hamel, Martin Hénault, Huda Hyjazie, Stacia Kargman, Geneviève Lavallée, Jean-François Levesque, Lianhai Li, Yaël Mamane, Joseph Mancini, Nicolas Morin, Erin Mulrooney, Joël Robichaud, Michel Thérien, Geoffrey Tranmer, Zhaoyin Wang, Jin Wu & W. Cameron Black. (2011) The identification of 4,7-disubstituted naphthoic acid derivatives as UDP-competitive antagonists of P2Y14. Bioorganic & Medicinal Chemistry Letters 21:10, pages 2836-2839.
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Baojian Wu, John Kenneth Morrow, Rashim Singh, Shuxing Zhang & Ming Hu. (2011) Three-Dimensional Quantitative Structure-Activity Relationship Studies on UGT1A9-Mediated 3-O-Glucuronidation of Natural Flavonols Using a Pharmacophore-Based Comparative Molecular Field Analysis Model. Journal of Pharmacology and Experimental Therapeutics 336:2, pages 403-413.
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