279
Views
31
CrossRef citations to date
0
Altmetric
Reviews

New cytochrome P450 mechanisms: implications for understanding molecular basis for drug toxicity at the level of the cytochrome

Pages 1-15 | Published online: 30 Nov 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

C.A. Carrasquer, K. Batey, S. Qamar, A.R. Cunningham & S.L. Cunningham. (2014) Structure–activity relationship models for rat carcinogenesis and assessing the role mutagens play in model predictivity. SAR and QSAR in Environmental Research 25:6, pages 489-506.
Read now
Tewes Tralau & Andreas Luch. (2013) The evolution of our understanding of endo-xenobiotic crosstalk and cytochrome P450 regulation and the therapeutic implications. Expert Opinion on Drug Metabolism & Toxicology 9:12, pages 1541-1554.
Read now
T. Ferrari, D. Cattaneo, G. Gini, N. Golbamaki Bakhtyari, A. Manganaro & E. Benfenati. (2013) Automatic knowledge extraction from chemical structures: the case of mutagenicity prediction. SAR and QSAR in Environmental Research 24:5, pages 365-383.
Read now
ROMUALDO BENIGNI, CECILIA BOSSA, ALESSANDRO GIULIANI & OLGA TCHEREMENSKAIA. (2010) Exploring In Vitro/In Vivo Correlation: Lessons Learned from Analyzing Phase I Results of the US EPA's ToxCast Project. Journal of Environmental Science and Health, Part C 28:4, pages 272-286.
Read now
Hailong Zhou, Huifeng Wu, Chunyang Liao, Xiaoping Diao, Jiping Zhen, Linlin Chen & Qinzhao Xue. (2010) Toxicology mechanism of the persistent organic pollutants (POPs) in fish through AhR pathway. Toxicology Mechanisms and Methods 20:6, pages 279-286.
Read now

Articles from other publishers (26)

