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Expert Opinion on Drug Metabolism & Toxicology Volume 6, 2010 - Issue 2
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Issues in drug metabolism of major antihypertensive drugs: β-blockers, calcium channel antagonists and angiotensin receptor blockers

Christian Höcht Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Cátedra de Farmacología, Junín 956, (C1113AAD) Buenos Aires, Argentina +54 11 4964 8265; +54 11 4508 3645; [email protected]; Universidad de Buenos Aires, Instituto de Fisiopatología y Bioquímica Clínica, Junín 956, (C1113AAD) Buenos Aires, Argentina
, PhD,
Facundo Martín Bertera Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Cátedra de Farmacología, Junín 956, (C1113AAD) Buenos Aires, Argentina +54 11 4964 8265; +54 11 4508 3645; [email protected]
,
Marcos Alejandro Mayer Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Cátedra de Farmacología, Junín 956, (C1113AAD) Buenos Aires, Argentina +54 11 4964 8265; +54 11 4508 3645; [email protected]; Universidad de Buenos Aires, Instituto de Fisiopatología y Bioquímica Clínica, Junín 956, (C1113AAD) Buenos Aires, Argentina
&
Carlos Alberto Taira Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Cátedra de Farmacología, Junín 956, (C1113AAD) Buenos Aires, Argentina +54 11 4964 8265; +54 11 4508 3645; [email protected]; Universidad de Buenos Aires, Instituto de Fisiopatología y Bioquímica Clínica, Junín 956, (C1113AAD) Buenos Aires, Argentina
Pages 199-211 | Published online: 22 Jan 2010

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Christian Höcht, Facundo Martín Bertera, Julieta Sofía Del Mauro & Carlos Alberto Taira. (2014) Models for evaluating the pharmacokinetics and pharmacodynamics for β-blockers. Expert Opinion on Drug Metabolism & Toxicology 10:4, pages 525-541.
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Sze Wa Chan, Miao Hu & Brian Tomlinson. (2012) The pharmacogenetics of β-adrenergic receptor antagonists in the treatment of hypertension and heart failure. Expert Opinion on Drug Metabolism & Toxicology 8:7, pages 767-790.
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Articles from other publishers (16)

Pallavi SwarupGopal Prasad Agrawal. (2021) Solid Dispersion: A Mechanistic and Realistic Approach on Antihypertensive Drug as a Drug Carrier System. ASSAY and Drug Development Technologies 19:5, pages 282-289.
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Ru-Qiang Yuan, Lei Qian, Wei-Jing Yun, Xiao-Hui Cui, Guang-Xin Lv, Wei-Qi Tang, Ri-Chang Cao & Hu Xu. (2019) Cucurbitacins extracted from Cucumis melo L. (CuEC) exert a hypotensive effect via regulating vascular tone. Hypertension Research 42:8, pages 1152-1161.
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Aisha N. Iskakova, Aliya A. Romanova, Akbota M. Aitkulova, Nurgul S. Sikhayeva, Elena V. Zholdybayeva & Erlan M. Ramanculov. (2016) Polymorphisms in genes involved in the absorption, distribution, metabolism, and excretion of drugs in the Kazakhs of Kazakhstan. BMC Genetics 17:1.
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Christian Höcht, Facundo Martín Bertera, Julieta Sofía Del Mauro, Luciano Parola & Carlos Alberto Taira. (2016) PK/PD modeling of β-blockers in cardiovascular disease: an update. International Journal of Pharmacokinetics 1:1, pages 55-68.
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P Patel, P K C Gupta, C M J White, A G Stanley, B Williams & M Tomaszewski. (2015) Screening for non-adherence to antihypertensive treatment as a part of the diagnostic pathway to renal denervation. Journal of Human Hypertension 30:6, pages 368-373.
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Giovanna Gentile, Lorenza Chiossi, Luana Lionetto, Paolo Martelletti & Marina Borro. (2014) Pharmacogenetic insights into migraine treatment in children. Pharmacogenomics 15:11, pages 1539-1550.
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Facundo Martín Bertera, Julieta Sofía Del Mauro, Valeria Lovera, Diego Chiappetta, Ariel Héctor Polizio, Carlos Alberto Taira & Christian Höcht. (2013) Enantioselective pharmacokinetics and cardiovascular effects of nebivolol in L-NAME hypertensive rats. Hypertension Research 37:3, pages 194-201.
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Branislav Štrauch, Ondřej Petrák, Tomáš Zelinka, Ján Rosa, Zuzana Šomlóová, Tomáš Indra, Lukáš Chytil, Věra Marešová, Ivana Kurcová, Robert Holaj, Dan Wichterle & Jiří Widimský. (2013) Precise assessment of noncompliance with the antihypertensive therapy in patients with resistant hypertension using toxicological serum analysis. Journal of Hypertension 31:12, pages 2455-2461.
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Facundo Martín Bertera, Julieta Sofía Del Mauro, Valeria Lovera, Diego Chiappetta, Ariel Héctor Polizio, Carlos Alberto Taira & Christian Höcht. (2013) Acute effects of third generation β-blockers on short-term and beat-to-beat blood pressure variability in sinoaortic-denervated rats. Hypertension Research 36:4, pages 349-355.
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Sze Wa Chan, Miao Hu, Sara Shun Wah Ko, Catherine Wing Yan Tam, Benny Siu Pong Fok, Ophelia Qi Ping Yin, Moses Sing Sum Chow & Brian Tomlinson. (2012) CYP2C19 genotype has a major influence on labetalol pharmacokinetics in healthy male Chinese subjects. European Journal of Clinical Pharmacology 69:4, pages 799-806.
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Facundo Martín Bertera, Julieta Sofía Del Mauro, Ariel Héctor Polizio, Diego Chiappetta, Carlos Alberto Taira & Christian Höcht. (2012) Effect of nebivolol on beat-to-beat and short-term blood pressure variability in spontaneously hypertensive rats. Naunyn-Schmiedeberg's Archives of Pharmacology 385:8, pages 833-843.
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Jennifer J. Kiser, James R. Burton, Peter L. Anderson & Gregory T. Everson. (2012) Review and management of drug interactions with boceprevir and telaprevir. Hepatology 55:5, pages 1620-1628.
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Facundo Martín Bertera, Julieta Sofía Del Mauro, Diego Chiappetta, Ariel Héctor Polizio, Fabián Buontempo, Carlos Alberto Taira & Christian Höcht. (2011) Enantioselective pharmacokinetic and pharmacodynamic properties of carvedilol in spontaneously hypertensive rats: focus on blood pressure variability. Naunyn-Schmiedeberg's Archives of Pharmacology 385:3, pages 325-335.
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Maamoun Basheer, Herzl Schwalb, Irit Shefler, Lilia Levdansky, Yoseph A. Mekori & Raphael Gorodetsky. (2011) Blood pressure modulation following activation of mast cells by cationic cell penetrating peptides. Peptides 32:12, pages 2444-2451.
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Henk Visscher, Ursula Amstutz, Johanna Sistonen, Colin J Ross, Michael R Hayden & Bruce C Carleton. (2011) Pharmacogenomics of Cardiovascular Drugs and Adverse Effects in Pediatrics. Journal of Cardiovascular Pharmacology 58:3, pages 228-239.
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Thomas N. Kakuda, Monika Schöller-Gyüre & Richard M.W. Hoetelmans. (2011) Pharmacokinetic Interactions between Etravirine and Non-Antiretroviral Drugs. Clinical Pharmacokinetics 50:1, pages 25-39.
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