Xinwei Wang, Haibo Wu, Ka Hong Wong, Yixuan Wang, Baixiong Chen & Kun Feng. (2023) Biotransformation of triterpenoid ganoderic acids from exogenous diterpene dihydrotanshinone I in the cultures of Ganoderma sessile. Microbial Cell Factories 22:1.
Crossref
Luca Soraci, Antonio Cherubini, Luca Paoletti, Gianfranco Filippelli, Filippo Luciani, Pasqualina Laganà, Maria Elsa Gambuzza, Elvira Filicetti, Andrea Corsonello & Fabrizia Lattanzio. (2023) Safety and Tolerability of Antimicrobial Agents in the Older Patient. Drugs & Aging 40:6, pages 499-526.
Crossref
Shuaiqi Meng, Yu Ji, LeiLei Zhu, Gaurao V. Dhoke, Mehdi D. Davari & Ulrich Schwaneberg. (2022) The molecular basis and enzyme engineering strategies for improvement of coupling efficiency in cytochrome P450s. Biotechnology Advances 61, pages 108051.
Crossref
Tugba Kevser UYSAL, Muhammet ÖRNEK & Özen ÖZENSOY GÜLER. (2022) Oksidatif stres paraoksonaz enzim ailesinin (PON) kanser üzerindeki etkisini arttırır mı? Pon ailesinin oksidatif stres ve kanser ilişkisinin incelenmesini amaçlayan bir derleme. Sakarya Medical Journal.
Crossref
Shuaiqi Meng, Yu Ji, Luo Liu, Mehdi D. Davari & Ulrich Schwaneberg. (2022) Modulating the Coupling Efficiency of P450 BM3 by Controlling Water Diffusion through Access Tunnel Engineering. ChemSusChem 15:9.
Crossref
Musaddique Hussain, Mobeen Fatima, Saira Shaukat, Muhammad Qasim Barkat, Taha Alqahtani, Ali M. Alqahtani, Liu Mei, Wei Shi & Ximei Wu. 2022. Biochemistry of Drug Metabolizing Enzymes. Biochemistry of Drug Metabolizing Enzymes 521 544 .
Bryan J. Mathis, Misa Kusumoto, Alexander Zaboronok & Yuji Hiramatsu. (2021) Packaging and Delivery of Asthma Therapeutics. Pharmaceutics 14:1, pages 92.
Crossref
Yibo Zhang, Da He, Fang Chang, Chenyuan Dang & Jie Fu. (2021) Combined Effects of Sulfamethoxazole and Erythromycin on a Freshwater Microalga, Raphidocelis subcapitata: Toxicity and Oxidative Stress. Antibiotics 10:5, pages 576.
Crossref
Javier Gómez-Tabales, Elena García-Martín, José A. G. Agúndez & Carlos Gutierrez-Merino. (2020) Modulation of CYP2C9 activity and hydrogen peroxide production by cytochrome b5. Scientific Reports 10:1.
Crossref
Amelie Tsoutsoulopoulos, Sabrina Brockmöller, Horst Thiermann & Dirk Steinritz. (2020) Comparison of the toxicity of sulfur mustard and its oxidation products in vitro. Toxicology Letters 321, pages 69-72.
Crossref
William C. Wright, Jude Chenge, Jingheng Wang, Hazel M. GirvanLei Yang, Sergio C. Chai, Andrew D. Huber, Jing Wu, Peter O. Oladimeji, Andrew W. Munro & Taosheng Chen. (2020) Clobetasol Propionate Is a Heme-Mediated Selective Inhibitor of Human Cytochrome P450 3A5. Journal of Medicinal Chemistry 63:3, pages 1415-1433.
Crossref
Xiaoting Lan, Wei Yuan, Meng Wang & Han Xiao. (2019) Efficient biosynthesis of antitumor ganoderic acid HLDOA using a dual tunable system for optimizing the expression of CYP5150L8 and a Ganoderma P450 reductase . Biotechnology and Bioengineering 116:12, pages 3301-3311.
Crossref
Mohamed Ben-Eltriki, Mohamed Hassona, Gray Meckling, Hans Adomat, Subrata Deb & Emma S. Tomlinson Guns. (2019) Pharmacokinetic interaction of calcitriol with 20(S)-protopanaxadiol in mice: Determined by LC/MS analysis. European Journal of Pharmaceutical Sciences 130, pages 173-180.
Crossref
Dominique Darimont, Martin J. Weissenborn, Bernd A. Nebel & Bernhard Hauer. (2018) Modulating proposed electron transfer pathways in P450BM3 led to improved activity and coupling efficiency. Bioelectrochemistry 119, pages 119-123.
Crossref
Roberta Bernini, Maurizio Barontini, Valentina Cis, Isabella Carastro, Daniela Tofani, Rosa Chiodo, Paolo Lupattelli & Sandra Incerpi. (2018) Synthesis and Evaluation of the Antioxidant Activity of Lipophilic Phenethyl Trifluoroacetate Esters by In Vitro ABTS, DPPH and in Cell-Culture DCF Assays. Molecules 23:1, pages 208.
Crossref
Iwona Kaluzna, Thomas Schmitges, Harrie Straatman, Dennis van Tegelen, Monika Müller, Martin Schürmann & Daniel Mink. (2016) Enabling Selective and Sustainable P450 Oxygenation Technology. Production of 4-Hydroxy-α-isophorone on Kilogram Scale. Organic Process Research & Development 20:4, pages 814-819.
Crossref
Avanthika Venkatachalam, Abhinav Parashar & Kelath Murali Manoj. (2016) Functioning of drug-metabolizing microsomal cytochrome P450s: In silico probing of proteins suggests that the distal heme ‘active site’ pocket plays a relatively ‘passive role’ in some enzyme-substrate interactions. In Silico Pharmacology 4:1.
Crossref
Arianna Silva-Trujillo, José Correa-Basurto, Aurelio Romero-Castro, Arnulfo Albores & Jessica Elena Mendieta-Wejebe. (2015) A simple validated RP-HPLC bioanalytical method for the quantitative determination of a novel valproic acid arylamide derivative in rat hepatic microsomes. Biomedical Chromatography 29:4, pages 523-528.
Crossref
A. Corsonello, A.M. Abbatecola, S. Fusco, F. Luciani, A. Marino, S. Catalano, M.G. Maggio & F. Lattanzio. (2015) The impact of drug interactions and polypharmacy on antimicrobial therapy in the elderly. Clinical Microbiology and Infection 21:1, pages 20-26.
Crossref
Maria S. Zharkova, Boris N. Sobolev, Nina Yu. Oparina, Alexander V. Veselovsky & Alexander I. Archakov. (2013) Prediction of amino acid residues participated in substrate recognition by cytochrome P450 subfamilies with broad substrate specificity. Journal of Molecular Recognition 26:2, pages 86-91.
Crossref
Byoung-Joon Song, Mohamed A. Abdelmegeed, Lauren E. Henderson, Seong-Ho Yoo, Jie Wan, Vishnudutt Purohit, James P. Hardwick & Kwan-Hoon Moon. (2013) Increased Nitroxidative Stress Promotes Mitochondrial Dysfunction in Alcoholic and Nonalcoholic Fatty Liver Disease. Oxidative Medicine and Cellular Longevity 2013, pages 1-14.
Crossref
Joep P.J. de Hoon, Jürgen Veeck, Birgit E.P.J. Vriens, Tim G.A. Calon, Manon van Engeland & Vivianne C.G. Tjan-Heijnen. (2012) Taxane resistance in breast cancer: A closed HER2 circuit?. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1825:2, pages 197-206.
Crossref
R. Benigni, C. Bossa, O. Tcheremenskaia, C. L. Battistelli & P. Crettaz. (2011) The new ISSMIC database on in vivo micronucleus and its role in assessing genotoxicity testing strategies. Mutagenesis 27:1, pages 87-92.
Crossref
Teresita Mazzei. (2011) The difficulties of Polytherapy: examples from antimicrobial chemotherapy. Internal and Emergency Medicine 6:S1, pages 103-109.
Crossref
R. Benigni & C. Bossa. (2011) Alternative strategies for carcinogenicity assessment: an efficient and simplified approach based on in vitro mutagenicity and cell transformation assays. Mutagenesis 26:3, pages 455-460.
Crossref
Sarah Adler, David Basketter, Stuart Creton, Olavi Pelkonen, Jan van Benthem, Valérie Zuang, Klaus Ejner Andersen, Alexandre Angers-Loustau, Aynur Aptula, Anna Bal-Price, Emilio Benfenati, Ulrike Bernauer, Jos Bessems, Frederic Y. Bois, Alan Boobis, Esther Brandon, Susanne Bremer, Thomas Broschard, Silvia Casati, Sandra Coecke, Raffaella Corvi, Mark Cronin, George Daston, Wolfgang Dekant, Susan Felter, Elise Grignard, Ursula Gundert-Remy, Tuula Heinonen, Ian Kimber, Jos Kleinjans, Hannu Komulainen, Reinhard Kreiling, Joachim Kreysa, Sofia Batista Leite, George Loizou, Gavin Maxwell, Paolo Mazzatorta, Sharon Munn, Stefan Pfuhler, Pascal Phrakonkham, Aldert Piersma, Albrecht Poth, Pilar Prieto, Guillermo Repetto, Vera Rogiers, Greet Schoeters, Michael Schwarz, Rositsa Serafimova, Hanna Tähti, Emanuela Testai, Joost van Delft, Henk van Loveren, Mathieu Vinken, Andrew Worth & José-Manuel Zaldivar. (2011) Alternative (non-animal) methods for cosmetics testing: current status and future prospects—2010. Archives of Toxicology 85:5, pages 367-485.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.